388 resultados para Hicks, Heman N.
Resumo:
Recent work has suggested that the chromosomally encoded TetA(L) transporter of Bacillus subtilis, for which no physiological function had been shown earlier, not only confers resistance to low concentrations of tetracycline but is also a multifunctional antiporter protein that has dominant roles in both Na+- and K+-dependent pH homeostasis and in Na+ resistance during growth at alkaline pH. To rigorously test this hypothesis, TetA(L) has been purified with a hexahistidine tag at its C terminus and reconstituted into proteoliposomes. The TetA(L)–hexahistidine proteoliposomes exhibit high activities of tetracycline–cobalt/H+, Na+/H+, and K+/H+ antiport in an assay in which an outwardly directed proton gradient is artificially imposed and solute uptake is monitored. Tetracycline uptake depends on the presence of cobalt and vice versa, with the cosubstrates being transported in a 1:1 ratio. Evidence for the electrogenicity of both tetracycline–cobalt/H+ and Na+/H+ antiports is presented. K+ and Li+ inhibit Na+ uptake, but there is little cross-inhibition between Na+ and tetracycline–cobalt uptake activities. The results strongly support the conclusion that TetA(L) is a multifunctional antiporter. They expand the roster of such porters to encompass one with a complex organic substrate and monovalent cation substrates that may have distinct binding domains, and provide the first functional reconstitution of a member of the 14-transmembrane segment transporter family.
Resumo:
Induction of phase 2 enzymes and elevations of glutathione are major and sufficient strategies for protecting mammals and their cells against the toxic and carcinogenic effects of electrophiles and reactive forms of oxygen. Inducers belong to nine chemical classes and have few common properties except for their ability to modify sulfhydryl groups by oxidation, reduction, or alkylation. Much evidence suggests that the cellular “sensor” molecule that recognizes the inducers and signals the enhanced transcription of phase 2 genes does so by virtue of unique and highly reactive sulfhydryl functions that recognize and covalently react with the inducers. Benzylidene-alkanones and -cycloalkanones are Michael reaction acceptors whose inducer potency is profoundly increased by the presence of ortho- (but not other) hydroxyl substituent(s) on the aromatic ring(s). This enhancement correlates with more rapid reactivity of the ortho-hydroxylated derivatives with model sulfhydryl compounds. Proton NMR spectroscopy provides no evidence for increased electrophilicity of the β-vinyl carbons (the presumed site of nucleophilic attack) on the hydroxylated inducers. Surprisingly, these ortho-hydroxyl groups display a propensity for extensive intermolecular hydrogen bond formation, which may raise the reactivity and facilitate addition of mercaptans, thereby raising inducer potencies.
Resumo:
This book contains 19 essays that have been written by current LIS Students who were enrolled in the LIS4330: Library Instruction class at the University of Denver, 2016. Designed to provide a short and pithy overview of a topic that is related to instruction, education, or information literacy, each essays aims to be accessible and approachable for time-pressed librarians who may not have time to catch up.
Resumo:
Document addressed to Thomas Hicks (attorney for the defendant) informing him that Scott (attorney for the plaintiff) intends to bring the case to trial "at the next Supreme Court of Judicature to be held for the Province of New York." Signed by Scott.
Resumo:
Back Row: coaches Jerry Hanlon, Chuck Stobart, Gary Moeller, Tom Reed, Jack Harbaugh, Elliott Uzelac, Dennis Brown, Bill McCartney, Jed Hughes, Tirrell Burton</p>
8th Row: *Woody Brown, Jeff Golombiskey, Mike Smith, Rob Carian, Roger Bettis, *Kerry Bankus, Rex Mackall, Bill Cargile, *Bob Snyder, Greg Bartnick, Dave Harding, Dennis Richardson, Max Richardson, *Chuck Palanca
7th Row: Jim Pickens, Andy Jackson, Steve Nauta, Kevin King, Shaun Szenderski, Mike Kenn, *Mike Pawlowicz, Bill Dufek, Walt Downing, Mark Donahue, Paul Moore, Dominic Tedesco, Scott Corbin, John Anderson</p>
6th Row: Derek Howard, Ken Bush, Al Canaday, Phil Brown, Curt Stephenson, Jim Hackett, Terry Stefan, Jack Heffernan, *Steve Nault, Roger Szafranski, Bill Heneveld, Aubrey Miller, Alex Johnson, Joe Holland, Dwight Hicks
5th Row: Jim Bolden, Darrell Truitt, Jerry Zuver, Steve Anderson, Pete Traber, Phil Andrews, Jim Hall, *Gary Zolciak, *Mike Boik, Jerry Vogele, Gerry Szara, Bob Lang, Steve Graves, Eric Phelps, John Ceddia
4th Row: Bob Wood, Rob Lytle, John Hennessey, Jerry Collins, Mike Strabley, *Alan Wheeler, *Matt Caputo, Chuck Randolph, Greg Strinko, Rick Koschalk, Mike Holmes, Mike Coyne, Frank Moore, Jim Smith, Phil Brumbaugh
3rd Row: Dave Whiteford, *Eduardo Gonzales, Gordon Bell, Dave Devich, Les Miles, Dan Jilek, Calvin O'Neal, Kirk Lewis, Jim Czirr, Greg Morton, Tim Davis, Keith Johnson, George Przygodski, Mark Elzinga, Jack Fairbanks
2nd Row: *Glen Franklin, Jeff Perlinger, Mike Lantry, Jim Armour, Pat Tumpane, Carl Russ, Greg DenBoer, Dave Metz, Steve Strinko, Dennis Franks, Bill Hoban, Steve King, Tom Jensen, Don Dufek, coach Bo Schembechler
Front Row: Mark Jacoby, Kurt Kampe, *Kevin Casey, Larry Johnson, Dave Elliott, Tom Drake, co-captain Dave Brown, Chuck Heater, co-captain Dennis Franklin, Gil Chapman, Geoff Steger, Harry Banks, Larry Banks, Jeff Spahn, Doug McKenzie
* did not remain with team for the season</p>
Resumo:
Back Row: Chris Grieves, Bob Franks, Gregg Willner, Dave Goldwaithe, Mark Slaughter, John Mandich, Pat Watts, James Blue, Nick Labun, Tony Woodford, C. Newhof, Jeff Lawley
9th Row: Steve Knickerbocker, Kyron Williams, Stacy Johnson, John Weisenburger, Bob Hollway, Chip Pederson, Dale Keitz, Tim Malinak, Leon Richardson, Rock Lindsay, Lewis Smith, Woody Brown</p>
8th Row: Scott Smith, Mark Braman, Bob Patek, Jon Giesler, Mark Torzy, Curtis Greer, William Jackson, Jerry Meter, Rick Leach, Dave Stavale, Tom Melita
7th Row: Mike Smith, Tom Seabron, Mark DeSantis, Frank Bell, Harlan Huckleby, Gene Johnson, Mark Schmerge, Russell Davis, John Arbeznik, Andy Jackson, Dennis Richardson</p>
6th Row: Joe Holland, Steve Nauta, Kevin King, Max Richardson, Dave Harding, Mike Kenn, Dominic Tedesco, Jim Pickens, Ray Johnson, Phil Brown, Ken Bush, Roger Bettis
5th Row: Roger Szafranski, Dwight Hicks, Scott Corbin, Mark Donahue, Bill Dufek, Rex Mackall, John Anderson, Derek Howard, Greg Bartnick, Walt Downing, Terry Stefan, Asst. Coach Bill McCartney
4th Row: Asst. Coach Paul Schudel, Curt Stephenson, Rob Carian, Phil Andrews, Eric Phelps, Steve Graves, Gerry Szara, Jim Hackett, Pete Traber, Steve Anderson, Bob Wood, Darrell Truitt, Phil Brumbaugh, Asst. Coach Jack Harbaugh
3rd Row: Asst. Coach Gary Moeller, Asst. Coach Tom Reed, Asst. Coach Jed Hughes, Jerry Zuver, Rick White, Jim Hall, Mike Strabley, Jerry Vogele, Jim Smith, Rob Lytle, John Hennessy, Bob Lang, Jim Bolden, John Ceddia, A. Miller, Asst. Coach Dennis Brown</p>
2nd Row: Asst. Coach Tirrel Burton, Asst. Coach Jerry Hanlon, Greg Morton, Tom Jensen, George Przygodski, Mike Holmes, Co-Captain Kirk Lewis, Jeff Perlinger, Steve King, Dan Jilek, Jim Czirr, Bill Hoban, Calvin O'Neal, Chuck Randolph, Asst. Coach Chuck Stobart
Front Row: Mark Elzinga, Jerry Collins, Kurt Kampe, Rick Koschalk, Dave Devich, Co-captain Gordon Bell, Co-Captain Don Dufek, Tim Davis, Keith Johnson, Les Miles, Dave Whiteford, Greg Strinko, Head Coach Bo Schembechler
Resumo:
Back Row: Assistant Coaches: Larry Gustafson, Bob Thornbladh, Jerry Hanlon, Tirrel Burton, Dennis Brown, Chuck Stobart, Paul Schudel, Gary Moeller, Bill McCartney, Jack Harbaugh, Tom Reed, Dave Elliott, Tim Davis, Lou Angelo, Eqp. Mgr. Jon Falk, Trainer Lindsy McLean</p>
8th Row: Roger Gaudette, Jim Kozlowski, Virgil Williams, Chris Godfrey, Ron Pratl, Dick Novak, Doug Marsh, Irvin Johnson, Keith Gilmore, Jim Humphries, * , Dan Murray, * , Dave Angood
7th Row: Mike Harden, Mel Owens, Michael Davis, George Lilja, Mark Kochanski, John Powers, Chuck Hetts, Bob Taylor, Garrett Quinn, Mike Jolly, Ralph Clayton, John Wangler, David Payne
6th Row: Gerald Diggs, Gary Weber, Lawrence Reid, Gene Bell, Ron Simpkins, Roosevelt Smith, Lewis Smith, William Jackson, Stacy Johnson, Jeff Bednarek, Mike Leoni, Tony Leoni, Jay Allen, Larry Crockett
5th Row: Woody Brown, Gregg Willner, Chris Grieves, Tim Malinak, Mark Braman, * , Jon Giesler, Dave Kadela, Kyron Williams, * , * , Nick Labun, Tom Keller, * .
4th Row: Mgr. Bob Brown, Chip Pederson, Bob Patek, Dale Keitz, Curtis Greer, Tom Seabron, Jerry Meter, John Arbeznik, Mark DeSantis, Bob Hollway, Tom Melita, Mark Torzy, Rock Lindsay, Ed Kasparek
3rd Row: Roger Bettis, * , Dave Harding, Kevin King, Steve Nauta, Max Richardson, Dom Tedesco, Mark Schmerge, Gene Johnson, Russell Davis, Rick Leach, Greg Bartnick, Harlan Huckleby, Mike Smith, Ray Johnson, * .
2nd Row: Roger Szafranski, Jim Pickens, Dwight Hicks, Mark Donahue, Walt Downing, Steve Anderson, Eric Phelps, Rick White, Curt Stephenson, Phil Andrews, Steve Graves, John Anderson, Bill Dufek, Mike Kenn, Derek Howard, Rex Mackall
Front Row: Jim Hackett, Gerry Szara, Jerry Zuver, John Hennessy, Greg Morton, Co-Capt. Calvin O'Neal, Co-Capt. Kirk Lewis, Co-Capt. Rob Lytle, Jim Smith, Bob Wood, Jim Bolden, Bob Lang, Jerry Vogele, John Ceddia, Head Coach Bo Schembechler
* = left the team
Resumo:
Back Row: Asst. coaches Bob Thornbladh, Tom Reed, Jerry Hanlon, Tirrel Burton, Tim Davis, Bill McCartney, Jack Harbaugh, Paul Schudel, Dennis Brown, Don Nehlen, Barry Pierson, Jerry Zuver, Eqp. Mgr. Jon Falk, Trainer Lindsy McLean</p>
8th Row: Marcus Bond, Chuck Christian, Greg Wunderli, Kurt Becker, Tony Osbun, Dan Kwiatkowski, Tom Wandersleben, Fred Motley, Andy Cannavino, Mike Kligis, Jim Breaugh, Oliver Johnson</p>
7th Row: Kirk Yearian, B.J. Dickey, Alan Mitchell, Rodney Feaster, Stanley Edwards, Mike Trgovac, Dave Nicolau, Jeff Jackson, Neal Ginley, Kelley Keough, John Prepolec, Ben Needham, Stuart Harris, Rick Jones
6th Row: Derek Williams, Tony Woodford, Jay Allen, James Humphries, David Payne, Tom Keller, Ron Pratl, Rich Novak, David Angood, Craig Page, Dan Murray, Thomas Moss, Larry Jones, Brian Virgil
5th Row: Roger Gaudette, Virgil Williams, Gerald Diggs, Gene Bell, Dave Kadela, Gary Quinn, Ralph Clayton, Chuck Hetts, Mel Owens, Gary Weber, John Wangler, Keith Gilmore, Irvin Johnson, Tony Leoni, Jim Kozlowski
4th Row: Sr. Mgr. Don DiPaolo, Nick Labun, Mike Harden, Michael Davis, Lawrence Reid, Mike Jolly, John Powers, Chris Godfrey, Jeff Bednarek, George Lilja, Mike Leoni, Doug Marsh, Ron Simpkins, Roosevelt Smith, Gregg Willner, Tim Malinak
3rd Row: Ed Kasparek, Mark Braman, Bob Patek, Stacy Johnson, Dale Keitz, John Arbeznik, Curtis Greer, Jon Giesler, Chip Pederson, Mark DeSantis, Mark Torzy, Rock Lindsay, William Jackson, Bob Hollway, Tom Melita
2nd Row: Max Richardson, Curt Stephenson, Derek Howard, Steve Graves, John Anderson, Bill Dufek, Mark Donahue, Co-captain Walt Downing, Garry Szara, Mike Kenn, Rick White, Dominic Tedesco, Jim Pickens, Kevin King, Co-captain Dwight Hicks, Head Coach Bo Schembechler
Front Row: Raymond Johnson, Roger Bettis, Mike Smith, Russell Davis, Tom Seabron, Gene Johnson, Steve Nauta, Rex Mackall, Greg Bartnick, Dave Harding, Mark Schmerge, Jerry Meter, Rick Leach, Harlan Huckleby, Woody Brown</p>
Resumo:
Back Row: Fritz Seyferth, Bob Chmiel, Alex Agase, Jerry Meter, Elliot Uzelac, Paul Schudel, Jerry Hanlon, Gary Moeller, Tirrell Burton, Milan Vooletich, Lloyd Carr, Bob Thornbladh, Dennis Doornbos, Mike Gittleson</p>
9th Row: Chuck Ritter, Jon Falk, Ken Gear, Bob Kimball, Ed Hood, Camp Fellin, Marc Shevrin, Joe Mosketti, Charlie Fromm, Russ Miller
8th Row: Pat Moons, Derek Woodmore, Greg Randall, Triando Markray, Andy Moeller, Mike Krauss, Dan Decker, Jerry Quaerna, Rick Frazer, Dieter Heren, Ben Logue, Keith Cowan, Robert Harris
7th Row: Tony Gant, Steve Johnson, Thomas Wilcher, Eddie Garrett, Paul Schmerge, Mike Reinhold, Marty Shimko, John Mihic, Mark Hammerstein, Jim Harbaugh, Dan Rice, Bob Perryman, Gilvanni Johnson, Ivan Hicks
6th Row: Joe English, Todd Schlopy, Mike Melnyk, John Ferens, Mike Sessa, John Ghindia, Sim Nelson, Gil Zimmerman, Eric Kempthorn, Bruce Brown, Dave Simon, Sylvester Ogletree, John Paciorek, Bob Bergeron</p>
5th Row: Tom Knoebel, Mike Odioso, Phil Lewandowski, Bob Popowski, Clay Miller, Jeff Akers, Kevin Brooks, Art Balourdos, Mike Hammerstein, Brian Mercer, Bob Tabachino, Joe Gray, Jim Scarcelli, Riley McPhee
4th Row: Greg Powell, Brad Cochran, Al Sincinch, Mike Mallory, Eric Kattus, Vince DeFelice, Tim Anderson, Dave Meredith, Larry Sweeney, Mike Wilson, Nate Rodgers, Robert Dana, Rick Rogers, Fritz Burgess
3rd Row: Evan Cooper, Greg Armstrong, Don Bracken, Carlton Rose, Tom Hassell, Kerry Smith, Dave Hall, Jerry Diorio, Ron Prusa, Milt Carthens, Doug James, Rodney Lyles, Mickey Hanlon, Lou Kovacs
2nd Row: Vince Bean, Stefan Humphries, Nate Davis, Ricky Davis, John Lott, Scott Roberts, Todd Triplett, Dan Yarano, Rich Hewlett, Jeff Cohen, Jim Herrman, Steve Smith, Mike Boren, Tom Dixon</p>
Front Row: Marion Body, Jerald Ingram, Mike Lemirande, Winfred Carraway, Craig Dunaway, Keith Bostic, Rich Strenger, Robert Thompson, Anthony Carter, Lawrence Ricks, Paul Girgash, Tom Garrity, Jerry Burgei, Ali Haji-Sheikh, Bo Schembechler
Resumo:
Back Row: Bill Giarmo, Alex Agase, Jerry Hanlon, Bob Thornbladh, Elliott Uzelac, Gary Moeller, Lloyd Carr, Jerry Meter, Milan Vooletich, Tirrel Burton, Bob Chmiel, Jim Herrmann, Dave Magazu
9th Row: Doug Ham (Mgr.), Mike Gittleson, Lou Kovacs, Joe English, Joe Mosketti, James Rott, Garrett Smith, Phil Logas, John Whitledge, Andy Samosiuk, Dave Garlow, Russ Miller, Fritz Seyferth, Jon Falk
8th Row: Tim Schulte, Mike O'Connor, Billy Harris, Carlitos Bostic, Gene Cecchini, Steve Thibert, Jack Walker, John Balourdos, Pete Wentworth, Todd Schulte, Brandon Johns, Monte Robbins, John Zingales
7th Row: Billy Dawson, Doug Mallory, Gerald White, Garland Rivers, Dave Folkertsma, Andrew Borowski, Glenn Mogle, John Elliott, Andree McIntyre, Dwayne Freeman, Phil Webb, Chris Zurbrugg, Ken Higgins, Russell Rein</p>
6th Row: Gene Lawson, Camp Fellin, Marc Shevrin, Dieter Heren, John Mihic, Jerry Quaerna, Rick Frazer, Marty Shimko, Triando Markray, Dan Decker, Keith Cowan, Pat Moons, Ed Hood, Al Bishop
5th Row: Steve Johnson, Tony Gant, Greg Randall, Ben Logue, Gilvanni Johnson, Paul Schmerge, Mark Hammerstein, Mike Reinhold, Jim Harbaugh, Bob Perryman, Andy Moeller, Mike Krauss, Ivan Hicks
4th Row: Mike Melnyk, Todd Schlopy, John Paciorek, Dave Simon, John Ghindia, Phil Lewandowski, Jim Scarcelli, Brad Cochran, Tom Knoebel, Mike Sessa, Eddie Garrett, Dan Rice, John Ferens, Bob Bergeron, Tom Wilcher
3rd Row: Joe Gray, Mike Mallory, Clay Miller, Eric Kattus, Art Balourdos, Al Sincich, Kevin Brooks, Mike Hammerstein, Sim Nelson, Jeff Akers, Rick Rogers, Bob Popowski, Bob Tabachino, Brian Mercer
2nd Row: Fritz Burgess, Tim Anderson, Mike Wilson, Nate Rogers, Dave Meredith, Vince DeFelice, Greg Armstrong, Milt Carthens, Rodney Lyles, Larry Sweeney, Dan Yarano, Gerald Ingram, Don Bracken, Kerry Smith
Front Row: Jeff Cohen, Jerry Diorio, Dave Hall, Carlton Rose, Steve Smith, Tom Dixon, Stefan Humphries, Mike Boren, Doug James, Evan Cooper, Tom Hassel, John Lott, Vince Bean, Rich Hewlett, Coach Bo Schembechler
