Eosinophilic oesophagitis: latest intelligence.

Eosinophilic oesophagitis (EoE), first described in the early 1990s, has rapidly evolved as a distinctive chronic inflammatory oesophageal disease with increasing incidence and prevalence in the westernized countries. Currently, EoE represents the main cause of dysphagia in adult patients. This disease is more prevalent in males and is frequently associated with allergies. The diagnosis is established based on the presence of oesophageal symptoms and dense eosinophilic oesophageal infiltration once other conditions leading to oesophageal eosinophilia are excluded. It is currently under discussion to what extent and by which methods allergic testing should be performed. Topical corticosteroids lead to a rapid improvement of active EoE clinically and histologically. Especially in children, elimination diets can have similar efficacy as topical corticosteroids. Oesophageal dilation of EoE-induced oesophageal strictures can also be effective in improving symptoms, but this therapy has no effect on the underlying inflammation. Neither the diagnostic nor the long-term therapeutic strategies are as yet defined. Cite this as: A. M. Schoepfer, D. Simon and A. Straumann, Clinical & Experimental Allergy, 2011 (41) 630-639.

L'intelligence-led policing: un cadre pertinent pour soutenir la lutte contre les incendies volontaires répétitifs

Agir efficacement contre les incendies volontaires répétitifs représente un défi de taille pour la société et la police. Nous proposons d'utiliser l'intelligence-led policing et le cycle du renseignement comme cadre à une approche permettant une gestion et un suivi global et systématique de ces événements. Mais avant de pouvoir lancer ce processus, un certain nombre de défis doit être surmonté tel que la nature non spécifique des données. Il sera alors possible de mettre en place un processus qui permettra de faire des analyses pour obtenir une vision des incendies, détecter des situations répétitives et des liens entre les événements mettant en évidence des séries. Le renseignement obtenu par l'analyse des données rassemblées peut ensuite être utilisé pour mettre en place des moyens complémentaires d'enquête ou pour prendre des mesures préventives ou répressives.

Carte générale de l'Algérie ou des possessions françaises dans le nord de l'Afrique : pour servir à l'intelligence des opérations militaires et commerciales / dressée par A. B. Beaupré, géographe

Échelle(s) : [ca 1:4 732 000], 50 lieues de 25 au degré [= 4,7 cm]

Carte des environs d'Alger, pour l'intelligence des lignes du Capitaine Emile Grand / Ginoux, lith[ograph]e ; Toulon, lith[ographe] Imbert

Échelle(s) : 1:200 000

La Grèce et les pays voisins pour l'intelligence de Démosthène / Par J. N. Buache ; J. Dezauche sculpsit

Échelle(s) : [1:3 964 000 environ], 1200 stades olympiques dont 8 égalent un mille romain [= 5,6 cm]

Carte de la partie méridionale de la Grèce pour servir à l'intelligence de l'Histoire d'Epaminondas / Par M. Bellin, ... ; Dheulland sculp.

Échelle(s) : [1:1 682 000 environ], Lieues comunes de France de 25 au degré, 20 [= 5,2 cm]

La Carte de la Grèce ancienne suivant Hérodote, Thucydide, Xenophon, Sophian, Pausanias & autres : dressée pour l'intelligence de l'histoire grecque / Par P. Du Val, ...

Échelle(s) : [1:2 400 000 ca] Eschelle de 60 mille pas geométriques [= 4,9 cm]

Source inference of exogenous gamma-hydroxybutyric acid (GHB) administered to humans by means of carbon isotopic ratio analysis: novel perspectives regarding forensic investigation and intelligence issues.

γ-Hydroxybutyric acid (GHB) is an endogenous short-chain fatty acid popular as a recreational drug due to sedative and euphoric effects, but also often implicated in drug-facilitated sexual assaults owing to disinhibition and amnesic properties. Whilst discrimination between endogenous and exogenous GHB as required in intoxication cases may be achieved by the determination of the carbon isotope content, such information has not yet been exploited to answer source inference questions of forensic investigation and intelligence interests. However, potential isotopic fractionation effects occurring through the whole metabolism of GHB may be a major concern in this regard. Thus, urine specimens from six healthy male volunteers who ingested prescription GHB sodium salt, marketed as Xyrem(®), were analysed by means of gas chromatography/combustion/isotope ratio mass spectrometry to assess this particular topic. A very narrow range of δ(13)C values, spreading from -24.810/00 to -25.060/00, was observed, whilst mean δ(13)C value of Xyrem(®) corresponded to -24.990/00. Since urine samples and prescription drug could not be distinguished by means of statistical analysis, carbon isotopic effects and subsequent influence on δ(13)C values through GHB metabolism as a whole could be ruled out. Thus, a link between GHB as a raw matrix and found in a biological fluid may be established, bringing relevant information regarding source inference evaluation. Therefore, this study supports a diversified scope of exploitation for stable isotopes characterized in biological matrices from investigations on intoxication cases to drug intelligence programmes.

Apoio à Administração, Business Intelligence. O caso Unipiaget

A memória realizada no âmbito do regulamento dos Cursos de Graduação da Universidade Jean Piaget de Cabo Verde, apresenta um estudo exaustivo sobre Sistemas de Apoio à Decisão e Businees Intelligence, mais concretamente, o estudo da sua arquitectura, os benefícios que trazem a uma organização, bem como a sua integração às estratégias empresariais, com vista ao alcance dos objectivos traçados. Ainda, apresenta um estudo de caso sobre a Unipiaget, cujas conclusões indicam que essa Universidade, ainda tem muito o que fazer para que haja uma real partilha de conhecimento extraído do seu Sistema Informação, que ao contrário de muitas empresas em Cabo Verde, é apoiada por Tecnologias de Informação e Comunicação bem actuais e capazes. A memória permitiu alcançar os objectivos preconizados no início da elaboração da mesma, sem que tenha havido sobressaltos, apesar da escassa bibliografia.