Mujeres como beneficiarias de servicios financiados por recursos asignados en el presupuesto nacional de la República Dominicana

Incluye Bibliografía

A periferia de “nosotros”. O debate sobre o documentarismo na América Latina: uma análise do filme La Hora de los hornos (1968)

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Siegfried Kracauer: un pensador más allá de las fronteras

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Percepções de profissionais de uma organização de procura de órgãos sobre a entrevista com familiares de potenciais doadores

In the last twenty years, and more expressively in the past decade, the search for improvement in the organ transplantation system has contributed to the achievement of positive results in the Brazilian statistics related to the survival of transplanted individuals. However, for a transplantation to be performed, a number of phases must be followed by professionals working in organ search services. The phase that generates the greatest tension is undoubtedly that of family interviews, as it involves both the feelings of relatives who are facing a recent loss and those of interviewers who need to know how to deal with families at this time. The goal of this study was to apprehend perceptions of professionals working for an Organ Search Organization concerning interviews with relatives of potential donors. The qualitative methodology was used by adopting the Collective Subject Discourse for data organization. Interviews were conducted with six staff members of an organ search service whose experience as interviewers comprised from eight to fourteen years of work. It was possible to apprehend the professionals’ perceptions of family interviews and identify facilitating and hindering factors in this phase of the donation process. Such factors mainly involve: contact with the teams assisting patients, the difficult moment that families are experiencing and the teams’ as well as the institution’s preparation for rendering this type of service. The balance between the offer of and demand for organs in Brazil will only be achieved by means of an efficient and effective structure in transplantation organ search services and increased donation consent rates to be obtained by adequate communication between interviewers and relatives

Analysis of the chronic intake of and withdrawal from diazepam on emotional reactivity and sensory information processing in rats

It has been demonstrated that, on abrupt withdrawal, patients with chronic exposure can experience a number of symptoms indicative of a dependent state. In clinical patients, the earliest to arise and most persistent signal of withdrawal from chronic benzodiazepine (Bzp) treatment is anxiety. In laboratory animals, anxiety-like effects following abrupt interruption of chronic Bzp treatment can also be reproduced. In fact, signs that oscillate from irritability to extreme fear behaviours and seizures have been described already. As anxiety remains one of the most important symptoms of Bzp withdrawal, in this study we evaluated the anxiety levels of rats withdrawn from diazepam. Also studied were the effects on the motor performance and preattentive sensory gating process of rats under diazepam chronic treatment and upon 48-h withdrawal on three animal models of anxiety, the elevated plus-maze (EPM), ultrasonic vocalizations (USV) and startle + prepulse inhibition tests. Data obtained showed an anxiolytic- and anxiogenic-like profile of the chronic intake of and withdrawal from diazepam regimen in the EPM test, 22-KHz USV and startle reflex. Diazepam chronic effects or its withdrawal were ineffective in promoting any alteration in the prepulse inhibition (PPI). However, an increase of PPI was achieved in both sucrose and diazepam pretreated rats on 48-h withdrawal, suggesting a procedural rather than a specific effect of withdrawal on sensory gating processes. It is also possible that the prepulse can function as a conditioned stimulus to informing the delivery of an aversive event, as the auditory startling-eliciting stimulus. All these findings are indicative of a sensitization of the neural substrates of aversion in diazepam withdrawn animals without concomitant changes on the processing of sensory information

Dominant predators mediate the impact of habitat size on trophic structure in bromeliad invertebrate communities

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Combined measurement of the Higgs Boson Mass in pp collisions at root s=7 and 8 TeV with the ATLAS and CMS experiments

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Chitosan/Carbomer-based tablets containing Metronidazole for potential treatment of periodontal diseases

Mucoadhesive tablets with different mixtures of chitosan and carbomer homopolymer type B were prepared in order to obtain new formulations containing metronidazole for periodontal disease treatment. All tablets were characterized by swelling and erosion studies, ex vivo mucoadhesion force and in vitro drug release. The drug released mechanism was described by Korsmeyer-Peppas and Weibull models. Tablets containing increased amounts of chitosan presented higher swelling ability and the drug release was prolonged in the simulated saliva fluid. The mechanisms for the drug release from tablets were complex, including diffusion, swelling and erosion simultaneously. This kind of delivery system is suitable for formulating metronidazole mucoadhesive systems, representing a good alternative for the local treatment of periodontal diseases.

Motivos da recusa à doação de órgãos apontados familiares de pessoas com morte encefálica

Purpose: Study aiming to understand the reasons for the refusal to donate organs by relatives of potential donors living in the Mid-Western region of the São Paulo state. Method: Qualitative study performed after data collection by the Organ Procurement Organization (OPO) Division of a reference hospital in the region. Relatives were contacted to participate in a semi-structured interview, and after the subjects in the study were characterized, four guiding questions were presented; their respective answers were recorded to be transcribed later. The Analysis of Content method proposed by Bardin was used to organize the speeches. Results: From 2006 to 2008, 30 (35.3%) families contacted by OPO have refused to agree with the organ donation. From that universe, 16 family members were interviewed. Data was systematized in three major themes: The experience of being informed on a family member’s brain death, decision concerning to the organ donation and aspects that would facilitate the decision to agree with the organ donation. Conclusion: the identification of reasons for the refusal and the suggestions presented has provided subsidies to improve the organ donation for transplantation process.

Loss of Interleukin-10 Signaling and Infantile Inflammatory Bowel Disease: Implications for Diagnosis and Therapy

BACKGROUND & AIMS: Homozygous loss of function mutations in interleukin-10 (IL10) and interleukin-10 receptors (IL10R) cause severe infantile (very early onset) inflammatory bowel disease (IBD). Allogeneic hematopoietic stem cell transplantation (HSCT) was reported to induce sustained remission in 1 patient with IL-10R deficiency. We investigated heterogeneity among patients with very early onset IBD, its mechanisms, and the use of allogeneic HSCT to treat this disorder. METHODS: We analyzed 66 patients with early onset IBD (younger than 5 years of age) for mutations in the genes encoding IL-10, IL-10R1, and IL-10R2. IL-10R deficiency was confirmed by functional assays on patients' peripheral blood mononuclear cells (immunoblot and enzyme-linked immunosorbent assay analyses). We assessed the therapeutic effects of standardized allogeneic HSCT. RESULTS: Using a candidate gene sequencing approach, we identified 16 patients with IL-10 or IL-10R deficiency: 3 patients had mutations in IL-10, 5 had mutations in IL-10R1, and 8 had mutations in IL-10R2. Refractory colitis became manifest in all patients within the first 3 months of life and was associated with perianal disease (16 of 16 patients). Extraintestinal symptoms included folliculitis (11 of 16) and arthritis (4 of 16). Allogeneic HSCT was performed in 5 patients and induced sustained clinical remission with a median follow-up time of 2 years. In vitro experiments confirmed reconstitution of IL-10R-mediated signaling in all patients who received the transplant. CONCLUSIONS: We identified loss of function mutations in IL-10 and IL-10R in patients with very early onset IBD. These findings indicate that infantile IBD patients with perianal disease should be screened for IL-10 and IL-10R deficiency and that allogeneic HSCT can induce remission in those with IL-10R deficiency.

Underlying Event measurements in pp collisions at root s=0.9 and 7 TeV with the ALICE experiment at the LHC

We present measurements of Underlying Event observables in pp collisions at root s = 0 : 9 and 7 TeV. The analysis is performed as a function of the highest charged-particle transverse momentum p(T),L-T in the event. Different regions are defined with respect to the azimuthal direction of the leading (highest transverse momentum) track: Toward, Transverse and Away. The Toward and Away regions collect the fragmentation products of the hardest partonic interaction. The Transverse region is expected to be most sensitive to the Underlying Event activity. The study is performed with charged particles above three different p(T) thresholds: 0.15, 0.5 and 1.0 GeV/c. In the Transverse region we observe an increase in the multiplicity of a factor 2-3 between the lower and higher collision energies, depending on the track p(T) threshold considered. Data are compared to PYTHIA 6.4, PYTHIA 8.1 and PHOJET. On average, all models considered underestimate the multiplicity and summed p(T) in the Transverse region by about 10-30%.

Measurement of prompt J/psi and beauty hadron production cross sections at mid-rapidity in pp collisions at root s=7 TeV

The ALICE experiment at the LHC has studied J/psi production at mid-rapidity in pp collisions at root s = 7 TeV through its electron pair decay on a data sample corresponding to an integrated luminosity L-int = 5.6 nb(-1). The fraction of J/psi from the decay of long-lived beauty hadrons was determined for J/psi candidates with transverse momentum p(t) > 1,3 GeV/c and rapidity vertical bar y vertical bar < 0.9. The cross section for prompt J/psi mesons, i.e. directly produced J/psi and prompt decays of heavier charmonium states such as the psi(2S) and chi(c) resonances, is sigma(prompt J/psi) (p(t) > 1.3 GeV/c, vertical bar y vertical bar < 0.9) = 8.3 +/- 0.8(stat.) +/- 1.1 (syst.)(-1.4)(+1.5) (syst. pol.) mu b. The cross section for the production of b-hadrons decaying to J/psi with p(t) > 1.3 GeV/c and vertical bar y vertical bar < 0.9 is a sigma(J/psi <- hB) (p(t) > 1.3 GeV/c, vertical bar y vertical bar < 0.9) = 1.46 +/- 0.38 (stat.)(-0.32)(+0.26) (syst.) mu b. The results are compared to QCD model predictions. The shape of the p(t) and y distributions of b-quarks predicted by perturbative QCD model calculations are used to extrapolate the measured cross section to derive the b (b) over bar pair total cross section and d sigma/dy at mid-rapidity.

Fear state induced by diazepam withdrawal may be due to the sensitization of the neural substrates of aversion in the dPAG

This work was supported by FAPESP (P.N. 04/02859-0)

Levantamento ecológico rápido da ictiofauna e ictioplâncton na região do Arquipélago dos Alcatrazes, São Sebastião – SP, Brasil

Este trabalho teve como objetivo realizar um levantamento ecológico rápido da ictiofauna demersal, com ocorrência de pelágicos, e do ictioplâncton na região do Arquipélago dos Alcatrazes, São Sebastião (SP - Brasil), na Estação Ecológica Tupinambás. Foram realizadas 15 estações oceanográficas entre os dias 26 e 29 de setembro de 2011, a bordo do N/Pq. Soloncy Moura, do ICMBio. As amostras de ictiofauna foram coletadas com rede de arrasto de fundo com portas e para a coleta de ictioplâncton utilizou-se arrasto oblíquo com rede bongô. Os elasmobrânquios capturados foram pesados e medidos a bordo, sendo devolvidos vivos ao local de captura. Com relação à ictiofauna, foram registradas a ocorrência de 68 espécies, pertencentes a 32 famílias de actinopterígios e cinco de elasmobrânquios. Ctenosciaena gracilicirrhus, Pagrus pagrus, Prionotus punctatus, Porichthys porosissimus, Dactilopterus volitans, Stephanolepis hispidus e Cyclichthys spinosus representaram 81 % dos organismos coletados. Dentre as espécies capturadas, 42 % são de ocorrência comum, tanto ao litoral central (Santos) como às plataformas interna e média do estado de São Paulo. 25 % das espécies já haviam sido registradas em um levantamento, realizado em 1989. Observou-se a ocorrência de Rhinobatos sp., cujos exemplares não foram identificados por se tratar de juvenis de pequeno porte. Em relação ao ictioplâncton, foram identificadas seis famílias de actinopterígios. Sciaenidae e Engraulidae representaram 74 % de um total de 41 larvas. Também foram encontrados 203 ovos, sendo 64 % concentrados principalmente nas estações mais costeiras ou próximas das ilhas, localizadas entre o continente e a Ilha de São Sebastião e a de Alcatrazes. Foram também encontradas paralarvas de Loliginidae e Argonautidae. Este trabalho representou um levantamento rápido, no qual já se observa a importância da região, devido à alta diversidade de espécies e abundância de larvas, além da ocorrência de espécies ameaçadas de extinção.