The nucleophillic substitution of various chloroanthraquinones of their possible rearrangement via aryne intermediates

The work in this thesis deals mainly with nucleophilic substitution of chloroanthraquinones as a route to various starting materials which might rearrange, via aryne intermediates to afford fused-ring heterocy1ic carboxylic acids. 1-Amino-5-chloroanthraquinone was successfully prepared by reacting 1,5-dichloroanthraquinone with sodium aZide in ref1uxing dimethylsulfoxide (DMSO). It could also be prepared from the same starting material by reaction with ammonia (gas) in DMSO in the presence of potassium fluoride. Treatment of l-amino-5-chloroanthraquinone with potassium amide in liquid ammonia or with potassium t-butoxide in t-butylbenzene returned mainly starting material, although in the latter case some 1-amino-5-hydroxyanthraquinone was also isolated. 1-Hydroxy-5-chloroanthraquinone was ultimately prepared by diazotization of the amino-analog. It was recovered almost quantitatively after treatmenu'with potassium amide in liquid ammonia. The reaction with potassium t-butoxide in t-buty1benzene was anomalous and gave 1-hydroxyanthraquinone as the only iso1able product. Acridines were successfully prepared by the action of 70% sulfuric acid on 1,5-bis(p-toluidino)-anthraquinone and 1-p-toluidino-5- ch10roanthraquinone, and in the latter case, cleavage to give an acridinecarboxylate was attempted. Substituted anthraquinones reacted with sodium azide in sulfuric acid to give azepindiones by -NH insertion. Methods for separating and identifying isomeric mixtures of these compounds were examined. Attempted decarbonylation of selected azepindiones to give acridones gave mainly what were thought to be amino-benzophenone derivatives. Chloroanthraquinones were found to react with hexamethylphosphoramide (HMPA) to give mixtures of the dimethylamino- and methylaminoderivatives. Under the same conditions halogeno-nitrobenzenes and nitrophenols were substituted to give the appropriate dimethyl aminobenzenes, except in two cases. 3-Chloronitrobenzene reacted anomalously to give a small amount of 3,3'-dichloroazobenzene and a trace of 4-dimethylamino-nitrobenzene. Pentachlorophenol reacted to give a pentachlorophenylphosphorodiamidate in good yield.

Diastereoselective Lithiation-Substitution of N-Silyl-Protected-(S)-Tetrahydro-1H-pyrrolo[1,2-c]imidazole-3(2H)-ones and Applications of Their Derivatives

This thesis describes a method involving the preparation of an L-proline-derived imidazolone protected with an N-triethylsilyl group that undergoes diastereoselective lithiation followed by electrophile quench to give C5-substituted products with syn stereochemistry. The N-silylated derivatives may be more easily N-deprotected as compared to previous N-t-Bu analogues to give secondary ureas. These may serve as precursors to N-phenyl chiral bicyclic guanidines or as NHC precursors for synthesis of corresponding complexes.

Diastereoselective Lithiation-Substitution of N-Silyl-Protected-(S)-Tetrahydro-1H-pyrrolo[1,2-c]imidazole-3(2H)-ones and Applications of Their Derivatives

This thesis describes a method involving the preparation of an L-proline-derived imidazolone protected with an N-triethylsilyl group that undergoes diastereoselective lithiation followed by electrophile quench to give C5-substituted products with syn stereochemistry. The N-silylated derivatives may be more easily N-deprotected as compared to previous N-t-Bu analogues to give secondary ureas. These may serve as precursors to N-phenyl chiral bicyclic guanidines or as NHC precursors for synthesis of corresponding complexes.

Percepción entre el docente y el alumno de los niveles de aplicación del modelo por competencias en la asignatura de inglés en la preparatoria 9 de la U.A.N.L. en un período regular.

Tesis (Maestría en Psicología con orientación en Psicología Laboral y Organizacional) UANL, 2013.

Percepción entre el docente y el alumno de los niveles de aplicación del modelo por competencias en la asignatura de inglés en la preparatoria 9 de la U.A.N.L., en un período regular.

Tesis (Maestría en Psicología con orientación en Psicología Laboral y Organizacional) UANL, 2013.

Virtudes y milagros en vida, y muerte del venerable padre Fr. Sebastián de Aparicio, religioso lego de la regular observancia de nuestro seráfico Padre San Francisco, e hijo de la Provincia del Santo Evangelio de México, en la Nueva España, que floreció en el Convento de la Puebla de los Angeles.

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Vida prodigiosa del v. siervo de Dios Fray Sebastián de Aparicio, religioso lego de la regular obfervancia de N.S.P.S. Francifeo, é hijo de la Provincia del Santo Evangelio de México

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Historia Bethlehemítica : vida exemplar y admirable del venerable siervo de Dios, y padre Pedro de San Joseph Betancur, fundador de el regular Instituto de Bethlehen en las Indias Occidentales; frutos singulares de su fecundo espíritu y sucesos varios de de esta religión

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A pronouncing dictionary of the Spanish and English languages composed from the Spanish dictionaires of the Spanish Academy, Terreros and Salvá, upon the basis of Seoane's aedition of Neuman and Barretti and from the English dictionairres of Webster, Worcester, and Walker... [by] Mariano Velázquez de la Cadena.

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Sermón fúnebre en las solemnes exequias que celebraron en la Santa Iglesia Metropolitana de Valencia su excmo. e illmo. Arzobispo y cabildo con asistencia de la M. I. ciudad y de todo el clero secular y regular en sufragio por el alma de su difunto prelado el excmo. illmo. Señor Don Francisco Fabian y Fuero, el dia 13 de octubre de 1801,

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Primera carta pastoral del Ilustrísimo Señor Dr. Fr. Buenaventuradel Sagrado Corazón de María, Portillo y Tejeda tercer Obispo de Zacatecas, dirigida al V. clero secular y regular a todos los fieles de la diócesis

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Circular dirigida por el Ilmo. Sr. Arzobispo de México al Ilmo. y Ve. Cabildo Metropolitano, al de la insigne Colegiata de Guadalupe, al clero secular y regular y a todos sus diocesanos

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Carta pastoral del Illmo. y Rmo. Sr. D. F. Buenaventura del Sagrado Corazón de María, Portillo y Tejeda, tercer Obispo de Zacatecas dirigido al M.I. y venerable cabildo al clero secular y regular y a todos sus amados diocesanos, convocándolos para la próxima peregrinación que Dios mediante tendrá lugar el día tres del próximo octubre...

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Carta pastoral que el Ilmo. Sr. Dr. D. Francisco de P. Verea Obispo de Linares, dirige al venerable clero secular y regular y a todos los fieles de su Diócesis, con motivo de la enciclica que su santidad el señor Pio IX dirigió al orbe católico, el 19 de Enero del corriente año

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