Portal cholangiopathy: case report

The present report describes the case of a child that after blunt abdominal trauma presented with portal thrombosis followed by progressive splenomegaly and jaundice. Ultrasonography and percutaneous cholangiography revealed biliary dilatation secondary to choledochal stenosis caused by dilated peribiliary veins, characterizing a case of portal biliopathy. The present case report is aimed at presenting an uncommon cause of this condition.

Leiomiossarcoma da veia cava inferior: relato de caso

Relatamos um caso de paciente do sexo feminino, 48 anos, com quadro clínico de dor abdominal de moderada intensidade e abaulamento do abdome. Ao exame físico constatou-se massa abdominal palpável. A tomografia computadorizada mostrou volumosa massa retroperitoneal, com realce heterogêneo e íntima relação com a veia cava inferior. Realizou-se ressecção em bloco da massa e do segmento invadido da veia cava. A histologia revelou leiomiossarcoma.

The personal research portal : web 2.0 driven individual commitment with open access for development

Peer-reviewed

Terutroban, A TP-receptor antagonist, reduces portal pressure in cirrhotic rats.

Increased production of vasoconstrictive prostanoids, such as thromboxane A2 (TXA2 ), contributes to endothelial dysfunction and increased hepatic vascular tone in cirrhosis. TXA2 induces vasoconstriction by way of activation of the thromboxane-A2 /prostaglandin-endoperoxide (TP) receptor. This study investigated whether terutroban, a specific TP receptor blocker, decreases hepatic vascular tone and portal pressure in rats with cirrhosis due to carbon tetrachloride (CCl4 ) or bile duct ligation (BDL). Hepatic and systemic hemodynamics, endothelial dysfunction, liver fibrosis, hepatic Rho-kinase activity (a marker of hepatic stellate cell contraction), and the endothelial nitric oxide synthase (eNOS) signaling pathway were measured in CCl4 and BDL cirrhotic rats treated with terutroban (30 mg/kg/day) or its vehicle for 2 weeks. Terutroban reduced portal pressure in both models without producing significant changes in portal blood flow, suggesting a reduction in hepatic vascular resistance. Terutroban did not significantly change arterial pressure in CCl4 -cirrhotic rats but decreased it significantly in BDL-cirrhotic rats. In livers from CCl4 and BDL-cirrhotic terutroban-treated rats, endothelial dysfunction was improved and Rho-kinase activity was significantly reduced. In CCl4 -cirrhotic rats, terutroban reduced liver fibrosis and decreased alpha smooth muscle actin (α-SMA), collagen-I, and transforming growth factor beta messenger RNA (mRNA) expression without significant changes in the eNOS pathway. In contrast, no change in liver fibrosis was observed in BDL-cirrhotic rats but an increase in the eNOS pathway. CONCLUSION: Our data indicate that TP-receptor blockade with terutroban decreases portal pressure in cirrhosis. This effect is due to decreased hepatic resistance, which in CCl4 -cirrhotic rats was linked to decreased hepatic fibrosis, but not in BDL rats, in which the main mediator appeared to be an enhanced eNOS-dependent vasodilatation, which was not liver-selective, as it was associated with decreased arterial pressure. The potential use of terutroban for portal hypertension requires further investigation.

Portal per a empreses de hosting

Memòria del projecte final de carrera en l'àrea de J2EE que explica la creació d'un portal d'automatització d'empreses de hosting.

Anàlisi, disseny i implementació del Portal web FutbolAlpicat.com

L’objectiu del treball és desenvolupar un portal web pel club Atlètic Alpicat i la Unió Esportiva Alpicat. A més aquest Portal que ha d’estar adaptat als requeriments de clubs i usuaris del Portal, ha de ser fàcil d’usar i de mantenir. Un cop finalitzat el Portal es guiarà els clubs per tal de que puguin gestionar-lo de forma autònoma.A la present memòria trobarem explicades les accions dutes a terme abans, durant i després del desenvolupament del Portal web dels Clubs de Futbol Alpicat.

Avaluació de la usabilitat del portal de compra electrònica de la cadena de supermercats Plus Fresc

Aquest treball de final de carrera té com a finalitat analitzar els problemes d’usabilitat d’una botiga online. Aplicant aquesta avaluació podrem obtenir les mancances i els punts forts i/o febles que pot tenir aquesta botiga. L’avaluació es realitzarà amb una aplicació anomenada MORAE. Aquesta aplicació ens proporcionarà les dades necessàries i ens permetrà establir paràmetres indicatius de possibles problemes d’usabilitat de la citada botiga. L’anàlisi estadística ens permet extreure un conjunt de dades que, en analitzar-les, ens permetran establir un conjunt divers d’informació que ens facilitarà, alhora, diferents formes d’anàlisi, tant comparativa com inductiva. L’objectiu d’aquest projecte és avaluar l’eficàcia de la botiga i establir si els usuaris tenen dificultats per treballar amb ella o no. A més a més, es proposaran idees de millora per facilitar el bon ús per als usuaris per tal de fer més gratificant la seva experiència.

Portal Liferay : Intranet Ajuntament de Vinaròs

Construcció d'una intranet per a l'ajuntament de Vinaròs utilitzant el gestor de continguts Liferay, usant la tecnologia J2EE per desenvolupar els portlets.

Effect of meal ingestion on liver stiffness in patients with cirrhosis and portal hypertension.

BACKGROUND AND AIMS: Liver stiffness is increasingly used in the non-invasive evaluation of chronic liver diseases. Liver stiffness correlates with hepatic venous pressure gradient (HVPG) in patients with cirrhosis and holds prognostic value in this population. Hence, accuracy in its measurement is needed. Several factors independent of fibrosis influence liver stiffness, but there is insufficient information on whether meal ingestion modifies liver stiffness in cirrhosis. We investigated the changes in liver stiffness occurring after the ingestion of a liquid standard test meal in this population. METHODS: In 19 patients with cirrhosis and esophageal varices (9 alcoholic, 9 HCV-related, 1 NASH; Child score 6.9±1.8), liver stiffness (transient elastography), portal blood flow (PBF) and hepatic artery blood flow (HABF) (Doppler-Ultrasound) were measured before and 30 minutes after receiving a standard mixed liquid meal. In 10 the HVPG changes were also measured. RESULTS: Post-prandial hyperemia was accompanied by a marked increase in liver stiffness (+27±33%; p<0.0001). Changes in liver stiffness did not correlate with PBF changes, but directly correlated with HABF changes (r = 0.658; p = 0.002). After the meal, those patients showing a decrease in HABF (n = 13) had a less marked increase of liver stiffness as compared to patients in whom HABF increased (n = 6; +12±21% vs. +62±29%,p<0.0001). As expected, post-prandial hyperemia was associated with an increase in HVPG (n = 10; +26±13%, p = 0.003), but changes in liver stiffness did not correlate with HVPG changes. CONCLUSIONS: Liver stiffness increases markedly after a liquid test meal in patients with cirrhosis, suggesting that its measurement should be performed in standardized fasting conditions. The hepatic artery buffer response appears an important factor modulating postprandial changes of liver stiffness. The post-prandial increase in HVPG cannot be predicted by changes in liver stiffness.

Proyecto portal web FastJob.net

El portal web FastJob tiene como objetivo principal la gestión de ofertas de trabajo tanto a nivel de empresa como de la persona que busca un nuevo empleo. Este proyecto también recogerá la funcionalidad necesaria para el mantenimiento de los usuarios y las ofertas de trabajo, facilitando así el cumplimiento del objetivo principal.

Guidelines for CERIF-XML Data Exchange with CSUC’s Catalan Research Portal (PRC) (Version 2.2)

The Catalan Research Portal (Portal de la Recerca de Catalunya or PRC) is an initiative carried out by the Consortium for University Services in Catalonia (CSUC) in coordination with nearly all universities in Catalonia. The Portal will provide an online CERIF-compliant collection of all research outputs produced by Catalan HEIs together with an appropriate contextual information describing the specific environment where the output was generated (such as researchers, research group, research project, etc). The initial emphasis of the Catalan Research Portal approach to research outputs will be made on publications, but other outputs such as patents and eventually research data will eventually be addressed as well. These guidelines provide information for PRC data providers to expose and exchange their research information metadata in CERIFXML compatible structure, thus allowing them not just to exchange validated CERIF XML data with the PRC platform, but to improve their general interoperability by being able to deliver CERIFcompatible outputs.

Gestió d'un portal web d'intercanvi de coneixement

En aquest món on ens ha tocat viure i patir canvis tan durs amb la crisi econòmica que patim, que ens ha fet passar de lligar els gossos amb llonganisses a vigilar en les despeses del dia a dia per poder arribar just a final de mes, és el moment de reinventar-se. És per aquest motiu que presento aquesta idea, on el seu objectiu és desenvolupar una pàgina web que esdevingui un punt de trobada entre usuaris que volen transmetre o ampliar el seu coneixement i oferir-los la possibilitat que entre ells puguin compartir les seves habilitats i destreses. El web consistirà en un panell d’activitats on els usuaris un cop s’hagin registrat puguin crear les activitats que vulguin aprendre o bé ensenyar, tot demanant, si ho desitgen, quelcom a canvi. Aleshores la resta d’usuaris si els interessa l’activitat, poden acceptar la demanda o bé fer una proposta pròpia. A partir d’aquí els usuaris s’han de posar d’acord a l’hora de dur a terme l’activitat. El web disposarà d’una part pels usuaris amb permisos d’administrador perquè puguin gestionar el portal. Aquest projecte s’ha desenvolupat amb el framework de PHP Codeigniter, el qual utilitza la programació per capes MVC, la qual separa la programació en tres parts: el Model, la Vista i el Controlador. També s’han utilitzat els llenguatges HTML5 i CSS3, i jQuery, que és una llibreria de JavaScript. Com a sistema gestor de base de dades s’ha utilitzat el MySQL.

Química Nova Interativa - QNInt - o portal do conhecimento da SBQ: conectando ciência e educação

The Química Nova Interativa (QNInt) portal was launched in 2009 by the Brazilian Chemical Society (SBQ) to offer free quality content for broad audiences. QNInt provides peer-reviewed articles from SBQ journals on science & society, chemical concepts, classroom activities and educational research. With 3,000,000 visits, QNInt also offers a unique library of interactive molecules. In the International Year of Chemistry QNInt served for distributing pH kits and registering data from IUPAC's Global Water Experiment, yielding Brazil the largest share of the global pH data set. The portal performance makes QNInt a valuable resource for connecting science to education.