993 resultados para APPEAR


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National Highway Traffic Safety Administration, Washington, D.C.

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Half wine colored calf, original paper label preserved at the end, top edges gilt, and others trimmed.

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Mode of access: Internet.

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To some copies of the work John Cotton's "The way of Congregational churches cleared" was appended. Mr. Cotton's treatise continues the answers to Rutherford, begun by Mr. Hooker in pt. 1, chap. 10, which ends on p. 139, the next page is blank, and chapter 11 follows, numbered 185 with a new signature. It is thought that it may have been the intention of the editors to incorporate Mr. Cotton's work in this division of the Survey, between p. 139 and 185.

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Objectives: To investigate the effectiveness of valerian for the management of chronic insomnia in general practice. Design: Valerian versus placebo in a series of n-of-1 trials, in Queensland, Australia. Results: Of 42 enrolled patients, 24 (57%) had sufficient data for inclusion into the n-of-1 analysis. Response to valerian was fair for 23 (96%) participants evaluating their 'energy level in the previous day' but poor or modest for all 24 (100%) participants' response to 'total sleep time' and for 23 (96%) participants' response to 'number of night awakenings' and 'morning refreshment'. As a group, the proportion of treatment successes ranged from 0.35 (95% CI 0.23, 0.47) to 0.55 (95% CI 0.43, 0.67) for the six elicited outcome sleep variables. There was no significant difference in the number (P = 0.06), distribution (P = 1.00) or severity (P = 0.46) of side effects between valerian and placebo treatments. Conclusions: Valerian was not shown to be appreciably better than placebo in promoting sleep or sleep-related factors for any individual patient or for all patients as a group. (C) 2003 Elsevier Ltd. All rights reserved.