Transcender Deus: de Eckhart a Silesius

O nosso objectivo é reflectir sobre o tema de “Transcender Deus”, enquanto núcleo essencial da demanda e viagem espiritual e mística, em Mestre Eckhart e Angelus Silesius. Comentamos afirmações como “Por isso rogamos a Deus que de “Deus” nos livremos” (Eckhart) e “Devo ir ainda além de Deus, para um deserto” (Silesius), situando-as no contexto da experiência e tradição neoplatónicas. Por fim, interrogamo-nos se não poderíamos surpreender aqui uma anterior e mais radical “morte de Deus”, onde a religião é simultaneamente cumprida e ultrapassada pela espiritualidade mística. Este poderia ser o outro lado da “morte de Deus” proclamada por Nietzsche.

Histoire du panthéisme populaire au Moyen Age et au seizième siècle : (suivie de pièces inédites concernant les Frères du libre esprit, maître Eckhart, les libertins spirituels, etc.) / par Auguste Jundt.

French or German.

Tangokuningasta kunnioittaen

Luettua

Perusyksikön odotukset kranaatinheittimistön ammattialiupseereille : tapaustutkimus Uudenmaan Prikaatin Kranaatinheitinkomppaniasta

Useissa varusmieskoulutusta antavissa perusyksiköissä on ollut viime vuosina kova henkilöstöpula. Opistoupseerikoulutuksen päätyttyä vuonna 2003 kouluttajien ja etenkin kokeneiden kouluttajien määrä on vähentynyt huolestuttavalle tasolle. Uusimuotoisesta ammattialiupseeristosta on suunniteltu opistoupseerien korvaajia. Ylimenovaiheessa tarkoituksena on periyttää ammattitaitoisten opistoupseereiden tiedot ja taidot aliupseereille mentoroinnin avulla. Tämä on osa puolustusvoimien osaamisen kehittämisen hanketta, jonka perimmäisenä tarkoituksena on varmistaa Suomen sotilaallinen suorituskyky keskittymällä sen ydintoimintojen vaatiman osaamisen kehittämiseen.

Le rôle de l’imagination dans l’expérience spirituelle d’Ibn al-ʿArabī et de Jakob Böhme

Henry Corbin a écrit qu’« un Maître Eckhart et un Jacob Boehme eussent parfaitement compris Ibn ʿArabî, et réciproquement. » Mais comment assurer ce dialogue et cette compréhension réciproque pressentie par Henry Corbin? Cette recherche porte essentiellement sur les conditions de possibilités de ce dialogue, puisque la comparaison entre Ibn al-ʿArabī et Böhme n’est encore qu’à ses balbutiements. En choisissant le prisme de l’imagination, le but est double : pouvoir traiter de manière non réductrice les phénomènes spirituels en parcourant et analysant la logique spécifique de l’imagination ; et, sous l’égide de la hiérohistoire, explorer le rôle de l’imagination dans la métaphysique et l’éthique d’Ibn al-ʿArabī et de Böhme. Il s’agit donc d’essayer de lire Ibn al-ʿArabī et Böhme comme ils lisaient eux-mêmes le Livre révélé de leur tradition respective. Au final, il appert que le théophanisme caractéristique tant de la métaphysique d’Ibn al-ʿArabī que de celle de Böhme est une riche terre d’accueil de l’imagination et de l’imaginal. Et que, si la comparaison strictu sensu entre Ibn al-ʿArabī et Böhme est impossible, l’esprit comparatif et transdisciplinaire de cette recherche, ainsi que la méthode phénoménologico-herméneutique, offrent de nouvelles avenues de réappropriation pour l’ensemble des phénomènes spirituels.

La pedagogía teológica en Edith Stein (1891-1942).

Resumen tomado de la revista

The inotropic peptide ?ARKct improves ?AR responsiveness in normal and failing cardiomyocytes through G(??)-mediated L-type calcium current disinhibition

The G(βγ)-sequestering peptide β-adrenergic receptor kinase (βARK)ct derived from the G-protein-coupled receptor kinase (GRK)2 carboxyl terminus has emerged as a promising target for gene-based heart failure therapy. Enhanced downstream cAMP signaling has been proposed as the underlying mechanism for increased β-adrenergic receptor (βAR) responsiveness. However, molecular targets mediating improved cardiac contractile performance by βARKct and its impact on G(βγ)-mediated signaling have yet to be fully elucidated.

Level of G protein-coupled receptor kinase-2 determines myocardial ischemia/reperfusion injury via pro- and anti-apoptotic mechanisms

Activation of prosurvival kinases and subsequent nitric oxide (NO) production by certain G protein-coupled receptors (GPCRs) protects myocardium in ischemia/reperfusion injury (I/R) models. GPCR signaling pathways are regulated by GPCR kinases (GRKs), and GRK2 has been shown to be a critical molecule in normal and pathological cardiac function.

Regulation of GPCR signaling in hypertension

Hypertension represents a complex, multifactorial disease and contributes to the major causes of morbidity and mortality in industrialized countries: ischemic and hypertensive heart disease, stroke, peripheral atherosclerosis and renal failure. Current pharmacological therapy of essential hypertension focuses on the regulation of vascular resistance by inhibition of hormones such as catecholamines and angiotensin II, blocking them from receptor activation. Interaction of G-protein coupled receptor kinases (GRKs) and regulator of G-protein signaling (RGS) proteins with activated G-protein coupled receptors (GPCRs) effect the phosphorylation state of the receptor leading to desensitization and can profoundly impair signaling. Defects in GPCR regulation via these modulators have severe consequences affecting GPCR-stimulated biological responses in pathological situations such as hypertension, since they fine-tune and balance the major transmitters of vessel constriction versus dilatation, thus representing valuable new targets for anti-hypertensive therapeutic strategies. Elevated levels of GRKs are associated with human hypertensive disease and are relevant modulators of blood pressure in animal models of hypertension. This implies therapeutic perspective in a disease that has a prevalence of 65million in the United States while being directly correlated with occurrence of major adverse cardiac and vascular events. Therefore, therapeutic approaches using the inhibition of GRKs to regulate GPCRs are intriguing novel targets for treatment of hypertension and heart failure.