967 resultados para Anthologia epigrammatum. P.-D. Huet Anthologia epigrammatum in collectione Max. Planudæ prætermissarum


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Port. con esc. xil. del Papa Urbano VIII

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Port. con esc. xil. del Papa Urbano VIII

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Port. con esc. xil. del Papa Urbano VIII

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Port. con esc. xil. del Papa Urbano VIII

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Forty-six-page notebook in modern hardcover binding containing John Leverett's edited version of Henry More's "Enchiridion ethicum" transcribed in Latin in 1694. The last page of the document includes entries in Leverett's hands: "Colom // January 17 1690/1," "Winth // January 31 1692/3", and "Vaug // Marty 10 1695/6." The inscriptions and notes likely refer to Benjamin Colman (Harvard AB 1692), Adam Winthrop (Harvard AB 1694), and George Vaughn (Harvard AB 1696).

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During limb development, expression of the TALE homeobox transcription factor Meis1 is activated by retinoic acid in the proximal-most limb bud regions, which give rise to the upper forelimb and hindlimb. Early subdivision of the limb bud into proximal Meis-positive and distal Meis-negative domains is necessary for correct proximo-distal (P-D) limb development in the chick, since ectopic Meis1 overexpression abolishes distal limb structures, produces a proximal shift of limb identities along the P-D axis, and proximalizes distal limb cell affinity properties. To determine whether Meis activity is also required for P-D limb specification in mammals, we generated transgenic mice ectopically expressing Meis1 in the distal limb mesenchyme under the control of the Msx2 promoter. Msx2:Meis1 transgenic mice display altered P-D patterning and shifted P-D Hox gene expression domains, similar to those previously described for the chicken. Meis proteins function in cooperation with PBX factors, another TALE homeodomain subfamily. Meis-Pbx interaction is required for nuclear localization of both proteins in cell culture, and is important for their DNA-binding and transactivation efficiency. During limb development, Pbx1 nuclear expression correlates with the Meis expression domain, and Pbx1 has been proposed as the main Meis partner in this context; however, we found that Pbx1 deficiency did not modify the limb phenotype of Msx2:Meis1 mice. Our results indicate a conserved role of Meis activity in P-D specification of the tetrapod limb and suggest that Pbx function in this context is either not required or is provided by partners other than Pbx1.

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Work performed at the University of California Radiation Laboratory.

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Contiene con port. y pag. propia: R.P.D. Antonini Diana ... Tractatus duo : addendi ad superiores Tractatus Decimae Partis ...