A utilização do risco na planificação das ações de controle da Secretaria de Controle Interno da Câmara dos Deputados

Estabelece a metodologia de planejamento anual dos trabalhos eletivos da Secretaria de Controle Interno da Câmara dos Deputados - SECIN. O planejamento se baseia na avaliação dos riscos incidentes sobre áreas, processos ou negócios corporativos sujeitos a ações de controle, visando priorizar os objetos que representem maiores riscos para a consecução dos objetivos institucionais e estratégicos da Câmara dos Deputados. O direcionamento das ações de controle para os objetos mais críticos permite a melhor alocação dos recursos humanos e materiais disponíveis pela Secretaria de Controle Interno e a maior agregação de valor de seus trabalhos. O modelo proposto se fundamenta em doutrina atualizada e nas melhores práticas observadas em órgãos de controle interno e externo dos setores público e privado de diversos países. A principal orientação teórica do modelo segue o Committee of Sponsoring Organization of the Treadway Comission (COSO). A avaliação de risco se fundamenta na modelagem estatística de fatores predefinidos pela SECIN, todos relacionados aos objetivos da Casa. Esses fatores são submetidos a modelagem estatística de dados, cujos resultados permitem a comparação dos objetos auditáveis entre si e a caracterização de prioridades em relação aos riscos totais apurados.

O estudo do lobby no legislativo pela abordagem de redes

O estudo objetiva mostrar que analisar o lobby no Legislativo pela perspectiva de redes colabora para a melhor percepção do fenômeno da participação política da sociedade organizada no âmbito das comissões de mérito do Legislativo. A lógica de redes permite focar na práxis democrática, em seu aperfeiçoamento e nas garantias para que a participação dos interesses organizados colabore para a eficiência e para a socialização das resoluções dos problemas no contexto democrático. Pela abordagem de redes, torna-se claro que, muito mais que uma mera regulamentação, é necessário aperfeiçoar a práxis política, conhecer melhor seus atores e fomentar o ambiente propício para que o desenvolvimento do lobby não seja fator de degeneração do desempenho do governo democrático, não se transforme em mera manipulação política pelo poder econômico nem corrobore uma ditadura de minorias sociais refratárias à maior parte dos interesses públicos.

Key business factors for eco-innovation: an overview of recent firm-level empirical studies

[EN] The increasing interest in eco-innovation or environmental innovation as a strategy not only to address the serious global environmental problems but also as a source of competitive advantages for companies and for the emergence of new business areas, leads us to try to identify the different factors that act as determinants of its development and adoption at the micro level.

Sermoens do P. Antonio Vieira, da Companhia de Jesu, pregador de Sua Alteza

Padre Antônio Vieira nasceu em Lisboa em 6 de novembro de 1608 e morreu na Bahia em 18 de julho de 1697. Ordenado sacerdote em 1634, logo se destacou como excepcional pregador. Exerceu importante papel politico e diplomático durante o reinado de D. João IV e fez do púlpito uma tribuna a serviço da nação, em guerra com a Espanha. De 1652 a 1661 atuou como missionário no Maranhão. Em Portugal foi denunciado como herético ao Tribunal da Inquisição. Doente e encarcerado defendeu-se com extraordinário vigor, mas foi condenado a internamento numa casa jesuítica e proibido de pregar. Retirou-se em 1681 para o Brasil, onde trabalhou na edição completa dos Sermoens. Os Sermoens de Padre Vieira, cuja edição princeps se deu em quinze volumes, estabelecem uma analogia entre o presente vivo e os textos bíblicos. Alguns dos mais conhecidos sermões de Vieira refletem momentos históricos, tais como o Sermão da Sexagésima, que, proferido na Capela Real, em 1655, contra os gongoristas, discorre sobre a arte de pregar; o Sermão pelo Bom Sucesso das Armas de Portugal contra as da Holanda, cujo tema é a invasão holandesa de 1610; o Sermão de Santo Antônio, também conhecido como Sermão dos Peixes, pronunciado em São Luís, Maranhão, em 1654, e que discorre sobre a escravidão indígena; e o Sermão da Primeira Oitava da Páscoa, onde comenta as verdadeiras e falsas riquezas, cuja pregação se deu em 1656, na Igreja Matriz de Belém, Pará. Esta edição, chamada ‘completa’, não apresenta todos os sermões proferidos por Vieira: mas traduz seu pensamento e estilo na última fase de sua vida

Chronica do muito alto, e muito esclarecido Principe D. Affonso Henriques Primeiro Rey de Portugal composta por Duarte Galvão, Fidalgo da Casa Real, e Chronista Mor do Reyno, Fielmente Copiada do seu Original, Que Se Conserva no Archivo Real da Torre do Tombo; offerecida a magestade sempre augusta delrey D. João V. nosso senhor por Miguel Lopes Ferreyra

Duarte Galvão nasceu em Évora, por volta de 1445, e morreu na Ilha de Camarão, em 1517. Alguns biógrafos atribuem-lhe o cargo de cronista-mor do reino, nomeado por D. Afonso V. Foi secretário de D. João II e embaixador de D. Manuel I junto ao Papa Alexandre VI, ao Imperador Maximiliano I, e ao Rei Luís XII, de França. Embora preparada na segunda metade do século XV, Chronica del muito alto... conservou-se em forma de manuscrito até 1726, quando foi impressa pela primeira vez. Pertence à Chronica geral del reyno e foi elaborada por ordem de D. Manuel, para completar a sequencia das crônicas reais. O exemplar que a Biblioteca da Câmara possui traz os capítulos XXI e XXII, XXIII e XXIV, cortados pela Inquisição, na edição de 1726. É considerado, por isso, não só um exemplar raro, mas raríssimo, a julgar pelo testemunho do Cavalheiro Francisco Xavier de Oliveira, que afirma, em artigo publicado no “Popular”, impresso em Londres, no ano de 1825, haver apenas dois exemplares desta edição em que figuram os citados capítulos.

A colorectal cancer genome-wide association study in a Spanish cohort identifies two variants associated with colorectal cancer risk at 1p33 and 8p12

Background: Colorectal cancer (CRC) is a disease of complex aetiology, with much of the expected inherited risk being due to several common low risk variants. Genome-Wide Association Studies (GWAS) have identified 20 CRC risk variants. Nevertheless, these have only been able to explain part of the missing heritability. Moreover, these signals have only been inspected in populations of Northern European origin. Results: Thus, we followed the same approach in a Spanish cohort of 881 cases and 667 controls. Sixty-four variants at 24 loci were found to be associated with CRC at p-values <10-5. We therefore evaluated the 24 loci in another Spanish replication cohort (1481 cases and 1850 controls). Two of these SNPs, rs12080929 at 1p33 (P-replication=0.042; P-pooled=5.523x10(-03); OR (CI95%)=0.866(0.782-0.959)) and rs11987193 at 8p12 (P-replication=0.039; P-pooled=6.985x10(-5); OR (CI95%)=0.786(0.705-0.878)) were replicated in the second Phase, although they did not reach genome-wide statistical significance. Conclusions: We have performed the first CRC GWAS in a Southern European population and by these means we were able to identify two new susceptibility variants at 1p33 and 8p12 loci. These two SNPs are located near the SLC5A9 and DUSP4 loci, respectively, which could be good functional candidates for the association signals. We therefore believe that these two markers constitute good candidates for CRC susceptibility loci and should be further evaluated in other larger datasets. Moreover, we highlight that were these two SNPs true susceptibility variants, they would constitute a decrease in the CRC missing heritability fraction.

Query-by-Example Spoken Term Detection ALBAYZIN 2012 evaluation: overview, systems, results, and discussion

Query-by-Example Spoken Term Detection (QbE STD) aims at retrieving data from a speech data repository given an acoustic query containing the term of interest as input. Nowadays, it has been receiving much interest due to the high volume of information stored in audio or audiovisual format. QbE STD differs from automatic speech recognition (ASR) and keyword spotting (KWS)/spoken term detection (STD) since ASR is interested in all the terms/words that appear in the speech signal and KWS/STD relies on a textual transcription of the search term to retrieve the speech data. This paper presents the systems submitted to the ALBAYZIN 2012 QbE STD evaluation held as a part of ALBAYZIN 2012 evaluation campaign within the context of the IberSPEECH 2012 Conference(a). The evaluation consists of retrieving the speech files that contain the input queries, indicating their start and end timestamps within the appropriate speech file. Evaluation is conducted on a Spanish spontaneous speech database containing a set of talks from MAVIR workshops(b), which amount at about 7 h of speech in total. We present the database metric systems submitted along with all results and some discussion. Four different research groups took part in the evaluation. Evaluation results show the difficulty of this task and the limited performance indicates there is still a lot of room for improvement. The best result is achieved by a dynamic time warping-based search over Gaussian posteriorgrams/posterior phoneme probabilities. This paper also compares the systems aiming at establishing the best technique dealing with that difficult task and looking for defining promising directions for this relatively novel task.

Analytical efficiency evaluation of a network mobility management protocol for Intelligent Transportation Systems

One of the major concerns in an Intelligent Transportation System (ITS) scenario, such as that which may be found on a long-distance train service, is the provision of efficient communication services, satisfying users' expectations, and fulfilling even highly demanding application requirements, such as safety-oriented services. In an ITS scenario, it is common to have a significant amount of onboard devices that comprise a cluster of nodes (a mobile network) that demand connectivity to the outside networks. This demand has to be satisfied without service disruption. Consequently, the mobility of the mobile network has to be managed. Due to the nature of mobile networks, efficient and lightweight protocols are desired in the ITS context to ensure adequate service performance. However, the security is also a key factor in this scenario. Since the management of the mobility is essential for providing communications, the protocol for managing this mobility has to be protected. Furthermore, there are safety-oriented services in this scenario, so user application data should also be protected. Nevertheless, providing security is expensive in terms of efficiency. Based on this considerations, we have developed a solution for managing the network mobility for ITS scenarios: the NeMHIP protocol. This approach provides a secure management of network mobility in an efficient manner. In this article, we present this protocol and the strategy developed to maintain its security and efficiency in satisfactory levels. We also present the developed analytical models to analyze quantitatively the efficiency of the protocol. More specifically, we have developed models for assessing it in terms of signaling cost, which demonstrates that NeMHIP generates up to 73.47% less signaling compared to other relevant approaches. Therefore, the results obtained demonstrate that NeMHIP is the most efficient and secure solution for providing communications in mobile network scenarios such as in an ITS context.

Evidence for classification of c.1852_1853AA > GC in MLH1 as a neutral variant for Lynch syndrome

Background: Lynch syndrome (LS) is an autosomal dominant inherited cancer syndrome characterized by early onset cancers of the colorectum, endometrium and other tumours. A significant proportion of DNA variants in LS patients are unclassified. Reports on the pathogenicity of the c.1852_1853AA>GC (p.Lys618Ala) variant of the MLH1 gene are conflicting. In this study, we provide new evidence indicating that this variant has no significant implications for LS. Methods: The following approach was used to assess the clinical significance of the p.Lys618Ala variant: frequency in a control population, case-control comparison, co-occurrence of the p.Lys618Ala variant with a pathogenic mutation, co-segregation with the disease and microsatellite instability in tumours from carriers of the variant. We genotyped p.Lys618Ala in 1034 individuals (373 sporadic colorectal cancer [CRC] patients, 250 index subjects from families suspected of having LS [revised Bethesda guidelines] and 411 controls). Three well-characterized LS families that fulfilled the Amsterdam II Criteria and consisted of members with the p.Lys618Ala variant were included to assess co-occurrence and co-segregation. A subset of colorectal tumour DNA samples from 17 patients carrying the p.Lys618Ala variant was screened for microsatellite instability using five mononucleotide markers. Results: Twenty-seven individuals were heterozygous for the p.Lys618Ala variant; nine had sporadic CRC (2.41%), seven were suspected of having hereditary CRC (2.8%) and 11 were controls (2.68%). There were no significant associations in the case-control and case-case studies. The p.Lys618Ala variant was co-existent with pathogenic mutations in two unrelated LS families. In one family, the allele distribution of the pathogenic and unclassified variant was in trans, in the other family the pathogenic variant was detected in the MSH6 gene and only the deleterious variant co-segregated with the disease in both families. Only two positive cases of microsatellite instability (2/17, 11.8%) were detected in tumours from p.Lys618Ala carriers, indicating that this variant does not play a role in functional inactivation of MLH1 in CRC patients. Conclusions: The p.Lys618Ala variant should be considered a neutral variant for LS. These findings have implications for the clinical management of CRC probands and their relatives.

A High Degree of LINE-1 Hypomethylation Is a Unique Feature of Early-Onset Colorectal Cancer

12 p.

Alvará com força de Lei, pelo qual ha Vossa Alteza Real por bem (por effeito dos augustos sentimentos da sua paternal affeição pelos seus fieis vassallos) mandar estabelecer nas Capitaes dos Governos, e Capitanias dos seus domínios ultramarinos Juntas, para resolver aquelles negocios, que antes se expedião pelo recurso à Meza do Desembargo do Paço, em grande detrimento das partes, pelas demoras, nocivas de longas, e pezadas despezas, que os vassallos de Vossa Alteza Real experimentavão, e soffrião no trato, e decisão das suas dependencias ; tudo na fórma acima declarada : para Vossa Alteza Real ver

Ao alto do título: Conde das Galveas.

Alvará, pelo qual Vossa Alteza Real ha por bem crear huma Contadoria da Marinha, na fórma acima declarada : para Vossa Alteza Real ver

Ao alto do título: Visconde de Anadia.

Una aproximación psicosocial al conflicto vasco. Construyendo la paz en espacio abierto

450 p.

Electron energy-loss spectroscopy study of polyatomic molecular systems under pyrolytic conditions

The technique of variable-angle, electron energy-loss spectroscopy has been used to study the electronic spectroscopy of the diketene molecule. The experiment was performed using incident electron beam energies of 25 eV and 50 eV, and at scattering angles between 10° and 90°. The energy-loss region from 2 eV to 11 eV was examined. One spin-forbidden transition has been observed at 4.36 eV and three others that are spin-allowed have been located at 5.89 eV, 6.88 eV and 7.84 eV. Based on the intensity variation of these transitions with impact energy and scattering angle, and through analogy with simpler molecules, the first three transitions are tentatively assigned to an n → π* transition, a π - σ* (3s) Rydberg transition and a π → π* transition.

Thermal decomposition of chlorodifluoromethane, chloroform, dichloromethane and chloromethane under flash-vacuum pyrolysis conditions (900-1100°C) was investigated by the technique of electron energy-loss spectroscopy, using the impact energy of 50 eV and a scattering angle of 10°. The pyrolytic reaction follows a hydrogen-chloride α-elimination pathway. The difluoromethylene radical was produced from chlorodifluoromethane pyrolysis at 900°C and identified by its X^1 A_1 → A^1B_1 band at 5.04 eV.

Finally, a number of exploratory studies have been performed. The thermal decomposition of diketene was studied under flash vacuum pressures (1-10 mTorr) and temperatures ranging from 500°C to 1000°C. The complete decomposition of the diketene molecule into two ketene molecules was achieved at 900°C. The pyrolysis of trifluoromethyl iodide molecule at 1000°C produced an electron energy-loss spectrum with several iodine-atom, sharp peaks and only a small shoulder at 8.37 eV as a possible trifluoromethyl radical feature. The electron energy-loss spectrum of trichlorobromomethane at 900°C mainly showed features from bromine atom, chlorine molecule and tetrachloroethylene. Hexachloroacetone decomposed partially at 900°C, but showed well-defined features from chlorine, carbon monoxide and tetrachloroethylene molecules. Bromodichloromethane molecule was investigated at 1000°C and produced a congested, electron energy-loss spectrum with bromine-atom, hydrogen-bromide, hydrogen-chloride and tetrachloroethylene features.