En el primer aniversario de la desaparición de José Medina Echavarría

Incluye Bibliografía

Las teorías neoclásicas del liberalismo económico

Incluye Bibliografía

Reinventing development: utopias devised by committees and seeds of change in the real world

Includes bibliography

The internationalization of the Latin American economies: some reservations

Includes bibliography

Economic policy: science or ideology?, part I

Includes bibliography

The Latin American regional market: the project and the reality

Includes bibliography

On the first anniversary of the death of José Medina Echavarría

Includes bibliography

Exploring the multifactorial nature of autism through computational systems biology: Calcium and the Rho GTPase RAC1 under the spotlight

Autism is a neurodevelopmental disorder characterized by impaired social interaction and communication accompanied with repetitive behavioral patterns and unusual stereotyped interests. Autism is considered a highly heterogeneous disorder with diverse putative causes and associated factors giving rise to variable ranges of symptomatology. Incidence seems to be increasing with time, while the underlying pathophysiological mechanisms remain virtually uncharacterized (or unknown). By systematic review of the literature and a systems biology approach, our aims were to examine the multifactorial nature of autism with its broad range of severity, to ascertain the predominant biological processes, cellular components, and molecular functions integral to the disorder, and finally, to elucidate the most central contributions (genetic and/or environmental) in silico. With this goal, we developed an integrative network model for gene-environment interactions (GENVI model) where calcium (Ca2+) was shown to be its most relevant node. Moreover, considering the present data from our systems biology approach together with the results from the differential gene expression analysis of cerebellar samples from autistic patients, we believe that RAC1, in particular, and the RHO family of GTPases, in general, could play a critical role in the neuropathological events associated with autism. © 2013 Springer Science+Business Media New York.

La manufactura mexicana, diagnóstico de su estructura y programas locales de apoyo : prácticas, logros y pendientes hacia una política industrial nacional

Incluye bibliografía

Educación y transformación productiva con equidad en la agricultura: problemas y propuestas

Incluye Bibliografía

Estímulo da síntese da glutationa na maturação in vitro de oócitos bovinos e sua influência no desenvolvimento embrionário

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)