Aquaculture genetics research and issues in INGA member countries/institutions

The information presented here is extracted from the presentations and discussions at the Sixth Steering Committee Meeting of the International Network on Genetics in Aquaculture (INGA) held in Hanoi, Vietnam on 8-10 May 2001. The main topics discussed were: review of genetics research progress and planned activities in member countries and Associate Member institutions; genetics improvement technologies; strategies and action plans for distribution of improved fish breeds to small-scale farmers; ecological risk assessment for genetically improved fish breeds; methods for monitoring the uptake of improved strains and impact assessment; and network activities and collaborations.

Semblanzas Ictiológicas Iberoamericanas: Héctor Samuel Vera Alcaraz.

A través de esta nueva serie tratamos de conocer diferentes aspectos personales de los integrantes de la comunidad ictiológica iberoamericana. Esta iniciativa, comparte el espíritu y objetivo de las semblanzas nacionales buscando informalmente, otro punto de unión en la “comunidad de ictiólogos iberoamericanos”. Quizás esté equivocado en mi apreciación, pero creo que vale la pena este intento, ya que, con la colaboración generosa e insoslayable de los integrantes de este “universo”, señalaremos un registro en el tiempo de la Ictiología Neotropical.

赝形δ掺杂 AlGaAs/InGa As/GaAs量子阱的光致发光性质研究

测量了一系列不同隔离层(spacer)厚度、阱宽和硅δ掺杂浓度的单边掺杂的赝形高电子迁移率晶体管(p-HEMTs)量子阱的变温和变激发功率光致发光谱，详细研究了(el-hh1)和(e2-hh1)两个发光峰之间的动态竞争发光机制，并运用有限差分法自洽求解薛定谔和泊松方程以得出电子限制势、子带能级以及相应的电子包络波函数、子带占据几率和δ掺杂电子转移效率，研究了两个峰的相对积分发光强度随隔离层厚度、阱宽和δ掺杂浓度的变化。

Levantamento pedológico semidetalhado (1:25.000) da microbacia da Água Três Unidos, município de Vera Cruz (SP).

2002

Caracterización y diagnóstico de calidad tejeduría en guanga Inga y Camëntsá, departamento del Putumayo, diagnóstico de calidad.

50 hojas : ilustraciones, fotografías.

Caracterización y diagnóstico de calidad tejeduría en guanga Inga y Camëntsá departamento del Putumayo.

49 hojas : ilustraciones : fotografías.

Posibilidades agroclimáticas para el cultivo del pistachero (Pistacia vera L.) en la Argentina

p.1-21

JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis

Background The V617F mutation, which causes the substitution of phenylalanine for valine at position 617 of the Janus kinase (JAK) 2 gene (JAK2), is often present in patients with polycythemia vera, essential thrombocythemia, and idiopathic myelofibrosis. However, the molecular basis of these myeloproliferative disorders in patients without the V617F mutation is unclear. Methods We searched for new mutations in members of the JAK and signal transducer and activator of transcription (STAT) gene families in patients with V617F-negative polycythemia vera or idiopathic erythrocytosis. The mutations were characterized biochemically and in a murine model of bone marrow transplantation. Results We identified four somatic gain-of-function mutations affecting JAK2 exon 12 in 10 V617F-negative patients. Those with a JAK2 exon 12 mutation presented with an isolated erythrocytosis and distinctive bone marrow morphology, and several also had reduced serum erythropoietin levels. Erythroid colonies could be grown from their blood samples in the absence of exogenous erythropoietin. All such erythroid colonies were heterozygous for the mutation, whereas colonies homozygous for the mutation occur in most patients with V617F-positive polycythemia vera. BaF3 cells expressing the murine erythropoietin receptor and also carrying exon 12 mutations could proliferate without added interleukin-3. They also exhibited increased phosphorylation of JAK2 and extracellular regulated kinase 1 and 2, as compared with cells transduced by wild-type JAK2 or V617F JAK2. Three of the exon 12 mutations included a substitution of leucine for lysine at position 539 of JAK2. This mutation resulted in a myeloproliferative phenotype, including erythrocytosis, in a murine model of retroviral bone marrow transplantation. Conclusions JAK2 exon 12 mutations define a distinctive myeloproliferative syndrome that affects patients who currently receive a diagnosis of polycythemia vera or idiopathic erythrocytosis.