997 resultados para agenesis of the corpus callosum
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El drama migratorio del cual está siendo Europa testigo en estas últimas semanas es en parte el resultado de una falta de políticas comunitarias en relación a este tema, hecho del cual, en los últimos años, se han hecho eco multitud de medios. Europa, y en especial los países del Mediterráneo, ha experimentado un incremento sustancial en el número de inmigrantes que llegan a sus costas en condiciones cada vez más deplorables y arriesgando gravemente su integridad física. Este hecho está principalmente motivado por el aumento y la intensidad de los conflictos bélicos en países de África y Oriente próximo. En el caso de Malta, un diminuto archipiélago ubicado entre los territorios de Libia y Sicilia, el cambio en la tendencia migratoria que se produjo en 2002 le hizo pasar de ser un país de emigrantes a un país receptor de inmigrantes. Este cambio dio como resultado la aparición de grupos y partidos anti-inmigración, como Azzjoni Nazzjonali, y de un sentimiento de preocupación frente a la llegada de inmigrantes que crece de manera constante según se refleja en encuestas europeas (véase Eurobarometer 82-83). Desde el punto de vista lingüístico, el discurso discriminatorio empleado por los medios de comunicación, organismos y figuras políticas ha sido ampliamente estudiado dentro de la rama del Análisis Crítico del Discurso (Charteris-Black, 2006; Fairclough, 1989, Reisigl & Wodak, 2001; Santa Ana, 1999; Van Dijk, 1984, 1992, 1999, 2000, 2006, Van Leeuwen & Wodak, 1999). En los últimos años, se ha potenciado el uso de un enfoque cognitivo en el análisis de este tipo de discursos. Dicho enfoque utiliza elementos tomados de la lingüística cognitiva para explicar cómo la representación de eventos y participantes en el discurso atiende, o está motivada por la conceptualización mental de dichos eventos y participantes (Charteris-Black, 2006; Hart, 2011; Musolff, 2012; Núñez-Perucha, 2011; O’Brien, 2003; Santa Ana, 1999; Van Dijk, 1992, 1998, 1999, 2000, 2006; Wodak, 2006). El Análisis Crítico del Discurso es una disciplina cuyo principal objetivo es analizar cómo ciertos fenómenos sociales que se basan en relaciones de abuso de poder y dominación se representan en el discurso de las denominadas élites (Van Dijk, 2001). Muchos de estos discursos atienden a lo que en lingüística se ha denominado discurso de discriminación, en donde un grupo dominante ejerce poder sobre otro mediante el uso de diversas herramientas discursivas. Generalmente, estos estudios sobre discursos de discriminación se han centrado en fenómenos como el machismo o el racismo. Dentro de este último campo, cabe destacar el trabajo de Van Dijk en el análisis del discurso del racismo y del discurso de la inmigración (Van Dijk, 1992, 1999, 2000, 2001, 2006). El presente trabajo se centra en analizar cómo la prensa maltesa ha representado el fenómeno de la inmigración y a los inmigrantes desde 2005 hasta 2015. Dentro de esta línea temporal, se presta especial atención al día 2 de abril de 2013. Esta es la fecha en la que la Associated Press, una organización de prensa independiente con subscriptores alrededor del mundo, decidió incluir un importante cambio léxico en su manual de estilo. El motivo del mismo era modificar el uso del adjetivo “ilegal” recomendando su uso para referirse exclusivamente a acciones (ej. Inmigración ilegal) pero nunca para referirse a individuos (ej. Inmigrante ilegal). Nuestro estudio pretende identificar hasta qué punto esta medida se ha puesto en práctica en los periódicos malteses y qué repercusiones ha tenido su incorporación en la representación de los inmigrantes y la inmigración. Para ello, se ha seleccionado como caso de estudio uno de los periódicos en lengua inglesa más leídos en el archipiélago, Times of Malta. El estudio se ha centrado en el análisis de un total de treinta artículos de opinión repartidos de manera homogénea (quince y quince) en dos corpus. El primer corpus contiene artículos pertenecientes a un periodo de tiempo que va desde 2005 hasta la fecha en la cual el cambio léxico de la Associated Press fue publicado, es decir, el 2 de abril de 2013. Por otro lado, el segundo corpus contiene artículos desde el 2 de abril de 2013 hasta mediados de 2015. Para agilizar y facilitar el análisis de los artículos, se ha hecho uso del programa llamado WordSmith Tools, el cual está especializado en el trabajo con corpus. Este programa se utilizó principalmente para analizar la representación semántica de los distintos participantes y eventos. Los resultados del análisis demuestran que el periódico ha aplicado el cambio léxico sugerido por la Associated Press al no encontrarse ningún ejemplo de “inmigrante ilegal” o “migrante ilegal” a partir del 2 de abril de 2013. En estos mismos resultados también se aprecia una representación más positiva de la figura del inmigrante en el segundo corpus, dónde el inmigrante abandona la categoría léxica de “criminal” para comenzar a ser visto cada vez más como la víctima. También a nivel léxico, se puede observar cómo los autores tienden a usar cada vez más el término “migrante” en lugar de “inmigrante”. A pesar de que este último continúa siendo el término más utilizado para referirse a la persona que llega desde otro país, el significativo incremento del uso de la palabra “migrante” en el segundo corpus es llamativo y puede deberse a que la palabra “inmigrante” haya adquirido connotaciones negativas por su repetido uso junto al adjetivo “ilegal”. De entre las estrategias discursivas empleadas en la representación de la sociedad maltesa, cabe destacar dos. Por un lado, tenemos el uso de la victimización, mediante la cual la población maltesa aparece como una víctima frente a la inmigración, que es vista como una amenaza, al mismo tiempo que Malta es también víctima de la falta de apoyo internacional. En segundo lugar, es también común encontrar artículos en donde el autor destaca las cualidades positivas de la sociedad maltesa, especialmente su generosidad. Esta última estrategia es lo que Van Dijk denomina national self-glorifiation (2000:220; 2006:738). En cuanto al uso de las metáforas, el cambio es menos significativo. En general, ambos corpus muestran ejemplos de metáforas en las que el inmigrante aparece conceptualizado como parte de un fenómeno natural incontrolable, un invasor o un organismo dispuesto a infectar o dañar de algún modo el país. En el segundo corpus, sin embargo, desaparecen las metáforas en las que el inmigrante se percibe como un animal inferior, que sí aparecían en el primer corpus. Esto supone un cambio positivo. Hasta este punto hemos resumido los cambios en la representación de los inmigrantes. Respecto al modo en el cual el fenómeno de la inmigración aparece representado en los periódicos, también encontramos cambios importantes. A nivel léxico, el cambio que mencionábamos relativo a los términos “inmigrante” y “migrante” también se produce a la hora de nombrar este fenómeno social. De este modo, la palabra “migración” es más usada en el segundo corpus que en el primero, aunque sigue ocupando el segundo lugar por detrás de la palabra “inmigración”. En cuanto a los contenidos, se puede observar un cambio positivo hacia una mayor concienciación social. Por ejemplo, vemos cómo en el segundo corpus en ocasiones se pide una respuesta estatal a temas como la integración de los inmigrantes o el racismo entre la sociedad, mientras que en el primer corpus la integración era una labor del inmigrante y el racismo era un tema incómodo. En el segundo corpus también encontramos la queja más clara hacia el uso de centros de detención en la isla. En el primer corpus, aunque algunos autores manifestaban su disconformidad con las condiciones en las cuales los inmigrantes vivían dentro de los centros de detención, todos asumían que tener dichos centros era una medida necesaria. Esta especie de consenso social y político acerca del uso de centros de detención se consigue mediante el empleo de herramientas discursivas que representen la inmigración como una amenaza de la cual hay que protegerse (negative other-presentation Van Dijk, 2000:221; 2006:738). En resumen, podemos decir que este trabajo muestra una progresión en el discurso de inmigración en Malta hacia una representación más positiva y amable del inmigrante y de la inmigración. Aunque las limitaciones de este estudio hacen imposible establecer una relación única y directa entre los cambios experimentados por el periódico y el cambio léxico sugerido por la Associated Press, lo cierto es que la descriminalización de los inmigrantes a nivel léxico (mediante la supresión de términos como “ilegal” o “detenidos”) ha influido de manera positiva en el tono y la forma en que este periódico se refiere al fenómeno social de la inmigración
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The BLM-OCS (Bureau of Land Management-Outer Continental Shelf) program was designed to establish chemical, biological, and geological baseline on the South Texas Continental Shelf. The focus for the geological program was to establish the nature and amount of the suspended sediment in the water column, of the Holocene sediments on the shelf, and to identify and locate regions of geology conditions which may be hazardous to OCS operations. To accomplish these goals three cruises were planned. The report constitutes results of the first cruise. The results of these cruises associated with the subsequent laboratory analysis, enabled to establish a detailed baseline in order to provide significant geologic and biologic data for environmental assessment. Dredges recovered are available at University of Texas (see: BLM/OCS South Texas Outer Continental Shelf (STOCS) Project Sediment Data http://www.ngdc.noaa.gov/docucomp/page?xml=NOAA/NESDIS/NGDC/MGG/Geology/iso/xml/G02888.xml&view=getDataView&header=none).
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The BLM-OCS (Bureau of Land Management-Outer Continental Shelf) program was designed to establish chemical, biological, and geological baseline on the South Texas Continental Shelf. The focus for the geological program was to establish the nature and amount of the suspended sediment in the water column, of the Holocene sediments on the shelf, and to identify and locate regions of geology conditions which may be hazardous to OCS operations. To accomplish these goals three cruises were planned. The report constitutes results of the second cruise. The results of these cruises associated with the subsequent laboratory analysis, enabled to establish a detailed baseline in order to provide significant geologic and biologic data for environmental assessment. Dredges recovered are available at University of Texas (see: BLM/OCS South Texas Outer Continental Shelf (STOCS) Project Sediment Data http://www.ngdc.noaa.gov/docucomp/page?xml=NOAA/NESDIS/NGDC/MGG/Geology/iso/xml/G02888.xml&view=getDataView&header=none).
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In June 2015, legal frameworks of the Asian Infrastructural Investment Bank were signed by its 57 founding members. Proposed and initiated by China, this multilateral development bank is considered to be an Asian counterpart to break the monopoly of the World Bank and the International Monetary Fund. In October 2015, China’s Central Bank announced a benchmark interest rate cut to combat the economic slowdown. The easing policy coincides with the European Central Bank’s announcement of doubts over US Fed’s commitment to raise interest rates. Global stock markets responded positively to China’s move, with the exception of the indexes from Wall Street (Bland, 2015; Elliott, 2015). In the meantime, China’s ‘One Belt, One Road’ (or New Silk Road Economic Belt) became atopic of discourse in relation to its growing global economy, as China pledged $40 billion to trade and infrastructure projects (Bermingham, 2015). The foreign policy aims to reinforce the economic belt from western China through Central Asia towards Europe, as well as to construct maritime trading routes from coastal China through the South China Sea (Summers, 2015). In 2012, The Economist launched a new China section, to reveal the complexity of the‘meteoric rise’ of China. John Micklethwait, who was then the chief editor of the magazine, said that China’s emergence as a global power justified giving it a section of its own(Roush, 2012). In July 2015, Hu Shuli, the former chief editor of Caijing, announced the launch of a think tank and financial data service division called Caixin Insight Group, which encompasses the new Caixin China Purchasing Managers Index (PMI). Incooperation with with Markit Group, a principal global provider of PMI, the index soon became a widely cited economic indicator. One anecdote from November’s Caixin shows how much has changed: in a high-profile dialogue between Hu Shuli and Kevin Rudd, Hu insisted on asking questions in English; interestingly, the former Prime Minister of Australia insisted on replying in Chinese. These recent developments point to one thing: the economic ascent of China and its increasing influence on the power play between economics and politics in world markets. China has begun to take a more active role in rule making and enforcement under neoliberal frameworks. However, due to the country’s size and the scale of its economy in comparison to other countries, China’s version of globalisation has unique characteristics. The ‘Capitalist-socialist’ paradox is vital to China’s market-oriented transformation. In order to comprehend how such unique features are articulated and understood, there are several questions worth investigating in the realms of media and communication studies,such as how China’s neoliberal restructuring is portrayed and perceived by different types of interested parties, and how these portrayals are de-contextualised and re-contextualised in global or Anglo-American narratives. Therefore, based on a combination of the themes of globalisation, financial media and China’s economic integration, this thesis attempts to explore how financial media construct the narratives of China’s economic globalisation through the deployment of comparative and multi-disciplinary approaches. Two outstanding elite financial magazines, Britain’s The Economist, which has a global readership and influence, and Caijing, China’s leading financial magazine, are chosen as case studies to exemplify differing media discourses, representing, respectively, Anglo-American and Chinese socio-economic and political backgrounds, as well as their own journalistic cultures. This thesis tries to answer the questions of how and why China’s neoliberal restructuring is constructed from a globally-oriented perspective. The construction primarily involves people who are influential in business and policymaking. Hence, the analysis falls into the paradigm of elite-elite communication, which is an important but relatively less developed perspective in studying China and its globalisation. The comparing of characteristics of narrative construction are the result of the textual analysis of articles published over a ten-year period (mid-1998 to mid-2008). The corpus of samples come from the two media outlets’ coverage of three selected events:China becoming a member of the World Trade Organization, its outward direct investment, and the listing of stocks of Chinese companies in overseas exchanges, which are mutually exclusive in sample collection and collectively exhaustive in the inclusion of articles regarding China’s economic globalisation. The findings help to understand that, despite language, socio-economic and political differences, elite financial media with globally-oriented readerships share similar methods of and approaches to agenda setting, the evaluation of news prominence, the selection of frame, and the advocacy of deeply rooted neoliberal ideas. The comparison of their distinctive features reflects the different phases of building up the sense of identity in their readers as global elites, as well as the different economic interests that are aligned with the corresponding readerships. However, textual analysis is only relevant in terms of exploring how the narratives are constructed and the elements they include; textual analysis alone prevents us from seeing the obstacles and the constrains of the journalistic practices of construction. Therefore, this thesis provides a brief discussion of interviews with practitioners from the two media, in order to understand how similar or different narratives are manifested and perceived, how the concept of neoliberalism deviates from and is justified in the Chinese context, and how and for what purpose deviations arise from Western to Chinese contexts. The thesis also contributes to defining financial media in the domain of elite communication. The relevant and closely interlocking concepts of globalisation, elitism and neoliberalism are discussed, and are used as a theoretical bedrock in the analysis of texts and contexts. It is important to address the agenda-setting and ideological role of elite financial media, because of its narrative formula of infusing business facts with opinions,which is important in constructing the global elite identity as well as influencing neoliberal policy-making. On the other hand, ‘journalistic professionalism’ has been redefined, in that the elite identity is shared by the content producer, reader and the actors in the news stories emerging from the much-compressed news cycle. The professionalism of elite financial media requires a dual definition, that of being professional in the understanding of business facts and statistics, and that of being professional in the making sense of stories by deploying economic logic.
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The recent archaeological works in Hinojosa, allowed us to discover a camp from Roman republic period. It is located in the center of the Celtiberian area and its study could open interesting perspectives to study this historical period. This paper shows the results of its preliminary studies.
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Tras mi reciente edición de los pseudo-aristotélicos Pepli Epitaphia, el presente trabajo se centra en los apochrypha a dichos epitafios que compuso Juan Tzetzes en el siglo xii, un conjunto de ocho dísticos elegíacos para los héroes que consideró meritorios de tal tarea, y para quienes no pudo encontrar un epitafio conservado en las fuentes manuscritas a las que tuvo acceso. Para lograr dicho propósito, también se investiga el grado de conocimiento y la transmisión de ese corpus epigramático en la literatura bizantina, además de considerar las lecciones y el sentido mismo de dos códices guardados en la Biblioteca Nacional de España (M y Md). En ellos, Constantino Láscaris copió, directamente a partir de Tzetzes, dos breves antologías de dichos componentes.
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With the development of information technology, the theory and methodology of complex network has been introduced to the language research, which transforms the system of language in a complex networks composed of nodes and edges for the quantitative analysis about the language structure. The development of dependency grammar provides theoretical support for the construction of a treebank corpus, making possible a statistic analysis of complex networks. This paper introduces the theory and methodology of the complex network and builds dependency syntactic networks based on the treebank of speeches from the EEE-4 oral test. According to the analysis of the overall characteristics of the networks, including the number of edges, the number of the nodes, the average degree, the average path length, the network centrality and the degree distribution, it aims to find in the networks potential difference and similarity between various grades of speaking performance. Through clustering analysis, this research intends to prove the network parameters’ discriminating feature and provide potential reference for scoring speaking performance.
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Following the intrinsically linked balance sheets in his Capital Formation Life Cycle, Lukas M. Stahl explains with his Triple A Model of Accounting, Allocation and Accountability the stages of the Capital Formation process from FIAT to EXIT. Based on the theoretical foundations of legal risk laid by the International Bar Association with the help of Roger McCormick and legal scholars such as Joanna Benjamin, Matthew Whalley and Tobias Mahler, and founded on the basis of Wesley Hohfeld’s category theory of jural relations, Stahl develops his mutually exclusive Four Determinants of Legal Risk of Law, Lack of Right, Liability and Limitation. Those Four Determinants of Legal Risk allow us to apply, assess, and precisely describe the respective legal risk at all stages of the Capital Formation Life Cycle as demonstrated in case studies of nine industry verticals of the proposed and currently negotiated Transatlantic Trade and Investment Partnership between the United States of America and the European Union, TTIP, as well as in the case of the often cited financing relation between the United States and the People’s Republic of China. Having established the Four Determinants of Legal Risk and its application to the Capital Formation Life Cycle, Stahl then explores the theoretical foundations of capital formation, their historical basis in classical and neo-classical economics and its forefathers such as The Austrians around Eugen von Boehm-Bawerk, Ludwig von Mises and Friedrich von Hayek and most notably and controversial, Karl Marx, and their impact on today’s exponential expansion of capital formation. Starting off with the first pillar of his Triple A Model, Accounting, Stahl then moves on to explain the Three Factors of Capital Formation, Man, Machines and Money and shows how “value-added” is created with respect to the non-monetary capital factors of human resources and industrial production. Followed by a detailed analysis discussing the roles of the Three Actors of Monetary Capital Formation, Central Banks, Commercial Banks and Citizens Stahl readily dismisses a number of myths regarding the creation of money providing in-depth insight into the workings of monetary policy makers, their institutions and ultimate beneficiaries, the corporate and consumer citizens. In his second pillar, Allocation, Stahl continues his analysis of the balance sheets of the Capital Formation Life Cycle by discussing the role of The Five Key Accounts of Monetary Capital Formation, the Sovereign, Financial, Corporate, Private and International account of Monetary Capital Formation and the associated legal risks in the allocation of capital pursuant to his Four Determinants of Legal Risk. In his third pillar, Accountability, Stahl discusses the ever recurring Crisis-Reaction-Acceleration-Sequence-History, in short: CRASH, since the beginning of the millennium starting with the dot-com crash at the turn of the millennium, followed seven years later by the financial crisis of 2008 and the dislocations in the global economy we are facing another seven years later today in 2015 with several sordid debt restructurings under way and hundred thousands of refugees on the way caused by war and increasing inequality. Together with the regulatory reactions they have caused in the form of so-called landmark legislation such as the Sarbanes-Oxley Act of 2002, the Dodd-Frank Act of 2010, the JOBS Act of 2012 or the introduction of the Basel Accords, Basel II in 2004 and III in 2010, the European Financial Stability Facility of 2010, the European Stability Mechanism of 2012 and the European Banking Union of 2013, Stahl analyses the acceleration in size and scope of crises that appears to find often seemingly helpless bureaucratic responses, the inherent legal risks and the complete lack of accountability on part of those responsible. Stahl argues that the order of the day requires to address the root cause of the problems in the form of two fundamental design defects of our Global Economic Order, namely our monetary and judicial order. Inspired by a 1933 plan of nine University of Chicago economists abolishing the fractional reserve system, he proposes the introduction of Sovereign Money as a prerequisite to void misallocations by way of judicial order in the course of domestic and transnational insolvency proceedings including the restructuring of sovereign debt throughout the entire monetary system back to its origin without causing domino effects of banking collapses and failed financial institutions. In recognizing Austrian-American economist Schumpeter’s Concept of Creative Destruction, as a process of industrial mutation that incessantly revolutionizes the economic structure from within, incessantly destroying the old one, incessantly creating a new one, Stahl responds to Schumpeter’s economic chemotherapy with his Concept of Equitable Default mimicking an immunotherapy that strengthens the corpus economicus own immune system by providing for the judicial authority to terminate precisely those misallocations that have proven malignant causing default perusing the century old common law concept of equity that allows for the equitable reformation, rescission or restitution of contract by way of judicial order. Following a review of the proposed mechanisms of transnational dispute resolution and current court systems with transnational jurisdiction, Stahl advocates as a first step in order to complete the Capital Formation Life Cycle from FIAT, the creation of money by way of credit, to EXIT, the termination of money by way of judicial order, the institution of a Transatlantic Trade and Investment Court constituted by a panel of judges from the U.S. Court of International Trade and the European Court of Justice by following the model of the EFTA Court of the European Free Trade Association. Since the first time his proposal has been made public in June of 2014 after being discussed in academic circles since 2011, his or similar proposals have found numerous public supporters. Most notably, the former Vice President of the European Parliament, David Martin, has tabled an amendment in June 2015 in the course of the negotiations on TTIP calling for an independent judicial body and the Member of the European Commission, Cecilia Malmström, has presented her proposal of an International Investment Court on September 16, 2015. Stahl concludes, that for the first time in the history of our generation it appears that there is a real opportunity for reform of our Global Economic Order by curing the two fundamental design defects of our monetary order and judicial order with the abolition of the fractional reserve system and the introduction of Sovereign Money and the institution of a democratically elected Transatlantic Trade and Investment Court that commensurate with its jurisdiction extending to cases concerning the Transatlantic Trade and Investment Partnership may complete the Capital Formation Life Cycle resolving cases of default with the transnational judicial authority for terminal resolution of misallocations in a New Global Economic Order without the ensuing dangers of systemic collapse from FIAT to EXIT.
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This thesis is an edition of the correspondence of the Yorkshirean Wentworth family. The aim of the edition is to provide these handwritten manuscripts to a wider audience by transcribing them. The material has been acquired from the Folger Shakespeare Library, and the transcriptions presented in this thesis are a part of their database called Early Modern Manuscripts Online. My material consists of fifteen documents from the early modern period which have been sent to or sent by members of the Wentworth family. Fourteen of these documents are letters, and one is a warrant written in the form of a letter. In the Folger Shakespeare Library the documents form the section 2.1. Correspondence of the Wentworth family in a larger collection called Papers of the Cavendish-Talbot family. The documents have been transcribed diplomatically in order to retain the character of the original manuscripts. In addition to the transcriptions, background chapters on letter writing, the historical and linguistic context, and palaeography are provided. Furthermore, each text includes a commentary containing a brief summary of the text and a description of the manuscript. Notes concerning specific words or concepts are also provided to make the texts easier to understand. Additionally, the transcriptions are encoded in XML for the purposes of the Folger Shakespeare Library. These earlier unedited manuscripts reassert the status of the Wentworth family in the early modern English society and provide information about letter writing conventions, language, and palaeographical conventions in early modern England. This edition can be used in further studies, for example as part of a larger corpus.
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Few studies relating to librarianship as a science, because it is argued that the Library lacks a body of theory, an object of study and methodology of its own. According to Murcia and Tamayo "science is a critical task not dogmatic, that puts all its cases to trial and criticism." 0 is, science tests the presumed knowledge. He adds that science related facts and interconnected with each other, in order to achieve logical connections that allow the provision of postulates and axioms from the systematization achieved through research and the scientific method to determine the objectivity that exists between facts and phenomena. For him, scientific research is the instrument by which science makes it to scientific knowledge. (1982, p. 11)
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When first approaching a topic such as the concept of material or natural soul in Greek literature, the researcher might be puzzled. While in diverse contemporary cultures, numerous theriomorphic figures (bears, ravens, mice, wasps, bees, dragonflies, and dung-beetles) serve to represent the human soul in its transmigration from life to death, this is not the case in Greek culture. At least, this is what one may conclude from the monograph written by the Dutch scholar J. Bremmer, The early Greek Concept of the Soul: "importunely, there are no other indications of a possible connection between the butterfly and the soul of the living and the dead" (1987: 64). Given Plutarch’s great interest in the soul, which can be seen in a variety of texts referring to its generation, form, internal dichotomy, material substance, origin and destination, etc., the question arises as to whether Plutarch also includes such a representation of the soul when departing from the dead body. Does the corpus plutarcheum preserve and transmit such conception of the human soul? And if it does, are we dealing with survival of ancestral beliefs or motifs or is it a simple metaphor by means of which ancients intended to express the departing of the life-breath? In the following pages I will focus on three texts that allegedly include the butterfly-motif to represent the human soul, to wit, Table Talks 636C, Consolation to his Wife 611F, and the fragment 177 Sandbach.
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A Digital Scholarly Edition is a conceptually and structurally sophisticated entity. Throughout the centuries, diverse methodologies have been employed to reconstruct a text transmitted through one or multiple sources, resulting in various edition types. With the advent of digital technology in philology, these practices have undergone a significant transformation, compelling scholars to reconsider their approach in light of the web. In the digital age, philologists are expected to possess (too) advanced technical skills to prepare interactive and enriched editions, even though, in most cases, only mechanical or documentary editions are published online. The Śivadharma Database is a web Content Management System (CMS) designed to facilitate the preparation, publication, and updating of Digital Scholarly Editions. By providing scholars with a user-friendly CRUD web application to reconstruct and annotate a text, they can prepare their textus with additional components such as apparatus, notes, translations, citations, and parallels. It is possible by leveraging an annotation system based on HTML and graph data structure. This choice is made because the text entity is multidimensional and multifaceted, even if its sequential presentation constrains it. In particular, editions of South Asian texts of the Śivadharma corpus, the case study of this research, contain a series of phenomena that are difficult to manage formally, such as overlapping hierarchies. Hence, it becomes necessary to establish the data structure best suited to represent this complexity. In Śivadharma Database, the textus is an HTML file readily displayable. Textual fragments, annotated via an interface without requiring philologists to write code and saved in the backend, form the atomic unit of multiple relationships organised in a graph database. This approach enables the formal representation of complex and overlapping textual phenomena, allowing for good annotation expressiveness with minimal effort to learn the relevant technologies during the editing workflow.
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The Fourier transform-infrared (FT-IR) signature of dry samples of DNA and DNA-polypeptide complexes, as studied by IR microspectroscopy using a diamond attenuated total reflection (ATR) objective, has revealed important discriminatory characteristics relative to the PO2(-) vibrational stretchings. However, DNA IR marks that provide information on the sample's richness in hydrogen bonds have not been resolved in the spectral profiles obtained with this objective. Here we investigated the performance of an all reflecting objective (ARO) for analysis of the FT-IR signal of hydrogen bonds in DNA samples differing in base richness types (salmon testis vs calf thymus). The results obtained using the ARO indicate prominent band peaks at the spectral region representative of the vibration of nitrogenous base hydrogen bonds and of NH and NH2 groups. The band areas at this spectral region differ in agreement with the DNA base richness type when using the ARO. A peak assigned to adenine was more evident in the AT-rich salmon DNA using either the ARO or the ATR objective. It is concluded that, for the discrimination of DNA IR hydrogen bond vibrations associated with varying base type proportions, the use of an ARO is recommended.
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The aim of this study was to evaluate the structural and molecular effects of antiangiogenic therapies and finasteride on the ventral prostate of senile mice. 90 male FVB mice were divided into: Young (18 weeks old) and senile (52 weeks old) groups; finasteride group: finasteride (20mg/kg); SU5416 group: SU5416 (6 mg/kg); TNP-470 group: TNP-470 (15 mg/kg,) and SU5416+TNP-470 group: similar to the SU5416 and TNP-470 groups. After 21 days, prostate ventral lobes were collected for morphological, immunohistochemical and Western blotting analyses. The results demonstrated atrophy, occasional proliferative lesions and inflammatory cells in the prostate during senescence, which were interrupted and/or blocked by treatment with antiangiogenic drugs and finasteride. Decreased AR and endostatin reactivities, and an increase for ER-α, ER-β and VEGF, were seen in the senile group. Decreased VEGF and ER-α reactivities and increased ER-β reactivity were verified in the finasteride, SU5416 groups and especially in SU5416+TNP-470 group. The TNP-470 group showed reduced AR and ER-β protein levels. The senescence favored the occurrence of structural and/or molecular alterations suggesting the onset of malignant lesions, due to the imbalance in the signaling between the epithelium and stroma. The SU5416+TNP-470 treatment was more effective in maintaining the structural, hormonal and angiogenic factor balance in the prostate during senescence, highlighting the signaling of antiproliferation via ER-β.
Resumo:
To compare time and risk to biochemical recurrence (BR) after radical prostatectomy of two chronologically different groups of patients using the standard and the modified Gleason system (MGS). Cohort 1 comprised biopsies of 197 patients graded according to the standard Gleason system (SGS) in the period 1997/2004, and cohort 2, 176 biopsies graded according to the modified system in the period 2005/2011. Time to BR was analyzed with the Kaplan-Meier product-limit analysis and prediction of shorter time to recurrence using univariate and multivariate Cox proportional hazards model. Patients in cohort 2 reflected time-related changes: striking increase in clinical stage T1c, systematic use of extended biopsies, and lower percentage of total length of cancer in millimeter in all cores. The MGS used in cohort 2 showed fewer biopsies with Gleason score ≤ 6 and more biopsies of the intermediate Gleason score 7. Time to BR using the Kaplan-Meier curves showed statistical significance using the MGS in cohort 2, but not the SGS in cohort 1. Only the MGS predicted shorter time to BR on univariate analysis and on multivariate analysis was an independent predictor. The results favor that the 2005 International Society of Urological Pathology modified system is a refinement of the Gleason grading and valuable for contemporary clinical practice.