SOME UNSTABLE CRITICAL METRICS FOR THE L-n/2-NORM OF THE CURVATURE TENSOR

We consider the Riemannian functional defined on the space of Riemannian metrics with unit volume on a closed smooth manifold M given by R-n/2(g) := integral(M) vertical bar R(g)vertical bar(n//2) dv(g) where R(g), dv(g) denote the Riemannian curvature and volume form corresponding to g. We show that there are locally symmetric spaces which are unstable critical points for this functional.

AN EXPEDITIOUS COUMARIN SYNTHESIS VIA A ``PSEUDOCYCLOADDITION'' BETWEEN SALICYLALDEHYDES AND KETENE

A variety of salicylaldehydes effected tandem nucleophilic addition onto ketene, leading to corresponding coumarins in good yields under mild conditions. This pseudocycloaddition represents a very mild variant of the historic Perkin synthesis of coumarin (which remains of key interest in both perfumery and several emerging areas).

How Does Effectual Logic Impact Survival of High-tech Startups in an Emerging Economy? - Evidence from 99tests.com Case Study

During the early stages of operation, high-tech startups need to overcome the liability of newness and manage high degree of uncertainty. Several high-tech startups fail due to inability to deal with skeptical customers, underdeveloped markets and limited resources in selling an offering that has no precedent. This paper leverages the principles of effectuation (a logic of entrepreneurial decision making under uncertainty) to explain the journey from creation to survival of high-tech startups in an emerging economy. Based on the 99tests.com case study, this paper suggests that early stage high-tech startups in emerging economies can increase their probability of survival by adopting the principles of effectuation.

Experimental Study on Switching Characteristics of an Inverter Leg Consisting of IGBTs of Dissimilar Makes

Usually the top and bottom IGBT devices in an inverter leg are of the same make (i.e. from same manufacturer). At low power level, these two devices even may be contained in the same module. However at high power levels the top and bottom devices are in separate modules. Sometimes, in the event of device failure, device of particular make may be replaced by one of another make, but of same ratings (on account of non-availability of the original make). This paper investigates the effect of such intermixing of two different makes of high power IGBTs in an inverter leg on the switching characteristics. The switching transitions between IGBT and diode of similar make and those of IGBT and diode of dissimilar make are compared experimentally at various DC link voltages and currents. The comparisons are made in terms of, IGBT peak turn-on di/dt, IGBT peak turn-off di/dt, peak diode reverse recovery current (I-rr), peak IGBT voltage overshoot and switching energy losses.

Novel anti IGFBP2 single chain variable fragment inhibits glioma cell migration and invasion

Insulin like growth factor binding protein 2 (IGFBP2) is highly up regulated in glioblastoma (GBM) tissues and has been one of the prognostic indicators. There are compelling evidences suggesting important roles for IGFBP2 in glioma cell proliferation, migration and invasion. Extracellular IGFBP2 through its carboxy terminal arginine glycine aspartate (RGD) motif can bind to cell surface alpha 5 beta 1 integrins and activate pathways downstream to integrin signaling. This IGFBP2 activated integrin signaling is known to play a crucial role in IGFBP2 mediated invasion of glioma cells. Hence a molecular inhibitor of carboxy terminal domain of IGFBP2 which can inhibit IGFBP2-cell surface interaction is of great therapeutic importance. In an attempt to develop molecular inhibitors of IGFBP2, we screened single chain variable fragment (scFv) phage display libraries, Tomlinson I (Library size 1.47 x 10(8)) and Tomlinson J (Library size 1.37 x 10(8)) using human recombinant IGFBP2. After screening we obtained three IGFBP2 specific binders out of which one scFv B7J showed better binding to IGFBP2 at its carboxy terminal domain, blocked IGFBP2-cell surface association, reduced activity of matrix metalloprotease 2 in the conditioned medium of glioma cells and inhibited IGFBP2 induced migration and invasion of glioma cells. We demonstrate for the first time that in vitro inhibition of extracellular IGFBP2 activity by using human scFv results in significant reduction of glioma cell migration and invasion. Therefore, the inhibition of IGFBP2 can serve as a potential therapeutic strategy in the management of GBM.

Effect of Size Reduction on Magnetic Ordering in Sm1-x Ca (x) MnO3 (x=0.35, 0.65 and 0.92) Manganites: Magnetic and EMR Studies

We have employed the highly sensitive electron magnetic resonance technique complimented by magnetization measurements to study the impact of size reduction on the magnetic ordering in nanosized Sm1-x Ca (x) MnO3 (x = 0.35, 0.65 and 0.92). In the bulk form, x = 0.35 sample shows a charge ordering transition at 235 K followed by a mixed magnetic phase, the sample with x = 0.65 exhibits charge order below 275 K and shows an antiferromagnetic insulator phase below 135 K while that with x = 0.92 has a ferromagnetic-cluster glass ground state. Thus, a comparative study of magnetic ground states of bulk and nanoparticles (diameter similar to 25 nm) enables us to investigate size-induced effects on different types of magnetic ordering. It is seen that in the bulk samples the temperature dependences of the EPR parameters are quite different from each other. This difference diminishes for the nanosamples where all the three samples show qualitatively similar behavior. The magnetization measurements corroborate this conclusion.

Yellow-red luminescence in ZnO nanoparticles synthesized from zinc acetylacetonate phenanthroline

ZnO powders/thin films/coatings when excited by a suitable excitation source, usually yield green luminescence in the visible wavelength range along with characteristic ultra-violet emission. We report yellow-red emission from ZnO nanoparticles synthesized within 5 min of microwave irradiation by using zinc acetylacetonate phenanthroline as the starting precursor material. The emission is strongly dependent on the typical structure of the starting precursor for ZnO synthesis, where one phenanthroline moiety is attached with zinc acetylacetonate hydrate complex. These ZnO nanoparticles could be potentially suitable phosphor for white light generation when excited by a blue laser. In contrast, the ZnO nanoparticles obtained from zinc acetylacetonate by similar method yield weak green emission. (C) 2015 Elsevier B.V. All rights reserved.

Microhomology-mediated end joining is the principal mediator of double-strand break repair during mitochondrial DNA lesions

Mitochondrial DNA (mtDNA) deletions are associated with various mitochondrial disorders. The deletions identified in humans are flanked by short, directly repeated mitochondrial DNA sequences; however, the mechanism of such DNA rearrangements has yet to be elucidated. In contrast to nuclear DNA (nDNA), mtDNA is more exposed to oxidative damage, which may result in double-strand breaks (DSBs). Although DSB repair in nDNA is well studied, repair mechanisms in mitochondria are not characterized. In the present study, we investigate the mechanisms of DSB repair in mitochondria using in vitro and ex vivo assays. Whereas classical NHEJ (C-NHEJ) is undetectable, microhomology-mediated alternative NHEJ efficiently repairs DSBs in mitochondria. Of interest, robust microhomology-mediated end joining (MMEJ) was observed with DNA substrates bearing 5-, 8-, 10-, 13-, 16-, 19-, and 22-nt microhomology. Furthermore, MMEJ efficiency was enhanced with an increase in the length of homology. Western blotting, immunoprecipitation, and protein inhibition assays suggest the involvement of CtIP, FEN1, MRE11, and PARP1 in mitochondrial MMEJ. Knock-down studies, in conjunction with other experiments, demonstrated that DNA ligase III, but not ligase IV or ligase I, is primarily responsible for the final sealing of DSBs during mitochondrial MMEJ. These observations highlight the central role of MMEJ in maintenance of mammalian mitochondrial genome integrity and is likely relevant for deletions observed in many human mitochondrial disorders.

Reply to Discussion on ``Bearing capacity of circular footings over rock mass by using axisymmetric quasi lower bound finite element limit analysis'' Comput. Geotech. 70 (2015) 138-149]

A discussion has been provided for the comments raised by the discusser (Clausen, 2015)1] on the article recently published by the authors (Chakraborty and Kumar, 2015). The effect of exponent alpha for values of GSI approximately smaller than 30 becomes more critical. On the other hand, for greater values of GSI, the results obtained by the authors earlier remain primarily independent of alpha and can be easily used. (C) 2015 Elsevier Ltd. All rights reserved.

El gnosticismo político

Introducción: El Sínodo de Obispos reunido en 2012 identificó como uno de los grandes desafíos para la evangelización de hoy día la aparición de nuevas formas de gnosis, a través de la cuales «(...) la ciencia y la técnica corren el riesgo de transformarse en los nuevos ídolos del presente (...) es fácil hacer de la ciencia nuestra religión a la cual dirigir nuestras preguntas sobre la verdad y el sentido de la esperanza sabiendo que sólo recibiremos respuestas parciales e inadecuadas»...

Monseñores Octavio Nicolás Derisi y Guillermo Pedro Blanco

Qué mejor apertura para hablar de Mons. Derisi y Mons. Blanco que invocar las palabras de Etienne Gilson en la Introducción a Le Thomisme2: «Lo propio del Doctor es enseñar; ahora, la enseñanza (doctrina) consiste en comunicar a los otros la verdad que se ha meditado previamente, lo que requiere la reflexión del contemplativo para descubrir la verdad y la acción del profesor para transmitir los resultados a sus alumnos. Pero, lo que tiene de destacable esta acción tan compleja, es que lo superior preside exactamente lo inferior, es decir la contemplación a la acción... La función del Doctor está orientada naturalmente hacia un doble objeto, interior y exterior, según se refiera a la verdad que el Doctor medita y contempla frente a sí o frente a los alumnos. De las dos partes de su vida, la primera es la mejor y a la que él ha de ordenarse...

La fe en San Juan de la Cruz y en Santo Tomás de Aquino

Introducción: «La fe es la firme seguridad de lo que esperamos, la convicción de lo que no vemos», dice San Pablo en la Epístola a los Hebreos, y Santo Tomás en la Suma Teológica muestra que estas luminosas palabras encierran todos los elementos necesarios para alcanzar el concepto que nos permita entender nuestro tema. Es así que podemos distinguir a la fe de todos los demás actos que pertenecen al entendimiento, es decir que esta afirmación del Apóstol expresada no en forma de definición, al menos no en la forma que hubieran exigido Aristóteles y el mismo Santo Tomás, contiene todos los elementos de una definición conceptual como exigiría el Organon aristotélico. Porque al decir: es la firme seguridad de lo que esperamos, relaciona el acto de la fe con el fin, que es objeto de la voluntad, y al decir que es la convicción de lo que no vemos, lo relaciona con el entendimiento y lo distingue de todos los demás actos de éste, ya que la convicción se distingue de la opinión, de la sospecha y de la duda, y al decir lo que no vemos distingue el acto de fe respecto de la ciencia y del entendimiento...

Del Noce y el tomismo

Resumen: Augusto Del Noce es un reconocido intérprete filosófico del siglo XX. Sin embargo, su método de filosofar a través de la historia y su diálogo con distintas corrientes del pensamiento han dificultado la tarea de los estudiosos a la hora de ubicar su filosofía. El estudio que aquí ofrecemos acerca de la relación del pensamiento de Del Noce con el tomismo es un aporte para comprender mejor cuáles son los supuestos metafísicos de este autor, cuál es el fundamento último de su propuesta de interpretación de la historia y de la modernidad en general. Frente a quienes entienden que Del Noce no toma suficiente distancia respecto del pensamiento idealista e inmanentista, y frente a quienes cuestionan la solidez de sus fundamentos metafísicos, sostenemos aquí que se trata de un autor que adhiere profunda y coherentemente a la metafísica del ser, y lo hace con referencias explícitas al tomismo. Para llegar a esta conclusión reconstruiremos su período de formación, su relación filosófica con el tomista Gilson y su idea de filosofía cristiana.