994 resultados para P-ii


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Contient : Réception d'ambassadeurs (1663-1686) ; Pièces sur l'Acadie et le Canada ; « Lettera scritta da Venetia da un partiale del popolo di Messina all' Eccellentiss. Senato de quella città ». Impr. S. l. n. d., in-8° de 14 pages ; « Arrest de la Cour du Parlement contre la nommée Jeanne Moyon, veuve Jean Lesur, et autres, accusées de prostitution publique. » Impr. Paris, P.-G. Simon, 1750, in-4° de 4 pages ; Extrait de la relation envoyée par M. de Terron du combat naval du 8 janvier 1776 ; Inscriptions de l'Arsenal de Brest, par Victorin Santeul et P. Corneille ; « Discorso sopra le due comete apparse l'anno corrente 1682 gl'ultimi giorni d'agosto... dedicate all' ill. et eccell. sig. Nicolo Doria, senatore della Republica de Genova... » Impr. Gênes, Antonio Casamara, s. d., in-4° de 8 pages ; « Coppie d'une lettre qu'un François écrit à un de ses amis, contenant ce qui s'est passé à Gênes pour célébrer la naissance de Mgr le duc de Bourgogne. » Impr. Marseille, P. Mesnier, 1682, in-4° de 12 pages ; Liste des vaisseaux danois armés à Copenhague en 1683 ; « Liste des officiers qui sont dans les forts Cataracoüy et Niagara. » ; Pièces sur Cayenne ; Pêche de la baleine ; Envoi de denrées en Irlande

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El prop??sito de la autora es trazar de forma m??s bien esquem??tica la evoluci??n de la pol??tica educativa desde la Ley Moyano hasta la v??spera de la Segunda Rep??blica en cuanto afecta a la instrucci??n femenina. Destaca que en el proceso de organizaci??n de la instrucci??n p??blica iniciado en el siglo XIX con la implantaci??n del r??gimen liberal se dedic?? una atenci??n preferente a la educaci??n masculina: gran parte de las reformas, sobre todo las que se refer??an a la ense??anza secundaria y superior, tuvieron poca repercusi??n en la instrucci??n femenina.

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Habla sobre el funcionamiento del colegio p??blico Pr??cticas II de Lleida. Es un Colegio que, siendo un centro educativo de integraci??n, desarrolla su labor con un alto nivel de calidad. Esto se debe a los pilares sobre los que se asienta el quehacer de ese centro educativo, que son: la buena relaci??n entre la direcci??n y la Asociaci??n de Madres y Padres de Alumnos; la participaci??n, la innovaci??n pedag??gica, la apertura al entorno a trav??s de actividades extraescolares, el m??ximo aprovechamiento de los recursos existentes como el comedor , la biblioteca, el aula de inform??tica y el gimnasio; y, sobre todo, atenci??n a la diversidad de su alumnado.

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The mammalian bradykinin-degrading enzyme aminopeptidase P (AP-P; E. C. 3.4.11.9) is a metal-dependent enzyme and is a member of the peptidase clan MG. AP-P exists as membrane-bound and cytosolic forms, which represent distinct gene products. A partially truncated clone encoding the cytosolic form was obtained from a human pancreatic cDNA library and the 5' region containing the initiating Met was obtained by 5' rapid accumulation of cDNA ends (RACE). The open reading frame encodes a protein of 623 amino acids with a calculated molecular mass of 69,886 Da. The full-length cDNA with a C-terminal hexahistidine tag was expressed in Escherichia coli and COS-1 cells and migrated on SDS-PAGE with a molecular mass of 71 kDa. The expressed cytosolic AP-P hydrolyzed the X-Pro bond of bradykinin and substance P but did not hydrolyze Gly-Pro-hydroxyPro. Hydrolysis of bradykinin was inhibited by 1,10-phenanthroline and by the specific inhibitor of the membrane-bound form of mammalian AP-P, apstatin. Inductively coupled plasma atomic emission spectroscopy of AP-P expressed in E. coli revealed the presence of 1 mol of manganese/mol of protein and insignificant amounts of cobalt, iron, and zinc. The enzymatic activity of AP-P was promoted in the presence of Mn(II), and this activation was increased further by the addition of glutathione. The only other metal ion to cause slight activation of the enzyme was Co(II), with Ca(II), Cu(II), Mg(II), Ni(II), and Zn(II) all being inhibitory. Removal of the metal ion from the protein was achieved by treatment with 1,10-phenanthroline. The metal-free enzyme was reactivated by the addition of Mn(II) and, partially, by Fe(II). Neither Co(II) nor Zn(II) reactivated the metal-free enzyme. On the basis of these data we propose that human cytosolic AP-P is a single metal ion-dependent enzyme and that manganese is most likely the metal ion used in vivo.