Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization

The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate the presence of the potentially lethal mendelian long-QT syndrome (LQTS). Using a genome-wide association and replication study in up to 100,000 individuals, we identified 35 common variant loci associated with QT interval that collectively explain ∼8-10% of QT-interval variation and highlight the importance of calcium regulation in myocardial repolarization. Rare variant analysis of 6 new QT interval-associated loci in 298 unrelated probands with LQTS identified coding variants not found in controls but of uncertain causality and therefore requiring validation. Several newly identified loci encode proteins that physically interact with other recognized repolarization proteins. Our integration of common variant association, expression and orthogonal protein-protein interaction screens provides new insights into cardiac electrophysiology and identifies new candidate genes for ventricular arrhythmias, LQTS and SCD.

CO2 and inorganic nutrient enrichment affect the performance of a calcifying green alga and its noncalcifying epiphyte

Ocean acidification studies in the past decade have greatly improved our knowledge of how calcifying organisms respond to increased surface ocean CO2 levels. It has become evident that, for many organisms, nutrient availability is an important factor that influences their physiological responses and competitive interactions with other species. Therefore, we tested how simulated ocean acidification and eutrophication (nitrate and phosphate enrichment) interact to affect the physiology and ecology of a calcifying chlorophyte macroalga (Halimeda opuntia (L.) J.V. Lamouroux) and its common noncalcifying epiphyte (Dictyota sp.) in a 4-week fully crossed multifactorial experiment. Inorganic nutrient enrichment (+NP) had a strong influence on all responses measured with the exception of net calcification. Elevated CO2 alone significantly decreased electron transport rates of the photosynthetic apparatus and resulted in phosphorus limitation in both species, but had no effect on oxygen production or respiration. The combination of CO2 and +NP significantly increased electron transport rates in both species. While +NP alone stimulated H. opuntia growth rates, Dictyota growth was significantly stimulated by nutrient enrichment only at elevated CO2, which led to the highest biomass ratios of Dictyota to Halimeda. Our results suggest that inorganic nutrient enrichment alone stimulates several aspects of H. opuntia physiology, but nutrient enrichment at a CO2 concentration predicted for the end of the century benefits Dictyota sp. and hinders its calcifying basibiont H. opuntia.

Resolving taxonomic uncertainty in vulnerable elasmobranchs : are the Madeira skate (Raja maderensis) and the thornback ray (Raja clavata) distinct species?

We are grateful to all those who helped with sample collection. This includes the MEDITS survey programme (IEO Mallorca) for Mediterranean samples. Portugal mainland samples were collected under the EU Data Collection Framework (DCF, PNAB). Azores specimens from the Department of Oceanography and Fisheries (DOP) of the University of the Azores (UAc) were collected under the project DEMERSAIS “Monitorização das espécies demersais dos Açores” financed by the Azorean government, and the project DEECON “Unravelling population connectivity for sustainable fisheries in the Deep Sea” project approved by the European Science Foundation (ESF) under the EUROCORES programme (proposal No 06-EuroDEEP-FP-008 & SFRH-EuroDEEP/0002/2007). This study was funded by the UK Natural Environment Research Council (NERC) Oceans 2025 Strategic Research Programme Theme 6 (Science for Sustainable Marine Resources). REB was supported by the Fisheries Society of the British Isles (FSBI), BSP was funded by the Fundação para a Ciência e a Tecnologia, SFRH/BPD/72351/2010 and JL was supported by The Alasdair Downes Marine Conservation Fund.

1980 UM Track Team

Top Row: trainer Len Paddock, Dave Walmroth, James Ross, Darold Gholston, Mike Brown, Mike Kilpela, James Henry, Brian Diemer, Phillip Wells.

3rd Row: Craig Camp, Shelby Johnson, Andrew Bruce, Ron Affoon, Steve Brandt, Michael Petsch, Mike Finn, Mark Pruente, Rodney Feaster, Mike Lamping.

2nd Row: asst. coach Kent Bernard, Sam Angell, Butch Woolfolk, Michael Shea, Marshall Parks, Neil Fairclough, Scott Koepke, Dan Beck, Bill Weidenbach, Mark Poelman, Bill O'Reilly, distance coach Ron Warhurst.

Front Row: Gary Hicks, Tim Thomas, Mike Lattany, Ted Dobson, Dan Heikkinen, Coach Jack Harvey, Greg Thomas, Mike Boehmer, Calvin Williams, Kevin Robbins, Dave Lewis.

1981 UM Track Team

Top Row: Mike Murphy, Chris Fitzpatrick, Phil Wells, James Ross, Dave Walmroth

4th Row: Dave Hall, Scott Ericksson, George Yoanides, Dave Lugin, Johnny Nielsen, Mike Finn

3rd Row: asst. coach Ron Warhurst, Dorian Diemer, Gerard Donakowski, Derek Harper, Bill O'Reilly, Vern Rottman

2nd Row: James Henry, Shelby Johnson, Andrew Bruce, Butch Woolfolk, Mike Shea, Craig Camp, Kent Bernard

Front Row: Dan Beck, Bill Weidenbach, Darold Gholston, coach Jack Harvey, Dave Lewis, Ken Gardner

Not Pictured: Marshall Parks, Tony Krpan, Mark Pruente, Vince Bean, Doug Heikkinen, Dan Heikkinen

The Iris : an illuminated souvenir for MDCCCLII /

Plates lithographed by Peter S. Duval after drawings by Capt. Seth Eastman.

Elements of discord in Secessia : [1.] &c.,&c.

Cover title.

Aurelii Prudentii Clementis quae exstant Carmina, ad vaticc. aliorumque codicum et optimarum editionum fidem recensuit, lectionum varietate illustravit,

Mode of access: Internet.

Das Westland; Magazin zur Kunde amerikanischer Verhèaltnisse.

Disbound Original Held in Oak Street Library Facility.