Efeito da participação e do desligamento de programa de mudança no estilo de vida sobre o nível de atividade e aptidão física, percepção de saúde e presença de síndrome metabólica em adultos da comunidade de Botucatu - SP

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

O estatuto teórico-metodológico do falado e do escrito para a pesquisa em mudança linguística

The objective of this paper is to reflect on the theoretical and methodological status of oral and written data as a source for investigating linguistic change phenomena. The per - spective we adopt here distances itself from a compartmentalized conception of oral and writ - ten texts writing since it is more closely associated with the writers’ relationship with historically and socially established practices of orality and literacy. We conducted an assessment of some of the specialized literature in order to gather arguments to defend the coexistence of written and oral enunciations, understood not as a form of interference, but as a constitutive blend, which, given its hybrid nature, enables the occurrence of the vernacular data, a locus of change also present in written records.

DESINDUSTRIALIZAÇÃO DO ABC: EMPREGO E DESEMPREGO EM TEMPOS DE MUDANÇA.

O presente trabalho pretende mapear a região do ABC dando ênfase ao processo de desenvolvimento industrial e ao aumento da densidade demográfica decorrente. Isto se dá a partir do estudo quantitativo da mão de obra necessária. que reflete diretamente no emprego. O enfoque será mais acurado nesse aspecto. Num primeiro momento, aborda-se o contexto histórico, análise do processo de urbanização do século passado, que culmina com a instalação das indústrias na região. A abertura econômica do início dos anos 90, a aplicação de novas tecnologias e novas ferramentas de administração também fazem parte desse contexto. Nesse período o processo de industrialização sofre uma reestruturação comprometendo a aptidão regional, a chamada desindustrialização . O foco principal será a indústria automobilista, sem dúvida a de maior importância para e na região. No segundo momento, descreve-se quantitativamente o processo de mudança do comportamento da região e, analisa-se em paralelo, o desemprego e emprego nos setores industrial e de serviços. no período que compreende a última década do século XX , início do XXI. Por fim, mas não de menor importância, busca-se descrever e entender o surgimento das novas aptidões, geradas principalmente pela mudança de alocação das indústrias. Analisando questões como transformação da aptidão regional emprego e desemprego com base nos dados disponibilizados pelas instituições de pesquisa, buscando correlações entre variáveis para enfim, determinar como de fato se encontra hoje o emprego, o trabalhador e principalmente o processo industrial da região.(AU)

DESINDUSTRIALIZAÇÃO DO ABC: EMPREGO E DESEMPREGO EM TEMPOS DE MUDANÇA.

O presente trabalho pretende mapear a região do ABC dando ênfase ao processo de desenvolvimento industrial e ao aumento da densidade demográfica decorrente. Isto se dá a partir do estudo quantitativo da mão de obra necessária. que reflete diretamente no emprego. O enfoque será mais acurado nesse aspecto. Num primeiro momento, aborda-se o contexto histórico, análise do processo de urbanização do século passado, que culmina com a instalação das indústrias na região. A abertura econômica do início dos anos 90, a aplicação de novas tecnologias e novas ferramentas de administração também fazem parte desse contexto. Nesse período o processo de industrialização sofre uma reestruturação comprometendo a aptidão regional, a chamada desindustrialização . O foco principal será a indústria automobilista, sem dúvida a de maior importância para e na região. No segundo momento, descreve-se quantitativamente o processo de mudança do comportamento da região e, analisa-se em paralelo, o desemprego e emprego nos setores industrial e de serviços. no período que compreende a última década do século XX , início do XXI. Por fim, mas não de menor importância, busca-se descrever e entender o surgimento das novas aptidões, geradas principalmente pela mudança de alocação das indústrias. Analisando questões como transformação da aptidão regional emprego e desemprego com base nos dados disponibilizados pelas instituições de pesquisa, buscando correlações entre variáveis para enfim, determinar como de fato se encontra hoje o emprego, o trabalhador e principalmente o processo industrial da região.(AU)

DESINDUSTRIALIZAÇÃO DO ABC: EMPREGO E DESEMPREGO EM TEMPOS DE MUDANÇA.

O presente trabalho pretende mapear a região do ABC dando ênfase ao processo de desenvolvimento industrial e ao aumento da densidade demográfica decorrente. Isto se dá a partir do estudo quantitativo da mão de obra necessária. que reflete diretamente no emprego. O enfoque será mais acurado nesse aspecto. Num primeiro momento, aborda-se o contexto histórico, análise do processo de urbanização do século passado, que culmina com a instalação das indústrias na região. A abertura econômica do início dos anos 90, a aplicação de novas tecnologias e novas ferramentas de administração também fazem parte desse contexto. Nesse período o processo de industrialização sofre uma reestruturação comprometendo a aptidão regional, a chamada desindustrialização . O foco principal será a indústria automobilista, sem dúvida a de maior importância para e na região. No segundo momento, descreve-se quantitativamente o processo de mudança do comportamento da região e, analisa-se em paralelo, o desemprego e emprego nos setores industrial e de serviços. no período que compreende a última década do século XX , início do XXI. Por fim, mas não de menor importância, busca-se descrever e entender o surgimento das novas aptidões, geradas principalmente pela mudança de alocação das indústrias. Analisando questões como transformação da aptidão regional emprego e desemprego com base nos dados disponibilizados pelas instituições de pesquisa, buscando correlações entre variáveis para enfim, determinar como de fato se encontra hoje o emprego, o trabalhador e principalmente o processo industrial da região.(AU)

Temporomandibular Dysfunction Post-craniotomy: Evaluation Between Pre- And Post-operative Status.

To identify risk factors associated with post-operative temporomandibular joint dysfunction after craniotomy. The study sample included 24 patients, mean age of 37.3 ± 10 years; eligible for surgery for refractory epilepsy, evaluated according to RDC/TMD before and after surgery. The primary predictor was the time after the surgery. The primary outcome variable was maximal mouth opening. Other outcome variables were: disc displacement, bruxism, TMJ sound, TMJ pain, and pain associated to mandibular movements. Data analyses were performed using bivariate and multiple regression methods. The maximal mouth opening was significantly reduced after surgery in all patients (p = 0.03). In the multiple regression model, time of evaluation and pre-operative bruxism were significantly (p < .05) associated with an increased risk for TMD post-surgery. A significant correlation between surgery follow-up time and maximal opening mouth was found. Pre-operative bruxism was associated with increased risk for temporomandibular joint dysfunction after craniotomy.

Changes In Liver Cell Dna Methylation Status In Diabetic Mice Affect Its Ft-ir Characteristics.

Lower levels of cytosine methylation have been found in the liver cell DNA from non-obese diabetic (NOD) mice under hyperglycemic conditions. Because the Fourier transform-infrared (FT-IR) profiles of dry DNA samples are differently affected by DNA base composition, single-stranded form and histone binding, it is expected that the methylation status in the DNA could also affect its FT-IR profile. The DNA FT-IR signatures obtained from the liver cell nuclei of hyperglycemic and normoglycemic NOD mice of the same age were compared. Dried DNA samples were examined in an IR microspectroscope equipped with an all-reflecting objective (ARO) and adequate software. Changes in DNA cytosine methylation levels induced by hyperglycemia in mouse liver cells produced changes in the respective DNA FT-IR profiles, revealing modifications to the vibrational intensities and frequencies of several chemical markers, including νas -CH3 stretching vibrations in the 5-methylcytosine methyl group. A smaller band area reflecting lower energy absorbed in the DNA was found in the hyperglycemic mice and assumed to be related to the lower levels of -CH3 groups. Other spectral differences were found at 1700-1500 cm(-1) and in the fingerprint region, and a slight change in the DNA conformation at the lower DNA methylation levels was suggested for the hyperglycemic mice. The changes that affect cytosine methylation levels certainly affect the DNA-protein interactions and, consequently, gene expression in liver cells from the hyperglycemic NOD mice.

Analysis Of The Contribution Of Immunologically-detectable Her2, Steroid Receptors And Of The Triple-negative" Tumor Status To Disease-free And Overall Survival Of Women With Epithelial Ovarian Cancer."

We assessed associations between steroid receptors including: estrogen-alpha, estrogen-beta, androgen receptor, progesterone receptor, the HER2 status and triple-negative epithelial ovarian cancer (ERα-/PR-/HER2-; TNEOC) status and survival in women with epithelial ovarian cancer. The study included 152 women with primary epithelial ovarian cancer. The status of steroid receptor and HER2 was determined by immunohistochemistry. Disease-free and overall survival were calculated and compared with steroid receptor and HER2 status as well as clinicopathological features using the Cox Proportional Hazards model. A mean follow-up period of 43.6 months (interquartile range=41.4 months) was achieved where 44% of patients had serous tumor, followed by mucinous (23%), endometrioid (9%), mixed (9%), undifferentiated (8.5%) and clear cell tumors (5.3%). ER-alpha staining was associated with grade II-III tumors. Progesterone receptor staining was positively associated with a Body Mass Index≥25. Androgen receptor positivity was higher in serous tumors. In stand-alone analysis of receptor contribution to survival, estrogen-alpha positivity was associated with greater disease-free survival. However, there was no significant association between steroid receptor expression, HER2 status, or TNEOC status, and overall survival. Although estrogen-alpha, androgen receptor, progesterone receptor and the HER2 status were associated with key clinical features of the women and pathological characteristics of the tumors, these associations were not implicated in survival. Interestingly, women with TNEOC seem to fare the same way as their counterparts with non-TNEOC.

Obesogenic Environment By Excess Of Dietary Fats In Different Phases Of Development Reduces Spermatic Efficiency Of Wistar Rats At Adulthood: Correlations With Metabolic Status.

This study compares the impact of obesogenic environment (OE) in six different periods of development on sperm parameters and the testicular structure of adult rats and their correlations with sex steroid and metabolic scenario. Wistar rats were exposed to OE during gestation (O1), during gestation/lactation (O2), from weaning to adulthood (O3), from lactation to adulthood (O4), from gestation to sexual maturity (O5), and after sexual maturation (O6). OE was induced by a 20% fat diet, and control groups were fed a balanced diet (4% fat). Serum leptin levels and adiposity index indicate that all groups were obese, except for O1. Three progressive levels of impaired metabolic status were observed: O1 presented insulin resistance, O2 were insulin resistant and obese, and groups O3, O4, and O5 were insulin resistant, obese, and diabetic. These three levels of metabolic damage were proportional to the increase of leptin and decreased circulating testosterone. The impairment in the daily sperm production (DSP) paralleled these three levels of metabolic and hormonal damage being marginal in O1, increasing in O2, and being higher in groups O3, O4, O5, and O6. None of the OE periods affected the sperm transit time in the epididymis, and the lower sperm reserves were caused mainly by impaired DSP. In conclusion, OE during sexual maturation markedly reduces the DSP at adulthood in the rat. A severe reduction in the DSP also occurs in OE exposure during gestation/lactation but not in gestation, indicating that breast-feeding is a critical period for spermatogenic impairment under obesogenic conditions.

Impact Of Severe Haemophilia A On Patients' Health Status: Results From The Guardian(™) 1 Clinical Trial Of Turoctocog Alfa (novoeight(®) ).

Haemophilia and its treatment interfere with patients' life and may affect adherence to treatment. This study explored the impact of severe haemophilia A on patients' health status, especially in young adults (YA), using data from guardian(™) 1, a multinational, open-label, non-controlled phase 3 trial investigating safety and efficacy of turoctocog alfa (NovoEight(®) ) in previously treated patients aged 12 years and older with severe haemophilia A (FVIII ≤ 1%). Health status was assessed using the EuroQoL-5 dimensions (EQ-5D-3L), covering 5 dimensions of health (mobility, self-care, usual activities, pain/discomfort and anxiety/depression), and a visual analogue scale (VAS) measuring self-rated overall health status. EQ-5D was administered pretreatment (screening/baseline) and posttreatment (end-of-trial). Baseline responses to the EQ-5D dimensions and VAS were described overall and by age and compared to reference values from UK general population. Guardian(™) 1 included 150 patients (16 adolescents, 83 YA aged 16-29 and 51 adults aged 30+). All five dimensions of patients' health status were impacted at baseline. The percentage of haemophilia patients reporting problems was consistently significantly greater than age-matched general population reference values. Likewise, for all age groups mean baseline EQ-5D VAS score was significantly lower for haemophilia patients (YA: 78.0) than for the general population (YA aged 18-29: 87.3). The health status of patients with severe haemophilia A entering guardian(™) 1 was markedly poorer than that of the general population, particularly regarding mobility and pain. YA patients reported better health status than older patients, but considerably lower than that of the general YA population.

[factors Impacting The Growth And Nutritional Status Of Cystic Fibrosis Patients Younger Than 10 Years Of Age Who Did Not Undergo Neonatal Screening.]

The aim of this study was to evaluate by clinical and laboratory parameters how cystic fibrosis (CF) affects growth and nutritional status of children who were undergoing CF treatment but did not receive newborn screening. A historical cohort study of 52 CF patients younger than 10 years of age were followed in a reference center in Campinas, Southeast Brazil. Anthropometric measurements were abstracted from medical records until March/2010, when neonatal screening program was implemented. Between September/2009 and March/2010, parental height of the 52 CF patients were also measured. Regarding nutritional status, four patients had Z-scores ≤ -2 for height/age (H/A) and body mass index/age (BMI/A). The following variables were associated with improved H/A ratio: fewer hospitalizations, longer time from first appointment to diagnosis, longer time from birth to diagnosis and later onset of respiratory disease. Forced vital capacity [FVC(%)], forced expiratory flow between 25-75% of FVC [FEF25-75(%)], forced expiratory volume in the first second [FEV1(%)], gestational age, birth weight and early respiratory symptoms were associated with IMC/A. Greater number of hospitalizations, diagnosis delay and early onset of respiratory disease had a negative impact on growth. Lower spirometric values, lower gestational age, lower birth weight, and early onset of respiratory symptoms had negative impact on nutritional status. Malnutrition was observed in 7.7% of cases, but 23% of children had nutritional risk.

Escola Nacional de Educação Fisica e Desportos : uma possivel historia

Universidade Estadual de Campinas . Faculdade de Educação Física

Analysis of the periodontal status of patients with mandibular-bonded retainers

PURPOSE: This clinical study evaluated the periodontal status of patients with bonded retainers as compared to a non-treated control group. METHODS: Forty dental students were included in the sample and divided into the following two groups: 1) a test group of 20 subjects that, after orthodontic treatment, have been bonded retainer users for at least 2 years and 2) a control group of 20 patients that never experienced orthodontic treatment nor used any bonded retainer. The region associated with the retainer in the test group and the lower canine-to-canine region in the control group were examined according to the following clinical parameters: plaque index (PI), bleeding on probing (BOP), gingival recession (GR), clinical attachment level (CAL) and probing depth (PD). RESULTS: No differences were observed for GR or BOP (P>0.05). In contrast, the test group showed higher values of CAL and PD at proximal sites when compared to controls (P<0.05). In addition, IP was significantly increased at buccal and lingual sites (P<0.05). CONCLUSION: The placement of orthodontic bonded retainers negatively affected periodontal health, resulting in increased PI, PD and CAL.

Influência do transporte e mudança de local de manejo nas variáveis fisiológicas e produtivas de cabras Alpinas

Estudaram-se o efeito do transporte e a mudança de local de manejo sobre a produção e a composição do leite e sobre as variáveis fisiológicas, utilizando-se 12 cabras da raça Alpina em final de lactação. Semanalmente, foram mensuradas a produção e composição do leite e a contagem de células somáticas, além do volume do leite residual após administração de ocitocina. Foram colhidas amostras de sangue para dosagem hormonal (cortisol) e enzimática (glicose) no plasma no dia do transporte: antes (7h10min) e após (8h20min, 8h30min e 10h30min) o transporte. Nas três semanas subsequentes ao transporte, também foram colhidas amostras de sangue às 8h20min. Obtiveram-se teores mais elevados (P<0,05) de cortisol e glicose após o transporte e a mudança de local de manejo, e menor produção de leite (P<0,05) um dia após o evento. Porcentagem de gordura (P<0,05) e contagem de células somáticas apresentaram diferenças significativas (P<0,05) após o transporte. Os resultados permitem concluir que o transporte é um agente estressor que pode, momentaneamente, influenciar a produção animal.

Rediscovery of the putatively extinct ant species Simopelta minima (Brandão) (Hymenoptera, Formicidae), with a discussion on rarity and conservation status of ant species

Simopelta minima (Brandão, 1989) was originally described based on four workers collected in soil samples from a small cocoa plantation in Ilhéus, state of Bahia, northeastern Brazil. In the subsequent years after the description, this cocoa plantation was eliminated and the species was then considered extinct by the Brazilian environmental institutions. The recent rediscovery of S. minima workers in subterranean pitfall trap samples from Viçosa, state of Minas Gerais, southeastern Brazil, over 1.000 km distant from type locality, suggests that the rarity and vulnerability status of some ant species may be explained by insufficient sampling of adequate microhabitats, in time and space.