Technology transfer in Britain: the case of monoclonal antibodies

In 1975 two Cambridge scientists published a short article in Nature which announced the discovery of monoclonal antibodies. The article concluded ‘Such cultures could be valuable for medical and industrial use’. The interest which developed by the end of the decade in the industrial and financial possibilities of the new prospects opening up in biotechnology was to throw the apparent ‘failure’ to follow‐up the potentialities of this discovery into a public prominence rarely achieved by scientific discoveries. By the time Mrs Thatcher came to power it had become a scandal, another example of Britain's apparent inability to exploit effectively the brilliance of its scientific base. It was to explore both the process of scientific discovery and the conditions in Cambridge which nurtured it, and the issues which this particular discovery raised in the area of technology transfer (and the changes of policy that ensued), that the Wellcome Trust's History of Twentieth Century Medicine Group and the Institute of Contemporary British History organised this special witness seminar. It was held at the Wellcome Trust in London on 24 September 1993. The seminar was chaired by Sir Christopher Booth and introduced by Dr Robert Bud of the Science Museum. Those participating included the two authors of the Nature article, Dr César Milstein and Dr Georges Köhler, who received a Nobel Prize for their research, Dr Basil Bard (National Research Development Corporation [NRDC] 1950–74), Sir James Gowans (Secretary of the Medical Research Council [MRC] 1977–87), Sir John Gray (Secretary of the MRC 1968–77), John Newell (BBC World Service science correspondent 1969–79), Dr David Owen (MRC), and Dr David Secher (Laboratory of Molecular Biology [LMB], Cambridge). There were also contributions from Dr Ita Askonas (former head of immunology at the National Institute for Medical Research), Dr John Galloway (former member of MRC headquarters staff), Dr David Tyrrell (former Director, MRC Common Cold Unit), Professor Miles Weatherall (head of Therapeutic Research Division, Wellcome Research Laboratories 1967–75), Dr Guil Winchester (post‐doctoral fellow, Wellcome Institute for the History of Medicine), and Dr Peter Williams (former Director of the Wellcome Trust). The organisers would like to thank the Wellcome Trust for hosting and sponsoring the seminar. We would like to dedicate this publication to the memory of Georges Köhler, who sadly died in April 1995 before this could appear.

Photograph - Robert Houston

A Photograph of Robert Houston of Port Dalhousie. He died 6 December 1889 at age 44 years and is buried in the Anglican Cemetary of Port Dalhousie. The photograph was taken at Thos. Charles, Photographer on Ontario Street in St. Catharines.

Indenture between Robert Loring and John Conolly

Indenture of bargain and sale between Robert Loring of Toronto and John Connolly of St. Catharines for lot no. 8 in the 12th concession of Durham. The instrument no. is 24283, January 28, 1861.

License of Occupation

License of occupation. This is a 2 ½ page handwritten document which states “By General Sir Peregrine Maitland, commanding his Majesty’s Forces in North America” license and permission is granted to Robert Hamilton of the Township of Niagara for water Lot no. 7 on the Niagara River. This section is signed by P. Maitland on March 15, 1825. The second half of the document states that Robert Hamilton of Queenston grants the land to Robert Melville, president of the Niagara Harbour and Dock Co. Sept. 15, 1832.

Indenture (vellum) of bargain and sale between William Dickson, Thomas Dickson and Thomas Clark

Indenture (vellum) of bargain and sale between William Dickson, Thomas Dickson and Thomas Clark, executors of the late Robert Hamilton of Queenston to George Moffat for land in Burford, Beverly and Grimsby, Ontario, Feb. 27, 1827.

Appointment of John B. Parkynn [Parkin] (J.P. Bradley’s brother) to be an Ensign of the 1st Company of the Royal Quebec Volunteers

Appointment of John B. Parkynn [Parkin] (J.P. Bradley’s brother) to be an Ensign of the 1st Company of the Royal Quebec Volunteers. This is signed by the Governor General, the Earl of Gosford and Governor General, Secretary J. Walcott, Nov. 27, 1837.

Osteopontin (OPN) and neoplastic disease: Circulating levels and tissue distribution

OPN is a secreted phosphate containing protein which is expressed by osteoblasts and a variety of other cells in vivo. Data from in vitro studies has accumulated which relates OPN to cellular transformation. We hypothesize that OPN expression is associated with neoplastic disease in humans as suggested by cell culture models. The overall objective of the current study was to determine the tissue distribution of OPN in human malignancy and to determine whether or not a correlation exists between OPN serum levels and malignancy. At the inception of this project, no study had been made demonstrating the relevance of OPN expression with naturally occurring neoplastic disease in humans. To date, few studies have reported OPN distribution in human neoplasia and are limited by either the number of specimens analyzed or the technique used in analysis. In this dissertation study, OPN was purified from human milk and $\alpha$-OPN antiserum developed and characterized. Following antibody development, the distribution and prevalence of OPN in human oral squamous cell carcinoma and human prostate carcinoma was evaluated using immunohistochemical localization. OPN immunolocalization was found in a high percentage of oral epithelial dysplasia and oral squamous cell carcinoma in humans. One oral squamous cell carcinoma cells line, UMSCC-1, was found to express OPN mRNA using Northern blotting. OPN localized to a high percentage of primary prostate adenocarcinomas. OPN localized to 52% of androgen dependent cases and 100% of androgen independent cases. Androgen dependent cell lines such as LNCap and NbE showed minimal OPN mRNA expression while the androgen independent lines C4-2 and PC3 produced ample OPN mRNA. An OPN sandwich assay was developed and used to determine the serum level of OPN in normal males, patients with BPH (benign prostate hypertrophy), and patients with prostate carcinoma. No statistically significant difference was found in OPN serum levels among the three groups. However, a trend of increasing OPN in the serum was noted in patients with BPH and prostate cancer. ^

Draft of the bond for Steward Jonathan Hastings. 1753 January 15

Mutilated draft of a bond of Steward Jonathan Hastings and Robert Sharp of Brooklyn, Mass. to the President and Fellows of Harvard College for 1,000 pounds.

Warrants from the governor and chief justice of New York, 1703-1704

Copies of warrants and writs concerning public unrest caused by an attempt to survey lands on Long Island in 1702.

Miscellaneous correspondence,

Includes letters from John Jervis, 1st Earl of St. Vincent, to Admiral Isaac Coffin Bart in London, and several other unaddressed or unsigned letters, as well as a copy of William Cullen Bryant’s poem, "Robert of Lincoln."

University of Michigan, 1856

Engraving, 19 x 19 cm. Original painting by J.F. Cropsey dated 1856. Publication information: New York : R. Leggett, 1856