Climate simulation for 125 kyr BP with a coupled ocean-atmosphere general circulation model

The ECHAM-1 T21/LSG coupled ocean-atmosphere general circulation model (GCM) is used to simulate climatic conditions at the last interglacial maximum (Eemian. 125 kyr BP). The results reflect thc expected surface temperature changes (with respect to the control run) due to the amplification (reduction) of the seasonal cycle of insolation in the Northern (Southern) Hemisphere. A number of simulated features agree with previous results from atmospheric GCM simulations e.g. intensified summer southwest monsoons) except in the Northern Hemisphere poleward of 30 degrees N. where dynamical feedback, in the North Atlantic and North Pacific increase zonal temperatures about 1 degrees C above what would be predicted from simple energy balance considerations. As this is the same area where most of the terrestrial geological data originate, this result suggests that previous estimates of Eemian global average temperature might have been biased by sample distribution. This conclusion is supported by the fact that the estimated global temperature increase of only 0.3 degrees C greater than the control run ha, been previously shown to be consistent a with CLIMAP sea surface temperature estimates. Although the Northern Hemisphere summer monsoon is intensified. globally averaged precipitation over land is within about 1% of the present, contravening some geological inferences bur not the deep-sea delta(13)C estimates of terrestrial carbon storage changes. Winter circulation changes in the northern Arabian Sea. driven by strong cooling on land, are as large as summer circulation changes that are the usual focus of interest, suggesting that interpreting variations in the Arabian Sea. sedimentary record solely in terms of the summer monsoon response could sometimes lead to errors. A small monsoonal response over northern South America suggests that interglacial paleotrends in this region were not just due to El Nino variations.

Petition to the General Court (photostat copy), 1646 May 15

Photostat copy of a petition from ferrymen James Heyden and Francis Hudson requesting compensation for unpaid fares of "magistrates & deputyes" using the ferry.

Petition to the General Court (photostat copy), 1662

Photostat copy of a petition from ferrymen Francis Hudson and John Burrage requesting the General Court coin twopenny and fourpenny pieces for change so the ferrymen could accommodate customers attempting to pay with larger currency denominations.

Draft of a petition to the General Court from the Corporation, 1743 October 26-27

Two-page handwritten draft of a petition to the General Court signed by President Edward Holyoke, and a half-page letter that accompanied the draft from President Holyoke to Tutor Flynt, a member of the Committee to draft the petition.

A copy of the general map the most part compiled from the actual survey by order of the commisioners appointed to settle the partition line between the provinces of New York and New Jersey : manuscript map, 1769

Map showing the whole of New Jersey and its borders with as well as part of Pennsylvania and New York. Map is drawn in black ink with green, pink, and yellow watercolors used to show features such as waterways, borders, and places of interest. Notes on map concern border disputes between New Jersey and New York.

What drives the European Parliament? The Case of the General Data Protection Regulation. Bruges Political Research Papers 47/2015.

This paper evaluates which factors influence the European Parliament’s decision-making, based on a case study: the 2012 proposal for a General Data Protection Regulation. Following a ‘competitive testing’ approach, six different hypotheses are successively challenged in order to explain why the EP adopted a fundamental rights- oriented position. The first three factors relate to the internal organization of the EP’s work, i.e. the role played by the lead committee, by the rapporteur and by secretariat officials. The last three factors are external-related, i.e. lobbying activities, outside events and institutional considerations. Based on the empirical findings, it is argued that even though the EP’s position is due to a range of various factors, some of them prove to be more relevant than others, in particular the rapporteur and lead committee’s roles. New institutionalism theories also provide a comprehensive explanation for the EP’s willingness to achieve a fundamental rights oriented outcome.

Angiogenesis in cancer - general pathways and their therapeutic implications

A vast amount of data shows that angiogenesis has a pivotal role in tumor growth, progression, invasiveness and metastasis. This is a complex process involving essential signaling pathways such as vascular endothelial growth factor (VEGF) and Notch in vasculature, as well as additional players such as bone marrow-derived endothelial progenitor cells. Primary tumor cells, stromal cells and cancer stem cells strongly influence vessel growth in tumors. Better understanding of the role of the different pathways and the crosstalk between different cells during tumor angiogenesis are crucial factors for developing more effective anticancer therapies. Targeting angiogenic factors from the VEGF family has become an effective strategy to inhibit tumor growth and so far the most successful results are seen in metastatic colorectal cancer (CRC), renal cell carcinoma (RCC) and non-small cell lung cancer (NSCLL). Despite the initial enthusiasm, the angiogenesis inhibitors showed only moderate survival benefit as monotherapy, along with a high cost and many side effects. Obviously, other important pathways may affect the angiogenic switch, among them Notch signaling pathway attracted a large interest because its ubiquitous role in carcinogenesis and angiogenesis. Herein we present the basics for VEGF and Notch signaling pathways and current advances of targeting them in antiangiogenic, antitumor therapy.

Transfer of interest on U.S. investment in the Panama Canal (GAO/AFMD-85-63).

Includes letter of April 8, 1985 from William R. Gianelli, Chairman, Board of Directors, Panama Canal Commission, to Frederick D. Wolf, Director, Accounting and Financial Management Division, U.S. General Accounting Office, Washington, D.C. (p. 12-17).

Samuel Fortrey on Englands interest and improvement, 1663.

"The present edition of the tract is a reproduction of the text of 1663. The general appearance of the title-page has been preserved, and the original pagination indicated."--Introd.

The Prospect : a monthly magazine for the colored people of America.

Not in J.P. Danky's African-American newspapers and periodicals, a national bibliography.

The Mineralogical magazine and journal of the Mineralogical Society.

No issues published 1958-1962.

On the Interest in Beauty and Disinterest

Contemporary philosophical attitudes toward beauty are hard to reconcile with its importance in the history of philosophy. Philosophers used to allow it a starring role in their theories of autonomy, morality, or the good life. But today, if beauty is discussed at all, it is often explicitly denied any such importance. This is due, in part, to the thought that beauty is the object of “disinterested pleasure”. In this paper I clarify the notion of disinterest and develop two general strategies for resisting the emphasis on it, in the hopes of getting a clearer view of beauty’s significance. I present and discuss several literary depictions of the encounter with beauty that motivate both strategies. These depictions illustrate the ways in which aesthetic experience can be personally transformative. I argue that they present difficulties for disinterest theories and suggest we abandon the concept of disinterest to focus instead on the special kind of interest beauty fuels. I propose a closer look at the Platonic thought that beauty is the object of love.

The Wiltshire archaeological and natural history magazine /

Includes proceedings of the annual general meetings of the Wiltshire Archaeological and Natural History Society.

Lady Hewley's charities : observations on the case of the attorney-general v. Shore and others.

"From the Law Magazine, no. 32."

Prison life of Jefferson Davis : embracing details and incidents in his captivity, particulars concerning his health and habits, together with many conversations on topics of great public interest /

In the Historical magazine for March, 1869, this work is erroneously ascribed to Gen. Halpine.