939 resultados para Sermones inter unius auctoris collectionem. In Ascensione
Resumo:
[Subprior Theobaldus]
Resumo:
Autor tomado de CCPB
Resumo:
Autor: Michele Angriani tomado de Adams
Resumo:
In this paper, the applicability of the FRA technique is discussed as a method for detecting inter-turn faults in stator windings. Firstly, this method is tested in an individual medium-voltage stator coil with satisfactory results. Secondly, the tests are extended to a medium-voltage induction motor stator winding, in which inter-turn faults are performed in every coil end of one phase. Results of the frequency response in case of inter-turn faults are evaluated in both cases for different fault resistance values. The experimental setup is also described for each experiment. The results of the application of this technique to the detection of inter-turn faults justify further research in optimizing this technique for preventive maintenance.
Resumo:
The brain cholecystokinin-B/gastrin receptor (CCK-BR) is a major target for drug development because of its postulated role in modulating anxiety, memory, and the perception of pain. Drug discovery efforts have resulted in the identification of small synthetic molecules that can selectively activate this receptor subtype. These drugs include the peptide-derived compound PD135,158 as well as the nonpeptide benzodiazepine-based ligand, L-740,093 (S enantiomer). We now report that the maximal level of receptor-mediated second messenger signaling that can be achieved by these compounds (drug efficacy) markedly differs among species homologs of the CCK-BR. Further analysis reveals that the observed differences in drug efficacy are in large part explained by single or double aliphatic amino acid substitutions between respective species homologs. This interspecies variability in ligand efficacy introduces the possibility of species differences in receptor-mediated function, an important consideration when selecting animal models for preclinical drug testing. The finding that even single amino acid substitutions can significantly affect drug efficacy prompted us to examine ligand-induced signaling by a known naturally occurring human CCK-BR variant (glutamic acid replaced by lysine in position 288; 288E → K). When examined using the 288E → K receptor, the efficacies of both PD135,158 and L-740,093 (S) were markedly increased compared with values obtained with the wild-type human protein. These observations suggest that functional variability resulting from human receptor polymorphisms may contribute to interindividual differences in drug effects.
Resumo:
Mode of access: Internet.
Resumo:
Mode of access: Internet.
Resumo:
Marca tipográfica en portada.
Resumo:
Includes index.
Resumo:
Mode of access: Internet.
Resumo:
Water marketing, or mechanisms to acquire and redistribute water such as temporary water transfers, can represent a valuable response to drought for irrigation districts. The Department of Ecology, the US Bureau of Reclamation, and a workgroup composed of members from various entities collaborated to develop the Yakima River Basin Integrated Water Resource Management Plan (Integrated Plan) to better manage water resources and address ecosystem issues in the Yakima River Basin. The Integrated Plan addresses water marketing but it does not provide specifics on how barriers to inter‐district water transfers will be eliminated. This study asks irrigation district managers in the Yakima River basin about the factors they consider when deciding whether to engage in a temporary inter‐district water transfer or not. Results show that institutional barriers are the most common barrier to inter‐district water transfers. This topic requires further research on fallowing and irrigation district behavior in relation to the other water supply efforts outlined in the Integrated Plan. Finally, the water market in the Yakima basin can benefit from education and outreach to senior water rights holders, shortening the time frame to process expedited transfers, and documentation from irrigation districts reporting denial reasons for temporary inter‐district water transfers.