Correlação entre autoimunidade tireoidiana e o vírus da hepatite C

As hepatites virais constituem um dos mais importantes assuntos de saúde pública, podendo ser causadas por diferentes agentes etiológicos. Dentre estes, encontra-se o vírus da hepatite C (VHC), que segundo a Organização Mundial da Saúde (OMS) afeta mundialmente cerca de 123 milhões de pessoas, com uma prevalência de 3%. A principal forma de transmissão do VHC é a exposição ao sangue contaminado. O VHC pertence à família Flaviviridae, gênero Hepacivirus, possui 6 genótipos e múltiplos subtipos. No Brasil, o genótipo 1 é observado em 70% dos pacientes infectados, seguido pelo genótipo 3 (25%) e o genótipo 2 (5%). Alguns fatores de risco são fortemente associados à transmissão do VHC, dentre eles: o uso de seringa de vidro esterilizada em domicílio; o compartilhamento de utensílios de higiene pessoal como a lâmina de barbear, escova de dente, alicates de manicure e cortadores de unhas e também a transfusão de sangue antes de 1993. A proposta do presente estudo foi investigar a frequência de auto-anticorpos em indivíduos brasileiros portadores de hepatite C crônica. Foram incluídos 14 indivíduos com diagnóstico clínico e laboratorial de VHC crônica e 45 indivíduos foram incluídos como controle. Foi realizada a pesquisa de auto-anticorpos tireoidianos por Imunoensaio Quimioluminescente de Micropartículas (CMIA). Em relação ao anti-TPO, os portadores do vírus da hepatite C foram negativos em 92,86% e no grupo controle foram encontrados 15,56% positivos e 84,44% negativos. Para antireoglobulina 92,86% dos portadores de HVC foram positivos e 88,37% no grupo controle. Neste estudo não foi encontrada diferença na frequência de desordens tireoidianas quando comparados os pacientes com Hepatite C sem tratamento específico com aqueles sem Hepatite C, justificado provavelmente, pela alta prevalência de DAT na população do grupo controle. Os resultados indicam a necessidade de uma amostragem maior de indivíduos para que comprovação do papel do vírus C isoladamente como desencadeador de DAT.

The Primary Closure Approach of Dog Bite Injuries of the Nose

The nose holds an outstanding position on the face, acquiring great importance within the context of facial aesthetics. Because of the functional, psychological, and social aspects of trauma in a society increasingly demanding about aesthetics, treatment institution must reduce, as accurate as possible, the sequelae that hinder social integration. This clinical report relates an immediate nasal reconstruction of a complex animal bite wound. A 7-year-old patient was victim of a dog bite with avulsion of the left nasal ala and part of the ipsilateral nasal tip. The treatment was immediate nasal reconstruction with auricular composite graft. After 1 year of follow-up, the shape of nasal ala was stable, and the color was consistent with the surrounding tissue. The 2 nasal sides exhibited satisfactory symmetry when evaluated. It can be concluded that the composite graft derived from the auricular helix is a safe option for reconstruction of nasal ala defects with compromised margins in pediatric patients when conditions of reimplantation do not exist.

Reconsideration of histopathology and ultrastructural aspects of the human liver in yellow fever

Yellow fever is a re-emerging infectious disease that currently is at risk of urbanization due to the advance of the Aedes aegypti vector. The disease affects about 200,000 individuals annually, mainly in tropical Africa and South America. It causes severe disease involving especially the liver, with lesions characterized by midzonal steatosis, apoptosis and lytic necrosis of the hepatocytes. Quantitative histological and immunohistochemical analysis of 53 human hepatic samples demonstrated apoptosis, steatosis and lytic necrosis of hepatocytes with midzonal pattern. No substantial alterations and reticular network were observed. The inflammatory infiltrate consisted of mononuclear cells and intensity was minimal or moderate, disproportionate to the intense death of the hepatocytes. Hepatic damage in yellow fever resulted mainly from a massive death of hepatocytes due to apoptosis and to a lesser extent due to lytic necrosis. It is recommended that therapeutic regimens for serious cases should include measures to protect against apoptosis. (c) 2005 Elsevier B.V. All rights reserved.

Atividade antibacteriana de plantas do cerrado da região de Botucatu - São Paulo

The studies related to research on new antimicrobial products have received special attention from researchers, especially given the emergence of microbial strains resistant to conventional antimicrobials. Thus, the present study was aimed to test the antimicrobial action of hydro-alcoholic extracts of plants collected in Cerrado region of Botucatu, following the species: Achyrocline satureioides (Lam) DC (macela), Stryphnodendron adstringens (Mart) Coville (barbatimão), Miconia rubiginosa (Bonpl.) DC (quaresma-branca), Davilla elliptica A. St-Hil (lixinha), Siparuna guianensis (negramina) e Solanum lycocarpum A.St-Hil (lobeira). The plants were always collected in the morning, in areas near the town of Botucatu, and extracts were prepared using a solvent such as methanol 70% from materials dried (50°C) and ground into mill knives. The extraction was performed for 48 hours at refrigerator temperature, followed by filtration, removal of methanol solvent in a rotary evaporator, determination of the dry weight of the extracts (mg / mL) and phytochemical analysis of the same. The sensitivity tests for 10 S. aureus, 11 E. coli and 11 P. aeruginosa, isolated from human clinical cases were performed by diluting volumes of the extracts in Mueller Hinton Agar (MHA) and determination of minimum inhibitory concentration (MIC) (mg / mL). According to the results and statistical analysis, it was found that depending on the bacteria tested, and in descending order of antibacterial activity for S. aureus: Lixinha sheet > Barbatimão sheet > Quaresma-Branca > Macela > Lixinha fruit > Barbatimão shell > Lobeira > Negramina; E. coli: Lixinha sheet > Barbatimão sheet > Lixinha fruit = barbatimão peel > Quaresma-Branca > Macela = Lobeira > Negramina and P. aeruginosa: Lixinha leaf > Barbatimão bark > Barbatimão leaf > Lixinha fruit > Macela > Lobeira > Quaresma - Branca = Negramina... (Complete abstract click electronic access below)

A graphical tool for the tomographic characterisation of microstructural features on metal matrix composites

Research on the micro-structural characterization of metal-matrix composites uses X-ray computed tomography to collect information about the interior features of the samples, in order to elucidate their exhibited properties. The tomographic raw data needs several steps of computational processing in order to eliminate noise and interference. Our experience with a program (Tritom) that handles these questions has shown that in some cases the processing steps take a very long time and that it is not easy for a Materials Science specialist to interact with Tritom in order to define the most adequate parameter values and the proper sequence of the available processing steps. For easing the use of Tritom, a system was built which addresses the aspects described before and that is based on the OpenDX visualization system. OpenDX visualization facilities constitute a great benefit to Tritom. The visual programming environment of OpenDX allows an easy definition of a sequence of processing steps thus fulfilling the requirement of an easy use by non-specialists on Computer Science. Also the possibility of incorporating external modules in a visual OpenDX program allows the researchers to tackle the aspect of reducing the long execution time of some processing steps. The longer processing steps of Tritom have been parallelized in two different types of hardware architectures (message-passing and shared-memory); the corresponding parallel programs can be easily incorporated in a sequence of processing steps defined in an OpenDX program. The benefits of our system are illustrated through an example where the tool is applied in the study of the sensitivity to crushing – and the implications thereof – of the reinforcements used in a functionally graded syntactic metallic foam.

Biopsia renal percutânea monitorizada por ultrassonografia em cães

Fundação de Apoio à Pesquisa do Estado de São Paulo (FAPESP)

Aplicação da teoria da confiabilidade em estacas escavadas de grande diâmetro para obtenção das superfícies resistentes de projeto

In this work, the author looks forward to develop a new method capable of incorporate the concepts of the Reliability Theory and Ruin Probability in Deep Foundations, in order to do a better quantification of the uncertainties, which is intrinsic in all geotechnical projects, meanly because we don't know all the properties of the materials that we work with. Using the methodologies of Decourt Quaresma and David Cabral, resistance surfaces have been developed utilizing the data achieved from the Standard Penetration Tests performed in the field of study, in conjecture with the loads defined in the executive project of the piles. The construction of resistance surfaces shows to be a very useful tool for decision making, no matter in which phase it is current on, projecting or execution. The surfaces were developed by Kriging (using the software Surfer® 12), making it easier to visualize the geotechnical profile of the field of study. Comparing the results, the conclusion was that a high safety factor doesn't mean higher security. It is fundamental to consider the loads and resistance of the piles in the whole field, carefully choosing the project methodology responsible to define the diameter and length of the piles

Previsão da capacidade de carga de estacas escavadas em solo arenoso da região de Araquari-SC

In Geotechnical engineering the foundation projects depend on the bearing capacity and the acceptable displacements. One of the possible ways to predict the bearing capacity of foundations is through semi-empirical statistical methods which correlate in-situ tests (SPT and CPT). The piles breaking loads are defined by the interpretation of the load x head displacement curve and the experimental data acquired through the load test. In this work it is studied the behavior of bored piles executed in the Araquari/SC region, comparing the bearing capacity values predicted by the methods DECOURT & QUARESMA MODIFICADO (1996), AOKI & VELLOSO MODIFICADO MONTEIRO (2000), MILITITISKY E ALVES (1985), DECOURT & QUARESMA (1978), MÉTODO DE AOKI & VELLOSO (1975) e PHILOPANNAT (1986), with the results of the load test, evaluating their differences and discussing parameters that have direct effects on the prediction

A sátira limabarretiana em Numa e a Ninfa

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Aplicação da teoria da confiabilidade em estacas escavadas de grande diâmetro para obtenção das superfícies resistentes de projeto

In this work, the author looks forward to develop a new method capable of incorporate the concepts of the Reliability Theory and Ruin Probability in Deep Foundations, in order to do a better quantification of the uncertainties, which is intrinsic in all geotechnical projects, meanly because we don't know all the properties of the materials that we work with. Using the methodologies of Decourt Quaresma and David Cabral, resistance surfaces have been developed utilizing the data achieved from the Standard Penetration Tests performed in the field of study, in conjecture with the loads defined in the executive project of the piles. The construction of resistance surfaces shows to be a very useful tool for decision making, no matter in which phase it is current on, projecting or execution. The surfaces were developed by Kriging (using the software Surfer® 12), making it easier to visualize the geotechnical profile of the field of study. Comparing the results, the conclusion was that a high safety factor doesn't mean higher security. It is fundamental to consider the loads and resistance of the piles in the whole field, carefully choosing the project methodology responsible to define the diameter and length of the piles

Previsão da capacidade de carga de estacas escavadas em solo arenoso da região de Araquari-SC

In Geotechnical engineering the foundation projects depend on the bearing capacity and the acceptable displacements. One of the possible ways to predict the bearing capacity of foundations is through semi-empirical statistical methods which correlate in-situ tests (SPT and CPT). The piles breaking loads are defined by the interpretation of the load x head displacement curve and the experimental data acquired through the load test. In this work it is studied the behavior of bored piles executed in the Araquari/SC region, comparing the bearing capacity values predicted by the methods DECOURT & QUARESMA MODIFICADO (1996), AOKI & VELLOSO MODIFICADO MONTEIRO (2000), MILITITISKY E ALVES (1985), DECOURT & QUARESMA (1978), MÉTODO DE AOKI & VELLOSO (1975) e PHILOPANNAT (1986), with the results of the load test, evaluating their differences and discussing parameters that have direct effects on the prediction

A sátira limabarretiana em Numa e a Ninfa

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Transforming growth factor beta and apoptosis in leprosy skin lesions: possible relationship with the control of the tissue immune response in the Mycobacterium leprae infection

The course of leprosy depends of the host immune response which ranges from the lepromatous pole (LL) to the tuberculoid pole (TT). A comparative study was conducted in 60 patients with the LL and TT The results showed a mean expression of TGF-beta of 339 +/- 99.4 cells/field for TT and of 519.2 +/- 68.2 cells/field for LL. Frequency of apoptosis was 6.3 +/- 1.8 in TT and 14.0 +/- 6.1 in LL. A correlation (p = 0.0251) between TGF-beta and caspase-3 in the LL was found. This finding indicates a role of TGF-beta and apoptosis in the immune response in leprosy. (C) 2012 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

Ossificação heterotópica em saco herniário incisional

O achado de ossificação heterotópica (OH) sobre cicatriz cirúrgica abdominal é um evento raro, mas que soma morbidade ao paciente. Manifesta-se por dor, endurecimento ou desconforto na cicatriz, levando a novas abordagens cirúrgicas. Relatamos um caso de OH no saco herniário incisional com o objetivo precípuo de chamar a atenção para o potencial "totipotente" do fibroblasto, já que sua íntima relação com a OH é inegável. A partir dessa prerrogativa, qualquer forma de tratamento das hérnias incisionais deveria associar o reparo tecidual ao uso de prótese (tela), para enriquecê-lo com os fibroblastos e seus fatores de crescimento celular do próprio paciente, todos autólogos e prontos para uso. A tática é oferecer uma abordagem combinada ou mista, com menores chances de recidiva na correção dessas afecções.

Lagrimas, gemidos y suspiros a la passion, muerte y sepultura de Christo crucificado

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