Formulation development and evaluation of lamivudine controlled release tablets using cross-linked sago starch

Objectives: Modified starches based polymeric substances find utmost applicability in pharmaceutical formulation development. Cross-linked starches showed very promising results in drug delivery application. The present investigation concerns with the development of controlled release tablets of lamivudine using cross-linked sago starch. Methods: The cross-linked derivative was synthesized with phosphorous oxychloride and native sago starch in basic pH medium. The cross-linked sago starch was tested for acute toxicity and drug-excipient compatibility study. The formulated tablets were evaluated for various physical characteristics, in vitro dissolution release study and in vivo pharmacokinetic study in rabbit model. Results: In vitro release study showed that the optimized formulation exhibited highest correlation (R) in case of zero order kinetic model and the release mechanism followed a combination of diffusion and erosion process. There was a significant difference in the pharmacokinetic parameters (T-max, C-max, AUC, V-d, T-1/2, and MDT) of the optimized formulation as compared to the marketed conventional tablet Lamivir (R). Conclusion: The cross-linked starch showed promising results in terms of controlling the release behavior of the active drug from the matrix. The hydrophilic matrix synthesized by cross-linking could be used with a variety of active pharmaceutical ingredients for making their controlled/sustained release formulations.

NUcache: an efficient multicore cache organization based on next-use distance

The effectiveness of the last-level shared cache is crucial to the performance of a multi-core system. In this paper, we observe and make use of the DelinquentPC - Next-Use characteristic to improve shared cache performance. We propose a new PC-centric cache organization, NUcache, for the shared last level cache of multi-cores. NUcache logically partitions the associative ways of a cache set into MainWays and DeliWays. While all lines have access to the MainWays, only lines brought in by a subset of delinquent PCs, selected by a PC selection mechanism, are allowed to enter the DeliWays. The PC selection mechanism is an intelligent cost-benefit analysis based algorithm that utilizes Next-Use information to select the set of PCs that can maximize the hits experienced in DeliWays. Performance evaluation reveals that NUcache improves the performance over a baseline design by 9.6%, 30% and 33% respectively for dual, quad and eight core workloads comprised of SPEC benchmarks. We also show that NUcache is more effective than other well-known cache-partitioning algorithms.

Evaluation of microwave assisted grafted sago starch as controlled release polymeric carrier

In the present investigation an attempt has been made to develop a new co-polymeric material for controlled release tablet formulations. The acrylamide grafting was successfully performed on the backbone of sago starch. The modified starch was tested for acute toxicity and drug-excipient compatibility study. The grafted material was used in making of controlled release tablets of lamivudine. The formulations were evaluated for physical characteristics such as hardness, friability, %drug content and weight variations. The in vitro release study showed that the optimized formulation exhibited highest correlation (R) value in case of Higuchi model and the release mechanism of the optimized formulation predominantly exhibited combination of diffusion and erosion process. There was a significant difference in the pharmacokinetic parameters (T-max, C-max, AUC, V-d, T-1/2 and MDT) of the optimized formulation as compared to the marketed conventional tablet Lamivir (R) was observed. The pharmacokinetics parameters were showed controlled pattern and better bioavailability. The optimized formulation exhibited good stability and release profile at the accelerated stability conditions. (c) 2013 Elsevier B.V. All rights reserved.

Behaviour simulation in computer aided product concept sketching

In the product conceptualization phase of design, sketches are often used for exploration of diverse behaviour patterns of the components to achieve the required functionality. This paper presents a method to animate the sketch produced using a tablet interface to aid verification of the desired behaviour. A sketch is a spatial organization of strokes whose perceptual organization helps one to visually interpret its components and their interconnections. A Gestalt based segmentation followed by interactive grouping and articulation, presented in this paper, enables one to use a mechanism simulation framework to animate the sketch in a “pick and drag” mode to visualize different configurations of the product and gain insight into the product’s behaviour.

Recognition of open vocabulary, online handwritten pages in Tamil script

In this work, we describe a system, which recognises open vocabulary, isolated, online handwritten Tamil words and extend it to recognize a paragraph of writing. We explain in detail each step involved in the process: segmentation, preprocessing, feature extraction, classification and bigram-based post-processing. On our database of 45,000 handwritten words obtained through tablet PC, we have obtained symbol level accuracy of 78.5% and 85.3% without and with the usage of post-processing using symbol level language models, respectively. Word level accuracies for the same are 40.1% and 59.6%. A line and word level segmentation strategy is proposed, which gives promising results of 100% line segmentation and 98.1% word segmentation accuracies on our initial trials of 40 handwritten paragraphs. The two modules have been combined to obtain a full-fledged page recognition system for online handwritten Tamil data. To the knowledge of the authors, this is the first ever attempt on recognition of open vocabulary, online handwritten paragraphs in any Indian language.

Delineation of homogeneous hydrometeorological regions using wavelet-based global fuzzy cluster analysis

Identification of homogeneous hydrometeorological regions (HMRs) is necessary for various applications. Such regions are delineated by various approaches considering rainfall and temperature as two key variables. In conventional approaches, formation of regions is based on principal components (PCs)/statistics/indices determined from time series of the key variables at monthly and seasonal scales. An issue with use of PCs for regionalization is that they have to be extracted from contemporaneous records of hydrometeorological variables. Therefore, delineated regions may not be effective when the available records are limited over contemporaneous time period. A drawback associated with the use of statistics/indices is that they do not provide effective representation of the key variables when the records exhibit non-stationarity. Consequently, the resulting regions may not be effective for the desired purpose. To address these issues, a new approach is proposed in this article. The approach considers information extracted from wavelet transformations of the observed multivariate hydrometeorological time series as the basis for regionalization by global fuzzy c-means clustering procedure. The approach can account for dynamic variability in the time series and its non-stationarity (if any). Effectiveness of the proposed approach in forming HMRs is demonstrated by application to India, as there are no prior attempts to form such regions over the country. Drought severity-area-frequency (SAF) curves are constructed corresponding to each of the newly formed regions for the use in regional drought analysis, by considering standardized precipitation evapotranspiration index (SPEI) as the drought indicator.

Divergence in Patterns of Leaf Growth Polarity Is Associated with the Expression Divergence of miR396

Lateral appendages often show allometric growth with a specific growth polarity along the proximo-distal axis. Studies on leaf growth in model plants have identified a basipetal growth direction with the highest growth rate at the proximal end and progressively lower rates toward the distal end. Although the molecular mechanisms governing such a growth pattern have been studied recently, variation in leaf growth polarity and, therefore, its evolutionary origin remain unknown. By surveying 75 eudicot species, here we report that leaf growth polarity is divergent. Leaf growth in the proximo-distal axis is polar, with more growth arising from either the proximal or the distal end; dispersed with no apparent polarity; or bidirectional, with more growth contributed by the central region and less growth at either end. We further demonstrate that the expression gradient of the miR396-GROWTH-REGULATING FACTOR module strongly correlates with the polarity of leaf growth. Altering the endogenous pattern of miR396 expression in transgenic Arabidopsis thaliana leaves only partially modified the spatial pattern of cell expansion, suggesting that the diverse growth polarities might have evolved via concerted changes in multiple gene regulatory networks.

Ellipse Fitting Using the Finite Rate of Innovation Sampling Principle

Standard approaches for ellipse fitting are based on the minimization of algebraic or geometric distance between the given data and a template ellipse. When the data are noisy and come from a partial ellipse, the state-of-the-art methods tend to produce biased ellipses. We rely on the sampling structure of the underlying signal and show that the x- and y-coordinate functions of an ellipse are finite-rate-of-innovation (FRI) signals, and that their parameters are estimable from partial data. We consider both uniform and nonuniform sampling scenarios in the presence of noise and show that the data can be modeled as a sum of random amplitude-modulated complex exponentials. A low-pass filter is used to suppress noise and approximate the data as a sum of weighted complex exponentials. The annihilating filter used in FRI approaches is applied to estimate the sampling interval in the closed form. We perform experiments on simulated and real data, and assess both objective and subjective performances in comparison with the state-of-the-art ellipse fitting methods. The proposed method produces ellipses with lesser bias. Furthermore, the mean-squared error is lesser by about 2 to 10 dB. We show the applications of ellipse fitting in iris images starting from partial edge contours, and to free-hand ellipses drawn on a touch-screen tablet.

Pressure Controlled Self-Assembly of High Quality Three-Dimensional Colloidal Photonic Crystals

A concise pressure controlled isothermal heating vertical deposition (PCIHVD) method is developed, which provides an optimal growing condition with better stability and reproducibility for fabricating photonic crystals (PCs) without the limitation of colloidal sphere materials and sizes. High quality PCs are fabricated with PCIHVD from polystyrene spheres with diameters ranging from 200 nm to 1 mu m. The deep photonic band gap and steep photonic band edge of the samples are most favorable for realizing ultrafast optical devices, photonic chips, and communications. This method makes a meaningful advance in the quality and diversity of PCs and greatly promotes their wide applications.

De madres, ciudades y tablillas : alcances políticos y literarios de un enigma familiar en la comedia media (Antífanes, Safo, fr. 194 K.-A)

Resumen: El fragmento 194 (Kassel-Austin) del poeta cómico Antífanes, proveniente de su obra Safo (c. 360 a.C.), reproduce un diálogo entre la poetisa y un personaje desconocido que da cuenta de una adivinanza. La imagen propuesta de una mujer que protege a sus hijos, silenciosos, mientras lloran ante quien los quiera escuchar es, pues, resemantizada en el pasaje, a la vez, desde una dimensión política y un plano autorreferencial. Examinada inicialmente como una pólis que cobija a los demagogos corruptos, la escena familiar termina siendo decodificada en términos poéticos: se trata de una tablilla de escritura con letras que resultan sus mudos descendientes. El enigma, por tanto, supone una interesante estrategia para consolidar desde una visión cómica la polivalencia de la imagen maternal como un mecanismo metafórico eficiente para cargar las tintas sobre aquellas temáticas a las que el género concede un tratamiento privilegiado.

Antiguo Oriente: Cuadernos del Centro de Estudios de Historia del Antiguo Oriente, 2006, n° 4 (número completo)

How old is the Kingdom of Edom? A review of new evidence and recent discussion / Eveline Van Der Steen ; Piotr Bienkowski -- A problem of pedubasts? / Dan´El Kahn -- Le ciel selon l´Hymne Orphique à Ouranos et selon des textes funéraires égyptiens (PT, CT, BD): une brève comparaison préliminaire / Amanda–Alice Marvelia -- An epigraphic reanalysis of Two Stelae from Firs Intermediate Period Dendera in the Cairo Museum / Tracy Musacchio -- Mass production in Mesopotamia / Morris Silver -- Iron Age “negative” pottery: a reassessment / Juan Manuel Tebes -- The Cordage from the 2001- Season of the excavations at Berenike (Egyptian Red Sea Coast): preliminary results / André J. Veldmeijer -- Article review. Carr, David M., Writing of the Tablet of the Heart: origins of scripture and literature / Itamar Singer -- Reseñas bibliográficas -- Política editorial

Adbi'ilu : an arab at Babylon (BM 78912)

An unpublished tablet from the archive of Šumā descendant of Nappāu contains a possible Arabic personal name. The treatment of non-Babylonian personal names in this tablet and CTMMA 3 6 from the same archive differs from the treatment of Babylonian names suggesting that the scribe distinguished between the kin-groupaffiliated Babylonians and the non-Babylonians who lacked such affiliations.

第八届国际海洋离岸与极地工程大会简况及一点感识

1．会议概况第八届国际海洋高岸与极地工程大会（The8th（1998）InternationalOffshoreandPolarEngineeringConference（ISOPE－98））于1998年5月24日～5月29日在加拿大Montreal召开．会议是由国际海洋离岸与极地工程师协会（ISOPE）会同大会技术委员会（TPC）及包括中国...

Cliente UCH para smartphones sobre Android

El objetivo del proyecto consiste en la creación de una aplicación cliente de UCH para Android, capaz de controlar “dispositivos objetivos”. Teniendo como base el PFC de Borja Gamecho, titulado “Estudio del estándar URC y su aplicación a sistemas embebidos usando una implementación Java del UCH”, proyecto que pertenece al campo de la inteligencia ambiental (AmI). La construcción de un sistema capaz de controlar dispositivos de manera sencilla y ubicua fue la motivación para la realización de este proyecto, ya que con él, se puede conseguir un control universal de nuestro entorno, permitiendo eliminar barreras por ejemplo, para personas con discapacidad. En este proyecto se ha estudiado el centro de control universal (UCH) junto con el protocolo URC-HTTP. También se ha investigado sobre la plataforma Android, para posteriormente usarlo como base para el desarrollo de un URC (cliente para el control del UCH y del entorno). Como principal conclusión, el presente trabajo permite avanzar en la propuesta de encontrar un estándar capaz de controlar nuestro entorno desde cualquier smartphone, tablet,... de forma ubicua y sencilla.

Urkiolaenea: Sistemas multidispositivo para negocios tradicionales

“Urkiolaenea: Sistemas multidispositivo para negocios tradicionales” es un proyecto realizado en la empresa OrekaI.T. dentro de un contexto formativo, ya que a su vez es el proyecto con el que finalizo mis estudios de Ingeniería Informática. Con él, se ha pretendido dar respuesta a las necesidades de un cliente real que dispone de un negocio tradicional.En este caso, Urkiolaenea, una negocio de alojamiento rural que requería de una imagen renovada en Internet para lograr ser más competitiva en el ámbito del turismo rural, además de un sistema de gestión para mejorar sus procesos de negocio. Por otra parte, con este proyecto no sólo se ha buscado cumplir con las expectativas del cliente sino ir más allá, buscando las soluciones más adecuadas ante el mercado actual en Internet, dominado por los dispositivos móviles inteligentes. Por ello, gran parte de los esfuerzos realizados en este proyecto se han enfocado en conseguir que Urkiolaenea sea accesible cómodamente por cualquier persona, independientemente del dispositivo desde el que acceda.