L'hermite en Suisse; ou Observations sur les mœurs et les usages suisses au commencement du XIXe siècle. Faisant suite à la Collection des mœurs françaises, anglaises, italiennes etc.

Attributed to Étienne Jouy.

La France et les ultramontains; esquisse historique.

Mode of access: Internet.

The twin brothers : being the lives of John and James Dixon, born at Naworth Park, Cumberland, England /

Includes poetry of John Dixon, p. 73-76.

Arnaldo, Gaddo, and other unacknowledged poems.

[Uncut.]

Le Siége de Paris par les Normands en 885 et 886 : poëme d'Abbon /

Poem originally published as "Des guerres de la ville de Paris par Abbon" near the end of the 9th century.

Théorie des machines à vapeur : l'ouvrage destiné à prouver l'inexactitude des méthodes en usage pour évaluer les effets ou les proportions des machines à vapeur /

Mode of access: Internet.

Kitāb al-Uns wa-al-īnās fī futūḥ Ifrīqīyah ilá madīnat Fās : manuscript, 1795

الحمد لله مانح النعم فضلا من عنده المحسن بما يقوم به احدا بحقه وان بالغ غاية جهده... :Incipit

“To laugh in tragic joy” – a linguagem poética de W. B. Yeats em Lapis Lazuli

Artigo em texto integral no link da versão do editor

Quinupristin-dalfopristin combined with beta-lactams for treatment of experimental endocarditis due to Staphylococcus aureus constitutively resistant to macrolide-lincosamide-streptogramin B antibiotics.

Quinupristin-dalfopristin (Q-D) is an injectable streptogramin active against most gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA). In experimental endocarditis, however, Q-D was less efficacious against MRSA isolates constitutively resistant to macrolide-lincosamide-streptogram B (C-MLS(B)) than against MLS(B)-susceptible isolates. To circumvent this problem, we used the checkerboard method to screen drug combinations that would increase the efficacy of Q-D against such bacteria. beta-Lactams consistently exhibited additive or synergistic activity with Q-D. Glycopeptides, quinolones, and aminoglycosides were indifferent. No drugs were antagonistic. The positive Q-D-beta-lactam interaction was independent of MLS(B) or beta-lactam resistance. Moreover, addition of Q-D at one-fourth the MIC to flucloxacillin-containing plates decreased the flucloxacillin MIC for MRSA from 500 to 1,000 mg/liter to 30 to 60 mg/liter. Yet, Q-D-beta-lactam combinations were not synergistic in bactericidal tests. Rats with aortic vegetations were infected with two C-MLS(B)-resistant MRSA isolates (isolates AW7 and P8) and were treated for 3 or 5 days with drug dosages simulating the following treatments in humans: (i) Q-D at 7 mg/kg two times a day (b.i.d.) (a relatively low dosage purposely used to help detect positive drug interactions), (ii) cefamandole at constant levels in serum of 30 mg/liter, (iii) cefepime at 2 g b.i.d., (iv) Q-D combined with either cefamandole or cefepime. Any of the drugs used alone resulted in treatment failure. In contrast, Q-D plus either cefamandole or cefepime significantly decreased valve infection compared to the levels of infection for both untreated controls and those that received monotherapy (P < 0.05). Importantly, Q-D prevented the growth of highly beta-lactam-resistant MRSA in vivo. The mechanism of this beneficial drug interaction is unknown. However, Q-D-beta-lactam combinations might be useful for the treatment of complicated infections caused by multiple organisms, including MRSA.