Chemistry of interstitial water of samples from DSDP Leg 38

Interstitial waters recovered during Leg 38 show large changes in major ion composition and also in oxygen isotope composition. Increases in Ca[++] and Sr[++] and decreases in K[+], Mg[++], and O18/O16 are interpreted in terms of extensive diagenesis of terrigenous, volcanic, or basaltic igneous materials in the sediments and underlying basalts. Slight, but well-established increases in chlorinity with depth indicate that these postulated weathering reactions involve uptake of water to a measurable extent. Interstitial waters from sites drilled on the Inner Voring Plateau suggest the infusion of fresh waters by aquifers from the mainland of Norway.

Chemical composition and isotopic ratios of basic lavas from Iceland and the surrounding ocean floor

Major and trace dement data are used to establish the nature and extent of spatial and temporal chemical variations in basalts erupted in the Iceland region of the North Atlantic Ocean. The ocean floor samples are those recovered by legs 38 and 49 of the Deep Sea Drilling Project. Within each of the active zones on Iceland there are small scale variations in the light rare earth elements and ratios such as K/Y: several central complexes and their associated fissure swarms erupt basalts with values of K/Y distinct from those erupted at adjacent centres; also basalts showing a wide range of immobile trace element ratios occur together within single vertical sections and ocean floor drill holes. Although such variations can be explained in terms of the magmatic processes operating on Iceland they make extrapolations from single basalt samples to mantle sources underlying the outcrop of the sample highly tenuous. 87Sr/86Sr ratios measured for 25 of the samples indicate a total range from 0.7028 in a tholeiite from the Reykjanes Ridge to 0.7034 in an alkali basalt from Iceland and are consistent with other published ratios from the region. A positive correlation between 87Sr/86Sr and Ce/Yb ratios indicates the existence of systematic isotopic and elemental variations in the mantle source region. An approximately fivefold variation in Ce/Yb ratio observed in basalts with the same 87Sr/86Sr ratio implies that different degrees and types of partial melting have been involved in magma genesis from a single mantle composition. 87Sr/86Sr ratios above 0.7028, Th/U ratios close to 4 and La/Ta ratios close to 10 distinguish most basalts erupted in this part of the North Atlantic Ocean from normal mid-ocean ridge basalt (N-type MORB) - although N-type MORB has been erupted at extinct spreading axes just to the north and northeast of Iceland as well as the presently active Iceland-Jan Mayen Ridge. Comparisons with the hygromagmatophile element and radiogenic isotope ratios of MORB and the estimated primordial mantle indicate that the mantle sources producing Iceland basalts have undergone previous depletion followed by more recent enrichment events. A veined mantle source region is proposed in preference to the mantle plume model to explain the chemical variations.

Chemical composition of bottom sediments and rocks from DSDP Holes 3-14 through 64-477

Data on analyses of chemical composition of DSDP samples of bottom sediments and rocks carried out in P.P. Shirshov Institute of Oceanology are reported. Basal sediments and sedimentary rocks prevail in the sample set.

Diui Mesue et noua quedam vltra ea que secum associari co[n]sueueru[n]t Opera ... Mundini de lentiis super canones eius vniversales expositio luculentissima. Christophori Georgii florentini super eius antidotarium expositio clarissima. Christophori eiusdem tractatus de aqua & ptisana ordeacea conficienda fo. 98. Petri Apponensis fructuose additiones. fo. 142. Nicolai medicorum expertissimi antidotarium paruum. fo. 271. Ioa[n]nis de Sancto amando super idem Nicolai antidotarium expositio facu[n]dissima. fo. 303. De quid pro quo. i. de simplicibus in eade[m] operatione co[m]municantibus assu[m]matio. fo. 342. Synonimorum medicinalium. i. nominum ide[m] medicinale significantium tractatus. fo. 342. Bulcasis siue seruitoris medicorum profundissimi libellus copiosissimus. fo. 346. Preclarum Saladini pro aromatariis compendium. fo. 357. Gentilis Fulginei de dosi medicinarum inuestiganda libellus. fo. 339. Alchi[n]di medicorum... de medicinaru[m] co[m]positar[um] gradib[us] i[n]uestiga[n]dis libellus. 373. Subtilissimus Habe[n]guefit de simplicibus medicinis libellus. fo. 369. Egregius Apulei... de ponderibus et mensuris libellus. fo. 372. Antidotorum in Mesue & Nicolai antidotariis contentorum index. fo. 377. Remediorum variis egritudinibus conferentium summula copiosissima. fo. 38. Additiones noue ad multa i[n] Mesue & Nicolai antidotariis...

Contiene además las adiciones de Francesco di Piedimonte al Grabadin de Mesue (f. 142-271), y el comentario de Matthaeus Platearius al Antidotarium de Nicolás Salernitano (f. 271-303), acompañado del texto original.

Diário da Constituinte [gravação de vídeo] : [programa n. 342]

O projeto da Mesa da Constituinte, entrou em negociação logo após a aprovação do projeto do Centrão, que tinha o mesmo objetivo: alterar o Regimento Interno. Agora prevalece o projeto de resolução da Mesa da Constituinte que deve ser votado terça ou quarta feira da próxima semana. Os principais pontos são: Ficam mantidas as emendas coletivas assinadas por 280 constituintes; as emendas coletivas podem ser a títulos, mas a votação será feita por capítulos; as propostas com maior número de assinaturas terão preferência para votação; o prazo para apresentação de emendas ao projeto de Constituição será de 7 dias; as emendas velhas não serão aceitas; cada constituinte pode apresentar 4 emendas e 6 destaques. A maioria dos constituintes já sabe o que quer manter e o que quer modificar no projeto aprovado pela Sistematização. Os movimentos sindicais se reunirão durante todo o dia de ontem no Congresso Nacional. Eles querem que o Plenário mantenham os avanços conseguidos na Comissão de Sistematização

Theater 38.3 : Censorship and Performance

Censorship and Performance, edited by Tom Sellar, examines the politics of censorship, and continuing contests over the ‘right’ to claim theatrical and cultural stages for controversial forms of social and self representation, at the start of the twenty-first century. In bringing this collection together, Sellar has taken a broad-based approach to the concept of censorship in theatrical performance—and, indeed, to the concept of theatrical performance itself. Sellar and his contributors clearly accept that surveillance, suppression and restriction of specific forms of representation is a complex, culturally specific phenomenon. In this sense, Censorship and Performance addresses direct political control over content, as well as thornier arguments about media controversy, moral panic, and the politics of self-censorship amongst artists and arts organisations.

Influence of UGT1A9 intronic I399C4T polymorphism on SN-38 glucuronidation in Asian cancer patients

Genetic polymorphisms in hepatically expressed UGT1A1 and UGT1A9 contribute to the interindividual variability i-n irinotecan disposition and toxicity. We screened UGT1A1 (UGT1A1*60, g.−3140G>A, UGT1A1*28 and UGT1A1*6) and UGT1A9 (g.−118(T)9>10 and I399C>T) genes for polymorphic variants in the promoter and coding regions, and the genotypic effect of UGT1A9 I399C>T polymorphism on irinotecan disposition in Asian cancer patients was investigated. Blood samples were collected from 45 patients after administration of irinotecan as a 90 min intravenous infusion of 375 mg/m2 once in every 3 weeks. Genotypic–phenotypic correlates showed that cancer patients heterozygous or homozygous for the I399C>T allele had approximately 2-fold lower systemic exposure to SN-38 (P<0.05) and a trend towards a higher relative extent of glucuronidation (REG) of SN-38 (P>0.05). UGT1A1–1A9 diplotype analysis showed that patients harbouring the H1/H2 (TG6GT10T/GG6GT9C) diplotype had 2.4-fold lower systemic exposure to SN-38 glucuronide (SN-38G) compared with patients harbouring the H1/H5 (TG6GT10T/GG6GT10C) diplotype (P=0.025). In conclusion, this in vivo study supports the in vitro findings of Girard et al. and suggests that the UGT1A9 I399C>T variant may be an important glucuronidating allele affecting the pharmacokinetics of SN-38 and SN-38G in Asian cancer patients receiving irinotecan chemotherapy.