高功率激光装置前端系统激光脉冲的时间整形及修正技术

针对激光惯性约束聚变实验研究对高功率激光驱动器前端系统复杂时间形状种子激光脉冲的需求, 应用孔径耦合带状线集成波导整形系统设计了满足需要的前端整形激光脉冲。用一种新方法精确计算了孔径耦合带状线电脉冲整形器的耦合系数和孔径宽度的数值关系, 并针对高衬比度整形激光脉冲的需求, 提出了高衬比度双极型集成波导整形系统方案。由该系统可以得到100 ps脉冲前沿、1～3 ns脉冲宽度可调、高衬比度(大于100∶1)、光滑无纹波调制、可精确满足神光II八路及第九路装置需求的前端整形激光脉冲。

基于电光调制的激光光谱整形技术

提出了一种新型的基于电光调制的激光光谱整形方案，该整形技术可以减轻啁啾脉冲放大系统中的增益窄化效应。傅立叶变换限的宽带种子激光脉冲通过光学展宽器线性展宽后，耦合到加载有整形电脉冲的集成波导调制器中进行整形，整形电脉冲由孔径耦合带状线电脉冲发生器产生。由于线性啁啾脉冲时间-频率的直接对应关系，在时域内对宽带种子激光脉冲整形，其光谱也得到了同样形状的整形。模拟了整形光谱形状，相应的整形电脉冲波形，分析了该整形技术的光谱整形分辨率，以及整形过程中引入的相位畸变。

光谱色散后的相位调制光束衍射特性研究

用数值方法研究了激光驱动器系统中使用光谱色散平滑单元后光束的衍射特性、模拟结果表明，光谱色散会使光束衍射光斑变大，近场空间强度均匀性改善，而远场光斑内部存在光强接近于均匀分布的区域．进一步分析了光谱色散平滑单元中相位调制器的调制深度、调制频率及光栅色散系数等主要元件参数对光束传输特性的影响，发现在一定情况下光斑内部会出现较强的强度调制。

输出高重复频率脉冲列的全固态激光器

报道了利用声光振幅调制锁模的方法，在激光二极管端面抽运Nd：YVO4激光器上获得320MHz高重复频率脉冲列的实验结果。实验采用平一平腔结构，腔长452mm，耦合输出镜透过率为3．6％。所用声光介质为熔融石英晶体，以铌酸锂作换能器，在驱动功率4．5W时，对1064nm波长衍射效率为50，相应的调制深度为0．31。在最佳锁模状态下，激光二极管抽运功率为3．5W，此时激光平均输出功率为15mw。示波器记录脉冲宽度680ps，实测光束质量因子M^2小于1．5。并在实验基础上对激光器工作的稳定性进行了分析，结果表

A planar waveguide Nd : YAG laser using active Q-switching of a hybrid unstable resonator

A planar waveguide laser operating in a negative branch unstable resonator is Q-switched by an acoustooptic mod latorin anew configuration, providing effective, high-speed switching. The laser using a 200-mu m Nd:YAG core, face pumped by 10 laser diode bars, has produced 100-W output in a good beam quality at 100-kHz pulse rate, and 4.5 mJ at lower frequency with 15-ns pulse duration.

High-repetition-rate MHz acoustooptic Q-switched fiber laser

A simple actively Q-switched double-clad fiber laser combining an amplifying cavity is reported by using a dynamic acoustooptic Q-switching as a beam splitter. Sub-100-ns. pulses independence of the repetition rate of acoustooptic modulator are almost changeless with repetition rate varied from 50 kHz to 1.5 MHz. With 4.5-W absorbed power, 9.4-W peak-power pulses at 1.5-MHz repetition rate with 75-ns pulse duration are generated.

A study of a Q-switched double-clad ytterbium-doped fiber laser with amplifying effect

A high repetition rate ytterbium-doped double-clad (YDDC) fiber laser with amplifying effect is described by using acousto-optic modulator. The characteristic of Q-switched pulses are studied with accurate control of opening gate time of modulator. The stable Q-switched pulses with tens of nanoseconds width can be observed at high repetition rate varied from 50 kHz to 500 kHz using this laser. The stable operation area of the Q-switched fiber laser is discussed and the analysis results agree well with that of the experiment. (c) 2007 Elsevier B.V. All rights reserved.

FTY720 attenuates excitotoxicity and neuroinflammation

Background: FTY720 (fingolimod, Gilenya(TM)), a structural analog of sphingosine-1-phosphate (S1P), is the first oral drug approved for treatment the relapsing-remitting form of multiple sclerosis (MS), and its efficacy has been related to induced lymphopenia and consequent immunosuppression via modulation of S1P(1) receptors (S1P(1)R). However, due to its lipophilic nature, FTY720 crosses the blood brain barrier (BBB) and could act directly on neural cells. In this study, we investigated the effectiveness of FTY720 as a neuroprotective agent using in vitro and in vivo models of excitotoxic neuronal death and examined if FTY720 exerts a direct action on neurons, or/and an indirect modulation of inflammation-mediated neurodegeneration as a possible mechanism of neuroprotection. Methods: Primary neuronal and organotypic cortical cultures were treated with N-methyl-D-aspartic acid (NMDA) to induce excitotoxic cell death (measured by lactate dehydrogenase (LDH) assay or propidium iodide uptake, respectively). The effects of FTY720 treatment (10, 100 and 1,000 nM) on neuronal survival were examined. As an in vivo model of neuronal death and inflammation, we used intracerebroventricular (icv) administration of kainic acid (KA; 0.5 mu g/2 mu l) in Sprague-Dawley rats. FTY720 was applied icv (1 mu g/2 mu l), together with KA, plus intraperitoneally (ip; 1 mg/kg) 24 h before, and daily, until sacrifice 3 days after icv. Rats were evaluated for neurological score, neuronal loss in CA3 hippocampal region and activation of microglia at the lesion site. In addition, we tested FTY720 as a modulator of microglia responses using microglial cell cultures activated with lipopolysaccharide (LPS) and its effects in stress signalling pathways using western blotting for p38 and JNK1/2 mitogen-activated protein kinases (MAPKs). Results: FTY720 was able to reduce excitotoxic neuronal death in vitro. Moreover, in vivo repeated FTY720 administration attenuated KA-induced neurodegeneration and microgliosis at the CA3 lesion site. Furthermore, FTY720 negatively modulates p38 MAPK in LPS-activated microglia, whereas it had no effect on JNK1/2 activation. Conclusions: These data support a role for FTY720 as a neuroprotective agent against excitotoxin-induced neuronal death and as a negative modulator of neuroinflammation by targeting the p38 MAPK stress signalling pathway in microglia.

Characterization of m-plane ZnO thin film on gamma-LiAlO2 (100) substrate by metal-organic chemical vapor deposition

Non-polar (1 (1) over bar 00)m-plane ZnO thin film has been prepared on gamma-LiAlO2 (100)substrate via the low pressure metal organic chemical vapor deposition. Obvious intensity variation of the E-2 mode in the polarized Raman spectra and the absorption edge shift in the polarized optical transmission spectra indicate that the m-plane film exhibits optical anisotropy, which have applications in certain optical devices, such as the UV modulator and polarization-dependent beam switch. From the atomic force microscopy images, highly-oriented uniform-sized grains of rectangular shape were observed. (c) 2008 Elsevier B.V. All rights reserved.

Efeito da suplementação dietética com L-glutamina na sepse abdominal induzida em rato

Após o estímulo deflagrador de um trauma ou infecção, a liberação de citocinas na circulação sanguínea desempenha um importante papel efetor e também modulador da resposta imune sistêmica. Essas citocinas podem ser pró-inflamatórias, que estimulam a liberação de diversos tipos celulares e de outras citocinas, como fator de necrose tumoral-alfa (TNF-α), interleucina 1 (IL-1), IL-2, IL-6, IL-8, IL-12 e interferon-gama (INF-); ou citocinas com efeitos antiinflamatórios, que inibem o processo inflamatório, em parte pela redução da produção de diversas citocinas que regulam positivamente a resposta, minimizando o comprometimento orgânico resultante, como IL-4, IL-10, IL-13. A L-glutamina é o aminoácido mais abundante no organismo, com importante papel no metabolismo protéico. Sua ação trófica sobre a mucosa do intestino delgado é bastante conhecida, o que o torna componente essencial para a manutenção estrutural e funcional do intestino. O objetivo deste trabalho foi avaliar o efeito da suplementação dietética com L-glutamina na modulação da resposta inflamatória em animais submetidos a sepse abdominal induzida por ligadura e perfuração cecal. Foram utilizados 24 ratos Wistar machos adultos, com peso inicial entre 200 e 230 g, distribuídos em três grupos, cada um com oito animais, da seguinte forma: grupo I (controle) submetidos a operação simulada (laparotomia e manipulação de alças intestinais); grupo II submetidos a laparotomia, com indução de sepse abdominal; e grupo III receberam suplementação dietética com L-glutamina por sete dias e, após, foram submetidos a indução de sepse abdominal. Foram coletadas amostras sanguíneas de todos os animais antes (tempo 0) e duas e quatro horas (tempos 1 e 2) após a indução da sepse abdominal. Foram verificados o número de leucócitos, a dosagem da concentração plasmática de citocinas pró- e antiinflamatórias (INF-γ, IL-6 e IL-10) e análise microbiológica de líquido peritoneal. A glicemia apresentou aumento significativo em todos os grupos, comparando-os ao início e ao final do experimento (p<0,05). No que concerne à IL-10, observou-se aumento significativo nos animais do grupo III entre os tempos 0 e 2, e entre os tempos 1 e 2 (p=0,0331 e p=0,0155, respectivamente). Não se observou qualquer outra diferença ao serem analisadas as demais citocinas (IFN- e IL-6), em todos os grupos e em todos os momentos analisados. Nossos achados sugerem que a suplementação dietética com L-glutamina em animais submetidos à indução de sepse abdominal com modelo CLP parece potencializar a resposta antiinflamatória, aumentando a concentração plasmática de IL-10, enquanto as concentrações de INF-γ e IL-6 não apresentaram variação significativa.

Electro-optic modulation of 1.5μm light in an active InGaAsP/InP quantum well waveguide

We report an InGaAsP/InP phase modulator operating in the 1.5μm wavelength band. Phase modulation of 7.5°/mA and 1.7°/mA of injected current have been measured for TE and TM polarised light respectively at a signal wavelength of 1.52 μm.

System model for studying fibre grating dispersion compensators

A complete optical system model has been developed and used to assess chirped fibre Bragg grating dispersion compensators. Gratings suitable for dispersion compensation in both laser based and modulator based optical communications systems have been modelled. A grating 10 cm in length has been shown to permit virtually dispersion free transmission over 425 km, when used in an externally modulated system. Long haul dispersion compensation using several 2 cm gratings spaced at intervals along the fibre is also modelled, illustrating viable 10Gbit/s transmission over a distance in excess of 168 km.

Numerical modelling of dynamic response of loss modulated monolithic multisection mode-locked semiconductor lasers

Monolithic multisection mode-locked semiconductor lasers with an integrated distributed Bragg reflector (DBR) have recently been demonstrated to generate stable picosecond pulses at high repetition rates suitable for optical communication systems. However, there has been very little theoretical work on understanding the physical mechanisms of the device and on optimisation of the absorber modulator design. This article presents numerical modeling of the loss modulated mode-locking process in these lasers. The model predicts most aspects experimentally observed within this type of device, and the results show the output waveform, optical spectrum, instantaneous frequency chirp, and stable operating range.

The silicon backplane design for an LCOS polarization-insensitive phase hologram SLM

Polarization-insensitivity is achieved in a reflective spatial light modulator by laying a quarter-wave plate (QWP) at the incident wavelength directly over the mirror pixels of a silicon backplane, and forming a nematle Fréedrickcz cell over the QWP to modulate the reflected phase. To achieve the highest drive voltage from the available silicon process, a switched voltage common front electrode design is described, with variable amplitude square wave drive to the pixels to maintain constant root-mean-square drive and minimize phase fluctuations during the dc balance refresh cycle. The silicon has been fabricated and liquid-crystal-on-silicon cells both with and without the QWP assembled; applications include optically transparent switches for optical networks, beam steering for add-drop multiplexers for wavelength-division- multiplexing telecommunications, television multicast, and holographic projection.

Free space adaptive optical interconnect, using a ferroelectric liquid crystal SLM for beam steering

A free-space, board-to-board, adaptive optical interconnect demonstrator has been developed. Binary phase gratings displayed on a Ferroelectric Liquid Crystal Spatial Light Modulator are used to maintain data transfer at 1.25Gbps, given varying optical misalignment © 2005 Optical Society of America.