Huambo Microbiology Laboratory : economical and financial viability

Mestrado em Finanças

Cost-Effectiveness of Rotavirus Vaccination for Under-Five Children in Iran

Background: Rotavirus diarrhea is one of the most important causes of death among under-five children. Anti-rotavirus vaccination of these children may have a reducing effect on the disease. Objectives: this study is intended to contribute to health policy-makers of the country about the optimal decision and policy development in this area, by performing cost-effectiveness and cost-utility analysis on anti-rotavirus vaccination for under-5 children. Patients and Methods: A cost-effectiveness analysis was performed using a decision tree model to analyze rotavirus vaccination, which was compared with no vaccination with Iran’s ministry of health perspective in a 5-year time horizon. Epidemiological data were collected from published and unpublished sources. Four different assumptions were considered to the extent of the disease episode. To analyze costs, the costs of implementing the vaccination program were calculated with 98% coverage and the cost of USD 7 per dose. Medical and social costs of the disease were evaluated by sampling patients with rotavirus diarrhea, and sensitivity analysis was also performed for different episode rates and vaccine price per dose. Results: For the most optimistic assumption for the episode of illness (10.2 per year), the cost per DALY averted is 12,760 and 7,404 for RotaTeq and Rotarix vaccines, respectively, while assuming the episode of illness is 300%, they will be equal to 2,395 and 354, respectively, which will be highly cost-effective. Number of life-years gained is equal to 3,533 years. Conclusions: Assuming that the illness episodes are 100% and 300% for Rotarix and 300% for Rota Teq, the ratio of cost per DALY averted is highly cost-effective, based on the threshold of the world health organization (< 1 GDP per capita = 4526 USD). The implementation of a national rotavirus vaccination program is suggested.

Energy Efficiency of Software Transactional Memory in a Heterogeneous Architecture

Hardware vendors make an important effort creating low-power CPUs that keep battery duration and durability above acceptable levels. In order to achieve this goal and provide good performance-energy for a wide variety of applications, ARM designed the big.LITTLE architecture. This heterogeneous multi-core architecture features two different types of cores: big cores oriented to performance and little cores, slower and aimed to save energy consumption. As all the cores have access to the same memory, multi-threaded applications must resort to some mutual exclusion mechanism to coordinate the access to shared data by the concurrent threads. Transactional Memory (TM) represents an optimistic approach for shared-memory synchronization. To take full advantage of the features offered by software TM, but also benefit from the characteristics of the heterogeneous big.LITTLE architectures, our focus is to propose TM solutions that take into account the power/performance requirements of the application and what it is offered by the architecture. In order to understand the current state-of-the-art and obtain useful information for future power-aware software TM solutions, we have performed an analysis of a popular TM library running on top of an ARM big.LITTLE processor. Experiments show, in general, better scalability for the LITTLE cores for most of the applications except for one, which requires the computing performance that the big cores offer.

Uma análise da influência do viés de otimismo no julgamento de probabilidades de ativos e passivos contingentes

Tese (doutorado)—Universidade de Brasília, Universidade Federal da Paraíba, Universidade Federal do Rio Grande do Norte, Programa Multi-Institucional e Inter-Regional de Pós-Graduação em Ciências Contábeis, 2016.

Regionalismos léxicos y paremiológicos en la narrativa de Jorge Amado: aspectos sociolingüístico y antropológico

The work of Jorge Amado collects and processes relevant aspects of Brazilian miscegenation and allows discussion on various issues relating to the cultural productions of the country. If on the one hand the racial mixture can be seen as the result of an harmonious process, as is traditional Brazilian thought that comes from XVIII century, on the other hand it portrays the customs of Bahian society at different times, mixing the humorous tone to the optimistic view of the world. As for the miscegenation, reality of the Bahian people, as of all Brazil, can also be analyzed in their heterogeneity, for whom observes that, in the end, the crossing of economic, social and cultural boundaries have been, in many cases, quite problematic. The aim of this work is to make a journey into reality, past and present in Brazil, to understand the lexical regionalisms present in each work; it is important to understand the history of slavery, indigenous groups and the relation that the white man had with this world. All that enormous database of spoken language (a true linguistic laboratory) served and is serving to describe the Portuguese in Brazil in its regional, ethnic and social varieties. (Bagno, 2011: 104-105) I analyze here two works by Jorge Amado, Gabriela, Clove and Cinnamon: Chronicle of an Inner City and Tieta of Agreste, which constitute the corpus of this work, which will consist in detecting an extensive glossary and the collection thereof as well as paremiological regionalisms; phrases or expressions corresponding to a region and time of Brazil...

Capital psicológico positivo: A influência da esperança e do optimismo nas redes sociais

Dissertação de Mestrado apresentada ao Instituto Superior de Psicologia Aplicada para obtenção de grau de Mestre na especialidade de Psicologia Social e das Organizações.

Fraude Fiscal: parte III

O que é a Fraude Fiscal? Perguntámos nas duas semanas anteriores. Fomos respondendo assim que as ciências jurídicas e a Constituição o permitem. Pois hoje vamos continuar. Na passada 6ª Feira tivemos uma aula magnífica ao vivo do Sr. Prof. Catedrático Doutor Costa Andrade que nos falou sobre “Crimes Tributários na Lei Vigente e Jurisprudência”. Sobre a mesma falaremos nos próximos episódios. É que o Mestre superou as expectativas mais optimistas e que já eram elevadas ao mais alto nível técnico. Cada palavra dava uma tese de mestrado e fartou-se de dar bofetadas científicas naqueles que julgam que as contraordenações são um fenómeno de somenos que pode ser tratado como se as mesmas pudessem ser desnecessárias, desadequadas, desproporcionais e de intervenção máxima, violando direitos fundamentais dos cidadãos. § What is Tax Fraud? We asked in the previous two weeks. We have responded as soon as the legal sciences and the Constitution permit. For today we will continue. Last Friday we had a magnificent live lesson from Mr. Prof. Professor Costa Andrade, who told us about "Tax Crimes in the Current Law and Jurisprudence". About the same we will speak in the next episodes. It is that the Master surpassed the most optimistic expectations and that they were already elevated to the highest technical level. Each word gave a master's thesis and was satisfied to give scientific slaps to those who think that the misconduct is a phenomenon of the same that can be treated as if they could be unnecessary, inadequate, disproportionate and of maximum intervention, violating fundamental rights of the Citizens.

Assessing mackerel scad, Decapterus macarellus, in Cape Verde: using a Bayesian approach to biomass dynamic modelling in a data-limited situation

The fisheries for mackerel scad, Decapterus macarellus, are particularly important in Cape Verde, constituting almost 40% of total catches at the peak of the fishery in 1997 and 1998 ( 3700 tonnes). Catches have been stable at a much lower level of about 2 100 tonnes in recent years. Given the importance of mackerel scad in terms of catch weight and local food security, there is an urgent need for updated assessment. Stock assessment was carried out using a Bayesian approach to biomass dynamic modelling. In order to tackle the problem of a non-informative CPUE series, the intrinsic rate of increase, r, was estimated separately, and the ratio B-0/X, initial biomass relative to carrying capacity, was assumed based on available information. The results indicated that the current level of fishing is sustainable. The probability of collapse is low, particularly in the short-term, and it is likely that biomass may increase further above B-msy, indicating a healthy stock level. It would appear that it is relatively safe to increase catches even up to 4000 tonnes. However, the marginal posterior of r was almost identical to the prior, indicating that there is relatively low information content in CPUE. This was also the case in relation to B-0/X There have been substantial increases in fishing efficiency, which have not been adequately captured by the measure used for effort (days or trips), implying that the results may be overly optimistic and should be considered preliminary. (c) 2006 Elsevier B.V. All rights reserved.

Combined Use of NMR, LC-ESIMS and Antifungal Tests for Rapid Detection of Bioactive Lipopeptides Produced by Bacillus

The science and technology interact with the art in several ways. Biotechnological coupled with analytical approaches can play an important role in protecting and preserving cultural heritage for future generations. Many microorganisms influenced by environmental conditions are the main responsible for biological contamination in built heritage. Biocides based on chemical compounds have been used to mitigate this problem. Thus, it is vitally important to develop proper remediation actions based on environmentally innocuous alternative. Bacillus specie is emerging as an optimistic alternative for built heritage treatment due to their capacity to produce secondary metabolites with antagonistic activities against many fungal pathogens. Therefore, the intent of this work was to access a rapid evaluation of antifungal potential of bioactive metabolites produced by Bacillus strains and simultaneously their characterization using spectroscopic (NMR) and chromatographic techniques (LCESI- MS). The high antifungal activity obtained for Bacillus sp. active compounds produced in this study confirms the great potential to suppress biodeteriogenic fungi growth on historical artworks. Additionally, the proposed methodology allowed to access bioactive metabolites produced without need of the laborious total previous isolation and could be used as a viable alternative to be employed for screening and production of new green biocides.