规范化管理高科技高效益企业

规范化管理高科技高效益企业中国科学院成都生物研究所王海燕中共成都市委组织部张松中科院成都生物研究所于１９８８年开始创办药厂，药厂产值六年翻了六番，原始投资增值数百倍。如今，药厂已更名为地奥制药公司，成为拥有净资产２亿多元、年利税１亿元的集高科技、新产...

波浪破碎散射模式的研究及应用

海面反射、散射或自发辐射的各个波段的电磁波携带着海表面温度、海平面高度、海表面粗糙度以及海水所含各种物质浓度的信息。波浪破碎是海洋的一种重要现象，波浪破碎支撑着海－气之间的热通量和气体通量的交换，这些通量对于天气和气候都有深远影响。同时，波浪破碎使得海表的粗糙度增加，这对于海表散射电磁波有极大的影响，因此在处理雷达散射问题时，考虑波浪破碎的影响十分必要。 本文分析了雷达散射的两种模式，并阐述了波浪破碎在海表电磁波散射过程中的重要性。论文的创新点在于利用Kudryavtsev03模式，反演得到了波浪破碎率与风速的两种新关系式，同时得到了较高精度的风速反演的隐含模式。针对波浪破碎微波散射模式问题，论文主要研究结果如下： 1.在Kudryavtsev03模式的基础上，以黄兴忠的白冠覆盖率公式替代破碎率，利用ERS-1散射计数据，对Bragg散射模式和Kudryavtsev03模式的结果进行了比较。结果表明：在相同条件下，考虑波浪破碎的Kudryavtsev03模式明显优于纯Bragg散射模式。 2 对Kudryavtsev03模式进行了修正。通过与实测ERS-1散射计数据比较，表明修正后，入射角在18-35°范围内，模式的结果具有较高的精度。 3 利用修正后的模式及散射计数据，在入射角为30-35°范围内，反演破碎率，并对反演结果进行了拟合，得到了两个新的破碎率与风速的关系式。 4 利用修正后的模式及新的破碎率公式，在入射角为30-35°范围内，反演风速，具有较高精度。 5 利用反演的风速，根据经验关系式，推算了各种海洋物理量。

Response of Polygonum viviparum species and community level to long-term livestock grazing in alpine shrub meadow in Qinghai-Tibet Plateau

Grazing by domestic herbivores is generally recognized as a major ecological factor and an important evolutionary force in grasslands. Grazing has both extensive and profound effects on individual plants and communities. We investigated the response patterns of Polygonum viviparum species and the species diversity of an alpine shrub meadow in response to long-term livestock grazing by a field manipulative experiment controlling livestock numbers on the Qinghai-Tibet Plateau in China. Here, we hypothesize that within a range of grazing pressure, grazing can alter relative allocation to different plant parts without changing total biomass for some plant species if there is life history trade-offs between plant traits. The same type of communities exposed to different grazing pressures may only alter relative species' abundances or species composition and not vary species diversity because plant species differ in resistant capability to herbivory. The results show that plant height and biomass of different organs differed among grazing treatments but total biomass remained constant. Biomass allocation and absolute investments to both reproduction and growth decreased and to belowground storage increased with increased grazing pressure, indicating the increasing in storage function was attained at a cost of reducing reproduction of bulbils and represented an optimal allocation and an adaptive response of the species to long-term aboveground damage. Moreover, our results showed multiform response types for either species groups or single species along the gradient of grazing intensity. Heavy grazing caused a 13.2% increase in species richness. There was difference in species composition of about 18%-20% among grazing treatment. Shannon-Wiener (H') diversity index and species evenness (E) index did not differ among grazing treatments. These results support our hypothesis.

东濮凹陷低阻油层形成机理与评价方法研究

In order to effectively identify and accurately evaluate low resistivity reservoir in Dongpu depression, using various logging data synthetically, geological and logging characteristics are summarized in term of different blocks on the basis of core analysis, cutting logging, oil testing and commissioning data. The formation mechanism of low resistivity reservoir is studied, and the main factors that cause low resistivity reservoir are discovered. The first factor is fine lithology, high shale content and hydrophilic rock. The second factor is high salinity formation water. The third factor is light oil, high gas quantity dissolved and large difference density of oil-water. The last factor is low amplitude structure of reservoir and low differential degree of oil-water. According to the characteristics of low resistivity reservoir, the method of compound lithology, the method of movable fluid, the method of phase permeability and the method of nuclear magnetic resonance logging are put forward. The compound lithology criterion of distinguishing hydrocarbon is founded in term of different blocks on the basis of electrical efficiency. The evaluation models of reservoir parameters are founded; whose core is oil saturation and phase permeability. In order to calculate oil saturation, the compound lithology model on the basis of electrical efficiency theory is chosen on condition that there is only the combination logging data of acoustic and induction; the W-S model is chosen on condition that there is all-around logging data. The calculational precision of oil saturation in low resistivity reservoir of work area is enhanced when the selection method is utilized. There are 1212 layers of reservoir newly added by the old well reexamination in the ten oil areas. The coincidence rate of logging interpretation reaches 83.2 percent according to the 74 well-times of oil testing or commissioning, which indicates that the distinguishing method and evaluation models of low resistivity reservoir above are feasible.By the reexamination, a ten million tons of proved reserves related to the low resistivity reservoir are newly added, consequently, the groundwork is established to increase reserve and production of old oilfields in the east of China and new livingness is added for the petroleum exploration and development in Dongpu depression.

渤海湾盆地前第三系构造演化与煤成气成藏研究

The disequilibrium between supply and demand the east part of North China accelerated natural gas exploration in Bohai bay basin. Exploration practice showed that coal-derived gas is important resource. In searching of big to middle scaled coal derived gas field, and realize successive gas supply, the paper carried out integrated study on structural evolution of Pre-Tertiary and evaluation of reservoir forming condition of coal-derived gas. Study work of the paper was based on the following condition: available achievement in this field at present, good understanding of multiphase of tectonic movement. Study work was focused on geological evolution, source rock evaluation and dissection key factors controlling reservoir forming. Based on analysis of seismic data, drilling data, tectonic style of Pre-Tertiary was subdivided, with different tectonic style representing different tectonic process. By means of state of the art, such as analysis of balanced cross section, and erosion restoration, the paper reestablished tectonic history and analyzed basin property during different tectonic phase. Dynamic mechanism for tectonic movement and influence of tectonic evolution on tectonic style were discussed. Study made it clear that tectonic movement is intensive since Mesozoic including 2 phase of compressional movement (at the end of Indo-China movement, and Yanshan movement), 2 phase of extensional movement (middle Yanshan movement, and Himalayan movement), 2 phase of strike slip movement, as well as 2 phase of reversal movement (early Yanshan movement, and early Himalayan movement). As a result, three tectonic provinces with different remnant of strata and different tectonic style took shape. Based on afore mentioned study, the paper pointed out that evolution of Bohai bay basin experienced the following steps: basin of rift valley type (Pt2+3)-craton basin at passive continental margin (∈1－2)-craton basin at active continental margin (∈3- O)-convergent craton basin (C-T1+2)-intracontinental basin (J＋K). Superposition of basins in different stage was discussed. Aimed at tectonic feature of multiple phases, the paper put forward concept model of superposition of tectonic unit, and analyzed its significance on reservoir forming. On basis of the difference among 3 tectonic movements in Mesozoic and Cenozoic, superposition of tectonic unit was classified into the following 3 categories and 6 types: continuous subsidence type (I), subsidence in Mesozoic and uplift for erosion in Cenozoic (II1), repeated subsidence and uplift in Mesozoic and subsidence in Cenozoic (II2), repeated subsidence and uplift in Mesozoic and uplift for erosion in Cenozoic (II3), uplift for erosion in Mesozoic and subsidence in Cenozoic (II4), and continuous uplift (III). Take the organic facies analysis as link, the paper established relationship between sedimentary environment and organic facies, as well as organic facies and organic matter abundance. Combined information of sedimentary environment and logging data, the paper estimated distribution of organic matter abundance. Combined with simulation of secondary hydrocarbon generation, dynamic mechanism of hydrocarbon generation, and thermal history, the paper made static and dynamic evaluation of effective source rock, i.e. Taiyuan formation and Shanxi formation. It is also pointed out that superposition of tectonic unit of type II2, type II4, and type I were the most favorable hydrocarbon generation units. Based on dissection of typical primary coal-derived gas reservoir, including reservoir forming condition and reservoir forming process, the paper pointed out key factors controlling reservoir forming for Carboniferous and Permian System: a. remnant thickness and source rock property were precondition; b. secondary hydrocarbon generation during Himalayan period was key factor; c. tectonic evolution history controlling thermal evolution of source rock was main factor that determine reservoir forming; d. inherited positive structural unit was favorable accumulation direction; e. fault activity and regional caprock determined hydrocarbon accumulation horizon. In the end, the paper established reservoir forming model for different superposition of tectonic units, and pointed out promising exploration belts with 11 of the first class, 5 of the second class and 6 of the third class.

Y Mudiad Drama, 1880-1940 : Y Meddwl Ar Dychymyg Cymreig

Williams, Ioan, Y Mudiad Drama yng Nghymru 1880-1940 (University of Wales Press, 2006), pp.vii+215

Nano-urchin: The formation and structure of high-density spherical clusters of vanadium oxide nanotubes

We report the observation of urchin-like nanostructures consisting of high-density spherical nanotube radial arrays of vanadium oxide nanocomposite, successfully synthesized by a simple chemical route using an ethanolic solution of vanadium tri-isopropoxide and alkyl amine hexadecylamine for 7 days at 180oC. The results show that the growth process of the NanoUrchin occurs in stages, starting with a radial self-organized arrangement of lamina followed by the rolling of the lamina into nanotubes. The longest nanotubes are measured to be several micrometers in length with diameters of ~120 nm and hollow centers typically measured to be ~75 nm. The NanoUrchin have an estimated density of nanotubes of ~40 sr-1. The tube walls comprise layers of vanadium oxide with the organic surfactant intercalated between atomic layers. The interlayer distance is measured to be 2.9 ± 0.1 nm and electron diffraction identified the vanadate phase in the VOx nanocomposite as orthorhombic V2O5. These nanostructures may be used as three-dimensional composite materials and as supports for other materials.

Genome-wide scan of copy number variation in late-onset Alzheimer's disease.

Alzheimer's disease is a complex and progressive neurodegenerative disease leading to loss of memory, cognitive impairment, and ultimately death. To date, six large-scale genome-wide association studies have been conducted to identify SNPs that influence disease predisposition. These studies have confirmed the well-known APOE epsilon4 risk allele, identified a novel variant that influences disease risk within the APOE epsilon4 population, found a SNP that modifies the age of disease onset, as well as reported the first sex-linked susceptibility variant. Here we report a genome-wide scan of Alzheimer's disease in a set of 331 cases and 368 controls, extending analyses for the first time to include assessments of copy number variation. In this analysis, no new SNPs show genome-wide significance. We also screened for effects of copy number variation, and while nothing was significant, a duplication in CHRNA7 appears interesting enough to warrant further investigation.

Characterization of B cells in muscle-specific kinase antibody myasthenia gravis.

OBJECTIVE: To characterize B-cell subsets in patients with muscle-specific tyrosine kinase (MuSK) myasthenia gravis (MG). METHODS: In accordance with Human Immunology Project Consortium guidelines, we performed polychromatic flow cytometry and ELISA assays in peripheral blood samples from 18 patients with MuSK MG and 9 healthy controls. To complement a B-cell phenotype assay that evaluated maturational subsets, we measured B10 cell percentages, plasma B cell-activating factor (BAFF) levels, and MuSK antibody titers. Immunologic variables were compared with healthy controls and clinical outcome measures. RESULTS: As expected, patients treated with rituximab had high percentages of transitional B cells and plasmablasts and thus were excluded from subsequent analysis. The remaining patients with MuSK MG and controls had similar percentages of total B cells and naïve, memory, isotype-switched, plasmablast, and transitional B-cell subsets. However, patients with MuSK MG had higher BAFF levels and lower percentages of B10 cells. In addition, we observed an increase in MuSK antibody levels with more severe disease. CONCLUSIONS: We found prominent B-cell pathology in the distinct form of MG with MuSK autoantibodies. Increased BAFF levels have been described in other autoimmune diseases, including acetylcholine receptor antibody-positive MG. This finding suggests a role for BAFF in the survival of B cells in MuSK MG, which has important therapeutic implications. B10 cells, a recently described rare regulatory B-cell subset that potently blocks Th1 and Th17 responses, were reduced, which suggests a potential mechanism for the breakdown in immune tolerance in patients with MuSK MG.

Incontinence and gait disturbance after intraventricular extension of intracerebral hemorrhage.

OBJECTIVE: We tested the hypothesis that intraventricular hemorrhage (IVH) is associated with incontinence and gait disturbance among survivors of intracerebral hemorrhage (ICH) at 3-month follow-ups. METHODS: The Genetic and Environmental Risk Factors for Hemorrhagic Stroke study was used as the discovery set. The Ethnic/Racial Variations of Intracerebral Hemorrhage study served as a replication set. Both studies performed prospective hot-pursuit recruitment of ICH cases with 3-month follow-up. Multivariable logistic regression analyses were computed to identify risk factors for incontinence and gait dysmobility at 3 months after ICH. RESULTS: The study population consisted of 307 ICH cases in the discovery set and 1,374 cases in the replication set. In the discovery set, we found that increasing IVH volume was associated with incontinence (odds ratio [OR] 1.50; 95% confidence interval [CI] 1.10-2.06) and dysmobility (OR 1.58; 95% CI 1.17-2.15) after controlling for ICH location, initial ICH volume, age, baseline modified Rankin Scale score, sex, and admission Glasgow Coma Scale score. In the replication set, increasing IVH volume was also associated with both incontinence (OR 1.42; 95% CI 1.27-1.60) and dysmobility (OR 1.40; 95% CI 1.24-1.57) after controlling for the same variables. CONCLUSION: ICH subjects with IVH extension are at an increased risk for developing incontinence and dysmobility after controlling for factors associated with severity and disability. This finding suggests a potential target to prevent or treat long-term disability after ICH with IVH.

Clinician judgment vs formal scales for predicting intracerebral hemorrhage outcomes.

OBJECTIVE: To compare the performance of formal prognostic instruments vs subjective clinical judgment with regards to predicting functional outcome in patients with spontaneous intracerebral hemorrhage (ICH). METHODS: This prospective observational study enrolled 121 ICH patients hospitalized at 5 US tertiary care centers. Within 24 hours of each patient's admission to the hospital, one physician and one nurse on each patient's clinical team were each asked to predict the patient's modified Rankin Scale (mRS) score at 3 months and to indicate whether he or she would recommend comfort measures. The admission ICH score and FUNC score, 2 prognostic scales selected for their common use in neurologic practice, were calculated for each patient. Spearman rank correlation coefficients (r) with respect to patients' actual 3-month mRS for the physician and nursing predictions were compared against the same correlation coefficients for the ICH score and FUNC score. RESULTS: The absolute value of the correlation coefficient for physician predictions with respect to actual outcome (0.75) was higher than that of either the ICH score (0.62, p = 0.057) or the FUNC score (0.56, p = 0.01). The nursing predictions of outcome (r = 0.72) also trended towards an accuracy advantage over the ICH score (p = 0.09) and FUNC score (p = 0.03). In an analysis that excluded patients for whom comfort care was recommended, the 65 available attending physician predictions retained greater accuracy (r = 0.73) than either the ICH score (r = 0.50, p = 0.02) or the FUNC score (r = 0.42, p = 0.004). CONCLUSIONS: Early subjective clinical judgment of physicians correlates more closely with 3-month outcome after ICH than prognostic scales.

El valor de la demostración en la educación secundaria

A lo largo de la licenciatura de Matemáticas (que terminamos el curso pasado), el rigor ha sido la característica predominante: siempre se ha demostrado todo lo afirmado o utilizado. Este hecho hizo que no concibiéramos unas matemáticas sin demostraciones. Con este enfoque de las matemáticas iniciamos nuestro periodo de prácticas (correspondientes a la asignatura "Prácticas de la Enseñanza" de quinto curso) y nos enfrentamos por primera vez con la realidad educativa: no todo lo que se le explica a los alumnos debe ser objeto de demostración. Mediante esta comunicación pretendemos compartir nuestras reflexiones sobre el valor de la demostración en las matemáticas de la Enseñanza Secundaria.

La imagen como recurso didáctico

La idea general del taller era que los participantes de estas jornadas conocieran que las imágenes obtenidas de la realidad pueden ser un instrumento de reflexión y un material didáctico para el conocimiento de conceptos e ideas matemáticas en los diferentes niveles educativos (desde primaria hasta universidad).

Unidad didáctica: ecuaciones de primer grado y sistemas de ecuaciones

Se presenta un ejemplo de análisis didáctico del tópico "Ecuaciones de primer grado y sistemas de ecuaciones"

Measuring the comprehensibility of Z specifications

The effects of natural language comments, meaningful variable names, and structure on the comprehensibility of Z specifications are investigated through a designed experiment conducted with a range of undergraduate and post-graduate student subjects. The times taken on three assessment questions are analysed and related to the abilities of the students as indicated by their total score, with the result that stronger students need less time than weaker students to complete the assessment. Individual question scores, and total score, are then analysed and the influence of comments, naming, structure and level of student's class are determined. In the whole experimental group, only meaningful naming significantly enhances comprehension. In contrast, for those obtaining the best score of 3/3 the only significant factor is commenting. Finally, the subjects' ratings of the five specifications used in the study in terms of their perceived comprehensibility have been analysed. Comments, naming and structure are again found to be of importance in the group when analysed as a whole, but in the sub-group of best performing subjects only the comments had an effect on perceived comprehensibility.