The IL-33/ST2 pathway contributes to intestinal tumorigenesis in humans and mice.

Colorectal cancer (CRC) develops through a multistep process and is modulated by inflammation. However, the inflammatory pathways that support intestinal tumors at different stages remain incompletely understood. Interleukin (IL)-33 signaling plays a role in intestinal inflammation, yet its contribution to the pathogenesis of CRC is unknown. Using immunohistochemistry on 713 resected human CRC specimens, we show here that IL-33 and its receptor ST2 are expressed in low-grade and early-stage human CRCs, and to a lesser extent in higher-grade and more advanced-stage tumors. In a mouse model of CRC, ST2-deficiency protects from tumor development. Moreover, bone marrow (BM) chimera studies indicate that engagement of the IL-33/ST2 pathway on both the radio-resistant and radio-sensitive compartment is essential for CRC development. Mechanistically, activation of IL-33/ST2 signaling compromises the integrity of the intestinal barrier and triggers the production of pro-tumorigenic IL-6 by immune cells. Together, this data reveals a tumor-promoting role of IL-33/ST2 signaling in CRC.

Horizontal profiles of longwave and shortwave radiation components over sea ice near Barrow, Alaska during the 2011 melt

An integrated instrument package for measuring and understanding the surface radiation budget of sea ice is presented, along with results from its first deployment. The setup simultaneously measures broadband fluxes of upwelling and downwelling terrestrial and solar radiation (four components separately), spectral fluxes of incident and reflected solar radiation, and supporting data such as air temperature and humidity, surface temperature, and location (GPS), in addition to photographing the sky and observed surface during each measurement. The instruments are mounted on a small sled, allowing measurements of the radiation budget to be made at many locations in the study area to see the effect of small-scale surface processes on the large-scale radiation budget. Such observations have many applications, from calibration and validation of remote sensing products to improving our understanding of surface processes that affect atmosphere-snow-ice interactions and drive feedbacks, ultimately leading to the potential to improve climate modelling of ice-covered regions of the ocean. The photographs, spectral data, and other observations allow for improved analysis of the broadband data. An example of this is shown by using the observations made during a partly cloudy day, which show erratic variations due to passing clouds, and creating a careful estimate of what the radiation budget along the observed line would have been under uniform sky conditions, clear or overcast. Other data from the setup's first deployment, in June 2011 on fast ice near Point Barrow, Alaska, are also shown; these illustrate the rapid changes of the radiation budget during a cold period that led to refreezing and new snow well into the melt season.

Meditationi pie, et diuote / di M. Giouanni Taulero sopra la vita, et passione di Giesu Christo ; tradotte in volgar fiorentino dal R. M. Alessandro Strozzi ..., appresso alcuni essercitij non men cattolici, che dotti, di M. Niccolô Eschio ; tradotte per

Segunda mención de imp. tomada del colofón

Itḥāf al-dhakī bi-sharḥ al-Tuḥfah al-mursalah ilá al-Nabī : manuscript, [ca. 1670]

Title from ff. 1r and f. 2r.

Maslak al-sadād ilá masʼalat khalq afʻāl al-ʻibād / taḥrīr ʻAbd Allāh Ibrāhīm ibn Ḥasan ibn Shihāb al-Dīn al-Kurdī al-Kūrānī al-Shahrazūrī al-Shahrānī thumma al-Madanī : manuscript, 1684

Title from f. 1r.

Dissecting the signaling mechanisms of IL-7-mediated autophagy regulation in T-cell acute lymphoblastic leukemia

Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2014

Formazione in un'azienda di auto supersportive e implementazione del Training Center: il caso di Automobili Lamborghini

la formazione aziendale

Il rilassamento spontaneo nei giunti bullonati

Nell'elaborato viene fatta una descrizione dei giunti bullonati, in seguito viene trattato il fenomeno dell'allentamento dei bulloni sotto carico esterno trasversale, infine vengono illustrate le prove sperimentali su provini estensimetrati serrati da bulloni, con una descrizione degli estensimetri e del loro funzionamento e una discussione dei risultati delle prove.

Il piano-forte : i suoi cultori e la sua missione... /

Mode of access: Internet.

Il salvatore co'dodici apostoli dappresso Raffaelle D'Vrbino : dipinti nella chiesa de' SS. Vincenzo ed Anastasio alle tre fontane fvori di porta S. Paolo e svlle stampe di Marcantonio /

Cover title.

Narrazione delle solenni reali feste : fatte celebrare in Napoli da Sua Maestà il re delle Due Sicilie Carlo infante di Spagna, duca di Parma, Piacenza &c. &c. per la nascita del suo primogenito Filippo real principe delle Due Sicilie.

The plates depict floor plans of the Palazzo reale and of the Teatro di San Carlo in Naples, a vertical cross section of the Palazzo reale; interior decoration of the Teatro di San Carlo; most plates depict festivities taking place in the decorated interiors of the theater and the royal palace, including a masquerade at the royal palace, the stage scenery and a scene from the opera "Il sogno di Olimpia" by Ranieri de Calzabigi, which was performed at the Teatro di San Carlo; a view of the illuminated Castello Nuovo in Naples, the fireworks installation at the Piazza del Castello Nuovo, and a floorplan of the fire works installation. Plate XI depicts the mythical land of plenty "Cuccagna", arranged as a landscaped hill with an architectural grotto, richly decorated with food and drink, which was offered as part of the festivities to the common people. Most plates have a detailed legend in the lower margin.

Il viaggio in Germania, Il carteggio letterario,

pte. I. Il viaggio di studio in Germania (1825-26) [per estratti le lettere, finora inedite, che Poerio scrisse alla famiglia, 1825-6] Appendice. Lettera di W. Goethe ad A. Poerio.--pte. II.Il carteggio letterario (1828-48)--pte. III. Pensieri di A. Poerio [Novantanove pensieri, publicati dall' Briani nel Giornale napoletano della domenica (n.1 27-8, 2 e 9 luglio 1882) e pol in un opuscolo fuori commercio]

Il primo [-secondo] libro d'Architettura, di Sabastiano Serlio, Bolognese. Le premier [-second] liure d'architecture de Sebastian Serlio, bolognois, mis en langue francoyse par Iehan Martin ...

"Premier liure de geometrie", h. 1-25, y "Il secondo libro de perspettiva di Sebastiano Serlio Bolognese. Le second livre de perspective, de Sebastian Serlio Bolognois, mis en langue francoise par Iehan Martin ...", h. 25-74.

Il corpo-umano, o breve storia, dove con nuovo metodo si descrivono in compendio tutti gli organi suoi, e i loro principali ufizi, per istruire a bene intendere, secondo il nuovo sistema, la teorica e pratica medicinale /

Georgii Baglivi ... De fibra motrice et morbosa ... Epistola ad Alexandrum Pascoli, 55 p.

Academia Francese : nella quale si tratta della institution de costumi, [et] di quello che concerne il bene [et] felicemente viuere, in ogni stato [et] conditione ... /

ICCu