Builder 1 and C

Mode of access: Internet.

The home builder's guide for earthquake design /

"FEMA-232"--Cover.

The five orders of architecture : containing the most plain and simple rules for drawing and executing them in the purest style, for the use of workmen : exhibiting the most approved modes of applying each in practice, suitably to the climate of Great Britain ; including an historical description of Gothic architecture, illustrated with specimens selected from the most celebrated structures now existing, and numerous plans, elevations, sections, and details of various buildings executed by architects of great eminence : to which are added treatises on projection, perspective, fractions, decimal arithmetic, &c. ...

Includes index.

"Sub Tiberio quies"? Judaea���s Political Situation under the Prefects (6-41 c.e.), between Reality and Ideology

Deeply conflicting views on the political situation of Judaea under the Roman prefects (6-41 c.e.) have been offered. According to some scholars, this was a period of persistent political unrest and agitation, whilst according to a widespread view it was a quiescent period of political calm (reflected in Tacitus��� phrase sub Tiberio quies). The present article critically examines again the main available sources ���particularly Josephus, the canonical Gospels and Tacitus��� in order to offer a more reliable historical reconstruction. The conclusions drawn by this survey calls into question some widespread and insufficiently nuanced views on the period. This, in turn, allows a reflection on the non-epistemic factors which might contribute to explain the origin of such views.

Dream Builder

Dream Builder es una aplicaci��n que te ayudar�� de manera cotidiana a materializar tus metas financieras a trav��s del ahorro. Todo al alcance de un "touch"

Frequency Of The Allelic Variant C.1150t > C In Exon 10 Of The Fibroblast Growth Factor Receptor 3 (fgfr3) Gene Is Not Increased In Patients With Pathogenic Mutations And Related Chondrodysplasia Phenotypes.

Mutations in the FGFR3 gene cause the phenotypic spectrum of FGFR3 chondrodysplasias ranging from lethal forms to the milder phenotype seen in hypochondroplasia (Hch). The p.N540K mutation in the FGFR3 gene occurs in ���70% of individuals with Hch, and nearly 30% of individuals with the Hch phenotype have no mutations in the FGFR3, which suggests genetic heterogeneity. The identification of a severe case of Hch associated with the typical mutation c.1620C > A and the occurrence of a c.1150T > C change that resulted in a p.F384L in exon 10, together with the suspicion that this second change could be a modulator of the phenotype, prompted us to investigate this hypothesis in a cohort of patients. An analysis of 48 patients with FGFR3 chondrodysplasia phenotypes and 330 healthy (control) individuals revealed no significant difference in the frequency of the C allele at the c.1150 position (p = 0.34). One patient carrying the combination `pathogenic mutation plus the allelic variant c.1150T > C' had a typical achondroplasia (Ach) phenotype. In addition, three other patients with atypical phenotypes showed no association with the allelic variant. Together, these results do not support the hypothesis of a modulatory role for the c.1150T > C change in the FGFR3 gene.

The C-terminal Region Of The Human P23 Chaperone Modulates Its Structure And Function.

The p23 protein is a chaperone widely involved in protein homeostasis, well known as an Hsp90 co-chaperone since it also controls the Hsp90 chaperone cycle. Human p23 includes a ��-sheet domain, responsible for interacting with Hsp90; and a charged C-terminal region whose function is not clear, but seems to be natively unfolded. p23 can undergo caspase-dependent proteolytic cleavage to form p19 (p231-142), which is involved in apoptosis, while p23 has anti-apoptotic activity. To better elucidate the function of the human p23 C-terminal region, we studied comparatively the full-length human p23 and three C-terminal truncation mutants: p23���������������; p23��������������� and p23���������������. Our data indicate that p23 and p19 have distinct characteristics, whereas the other two truncations behave similarly, with some differences to p23 and p19. We found that part of the C-terminal region can fold in an ��-helix conformation and slightly contributes to p23 thermal-stability, suggesting that the C-terminal interacts with the ��-sheet domain. As a whole, our results suggest that the C-terminal region of p23 is critical for its structure-function relationship. A mechanism where the human p23 C-terminal region behaves as an activation/inhibition module for different p23 activities is proposed.

Avalia����o do teor e da estabilidade de vitaminas do complexo B e vitamina C em bebidas isot��nicas e energ��ticas

Vitamin C stability and concentration was evaluated in isotonic beverages and B group vitamins (B1, B2, B3, B5 and B6) in power beverages. The amount of vitamins was found to be above of that declared on the labels, even after the shelf life had been exceeded. A small decrease in the amount of B group vitamins was observed during the shelf life of the products. In the case of vitamin C this decrease was slightly higher. The present research shows the need of increased quality control and inspection.

Caracteriza����o f��sico-qu��mica de filmes comest��veis de amido adicionado de acerola (Malphigia emarginata D.C.)

Edibles films are an alternative to synthetic materials used for packing food products. Barbados cherry is rich in vitamin C and carotenoids. The aim of this study was to characterize and develop films by casting from cassava starch, lyophilized Barbados cherry pulp and glycerol. The films were characterized with respect to thickness, water vapor permeability (WVP), water solubility, vitamin C, carotene and mechanical properties. The interaction of pulp and glycerol reduced film thickness. An increase in pulp concentration up to 60% increased WVP but beyond this concentration reduced both WVP and solubility leading to an increased level of vitamin C and β carotene in the films.

O uso da mitomicina C em cirurgia combinada

Purpose: To analyze the efficacy and safety of intraope-rative mitomycin C (MMC) in combined procedures (extra-capsular cataract extraction + trabeculectomy). Methods: Twenty-four patients were randomized to either MMC (0.5 mg/ml) (n = 14) or saline solution (n = 10) for 3 minutes during the combined procedure. Results: Twelve months after surgery, mean IOP in the MMC group (13.2 �� 2.9 mmHg) was significantly lower than in the control group (16.3 �� 3.9 mmHg) (p = 0.02). The mean number of medications used during the 12-month follow-up in the control group (1.33 �� 0.5) was significantly higher than in the MMC-treated group (0.5 �� 0.5) (p = 0.005). Life table analysis showed a significantly higher probability of IOP control in the MMC group than in the control group (p < 0.01). Conclusions: Intraoperative MMC is safe and effective in pro-moting a better IOP control and reducing the need for postoperative antiglaucoma medications. We suggest intraope-rative MMC to be routinely employed in combined procedures.

Central retinal vein thrombosis as an initial manifestation of heterozygous protein C deficiency: case report

The purpose of this paper is to report a case of central retinal vein thrombosis associated with isolated heterozygous protein C deficiency. Acute occlusion of the central retinal vein presents as one of the most dramatic pictures in ophthalmology. It is often a result of both local and systemic causes. A rare systemic cause is heterozygous protein C deficiency, and it usually occurs in combination with other thrombophilic conditions. This case highlights that isolated heterozygous protein C deficiency may be the cause of central retinal vein thrombosis and underscores the importance of its screening in young patients with this ophthalmologic disease.

O papel do trabalho na transforma����o do homem em macaco : estudo sobre a disciplina no trabalho do jogador profissional do Sert��ozinho F. C

Universidade Estadual de Campinas. Faculdade de Educa����o F��sica

Atividade fisica e a rela����o com a qualidade de vida, ansiedade e depress��o em pessoas com sequelas de acidente vascular cerebral isquemico (AVCI)/ c Alberto Martins da Costa

Universidade Estadual de Campinas . Faculdade de Educa����o F��sica

Estabilidade oxidativa e microbiol��gica em carne de galinha mecanicamente separada e adicionada de antioxidantes durante per��odo de armazenamento a -18 &deg;C

Com o objetivo de acompanhar a estabilidade f��sico-qu��mica e microbiol��gica da carne mecanicamente separada (CMS) de diferentes origens e estocada durante 99 dias a -18 &deg;C, foi realizada pr��via mistura de conservante (nitrito de s��dio) e antioxidante (eritorbato de s��dio) em CMS obtida de duas linhagens de aves: galinhas matrizes de corte e galinhas poedeiras comerciais brancas. Na CMS de cada linhagem foram realizados tr��s diferentes tratamentos: 1) controle (sem aditivos); 2) adi����o de 150 ppm de nitrito; e 3) adi����o de 150 ppm de nitrito e 500 ppm de eritorbato. Os resultados encontrados demonstraram que a adi����o de nitrito isoladamente n��o impediu a oxida����o lip��dica, avaliada atrav��s do ��ndice de TBARS, nem a altera����o na cor, avaliada em color��metro. Por outro lado, a adi����o de nitrito juntamente com eritorbato foi efetiva na redu����o dos problemas de oxida����o lip��dica na CMS de galinhas matrizes, e em menor grau, na CMS de poedeiras. A adi����o de nitrito e eritorbato na CMS tamb��m melhorou a preserva����o da cor vermelha desej��vel (a*) ao longo do tempo. A avalia����o da estabilidade microbiol��gica da CMS, realizada no primeiro e ��ltimo dia de estocagem congelada, para microrganismos mes��filos, Escherichia coli, Staphylococcus aureus, Clostridium perfringens e Pseudomonas spp., e quinzenalmente para microrganismos psicrotr��ficos, indicou que n��o houve uma varia����o significativa nas contagens em fun����o do tratamento utilizado (diferentes aditivos adicionados). N��o foi detectada Salmonella spp. em nenhuma das amostras analisadas. Em fun����o da melhoria da estabilidade oxidativa, recomenda-se a adi����o de nitrito (150 ppm) e eritorbato (500 ppm) em CMS de galinhas matrizes a ser estocada congelada por um per��odo prolongado.