Tuotannon ja varastonhallinnan kehittäminen kysyntäennusteiden avulla

Diplomityön tavoitteena on tutkia kysyntäennusteiden hyödyntämistä valmistavan teollisuusyrityksen tuotannossa ja varastonhallinnassa. Työn alussa esitellään kysynnän tuntemiseen ja ennustamiseen liittyvään teoriaan, jonka jälkeen tutkitaan teorian tarjoamia mahdollisuuksia linkittää kysyntäennusteet tuotannon ja varastonhallinnan avuksi. Työn empiria osassa kuvataan ensin Peikko Group Oy:n kysyntäennusteiden nykytilanne. Tämän jälkeen vertaillaan kahden eri lähestymistavan soveltuvuutta, joilla kohdeyritys voisi mahdollisesti rakentaa tuotannolle ja varastonhallinnalle tarpeellisia kysyntäennusteita päätöksenteon tueksi. Tuotannon kannalta työn keskeisin tulos on kysyntäennusteiden pohjalta muodostettu kuormaennuste ja varastonhallinnan kannalta tarvittavan ennustetarkkuuden määrittäminen, jotta ennusteita voitaisiin hyödyntää varastonohjausparametrien määrityksessä.

Ohjeita järjestykseen, suunnitelmia julkaisuun: Hallinnon ohjeistusten ja museokäytännön kohtaaminen Porin taidemuseon digitointiprojekteissa

Tutkimuksen tarkoituksena on tarkastella Suomen valtio- ja museohallinnon hankkeiden tuottamien ohjeistusten suhdetta museotason käytäntöön digitointiprojekteissa. Tutkimuksen käytännön tapauksena on Porin taidemuseon vuosien 2014-2016 digitointihankkeet, joissa hallinnon ohjeistuksia on käytetty apuna. Aineistona tutkimuksessa on käytetty Opetus- ja kulttuuriministeriön Kansallinen digitaalinen kirjasto-hankkeen ohjeistuksia, Museoviraston Museo2015-hankkeen ohjeistuksia ja Porin taidemuseon 2014-2016 vuosien digitointi- ja arkistohankkeissa tuotettuja loppuraportteja, luettelointimalleja ja projektipäiväkirjaa. Tutkimuksessa on käytetty hermenuttista sisällönanalyysia ja vertailua aineistojen analyysissä. Analyysissä on pyritty tarkastelemaan ohjeistuksia ja toisaalta museotason käytännössä tuotettuja luetteloinnin ratkaisumalleja. Pyrkimyksenä on ollut näitä aineistoja vertailemalla löytämään vastaus siihen, miten ohjeistukset ja käytäntö suhteutuvat toisiinsa ja digitointiin. Lopullisena tutkimustuloksena työssä on, että hallinnon ohjeistusten ja museotason käytännön suhteutuminen on näiden tasojen tarpeiden, tavoitteiden ja viitekehysten yhteensovittamista. Ohjeistukset ja käytäntö toimivat eri tasoilla, joilla on erilaiset tavoitteet. Näiden tavoitteiden yhteensovittaminen oli Porin taidemuseon 2014-2016 hankkeiden keskiössä.

PASSCLAIM - gut health and immunity

Background The gut and immune system form a complex integrated structure that has evolved to provide effective digestion and defence against ingested toxins and pathogenic bacteria. However, great variation exists in what is considered normal healthy gut and immune function. Thus, whilst it is possible to measure many aspects of digestion and immunity, it is more difficult to interpret the benefits to individuals of variation within what is considered to be a normal range. Nevertheless, it is important to set standards for optimal function for use both by the consumer, industry and those concerned with the public health. The digestive tract is most frequently the object of functional and health claims and a large market already exists for gut-functional foods worldwide. Aim To define normal function of the gut and immune system and describe available methods of measuring it. Results We have defined normal bowel habit and transit time, identified their role as risk factors for disease and how they may be measured. Similarly, we have tried to define what is a healthy gut flora in terms of the dominant genera and their metabolism and listed the many, varied and novel methods for determining these parameters. It has proved less easy to provide boundaries for what constitutes optimal or improved gastric emptying, gut motility, nutrient and water absorption and the function of organs such as the liver, gallbladder and pancreas. The many tests of these functions are described. We have discussed gastrointestinal well being. Sensations arising from the gut can be both pleasant and unpleasant. However, the characteristics of well being are ill defined and merge imperceptibly from acceptable to unacceptable, a state that is subjective. Nevertheless, we feel this is an important area for future work and method development. The immune system is even more difficult to make quantitative judgements about. When it is defective, then clinical problems ensure, but this is an uncommon state. The innate and adaptive immune systems work synergistically together and comprise many cellular and humoral factors. The adaptive system is extremely sophisticated and between the two arms of immunity there is great redundancy, which provides robust defences. New aspects of immune function are discovered regularly. It is not clear whether immune function can be "improved". Measuring aspects of immune function is possible but there is no one test that will define either the status or functional capacity of the immune system. Human studies are often limited by the ability to sample only blood or secretions such as saliva but it should be remembered that only 2% of lymphocytes circulate at any given time, which limits interpretation of data. We recommend assessing the functional capacity of the immune system by: measuring specific cell functions ex vivo, measuring in vivo responses to challenge, e. g. change in antibody in blood or response to antigens, determining the incidence and severity of infection in target populations during naturally occurring episodes or in response to attenuated pathogens.

The transformation of earth-system observations into information of socio-economic value in GEOSS

The Group on Earth Observations System of Systems, GEOSS, is a co-ordinated initiative by many nations to address the needs for earth-system information expressed by the 2002 World Summit on Sustainable Development. We discuss the role of earth-system modelling and data assimilation in transforming earth-system observations into the predictive and status-assessment products required by GEOSS, across many areas of socio-economic interest. First we review recent gains in the predictive skill of operational global earth-system models, on time-scales of days to several seasons. We then discuss recent work to develop from the global predictions a diverse set of end-user applications which can meet GEOSS requirements for information of socio-economic benefit; examples include forecasts of coastal storm surges, floods in large river basins, seasonal crop yield forecasts and seasonal lead-time alerts for malaria epidemics. We note ongoing efforts to extend operational earth-system modelling and assimilation capabilities to atmospheric composition, in support of improved services for air-quality forecasts and for treaty assessment. We next sketch likely GEOSS observational requirements in the coming decades. In concluding, we reflect on the cost of earth observations relative to the modest cost of transforming the observations into information of socio-economic value.

The design of probiotic studies to substantiate health claims

The EC Regulation No. 1924/2006 on Nutrition and Health claims made on foods has generated considerable debate and concern among scientists and industry. At the time of writing, the European Food Safety Authority (EFSA) has not approved any probiotic claims despite numerous human trials and meta-analyses showing evidence of beneficial effects. On 29th and 30th September 2010, ten independent, academic scientists with a documented record in probiotic research, met to discuss designs for future probiotic studies to demonstrate health benefits for gut and immune function. The expert panel recommended the following: (i) always formulate a precise and concrete hypothesis, and appropriate goals and parameters before starting a trial; (ii) ensure trials have sufficient sample size, such that they are adequately powered to reach statistically significant conclusions, either supporting or rejecting the a priori hypothesis, taking into account adjustment for multiple testing (this might necessitate more than one recruitment site); (iii) ensure trials are of appropriate duration; (iv) focus on a single, primary objective and only evaluate multiple parameters when they are hypothesis-driven. The panel agreed that there was an urgent need to better define which biomarkers are considered valuable for substantiation of a health claim. As a first step, the panel welcomed the publication on the day of the meeting of EFSA's draft guidance document on immune and gut health, although it came too late for study designs and dossiers to be adjusted accordingly. New validated biomarkers need to be identified in order to properly determine the range of physiological functions influenced by probiotics. In addition, validated biomarkers reflecting risk factors for disease, are required for article 14 claims (EC Regulation No. 1924/2006). Finally, the panel concluded that consensus among scientists is needed to decide appropriate clinical endpoints for trials.

Aga, disciplin och fostran i den svenska folkskolan 1945-1959. : En studie om 1947 års skoldisciplinutredning, Skolöverstyrelsens direktiv i fostrans- och disciplinfrågor samt hanteringen av frågan om skolagan i Tunabygdens lärarklubb.

Denna historieuppsats (15hp) handlar om aga- och skoldisciplinsfrågorna i den svenska folkskolan. Undersökningens syfte är att granska hur disciplinsfrågorna i folkskolan hanterades före och efter agaförbudet på både nationell och lokal nivå. För att uppnå detta mål har i första hand tre olika källor använts, nämligen 1947 års skoldisciplinutredning, protokoll från Tunabygdens lärarklubb och dess studiecirkel samt Skolöverstyrelsens anvisningar till folkskolelärarna efter att agan hade förbjudits i folkskolan. Skoldisciplinutredningen kom som en följd av protesterna från lärarkåren och Skolöverstyrelsen till ett agaförbud. Disciplinutredningen kom inte fram till något agaförbud utan snarare fram till flera disciplinsfrämjande förslag. I Tunabygdens lärarklubb och dess studiecirkel bedrevs diskussioner som berörde aga, disciplin och fostran överhuvudtaget. Lärarklubben och folkskolestyrelserna i landet var emot ett agaförbud, men inte enbart för rätten i sig att få aga elever, utan också för att de var emot en stark centralstyrning som de upplevde fanns och som ifrågasatte lärarnas yrkesprofession. Skolöverstyrelsens anvisningar kom 1959, året efter agaförbudet och den handlade mycket om skolans och lärarnas fostrande uppgifter. Fungerande disciplin i klassen ansågs vara lika viktig som innan agaförbudet och det handlade om att ändra formerna för denna disciplin. För att upprätthålla ett fungerande disciplin ansåg Skolöverstyrelsen att det var oerhört viktigt att lära känna igen skolbarnet och dess hemförhållanden. För att kontrollera detta hade bl.a. lärare och skolläkare viktiga roller i hemmens hjälp att fostra barnen rätt, då tilltron till barnens föräldrar och uppväxtmiljö var låg från Skolöverstyrelsens sida.

Underlying Event measurements in pp collisions at root s=0.9 and 7 TeV with the ALICE experiment at the LHC

We present measurements of Underlying Event observables in pp collisions at root s = 0 : 9 and 7 TeV. The analysis is performed as a function of the highest charged-particle transverse momentum p(T),L-T in the event. Different regions are defined with respect to the azimuthal direction of the leading (highest transverse momentum) track: Toward, Transverse and Away. The Toward and Away regions collect the fragmentation products of the hardest partonic interaction. The Transverse region is expected to be most sensitive to the Underlying Event activity. The study is performed with charged particles above three different p(T) thresholds: 0.15, 0.5 and 1.0 GeV/c. In the Transverse region we observe an increase in the multiplicity of a factor 2-3 between the lower and higher collision energies, depending on the track p(T) threshold considered. Data are compared to PYTHIA 6.4, PYTHIA 8.1 and PHOJET. On average, all models considered underestimate the multiplicity and summed p(T) in the Transverse region by about 10-30%.

Measurement of prompt J/psi and beauty hadron production cross sections at mid-rapidity in pp collisions at root s=7 TeV

The ALICE experiment at the LHC has studied J/psi production at mid-rapidity in pp collisions at root s = 7 TeV through its electron pair decay on a data sample corresponding to an integrated luminosity L-int = 5.6 nb(-1). The fraction of J/psi from the decay of long-lived beauty hadrons was determined for J/psi candidates with transverse momentum p(t) > 1,3 GeV/c and rapidity vertical bar y vertical bar < 0.9. The cross section for prompt J/psi mesons, i.e. directly produced J/psi and prompt decays of heavier charmonium states such as the psi(2S) and chi(c) resonances, is sigma(prompt J/psi) (p(t) > 1.3 GeV/c, vertical bar y vertical bar < 0.9) = 8.3 +/- 0.8(stat.) +/- 1.1 (syst.)(-1.4)(+1.5) (syst. pol.) mu b. The cross section for the production of b-hadrons decaying to J/psi with p(t) > 1.3 GeV/c and vertical bar y vertical bar < 0.9 is a sigma(J/psi <- hB) (p(t) > 1.3 GeV/c, vertical bar y vertical bar < 0.9) = 1.46 +/- 0.38 (stat.)(-0.32)(+0.26) (syst.) mu b. The results are compared to QCD model predictions. The shape of the p(t) and y distributions of b-quarks predicted by perturbative QCD model calculations are used to extrapolate the measured cross section to derive the b (b) over bar pair total cross section and d sigma/dy at mid-rapidity.

Maternal mental health in the first 3-week postpartum: the impact of caregiver support and the subjective experience of childbirth - a longitudinal path model

Acute stress reactions (ASR) and postpartum depressive symptoms (PDS) are frequent after childbirth. The present study addresses the change and overlap of ASR and PDS from the 1- to 3-week postpartum and examines the interplay of caregiver support and subjective birth experience with regard to the development of ASR/PDS within a longitudinal path model.