Morphological and physiological specialization for digging in amphisbaenians, an ancient lineage of fossorial vertebrates

Amphisbaenians are legless reptiles that differ significantly from other vertebrate lineages. Most species dig underground galleries of similar diameter to that of the animal. We studied the muscle physiology and morphological attributes of digging effort in the Brazilian amphisbaenid Leposternon microcephalum (Squamata; Amphisbaenia), which burrows by compressing soil against the upper wall of the tunnel by means of upward strokes of the head. The individuals tested (<72 g) exerted forces on the soil of up to 24 N. These forces were possible because the fibres of the longissimus dorsi, the main muscle associated with burrowing, are highly pennated, thus increasing effective muscle cross-sectional area. The muscle is characterized by a metabolic transition along its length: proximal, medial and distal fibres are fast contracting and moderately oxidative, but fibres closer to the head are richer in citrate synthase and more aerobic in nature. Distal fibres, then, might be active mainly at the final step of the compression stroke, which requires more power. For animals greater than a given diameter, the work required to compress soil increases exponentially with body diameter. Leposternon microcephalum, and probably some other highly specialized amphisbaenids, are most likely constrained to small diameters and can increase muscle mass and effective muscle cross-sectional area by increasing body length, not body diameter.

Cytogenetic Mapping of 5S and 18S rRNAs and H3 Histone Genes in 4 Ancient Proscopiidae Grasshopper Species: Contribution to Understanding the Evolutionary Dynamics of Multigene Families

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Leishmanial antigens in the diagnosis of active lesions and ancient scars of American tegumentary leishmaniasis patients

Cutaneous biopsies (n = 94) obtained from 88 patients with American tegumentary leishmaniasis were studied by conventional and immunohistochemical techniques. Specimens were distributed as active lesions of cutaneous leishmaniasis (n = 53) (Group I), cicatricial lesions of cutaneous leishmaniasis (n = 35) (Group II) and suggestive scars of healed mucosal leishmaniasis patients (n = 6) (Group III). In addition, active cutaneous lesions of other etiology (n = 24) (Group C1) and cutaneous scars not related to leishmaniasis (n = 10) (Group C2) were also included in the protocol. Amastigotes in Group I biopsies were detected by routine histopathological exam (30.2%), imprint (28.2%), culture (43.4%), immunofluorescence (41.4%) and immunoperoxidase (58.5%) techniques; and by the five methods together (79.3%). In Group II, 5.7% of cultures were positive. Leishmanial antigen was also seen in the cytoplasm of macrophages and giant cells (cellular pattern), vessel walls (vascular pattern) and dermal nerves (neural pattern). Positive reaction was detected in 49 (92.5%), 20 (57%) and 4 (67%) biopsies of Groups I, II and III, respectively. Antigen persistency in cicatricial tissue may be related to immunoprotection or, on the contrary, to the development of late lesions. We suggest that the cellular, vascular and neural patterns could be applied in the immunodiagnosis of active and cicatricial lesions in which leishmaniasis is suspected.

Myths and facts in the chronicles of the conquest of Ancient Peru

The chronicles of historical sources are difficult because they are a mix of myths and facts experienced by their authors. Starting from this premise, this study analyzes some of the Spanish and indigenous sources on the conquest of the Inca people and the description of this world and people who were so different. Among the chroniclers chosen, the article highlights the reports by Jose de Acosta on the Mundus Novus and by Cieza de Leon and Garcilaso de la Vega on the myths of the first Inca chief; finally, Francisco de Xerez, Juan de Betanzos, among others, on the event of the imprisonment and murder of Atahualpa, which resulted in the conquest of the "Tahuantinsuyu" by the Spanish.

Un análisis de la competitividad de las exportaciones de prendas de vestir de Centroamérica utilizando los programas y la metodología CAN y MAGIC

Incluye Bibliografía

Module for the analysis of growth in international commerce (MAGIC Plus): user guide (updated)

Includes bibliography

The discovery of Foxl2 paralogs in chondrichthyan, coelacanth and tetrapod genomes reveals an ancient duplication in vertebrates

The Foxl2 (forkhead box L2) gene is an important member of the forkhead domain family, primarily responsible for the development of ovaries during female sex differentiation. The evolutionary studies conducted previously considered the presence of paralog Foxl2 copies only in teleosts. However, to search for possible paralog copies in other groups of vertebrates and ensure that all predicted copies were homolog to the Foxl2 gene, a broad evolutionary analysis was performed, based on the forkhead domain family. A total of 2464 sequences for the forkhead domain were recovered, and subsequently, 64 representative sequences for Foxl2 were used in the evolutionary analysis of this gene. The most important contribution of this study was the discovery of a new subgroup of Foxl2 copies (ortholog to Foxl2B) present in the chondrichthyan Callorhinchus milii, in the coelacanth Latimeria chalumnae, in the avian Taeniopygia guttata and in the marsupial Monodelphis domestica. This new scenario indicates a gene duplication event in an ancestor of gnathostomes. Furthermore, based on the analysis of the syntenic regions of both Foxl2 copies, the duplication event was not exclusive to Foxl2. Moreover, the duplicated copy distribution was shown to be complex across vertebrates, especially in tetrapods, and the results strongly support a loss of this copy in eutherian species. Finally, the scenario observed in this study suggests an update for Foxl2 gene nomenclature, extending the actual suggested teleost naming of Foxl2A and Foxl2B to all vertebrate sequences and contributing to the establishment of a new evolutionary context for the Foxl2 gene. © 2013 Macmillan Publishers Limited All rights reserved.

The Magic Toyshop: A narrativa imagética como processo de recriação

Because it belongs to a cultural practice, the adaptation of a novel into a feature film will always exist within a context and, for being subject to changes, corresponding modifications in the political sphere and even variations in the meaning of the story may occur. This seems to be precisely the result of the transformation of Angela Carter's second novel, The Magic Toyshop, into the homonymous film, directed by David Whealtey in 1987. Removed from the context of the book's production and publication, a crucial period of questioning about the importance of women in society and culture, the plot created by the English author in the sixties, rewritten two decades later, with the author herself as the script writer, seems to have acquired another meaning during this time. Although the film maintains the same plot of the novel, the political engagement visibly present in the narrative, namely Carter's critical stance about the model of patriarchal society, seems to lose its strength, highlighting now its fantastic character. Briefly discussing issues such as loyalty and betrayal of one gender to another, we seek in this paper to observe the film, based on the re-writers perspective, in other words, the prospects of both writer and director, as a process of rebuilding the story. In this dialogue, the script was also used as an intertext for a better understanding of this process.

Sistema para analizar el crecimiento del comercio internacional: Module to Analyse the Growth of International Commerce (MAGIC): manual de uso

Incluye Bibliografía

Un análisis de la competitividad de las exportaciones de prendas de vestir de Centroamérica utilizando los programas y la metodología CAN y MAGIC

Incluye Bibliografía

Módulo para analizar el crecimiento del comercio internacional: Module to Analyse the Growth of International Commerce (MAGIC): manual de uso

Incluye Bibliografía

Confinamento e vastidão: a representação feminina e a subversão em The magic toyshop

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Módulo para analizar el crecimiento del comercio internacional (MAGIC PLUS)

El 12 de septiembre de 2006, el Secretario Ejecutivo de la CEPAL, José Luís Machinea, junto con el lanzamiento del informe Panorama de la inserción internacional de América Latina y el Caribe, 2005-2006, presentó la nueva versión del programa computacional Módulo para Analizar el Crecimiento del Comercio Internacional, conocido como MAGIC (según su sigla en inglés). El MAGIC es un software cuya primera versión fue creada por la Sede Subregional de la CEPAL en México, con el fin de analizar la competitividad expost de las exportaciones de los países en el mercado de Estados Unidos. El desarrollo de la nueva arquitectura de la aplicación fue posible gracias al apoyo financiero de la Agencia Canadiense para el Desarrollo Internacional (ACDI/CIDA) y el trabajo conjunto de la Sede Subregional de la CEPAL en México y las Divisiones de Comercio Internacional e Integración y Desarrollo Productivo y Empresarial de la sede central de la CEPAL en Santiago, Chile. Esta edición del Boletín presenta el recorrido del MAGIC en sus diez años de existencia y la evolución que lo ha llevado a convertirse en una de las aplicaciones más populares, versátiles, y tecnológicamente avanzada de la CEPAL.

Module for the Analysis of Growth of International Commerce (MAGIC PLUS)

On 12 September 2006, on the occasion of the launching of the report Latin America and the Caribbean in the World Economy, 2005-2006, the Executive Secretary of ECLAC, José Luis Machinea, presented a new version of the software program Module for the Analysis of Growth of International Commerce (MAGIC).  The first version of MAGIC was created by ECLAC Subregional Headquarters in Mexico , to conduct ex post analysis of the competitiveness of countries' exports to the United States market. The new application architecture was made possible thanks to financial support from the Canadian International Development Agency (CIDA) and the Division of Production, Productivity and Management of ECLAC headquarters in Santiago , Chile .  This issue of the FAL Bulletin reviews the progress of MAGIC in the ten years it has been functioning, and the evolution which has made it one of ECLAC's most popular, versatile, and technologically advanced applications.  

Módulo para analizar el crecimiento del comercio internacional (MAGIC Plus): manual para el usuario

Incluye Bibliografía