Cuestiones urbanas y regionales en Argentina : Procesos y prácticas en la ciudad contemporánea

En 2012 comenzaron las demoradas obras para soterrar el Ferrocarril Domingo Faustino Sarmiento, gestionado hasta mayo del mismo año por la concesionaria privada Trenes de Buenos Aires (TBA) -desligada del servicio por decisión del Gobierno Nacional tras una saga de demandas y accidentes que instalaron en la opinión pública la necesidad de una profunda reconfiguración técnica y administrativa-. El soterramiento se perfila como una de las obras de infraestructura más importantes de la Argentina, y -de cumplirse sus principales objetivos declarados (la desaparición del tendido ferroviario como barrera urbana y la mejora de la movilidad territorial)- detenta el potencial de modificar profundamente la trama de la megalópolis bonaerense por sus potenciales efectos urbanos. Sin embargo, el proyecto original ha sufrido numerosas reconfiguraciones (en variables tales como extensión, cantidad de vías, futura capacidad operativa y eventual utilización del suelo que sería liberado al desocupar el actual tendido ferroviario) y en términos de expertos es ampliamente considerado, en su versión en ejecución, excesivamente costoso y/o no lo suficientemente pertinente. ¿Cómo se llegó a esta instancia de desfasaje? Creemos que la respuesta tiene que ver con un cambio en los paradigmas de planeamiento urbanístico y los contextos de realización de grandes proyectos urbanos

Viajes, exilio y memoria en Milenio de Manuel Vázquez Montalbán

Algunas de las novelas de la saga Carvalho de Manuel Vázquez Montalbán (Asesinato en el comité central, Los Mares del Sur, El Balneario, Milenio) son particularmente interesantes para rastrear las tensiones que en las sociedades contemporáneas se registran en torno a la memoria y el olvido: ¿qué recordar y qué olvidar? parecen ser preguntas decisivas para el trazado de proyectos políticos y culturales que permitan a unos y otros convivir en la posmodernidad. En estos textos, la recuperación de la memoria aparece ligada en numerosas ocasiones a experiencias de viajes y exilio. Los viajeros de Vázquez Montalbán nunca son turistas, fieles a la consigna de Bowles, sólo saben dónde y cuándo empieza su viaje, nunca cuando termina. En Milenio esta conjunción viaje-memoria es el eje del relato, los personajes recorren el mundo y se encuentran en diferentes escenarios que son delineados con unos pocos trazos necesariamente gruesos, entre ellos los referentes a la historia y el pasado local. Lejos de conformar una postal remota, estas referencias configuran una red de factores que condicionan las vidas de quienes los transitan porque los recuerdos están enraizados en un lugar, y el espacio se convierte en tiempo y memoria cristalizados. En la novela todos los personajes están en movimiento, pasajeros en tránsito, unos y otros ofrecen sus propios relatos acerca de los hechos del pasado y el presente. Milenio resulta así una especie de balance (definitivamente el último de Vázquez Montalbán) de la memoria y la historia del mundo globalizado.

La Guerra de las Galaxias como metodología innovadora para mejorar la motivación

Numerosos estudiantes ven el estudio como algo aburrido, se sienten desmotivados. El docente no puede limitarse a aceptar la situación como un espectador. Es nuestra realidad y de la misma forma que cada estudiante debe responsabilizarse de su propia educación, los profesores tenemos que responsabilizarnos de cambiar ese sentimiento. Para ello se analizará en primer lugar el significado del término motivación y cuáles son los factores en los que los profesores podemos influir. Se verá que una de las formas de intervención es la innovación, por lo que también se analizará el vocablo y se discutirá qué constituye innovación y qué no. Por tanto, el docente se enfrenta a diario con la necesidad de encontrar nuevas formas de enseñar, que capten la atención de los alumnos. Se dice que no hay nada nuevo bajo el sol; sin embargo, hay que ser capaz de encontrar nuevos usos a con recursos que ya existen. Con el presente trabajo se pretende dar respuesta a esa necesidad. Se plantea el uso de una metodología que propone una innovación continua que consiste en establecer un paralelismo entre un relato o una historia y una unidad didáctica de la asignatura de Tecnología. Como historia se ha escogido la conocida película “La Guerra de las Galaxias” y el curso de referencia será el primer curso de Educación Secundaria Obligatoria (1º E.S.O.). En concreto se presenta un material adaptado con fotografías de la película, ejemplos inspirados en la saga y otras adaptaciones educativas. Con ello se consigue una sorpresa continua para el estudiante y así mantener su atención, facilitando su aprendizaje. Se tiene hecho parte del camino, aunque no todo. En este punto, se hace necesario introducir algunas medidas suplementarias, que refuercen y complementen esta metodología y que nos impidan apartarnos del objetivo pretendido: que los alumnos aprendan de manera significativa. ¿Quién dijo que estudiar es aburrido? A number of students see studying as something boring. The teacher cannot be a spectator. It is our reality and, so on one hand, the student has the responsibility of building his education and on the other, the teacher must change that feeling. In order to this, the term motivation will be analysed, and also which are the related aspects in which we have some influence. One of those ways of intervention is motivation. It is for that word, innovation will be analysed as well, discussing what innovation is and what is not. Therefore, teachers face, day by day, the need of finding new ways of teaching for students to pay attention in classes. As people say, there is nothing new under the sun; however, new uses for existing resources are required. This paper pretends to solve that problem. A continuous innovating methodology is set, consisting in establishing a parallelism between a story or tale and a didactic unit in Technology subject. As a story, the well-known film “Star Wars” is chosen, and as a reference course, the first course of Educación Secundaria Obligatoria (1st E.S.O.). Specifically, we introduce an adapted material with pictures from the movie, saga inspired examples and, some other educational adaptations. With it, students are continuously surprised and their attention grabbed, making his learning easier. Part of the problem is solved, but there is a long way to go. At this point, some supplementary steps are needed, in order to enforce and complement this methodology, and to avoid getting far away from the attempted objective: students learning in a significant way. Who said studying is annoying?

WEBJORNALISMO COLABORATIVO - A PRESENÇA DOS USUÁRIOS NO CONTEÚDO INFORMATIVO DO PORTAL R7

Este estudo procura verificar como ocorre a colaboração dos usuários no conteúdo informativo do Portal R7, a partir da nova configuração da internet, a web 2.0, criada em 2004. O termo web 2.0 surgiu para qualificar uma segunda geração de comunidades e serviços, em um ambiente de interação e participação que engloba diversas linguagens. Com o crescimento da adesão à tecnologia digital, algumas barreiras que limitavam a colaboração nos conteúdos informativos foram superadas e o ambiente comunicacional tornou-se um espaço de intercâmbio para experiências e práticas do cotidiano. Nesse cenário, os internautas passam a ter uma relação mais aproximativa nos processos midiáticos presentes no suporte digital, no qual o cidadão pode se expressar, ter maior visibilidade e se relacionar a partir do momento em que ele produz, publica e compartilha qualquer tipo de conteúdo, seja de caráter informativo ou de entretenimento. A revisão bibliográfica abrangeu autores como Ciro Marcondes Filho, José Marques de Melo, Nelson Traquina, Alex Primo, Ana Brambilla, Marcelo Träsel, Raquel Recuero, Polyana Ferrari, Squirra, entre outros. O método de investigação utilizado é o qualitativo, por meio de uma pesquisa exploratória descritiva, do tipo estudo de caso. Os instrumentos para a investigação foram a observação direta assistemática e a entrevista semiestruturada (ou semiaberta). O principal resultado obtido é que o webjornalismo colaborativo no Portal R7 é prioritariamente induzido pelas redes sociais, especialmente o Facebook e o Twitter, inspirado no “call for action”, como estratégia para chamar à colaboração. As práticas jornalísticas estão intrinsicamente dependentes da ação do usuário, sendo que o jornalista agrega às práticas de checagem uma nova etapa, a de relacionamento com o usuário do Portal, para agregar e fidelizar a audiência, valorizando a colaboração em todas as etapas de produção.

O AGENDAMENTO DE TELEJORNAIS BRASILEIROS EM SITES NOTICIOSOS DE CONTEÚDO COLABORATIVO

The thesis investigates if with the free news production, people who post information on collaborative content sites, known as interacting, tend to reproduce information that was scheduled for Tv news. This study is a comparison of the collaborative content vehicles Vc reporter, Vc no G1 and Eu reporter with TV news SBT Brasil, Jornal Nacional, Jornal da Record and Jornal da Band. We sought to determine whether those newscasts guide the collaborative platforms. The hypothesis assumes that Brazilian TV news have been building over time a credible relationship with the viewer, so it is possible to think that the interacting use the same criteria for selecting the broadcasts and reproduce similar information in collaborative content sites. The method used was content analysis, based on the study of Laurence Bardin and the type of research used was quantitative. This research concluded that, within a small portion of the universe surveyed, there are schedules of television news across the collaborative content.

Tertiary hypothyroidism and hyperglycemia in mice with targeted disruption of the thyrotropin-releasing hormone gene

Thyrotropin-releasing hormone (TRH) is a brain hypothalamic hormone that regulates thyrotropin (TSH) secretion from the anterior pituitary and is ubiquitously distributed throughout the brain and other tissues including pancreas. To facilitate studies into the role of endogenous TRH, we have used homologous recombination to generate mice that lack TRH. These TRH−/− mice are viable, fertile, and exhibit normal development. However, they showed obvious hypothyroidism with characteristic elevation of serum TSH level and diminished TSH biological activity. Their anterior pituitaries exhibited an apparent decrease in TSH immunopositive cells that was not due to hypothyroidism. Furthermore, this decrease could be reversed by TRH, but not thyroid hormone replacement, suggesting a direct involvement of TRH in the regulation of thyrotrophs. The TRH−/− mice also exhibited hyperglycemia, which was accompanied by impaired insulin secretion in response to glucose. These findings indicate that TRH−/− mice provide a model of exploiting tertiary hypothyroidism, and that TRH gene abnormalities cause disturbance of insulin secretion resulting in marked hyperglycemia.

Purified histone acetyltransferase complexes stimulate HIV-1 transcription from preassembled nucleosomal arrays

Protein acetylation has been implicated in the regulation of HIV-1 gene transcription. Here, we have exploited the activities of four native histone acetyltransferase (HAT) complexes from yeast to directly test whether acetylation regulates HIV-1 transcription in vitro. HAT activities acetylating either histone H3 (SAGA, Ada, and NuA3) or H4 (NuA4) stimulate HIV-1 transcription from preassembled nucleosomal templates in an acetyl CoA-dependent manner. HIV-1 transcription from histone-free DNA is not affected by the HATs, indicating that these activities function in a chromatin-specific fashion. For Ada and NuA4, we demonstrate that acetylation of only histone proteins mediates enhanced transcription, suggesting that these complexes facilitate transcription at least in part by modifying histones. To address a potential mechanism by which HAT complexes stimulate transcription, we performed a restriction enzyme accessibility analysis. Each of the HATs increases the cutting efficiencies of restriction endonucleases targeting the HIV-1 chromatin templates in a manner not requiring transcription, suggesting that histone acetylation leads to nucleosome remodeling.

Transcriptional adaptor and histone acetyltransferase proteins in Arabidopsis and their interactions with CBF1, a transcriptional activator involved in cold-regulated gene expression

The Arabidopsis CBF transcriptional activators bind to the CRT/DRE regulatory element present in the promoters of many cold-regulated genes and stimulate their transcription. Expression of the CBF1 proteins in yeast activates reporter genes carrying a minimal promoter with the CRT/DRE as an upstream regulatory element. Here we report that this ability of CBF1 is dependent upon the activities of three key components of the yeast Ada and SAGA complexes, namely the histone acetyltransferase (HAT) Gcn5 and the transcriptional adaptor proteins Ada2 and Ada3. This result suggested that CBF1 might function through the action of similar complexes in Arabidopsis. In support of this hypothesis we found that Arabidopsis has a homolog of the GCN5 gene and two homologs of ADA2, the first report of multiple ADA2 genes in an organism. The Arabidopsis GCN5 protein has intrinsic HAT activity and can physically interact in vitro with both the Arabidopsis ADA2a and ADA2b proteins. In addition, the CBF1 transcriptional activator can interact with the Arabidopsis GCN5 and ADA2 proteins. We conclude that Arabidopsis encodes HAT-containing adaptor complexes that are related to the Ada and SAGA complexes of yeast and propose that the CBF1 transcriptional activator functions through the action of one or more of these complexes.

Targeting cancer micrometastases with monoclonal antibodies: a binding-site barrier.

Monoclonal antibodies penetrate bulky tumors poorly after intravenous administration, in part because of specific binding to the target antigen. Experiments presented here demonstrate an analogous phenomenon in micrometastases; poor antibody penetration, attributable to a "binding-site barrier" phenomenon, can be seen in guinea pig micrometastases as small as 300 microns in diameter. Increasing the dose of antibody can partially overcome this limitation, but at a cost in specificity.

A cura pelo poder

Sarney revela em livro de memórias que conseguiu controlar seus medos com o exercício da presidência. Destaca a saga do cruzado e se diz ressentido com acusações de que o planp foi eleitoreiro.

Modelos urbanos y su proyección literaria en la novela criminal

La novela criminal experimenta en la actualidad un momento de esplendor en las distintas literaturas que se desarrollan en el Estado español, debido al aumento en el número de autores, lectores y obras publicadas. No ha sido un camino fácil, pues este género se ha adaptado tardíamente a la realidad española. De hecho, hasta la década de 1970, cuando la Dictadura franquista llegaba a su fin, no hubo una verdadera tradición de novela criminal urbana en España. En 1974, Manuel Vázquez Montalbán publicó la obra Tatuaje, primera en la que el personaje de Pepe Carvalho aparecía como detective e inicio de la saga más relevante en España. El desarrollo del género fue dispar en las diferentes literaturas del Estado, y mientras Cataluña ya contaba con un respetable bagaje –autores como Manuel de Pedrolo, Rafael Tasis, Jaume Fuster…–, en el País Vasco comenzaba a emplearse el género, y en Galicia y Canarias habría que esperar hasta las décadas de 1980 y de 1990, respectivamente. Esta desigual adaptación de la novela criminal propicia la aparición de diferentes modelos urbanos en las distintas obras y literaturas a las que se adscriben. La ciudad es un elemento característico del género, pues su nacimiento está directamente relacionado con la Revolución Industrial: es cuando surgen las urbes y las sociedades modernas y una burguesía con gran poder adquisitivo y aumenta la población alfabetizada. Es en las ciudades donde se desarrollan las tramas criminales y violentas, pues estas fomentan el anonimato de los asesinos, la creación de cuerpos policiales y la presencia de detectives privados...

Causation and Harm in a Multicomponent World

On September 17, 2015, the Federal Circuit issued another decision in the epic Apple v. Samsung smartphone war. This was the fourth court decision in the ongoing saga to deal with injunctions. Apple IV explained the level of proof necessary to satisfy the "causal nexus" requirement. This requirement had emerged as a response to patent litigations involving products with thousands of features, the vast majority of which are unrelated to the asserted patent. To prove a causal nexus, patentees seeking an injunction have to do more than just show that the infringing product caused the patentee irreparable harm. The harm must be specifically attributable to the infringing feature. In Apple IV, the Federal Circuit noted that proving causation was "nearly impossible" in these multicomponent cases. So it decided to water down the causal nexus requirement saying that it was enough for Apple to show that the infringing features were "important"and customer sought these particular features. This lower standard is an ill-advised mistake that leaves multicomponent product manufacturers more susceptible to patent holdup. My critique takes two parts. First, I argue that a single infringing feature rarely, if ever, "causes" consumers to buy the infringer’s multicomponent products. The minor features at issue in Apple IV illustrate this point vividly. Thus, the new causal nexus standard does not accurately reflect how causation and harm operate in a multicomponent world. Second, I explain why the court was so willing to accept such little evidence of real injury. It improperly applied notions of traditional property law to patents. Specifically, the court viewed patent infringement as harmful regardless of any concrete consequences. This view may resonate for other forms of property where an owner's rights are paramount and a trespass is considered offensive in and of itself. But the same concepts do not apply to patent law where the Supreme Court has consistently said that private interests must take a back seat to the public good. Based on these principles, the courts should restore the "causal nexus" requirement and not presume causation.