Au deçà de la Cité de Dieu

La Cité de Dieu a été rédigée dans une perspective polémique vis-à-vis les païens. La prise de Rome, en 410, a entraîné en Afrique du Nord la venue d’une élite cultivée, revivaliste et admirative du vieux polythéisme. Contre cette mouvance nostalgique, tributaire des anciens majoritairement sur le plan intellectuel et livresque, Augustin s’en prend à la bibliothèque des nouveaux arrivants. La Cité de Dieu peut, le cas échéant, être lue par la négative, c’est-à-dire par le biais de la critique qu’élabore Augustin de trois auteurs choisis, Varron, Cicéron et Salluste, qui résument et représentent conjointement l’essence de la culture classique. Tant chez les païens que chez l’évêque d’Hippone – leur détracteur –, Varron incarne la fine pointe de la théologie romano-hellénistique, Salluste est celui qui a mené à sa perfection la discipline de l’histoire, Cicéron a écrit le parachèvement des oeuvres sur la République, et chacun préconise sa structure idéologique propre, les trois domaines formant pourtant un ensemble systémique. Tout en louant ses illustres prédécesseurs, Augustin leur porte une critique générale et c’est à cette critique que seront consacrées nos analyses.

Comparação de materiais usados na confeção de facetas dentárias

A demanda na procura da reabilitação estética é um dos focos da história da humanidade ao longo das eras, mas que teve a sua acentuação nestes últimos dois séculos. Sendo a face um dos pontos que nos permite avaliar esteticamente uma pessoa, cabe ao médico dentista, como um dos profissionais que trabalha nessa zona do corpo humano, avaliar e procurar satisfazer as necessidades estéticas da população. Assim, por parte dos profissionais de Medicina Dentária, tem de haver uma procura constante para a satisfação das exigências estéticas, não só no conhecimento como no aprimoramento da técnica. Nos últimos tempos, com a necessidade de desenvolvimento de materiais para colmatar a cada vez maior busca para a perfeição estética, as facetas surgiram como tratamento de excelência. O presente trabalho teve como objectivo a comparação entre resina composta e cerâmica, na elaboração de restaurações estéticas. Para os dois tipos de materiais foram avaliados a estética e o comportamento biomecânico. Foram comparados benefícios e desvantagens, contra-indicações, indicações, plano de tratamento, diagnóstico e procedimentos clínicos dos dois materiais, utilizados na confecção das facetas cerâmicas e de resina composta. Foram utilizados os seguintes parâmetros de comparação: biocompatibilidade, adaptação marginal, preparação, resistência, cor, acabamento, potencial de reparação, custo e estética. A utilização de facetas cerâmicas tem sido um dos principais focos de desenvolvimento da Medicina Dentária no âmbito científico. A sua utilização permite uma maior predictibilidade e uma maior longevidade clínica. A sua qualidade estética, resistência à fractura, biodisponibilidade e estabilidade de cor, são as suas maiores vantagens na utilização clínica. Em sentido inverso, as facetas de resina composta apresentam menor custo, maior resistência à abrasão, possibilidade de reparação fácil e menor desgaste de estrutura dentária durante a sua preparação. Contudo apresentam menor estabilidade de cor. Portanto, torna-se esclarecedor que a escolha do material a utilizar na confecção de facetas, deve ser adaptada às especificidades de cada caso.

HTML5 no contexto de desenvolvimento e implementação de plataformas móveis com interfaces tácteis

Dissertação apresentada ao Instituto Politécnico de Castelo Branco para cumprimento dos requisitos necessários à obtenção do grau de Mestre em Desenvolvimento de Software e Sistemas Interativos, realizada sob a orientação científica do Doutor Pedro Nuno Moreira da Silva, Professor Adjunto da Unidade Técnico-Científica de Informática do Departamento da Escola Superior de Tecnologia do Instituto Politécnico de Castelo Branco.

Religious fundamentalism and utopianism in the 21st century

Why is it so difficult to respond to religious fundamentalism from within a liberal paradigm? This paper explores a core problem within religious fundamentalism, stemming from its relationship to the phenomenon of utopianism. This is a complex relationship, which occurs on several different levels, including the content of fundamentalist visions (religious fundamentalisms contain utopian visions of the good life), and its structural paradigm (utopianism and fundamentalism both stem from discontent with the now, challenge cornerstones of their contemporaneous world, and desire radically different alternatives). Of greatest concern is an attachment to perfection, which permits a malign form of utopianism to propel religious actors into a politics of ‘divinely sanctioned’ violence.

Pensamento de Remo Bodei sobre a filosofia do século XX : da estagnação ao retorno da responsabilidade

Dissertação (mestrado)—Universidade de Brasília,Instituto de Ciências Humanas, Programa de Pós-Graduação em Filosofia, 2014.

Igual consideração e respeito, independência ética e liberdade de expressão em Dworkin : uma reconciliação entre igualdade e liberdade e a possibilidade do discurso do ódio em um ordenamento coerente de princípios

Dissertação (mestrado)—Universidade de Brasília, Faculdade de Direito, Pós-Graduação Stricto Sensu em Direito, 2016.

Evaluation of Educational Environment for Medical Students of a Tertiary Pediatric Hospital in Tehran, Using DREEM Questionnaire

Background: Tertiary pediatric hospitals usually provide excellent clinical services, but such centers have a lot to do for educational perfection. Objectives: This study was performed to address under-graduate educational deficits and find feasible solutions. Patients and Methods: This cross-sectional study was done in a target population of 77 sixth year undergraduate medical students (response rate = 78%) who spent their 3-month pediatric rotation in the Children’s Medical Center, the Pediatrics Center of Excellence in Tehran, Iran. The Dundee ready educational environment measure (DREEM) instrument was used for assessing educational environment of this subspecialized pediatric hospital. Results: Among 60 students who answered the questionnaires, 24 were male (40%). Participants’ age ranged from 23 to 24 years. The mean total score was 95.8 (48%). Comparison of scores based on students’ knowledge showed no significant difference. Problematic areas were learning, academic self-perception, and social self-perception. Conclusions: Having an accurate schedule to train general practitioner, using new teaching methods, and providing a non-stressful atmosphere were suggested solutions.

Mechanisms of Chloroperoxidase-catalyzed Enantioselective Reactions as Probed by Site-directed Mutagenesis and Isotopic Labeling

Chloroperoxidase (CPO) is a heme-containing glycoprotein secreted by the marine fungus Caldariomyces fumago. Chloroperoxidase contains one ferriprotoporphyrin IX prosthetic group per molecule and catalyzes a variety of reactions, such as halogenation, peroxidation and epoxidation. The versatile catalytic activities of CPO coupled with the increasing demands for chiral synthesis have attracted an escalating interest in understanding the mechanistic and structural properties of this enzyme. In order to better understand the mechanisms of CPO-catalyzed enantioselective reactions and to fine-tune the catalytic properties of chloroperoxidase, asparagine 74 (N74) located in the narrow substrate access channel of CPO was replaced by a bulky, nonpolar valine and a polar glutamine using site-directed mutagenesis. The CPO N74 mutants displayed significantly enhanced activity toward nonpolar substrates compared to wild-type CPO as a result of changes in space and polarity of the heme distal environment. More interestingly, N74 mutants showed dramatically decreased chlorination and catalase activity but significantly enhanced epoxidation activity as a consequence of improved kinetic perfection introduced by the mutation as reflected by the favorable changes in kcat and kcat/KM of these reactions. It is also noted that the N74V mutant is capable of decomposing cyanide, the most notorious poison for many hemoproteins, as judged by the unique binding behavior of N74V with potassium cyanide. Histidine 105 (H105) was replaced by a nonpolar amino acid alanine using site-directed mutagenesis. The CPO H105 mutant (H105A) displayed dramatically decreased chlorination and catalase activity possibly because of the decreased polarity in the heme distal environment and loss of the hydrogen bonds between histidine 105 and glutamic acid 183. However, significantly increased enantioselectivity was observed for the epoxidation of bulky styrene derivatives. Furthermore, my study provides strong evidence for the proposed histidine/cysteine ligand switch in chloroperoxidase, providing experimental support for the structure of the 420-nm absorption maximum for a number of carbon monoxide complexes of heme-thiolate proteins. For the NMR study, [dCPO(heme)] was produced using 90% deuterated growth medium with excess heme precursors and [dCPO(Phe)] was grown in the same highly deuterated medium that had been supplemented with excess natural phenylalanine. To make complete heme proton assignments, NMR spectroscopy has been performed for high-resolution structural characterization of [dCPO(heme)] and [dCPO(Phe)] to achieve unambiguous and complete heme proton assignments, which also allows important amino acids close to the heme active center to be determined.

The Joycean Sublime

The purpose of my thesis is to analyze notions of the sublime in James Joyce’s Ulysses and how the sublime is evoked and presented in Joyce’s work. The present work will examine concepts of the sublime from the Classical and Medieval period, through the Enlightenment, and into the Romantic era to develop my own definition. Placing the sublime in a historical perspective allows me to discover how the sublime is at work through Joyce’s creative use of complex narrative approaches. The beauty of aesthetic perfection was achieved by employing all of Joyce’s artistic faculties. My thesis investigates how Ulysses’ experimental writing technique, unique structuring, and difficult prose created a work of genius which evokes the sublime. By analyzing Joyce’s use of language, unconventional narrative, and ambiguity in Ulysses I will explore how the sublime is aroused.

Dante y la imaginación agente: el "narrador" de la "Commedia" y la transparencia perfecta de la profetología árabo-judía

This research pursues two avenues of thought: 1. Prophetology—that is, the theory dealing with the gnoseological status of the prophetic gift—and 2. That of a rationalistic philosophical culture, common to Christians and Jews and used for mystical and “anthropological” ends—that is, the quest for the perfection of the human being. In the former instance, the discussion deals exclusively with natural prophesy as it appears in the Arab tradition, which was spread throughout the Christian and Jewish cultures of the thirteenth and fourteenth centuries through Maimonides’ Guide for the Perplexed. This type of prophecy, for the spread of which the Latin translation of Maimonides’ work was decisive, was adopted—with variations—by a number of authors who formed part of Dante’s culture, particularly Albertus Magnus, in the Christian sphere, and Judah Romano and Abulafia in the Jewish sphere. With regard to the latter—i.e., the common philosophical culture—this relates to the High Medieval sacralized formulation that instrumentalised—through the study and application of a given exegesis—an Averroist model of demonstration of the condition of the possibility of thought: the instrument of scientific demonstration becomes a propaedeutic for salvation; that is, an instrument of a mystical nature for the achievement of personal and civil perfection. The philosophy that supports this model— Averroes’ noetics—along with its exegetic instrumentalization, formed a fundamental part of the intellectual climate of the Italy (and, above all Florence) in which Dante’s works were written...