Voivatko kansalaiset vaikuttaa biotekniikan kehitykseen Suomessa?

Kirjoittaja on tutkija Teknillisen korkeakoulun Ympäristönsuojelun laboratoriossa. Kirjoitus perustuu esitykseen Tieteen Päivillä 8.-12.1.2003.

Mittaavatko ÄO ja Pisa-luvut samaa yksilön ominaisuutta?

Vastine professori Pertti Tötön kommenttiin TT -lehdessä 8/2004

Svinhufvudin-Paasikiven linja

Artikkeli perustuu kirjoittajan väitöskirjaan Pohjoismaa vai kansandemokratia? Sosiaalidemokraatit, kommunistit ja Suomen kansainvälinen asema 1945-51 (SKS 2004), joka tarkastettiin syyskuussa Helsingin yliopistossa

Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.

Chronic kidney disease (CKD), impairment of kidney function, is a serious public health problem, and the assessment of genetic factors influencing kidney function has substantial clinical relevance. Here, we report a meta-analysis of genome-wide association studies for kidney function-related traits, including 71,149 east Asian individuals from 18 studies in 11 population-, hospital- or family-based cohorts, conducted as part of the Asian Genetic Epidemiology Network (AGEN). Our meta-analysis identified 17 loci newly associated with kidney function-related traits, including the concentrations of blood urea nitrogen, uric acid and serum creatinine and estimated glomerular filtration rate based on serum creatinine levels (eGFRcrea) (P < 5.0 × 10(-8)). We further examined these loci with in silico replication in individuals of European ancestry from the KidneyGen, CKDGen and GUGC consortia, including a combined total of ∼110,347 individuals. We identify pleiotropic associations among these loci with kidney function-related traits and risk of CKD. These findings provide new insights into the genetics of kidney function.