Välskärin kertomuksia. 2 jakso, Kapinassa omaa onneaan vastaan ; Noita-akka ; Mainiemen linna

Zacharias Topeliuksen Fältskärns berättelser oli alkanut ilmestyä jatkokertomuksena Helsingfors Tidningarissa vuonna 1851. Viisiosainen teos julkaistiin kirjoina vuosina 1853-1867. Tämä suosittu romaanisarja kertoo Suomen ja Ruotsin historiasta Kustaa II Aadolfin ajoista Kustaa III:n aikoihin asti. Vaiherikkaissa tarinoissa suuret historialliset tapahtumat ja aikakaudet elävöityvät yksilöiden elämänkohtaloiden kautta. Suomen osuus Ruotsin valtakunnan historiassa nousee tärkeään asemaan. Kyseinen VÄLSKÄRIN KERTOMUKSIA on Juhani Ahon suomennos seitsemännestä ruotsinkielisestä painoksesta. Teoksen ovat kuvittaneet Albert Edelfelt ja Carl Larsson.

Maj Lind [1976] : [välierä] : Juhani Lagerspetz

Soitinnus: piano.

Maj Lind [1976] : [alkuerä] : Juhani Lagerspetz, Ritva Viitala

Soitinnus: piano.

Viipurissa 2.9.1939

2. uud. p.

Kevät ja takatalvi - 2, Takatalvi

Lisäpainokset: 2. p. 1908.

Katajainen kansani ja muita uusia ja vanhoja lastuja vuosilta 1891 ja 1899 - 2 sarja

Lisäpainokset: 2.p.

An Asp49 Phospholipase A2 From Snake Venom Induces Cyclooxygenase-2 Expression And Prostaglandin E2 Production Via Activation Of Nf-κb, P38mapk, And Pkc In Macrophages.

Phospholipases A2 (PLA2) are key enzymes for production of lipid mediators. We previously demonstrated that a snake venom sPLA2 named MT-III leads to prostaglandin (PG)E2 biosynthesis in macrophages by inducing the expression of cyclooxygenase-2 (COX-2). Herein, we explored the molecular mechanisms and signaling pathways leading to these MT-III-induced effects. Results demonstrated that MT-III induced activation of the transcription factor NF-κB in isolated macrophages. By using NF-κB selective inhibitors, the involvement of this factor in MT-III-induced COX-2 expression and PGE2 production was demonstrated. Moreover, MT-III-induced COX-2 protein expression and PGE2 release were attenuated by pretreatment of macrophages with SB202190, and Ly294002, and H-7-dihydro compounds, indicating the involvement of p38MAPK, PI3K, and PKC pathways, respectively. Consistent with this, MT-III triggered early phosphorylation of p38MAPK, PI3K, and PKC. Furthermore, SB202190, H-7-dihydro, but not Ly294002 treatment, abrogated activation of NF-κB induced by MT-III. Altogether, these results show for the first time that the induction of COX-2 protein expression and PGE2 release, which occur via NF-κB activation induced by the sPLA2-MT-III in macrophages, are modulated by p38MAPK and PKC, but not by PI3K signaling proteins.

Prognostic Value Of Dna And Mrna E6/e7 Of Human Papillomavirus In The Evolution Of Cervical Intraepithelial Neoplasia Grade 2.

This study aimed at evaluating whether human papillomavirus (HPV) groups and E6/E7 mRNA of HPV 16, 18, 31, 33, and 45 are prognostic of cervical intraepithelial neoplasia (CIN) 2 outcome in women with a cervical smear showing a low-grade squamous intraepithelial lesion (LSIL). This cohort study included women with biopsy-confirmed CIN 2 who were followed up for 12 months, with cervical smear and colposcopy performed every three months. Women with a negative or low-risk HPV status showed 100% CIN 2 regression. The CIN 2 regression rates at the 12-month follow-up were 69.4% for women with alpha-9 HPV versus 91.7% for other HPV species or HPV-negative status (P < 0.05). For women with HPV 16, the CIN 2 regression rate at the 12-month follow-up was 61.4% versus 89.5% for other HPV types or HPV-negative status (P < 0.05). The CIN 2 regression rate was 68.3% for women who tested positive for HPV E6/E7 mRNA versus 82.0% for the negative results, but this difference was not statistically significant. The expectant management for women with biopsy-confirmed CIN 2 and previous cytological tests showing LSIL exhibited a very high rate of spontaneous regression. HPV 16 is associated with a higher CIN 2 progression rate than other HPV infections. HPV E6/E7 mRNA is not a prognostic marker of the CIN 2 clinical outcome, although this analysis cannot be considered conclusive. Given the small sample size, this study could be considered a pilot for future larger studies on the role of predictive markers of CIN 2 evolution.