Effect of age and endometrial degenerative changes on uterine blood flow during early gestation in mares

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Restricted intake and lipid inclusion in Santa Inês ewe lambs diet: age, weight and progesterone concentration at first ovulation.

The age at first ovulation is influenced by several factors, and nutrition has an essential role on it. Lipids provide essential fatty acids that are positively associated to reproductive aspects. The aims of this study were to evaluate the effects of lipid inclusion and restricted intake on age and weight at the first ovulation and the serum progesterone (P4) concentration at the sixth day after first ovulation. The restricted intake imposed in this study did not delay the age at fist ovulation. The greater lipid intake did not favor reproductive parameters. Serum P4 did not increase with the soybean inclusion in the die.

The Effect of Eggs Shape Index on Embryo on Mortalities, Unhatched Eggs and Day Old duck Abnormalities of Selected and Control Tegal Duck

An experiment was conducted to study the effect of eggs shape index on embryo mortalities, unhatched egg and day old duck abnormalities of selected and control Tegal duck. A total of 1428 fertile eggs obtained from a selected duck group and a control group were divided in to 3 group according to their eggs shape index (ESI), i.e. small (ESI ,79 percent), medium ( ESI ,82 percent ) and large (ESI ,85 percent ). The ESI was measured as a ratio of wide and length of eggs and percentage. Three batches of incubation with 7 day interval were carried out as replicates. Parameter measured were embryo mortalities, number of unhatched eggs and number of abnormal day old duck. Candling of eggs were performed at 6, 14 and days of incubation and mortalities of embryo were detected by loup. Results of the experiment showed that lowest embryos mortalities was occurred on medium eggs (24 percent) and significantly ( p< 0,05 ) affected by eggs size. Abnormal DOD from medium eggs was significantly (p ,0,05 ) lower (13 percent ) than the small (23 percent ) and large (21 percent ) eggs. Similar trends on eggs from selected duck and control ducks. This may be due to short term of selection program and young age of the female duck (24 weeks ). These results conclude that medium eggs (ESI ,82 percent) were the best size for hatching eggs. (Animal Production 2(1): 25-32 (2000)Key word : duck , hatching eggs, selection, eggs shape index

Advanced paternal age is associated with impaired neurocognitive outcomes during infancy and childhood

Background Advanced paternal age (APA) is associated with an increased risk of neurodevelopmental disorders such as autism and schizophrenia, as well as with dyslexia and reduced intelligence. The aim of this study was to examine the relationship between paternal age and performance on neurocognitive measures during infancy and childhood. Methods and Findings A sample of singleton children (n = 33,437) was drawn from the US Collaborative Perinatal Project. The outcome measures were assessed at 8 mo, 4 y, and 7 y (Bayley scales, Stanford Binet Intelligence Scale, Graham-Ernhart Block Sort Test, Wechsler Intelligence Scale for Children, Wide Range Achievement Test). The main analyses examined the relationship between neurocognitive measures and paternal or maternal age when adjusted for potential confounding factors. Advanced paternal age showed significant associations with poorer scores on all of the neurocognitive measures apart from the Bayley Motor score. The findings were broadly consistent in direction and effect size at all three ages. In contrast, advanced maternal age was generally associated with better scores on these same measures. Conclusions The offspring of older fathers show subtle impairments on tests of neurocognitive ability during infancy and childhood. In light of secular trends related to delayed fatherhood, the clinical implications and the mechanisms underlying these findings warrant closer scrutiny.

Management and organisational barriers in the acquisition of computer usage skills by mature age workers

Aim: To investigate workplace cultures in the acquisition of computer usage skills by mature age workers. Methods: Data were gathered through focus groups conducted at job network centres in the Greater Brisbane metropolitan region. Participants who took part were a mixture of workers and job-seekers. Results: The results suggest that mature age workers can be exposed to inappropriate computer training practices and age-insensitive attitudes towards those with low base computer skills. Conclusions: There is a need for managers to be observant of ageist attitudes in the work place and to develop age-sensitive strategies to help mature age workers learn computer usage skills. Mature age workers also need to develop skills in ways which are practical and meaningful to their work.

Maternal age and paternal age are associated with distinct childhood behavioural outcomes in a general population birth cohort

Abstract Background Recent studies show that advanced paternal age (APA) is associated with an increased risk of neurodevelopmental disorders such as autism, bipolar disorder and schizophrenia. A body of evidence also suggests that individuals who develop schizophrenia show subtle deviations in a range of behavioural domains during their childhood. The aim of the study was to examine the relationship between paternal and maternal ages and selected behavioural measures in children using a large birth cohort. Method Participants were singleton children (n = 21,753) drawn from the US Collaborative Perinatal Project. The outcome measures were assessed at 7 years. The main analyses examined the relationship between parental age and behavioural measures when adjusted for a range of potentially confounding variables, including age of the other parent, maternal race, socio-economic measures, sex, gestation length, maternal marital status, parental mental illness, and child's age-at-testing. Results Advanced paternal age was associated with a significantly increased risk of adverse ‘externalizing’ behaviours at age seven years. For every five year increase in paternal age, the odds of higher ‘externalizing’ behaviours was increased by 12% (OR = 1.12; 95% CI = 1.03, 1.21, p < 0.0001). The relationship persisted after adjusting for potential confounding factors. ‘Internalizing’ behavioural outcome was not associated with advanced paternal age. In contrast, advanced maternal age was significantly protective against adverse ‘externalizing’ behavioural outcomes, but associated with an increased risk of adverse ‘internalizing’ behavioural outcomes. Discussion The offspring of older fathers show a distinctly different pattern of behaviours compared to the offspring of older mothers. The diverse socio-cultural and biologically-mediated factors that underpin these findings remain to be clarified. In light of secular trends related to delayed parenthood, the mechanisms underlying these findings warrant closer scrutiny.

Age-related development of a refractive index plateau in the human lens : evidence for a distinct nucleus

The human lens comprises two distinct regions in which the refractive index changes at different rates. The periphery contains a rapidly increasing refractive index gradient, which becomes steeper with age. The inner region contains a shallow gradient, which flattens with age, due to formation of a central plateau, of RI = 1.418, which reaches a maximum size of 7.0 × 3.05 mm around age 60 years. Formation of the plateau can be attributed to compression of fibre cells generated in prenatal life. Present in prenatal but not in postnatal fibre cells, γ-crystallin may play a role in limiting nuclear cell compression.