A hybrid data assimilation scheme for model parameter estimation: application to morphodynamic modelling

We present a novel algorithm for joint state-parameter estimation using sequential three dimensional variational data assimilation (3D Var) and demonstrate its application in the context of morphodynamic modelling using an idealised two parameter 1D sediment transport model. The new scheme combines a static representation of the state background error covariances with a flow dependent approximation of the state-parameter cross-covariances. For the case presented here, this involves calculating a local finite difference approximation of the gradient of the model with respect to the parameters. The new method is easy to implement and computationally inexpensive to run. Experimental results are positive with the scheme able to recover the model parameters to a high level of accuracy. We expect that there is potential for successful application of this new methodology to larger, more realistic models with more complex parameterisations.

Chitosan-based mucoadhesive tablets for oral delivery of ibuprofen

Chitosan and its half-acetylated derivative have been compared as excipients in mucoadhesive tablets containing ibuprofen. Initially the powder formulations containing the polymers and the drug were prepared by either co-spray drying or physical co-grinding. Polymer–drug interactions and the degree of drug crystallinity in these formulations were assessed by infrared spectroscopy and differential scanning calorimetry. Tablets were prepared and their swelling and dissolution properties were studied in media of various pHs. Mucoadhesive properties of ibuprofen-loaded and drug-free tablets were evaluated by analysing their detachment from pig gastric mucosa over a range of pHs. Greater polymer–drug interactions were seen for spray-dried particles compared to co-ground samples and drug loading into chitosan-based microparticles (41%) was greater than the corresponding half-acetylated samples (32%). Swelling and drug release was greater with the half-acetylated chitosan tablets than tablets containing the parent polymer and both tablets were mucoadhesive, the extent of which was dependent on substrate pH. The results illustrate the potential sustained drug delivery benefits of both chitosan and its half-acetylated derivative as mucoadhesive tablet excipients.

Effect of 830 nm low-level laser therapy applied before high-intensity exercises on skeletal muscle recovery in athletes

Our aim was to investigate the immediate effects of bilateral, 830 nm, low-level laser therapy (LLLT) on high-intensity exercise and biochemical markers of skeletal muscle recovery, in a randomised, double-blind, placebo-controlled, crossover trial set in a sports physiotherapy clinic. Twenty male athletes (nine professional volleyball players and eleven adolescent soccer players) participated. Active LLLT (830 nm wavelength, 100 mW, spot size 0.0028 cm(2), 3-4 J per point) or an identical placebo LLLT was delivered to five points in the rectus femoris muscle (bilaterally). The main outcome measures were the work performed in the Wingate test: 30 s of maximum cycling with a load of 7.5% of body weight, and the measurement of blood lactate (BL) and creatine kinase (CK) levels before and after exercise. There was no significant difference in the work performed during the Wingate test (P > 0.05) between subjects given active LLLT and those given placebo LLLT. For volleyball athletes, the change in CK levels from before to after the exercise test was significantly lower (P = 0.0133) for those given active LLLT (2.52 U l(-1) +/- 7.04 U l(-1)) than for those given placebo LLLT (28.49 U l(-1) +/- 22.62 U l(-1)). For the soccer athletes, the change in blood lactate levels from before exercise to 15 min after exercise was significantly lower (P < 0.01) in the group subjected to active LLLT (8.55 mmol l(-1) +/- 2.14 mmol l(-1)) than in the group subjected to placebo LLLT (10.52 mmol l(-1) +/- 1.82 mmol l(-1)). LLLT irradiation before the Wingate test seemed to inhibit an expected post-exercise increase in CK level and to accelerate post-exercise lactate removal without affecting test performance. These findings suggest that LLLT may be of benefit in accelerating post-exercise recovery.

Effect of 830 nm low-level laser therapy in exercise-induced skeletal muscle fatigue in humans

This study aimed to investigate the effect of 830 nm low-level laser therapy (LLLT) on skeletal muscle fatigue. Ten healthy male professional volleyball players entered a crossover randomized double-blinded placebo-controlled trial. Active LLLT (830 nm wavelength, 100 mW output, spot size 0.0028 cm(2), 200 s total irradiation time) or an identical placebo LLLT was delivered to four points on the biceps humeri muscle immediately before exercises. All subjects performed voluntary biceps humeri contractions with a load of 75% of the maximum voluntary contraction (MVC) force until exhaustion. After active LLLT the mean number of repetitions was significantly higher than after placebo irradiation [mean difference 4.5, standard deviation (SD) +/- 6.0, P = 0.042], the blood lactate levels increased after exercises, but there was no significant difference between the treatments. We concluded that 830 nm LLLT can delay the onset of skeletal muscle fatigue in high-intensity exercises, in spite of increased blood lactate levels.

Performance of balanced two-stage empirical predictors of realized cluster latent values from finite populations: A simulation study

Predictors of random effects are usually based on the popular mixed effects (ME) model developed under the assumption that the sample is obtained from a conceptual infinite population; such predictors are employed even when the actual population is finite. Two alternatives that incorporate the finite nature of the population are obtained from the superpopulation model proposed by Scott and Smith (1969. Estimation in multi-stage surveys. J. Amer. Statist. Assoc. 64, 830-840) or from the finite population mixed model recently proposed by Stanek and Singer (2004. Predicting random effects from finite population clustered samples with response error. J. Amer. Statist. Assoc. 99, 1119-1130). Predictors derived under the latter model with the additional assumptions that all variance components are known and that within-cluster variances are equal have smaller mean squared error (MSE) than the competitors based on either the ME or Scott and Smith`s models. As population variances are rarely known, we propose method of moment estimators to obtain empirical predictors and conduct a simulation study to evaluate their performance. The results suggest that the finite population mixed model empirical predictor is more stable than its competitors since, in terms of MSE, it is either the best or the second best and when second best, its performance lies within acceptable limits. When both cluster and unit intra-class correlation coefficients are very high (e.g., 0.95 or more), the performance of the empirical predictors derived under the three models is similar. (c) 2007 Elsevier B.V. All rights reserved.

Ativo intangível das empresas listadas na BM&FBovespa: comparativo do tratamento no Brasil antes e depois da Lei 11.638/07

Dissertação apresentada ao Programa de Pós- Graduação em Administração-Mestrado, como requisito parcial para obtenção do título de Mestre em Administração

O neomunícipe na comunicação pública das cidades do Grande ABC

artigo publicado na revista Parágrafo

Impactos do início da harmonização contábil internacional (lei 11.638/07) nos resultados de 2008 das empresas brasileiras abertas

Este estudo analisa os efeitos da primeira frase da transição para o IFRS no Brasil (Lei 11.638/07 e CPC 13) nos resultados publicados em 2009 (exercício de 2008 e republicações de 2007) pelas empresas listadas na Bovespa. É aplicado o inverso do “Índice de Conservadorismo” de Gray (1980,1988), renomeado “Índice de Comparabilidade” por Weetman et al. (1998), para determinar se e o quanto os resultados reportados pelas novas normas são superiores aos apurados pela norma brasileira anterior – indicando o conservadorismo do sistema contábil brasileiro, previsto por Gray e outros estudos – ou inferiores (otimismo). Reduziu-se gradativamente a amostra inicial conforme a compliance com o CPC 13 e a transparência das demonstrações e das Notas Explicativas. Isso permitiu, após aplicação do Teste de Wilcoxon, verificar em média resultados maiores conforme a nova norma em relação à norma tradicional – preconizando-se que persistirão aumentos até a adoção do full IFRS em 2010. Após o exame de ajustes ao resultado, foi possível relacionar certas inconsistências entre 2007 e 2008 a impactos da crise financeira de 2008 nos ajustes “custos de transação na emissão de títulos” e “valor justo (marcação a mercado) de instrumentos financeiros”.

Educação sexual: estudo exploratório num contexto escolar

Este trabalho de investigação consiste num estudo exploratório desenvolvido em contexto escolar na Região Autónoma da Madeira (RAM) e subjacente a este estudo na área educacional, está a legislação em vigor. Neste sentido, recolhemos dados num grupo de 51 professores do ensino secundário, através de inquérito por questionário e num grupo de alunos em situação de pré e pós-teste mediante a aplicação de 5 sessões de educação sexual. Face a esta premissa, o nosso estudo teve como principal objectivo, dar a conhecer a forma como está a ser implementada a educação sexual no ensino secundário e recolher de um grupo de alunos a sua percepção acerca das temáticas a abordar e a importância atribuída à educação sexual. Os resultados do estudo apontam para a aceitação por parte dos professores, para haver formação em educação sexual nas escolas secundárias e que esta deve ser trabalhada na sala de aula. No entanto, alguns dos inquiridos sentem dificuldades em desenvolver acções nesta matéria e consideram que esta formação deveria ser ministrada por profissionais com formação específica. No que se refere aos conhecimentos e aceitação da lei em vigor, podemos apurar que a maioria dos inquiridos concorda com o regime de aplicação da lei em meio escolar. Junto do grupo de alunos constatamos, no que refere à percepção que estes têm sobre os temas a abordar em educação sexual e qual a sua importância, as IST’s e HIV assumem um lugar de destaque. No entanto, há outras temáticas que são também referenciadas como a gravidez na adolescência, os métodos contraceptivos, o saber falar e os afectos. Dos resultados obtidos no estudo, estes sugerem, que as escolas secundárias têm mais uma responsabilidade social acrescida, na perspectiva da educação para a saúde e na promoção do desenvolvimento integral dos seus alunos.

Correlação linear entre componentes da produção e produtividade do arroz de terras altas em sistema plantio direto

The rice is one of the main sources of the humanity's feeding. During the agricultural year 2009/2010, in Selviria County, Mato Grosso do Sul State, in the Brazilian Savannah, an experiment was installed with rice upland in a Dystropherric Red Latosol (Typic Acrustox) under no-tillage, irrigated by central pivot, with the purpose of selecting the best components production to explain the variability the irrigated rice yield upland. The geostatistical grid was installed, to collect the data, with 120 sampling points, in an area of 3.0 ha and and homogeneous slope of 0.055 m m(-1). The medium rice yield was of the 5980 kg ha(-1). For the simple lineal regressions, the number of spikelets grenades for panicle presented the best direct potential correlation with the yield rice, given for: PGO = 115,5.NEG(0,770). However, for the multiple lineal regressions, the equation equacao PGO = 2754,30-411,55.NEG-461,07. NEC+436,59. NET it was the one that better she came to esteem the yield rice. However, spatial, it was not possible to establish correlation between the yield rice and the components production, once none of those it presented spatial dependence in their data.