375 resultados para resistências


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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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There is no vaccine available against leishmaniasis. Drug resistance, variable efficacy, toxicity, parenteral administration, and requirement for long courses of administration are the main drawbacks of current leishmanicidal drugs. Infections by protozoans of the genus Leishmania are the major worldwide health problem, with high endemicity in developing countries. The drugs of choice for the treatment of leishmaniasis are the pentavalent antimonials, which exert renal and cardiac toxicity, thus, there is a strong need for safer and more effective treatments against leishmaniasis.

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The central focus of this paper is to establish that the Brazilian Education Programa to prepare professionals in Technical-Agricultural Schools is suffering a kind of marginalization which comes from two distinct perspectives: the intention to prepare professionals (being a branch of Technical Education) and the relationship to the countryside (a community space historically seen as peripheral in its relation to urban culture). The paper discusses – from a historical and sociological point of view and using Oral History as methodological approach – the experiences of Math’s teachers in their daily struggles against some conceptions of other teachers (mainly those of technical areas) and against all the “regular” schooling system.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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This paper presents some results of the investigation on the Mathematical Education Centre (CEM), a group of mathematics teachers’ educators in São Paulo, Brazil, acting mainly between 1984 and 1997. The essay, marked by an effort to constitute the identity of the CEM based on Foucault, assumes that the identity constitution process is not about what CEM is or was, but mainly about a set of possibilities of apprehending it from its historically contextualized strategies and initiatives. In this Foucauldian reading, which brings about concepts such as "strategic device", "resistance" and "power relations", the CEM constitution appears while it creates conditions for the constitution of Brazilian modern mathematical education.

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Um conjunto de depoimentos coletados oralmente e de fontes escritas disponíveis no arquivo inativo de um antigo Grupo Escolar paulista é analisado em paralelo à literatura sobre o Movimento Escolanovista visando a compreender os modos como um ideário se impõe, no cotidiano das práticas escolares, num ritmo constante de avanços e resistências, alterações e manutenções. Ao mesmo tempo, defende-se que o Movimento Escolanovista – ou qualquer proposta educacional – não é um bloco maciço de significados fixos, mas uma leitura, uma mobilização, uma apropriação que, segundo os vários significados a ele atribuídos, implica a efetivação de algumas práticas no interior da escola.

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Saudada como consequência de um complexo processo de evolução do arcabouço jurídico-institucional brasileiro, a Lei Federal 12.527, denominada Lei de Acesso a Informações, sancionada em 18 de novembro de 2011 e regulamentada no âmbito do Poder Executivo federal pelo Decreto 7.724, de 16 de maio de 2012, atende o pressuposto do direito à informação fixado pela Constituição Federal de 1988. Valores e práticas historicamente construídos podem significar obstáculos e resistências importantes à sua aplicação. Características do próprio texto legal, que vêm à tona quando comparado aos seus congêneres internacionais, também sinalizam possíveis complicadores. Este artigo indica limites que a Lei de Acesso a Informações pode enfrentar à sua consolidação, originários principalmente do campo da cultura político-institucional, que se tornam mais nítidos com o exame de características brasileiras em comparação com outros países que possuem dispositivos semelhantes.

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The purpose of this essay is to reflect on the quality of the school and psychosocial aspects involved in the assimilation of educational innovations by teachers in their teaching practices.Innovations cause resistance which endanger the goals of improving education outcomes. This makes the possibilities of basic schooling fail, preventing contribute to the transformation of living conditions of the working classes.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

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Members of the genera Campylobacter and Helicobacter have been in the spotlight in recent decades because of their status as animals and/or humans pathogens, both confirmed and emerging, and because of their association with food-borne and zoonotic diseases. First observations of spiral shaped bacteria or Campylobacter-like organisms (CLO) date back to the end of the 19th century, however the lack of adequate isolation methods hampered further research. With the introduction of methods such as selective media and a filtration procedure during the 1970s led to a renewed interest in Campylobacter, especially as this enabled elucidation of their role in human hosts. On the other hand the classification and identification of these bacteria was troublesome, mainly because of the biochemical inertness and fastidious growth requirements. In 1991, the taxonomy of Campylobacter and related organisms was thoroughly revised, since this revision several new Campylobacter and Helicobacter species have been described. Moreover, thanks to the introduction of a polyphasic taxonomic practice, the classification of these novel species is well-founded. Indeed, a polyphasic approach was here followed for characterizing eight isolates obtained from rabbits epidemiologically not correlated and as a result a new Campylobacter species was proposed: Campylobacter cuniculorum (Chapter 1). Furthermore, there is a paucity of data regarding the occurrence of spiral shaped enteric flora in leporids. In order to define the prevalence both of this new species and other CLO in leporids (chapter 2), a total of 85 whole intestinal tracts of rabbits reared in 32 farms and 29 capture hares, epidemiologically not correlated, were collected just after evisceration at the slaughterhouse or during necroscopy. Examination and isolation methods were varied in order to increase the sensibility level of detection, and 100% of rabbit farms resulted positive for C. cuniculorum in high concentrations. Moreover, in 3.53% of the total rabbits examined, a Helicobacter species was detected. Nevertheless, all hares resulted negative both for Campylobacter or Helicobacter species. High prevalence of C. cuniculorum were found in rabbits, and in order to understand if this new species could play a pathological role, a study on some virulence determinants of C. cuniculorum was conducted (Chapter 3). Although this new species were able to adhere and invade, exert cytolethal distending toxin-like effects although at a low titre, a cdtB was not detected. There was no clear relationship between source of isolation or disease manifestation and possession of statistically significantly levels of particular virulence-associated factors although, cell adhesion and invasion occurred. Furthermore, antibiotic susceptibility was studied (chapter 4) in Campylobacter and in Escherichia coli strains, isolated from rabbits. It was possible to find acquired resistance of C. cuniculorum to enrofloxacin, ciprofloxacin and erytromycin. C. coli isolate was susceptible to all antimicrobial tested and moreover it is considered as a wild-type strain. Moreover, E. coli was found at low caecal concentration in rabbits and 30 phenotypes of antibiotic resistance were founded as well as the high rate of resistances to at least one antibiotic (98.1%). The majority of resistances were found from strains belonging to intensive farming system. In conclusion, in the course of the present study a new species isolated from rabbits was described, C. cuniculorum, and its high prevalence was established. Nevertheless, in hare samples no Campylobacter and Helicobacter species were detected. Some virulence determinants were further analyzed, however further studied are needed to understand the potential pathogenicity of this new species. On the other hand, antimicrobial susceptibility was monitored both in C. cuniculorum and indicator bacteria and acquired resistance was observed towards some antibiotics, indicating a possible role of rabbitries in the diffusion of antibiotic resistance. Further studies are necessary to describe and evaluate the eventual zoonotic role of Campylobacter cuniculorum.

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presente pesquisa apresenta-se em uma perspectiva qualitativa, de cunho etnográfico. Analisa o movimento da prática avaliativa de professores que participaram do curso sobre Avaliação numa perspectiva construtivista. Inicialmente, discute a hipótese de não-mudança em relação à prática avaliativa. Em uma trajetória reflexiva, a análise passa a ser inspirada nos estudos de Michel de Certeau, ao não se render à supremacia de produtos culturais impostos por uma ordem social dominante; ao não se limitar à perspectiva das teorias sobre Avaliação da aprendizagem. O foco da pesquisa direcionou-se à ação dos consumidores desses produtos os professores que, ao se apropriarem de tais teorias, o fazem à sua maneira, redimensionando-as e as resignificando, com astúcia, criatividade, inventividade. Ao entender que tais profissionais, em situações menos privilegiadas nas estruturas sociais de poder constituído, possuem uma inteligência que engendra uma multiplicidade de interpretações, abrimos nosso olhar para surpresas, possibilitando a apreciação de variados caminhos que delineiam as práticas avaliativas dos professores. No entanto, se elegêssemos um único padrão de referência para a análise das ações cotidianas, poderíamos nos fechar em apenas duas conclusões: obediências ou resistências. Optamos, todavia, por aproximarmo-nos de Certeau, e acreditar, como ele, na inteligência e criatividade também presentes nas ações dos mais fracos nas organizações sociais, que são os consumidores dos produtos culturais. Criamos, destarte, nova oportunidade para que a multidão adquira vida, evidenciando a diversidade de práticas avaliativas de um grupo de professores, focalizando a análise em ações concretas, de professores reais.