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Greenhouse and Science Complex

The Aumni Greenhouse and the Science Complex in the background.

Manual de literatura: principios generales de poética y retórica y resúmen histórico de la literatura española

UANL

Mild hypothermia prevents brain edema and attenuates up-regulation of the astrocytic benzodiazepine receptor in experimental acute liver failure.

BACKGROUND/AIMS: Mild hypothermia has proven useful in the clinical management of patients with acute liver failure. Acute liver failure in experimental animals results in alterations in the expression of genes coding for astrocytic proteins including the "peripheral-type" (astrocytic) benzodiazepine receptor (PTBR), a mitochondrial complex associated with neurosteroid synthesis. To gain further insight into the mechanisms whereby hypothermia attenuates the neurological complications of acute liver failure, we investigated PTBR expression in the brains of hepatic devascularized rats under normothermic (37 degrees C) and hypothermic (35 degrees C) conditions. METHODS: PTBR mRNA was measured using semi-quantitative RT-PCR in cerebral cortical extracts and densities of PTBR sites were measured by quantitative receptor autoradiagraphy. Brain pregnenolone content was measured by radioimmunoassay. RESULTS: At coma stages of encephalopathy, animals with acute liver failure manifested a significant increase of PTBR mRNA levels. Brain pregnenolone content and [(3)H]PK 11195 binding site densities were concomitantly increased. Mild hypothermia prevented brain edema and significantly attenuated the increased receptor expression and pregnenolone content. CONCLUSIONS: These findings suggest that an attenuation of PTBR up-regulation resulting in the prevention of increased brain neurosteroid content represents one of the mechanisms by which mild hypothermia exerts its protective effects in ALF.

Evaluaci??n : bibliotecas Escolares CREA

Resumen basado en el de la publicaci??n

Así funciona un molino.

Esta guía forma parte de un grupo de cuadernillos incluidos en una carpeta bajo el título 'Los Molinos informan' que el Museo Hidráulico realiza con motivo de las exposiciones allí mostradas

Curso de formación en atención básica a discapacitados : la integración social por el deporte.

Material multicopiado con anexo que incluye el Plan Estatal de Voluntariado y la Resolución aprobada por la Asamblea General del Consejo Económico y Social de Naciones Unidas sobre la Declaración del Año Internacional de los Voluntarios: 2001