1000 resultados para Intervalos de credibilidade e intervalos H.P.D.


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[Convention collective. Transport routier. France. 1960-]

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Contient : Noblesse d'Aragon, Biscaye, Bohême, Catalogne, Crète et Dalmatie, Guipuscoa, Irlande, Livonie, Majorque, Ostfrise, Poméranie, Prusse, Raguse ; « Tutte le famiglie che nel 1637 godono la nobiltà di Catania, raccolte da don Alberto Palizzi. » Impr. Palerme, Alfonso dell'Isola, 1638, placard [blasons gravés] ; « Quinta parte de' Lustri Ravennati, a P. D. Seraphino Pasolino, abbate congregationis [canonicorum regularium Lateranensium]... » Impr. S. l. n. d., [1684], in-4°, p. 215-239 [blasons gravés]

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Contient : « Remarques sur l'ouvrage du P. D. Jacques Le Clerc, composé en 1665, et intitulé Méthode facile et accomplie pour apprendre le chant de l'Église sans l'aide d'aucune gamme » ; c'est le traité dont une copie est contenue dans le ms. français 20001, fol. 1-26, et qui se trouve en plusieurs états dans le ms. français 19103, cf. infra ; Lettre de D. « Anselme Thevart » à D. Benoît de Jumilhac, 1667, orig ; Minute d'une lettre de D. Jacques Le Clerc, incomplète ; « Remarques sur les méthodes du chant de l'Église, aoust 1666 » ; « Deux méthodes pour apprendre le plein chant » ; Traités et fragments de traités de musique, de métrique et d'hymnologie, de la main de D. Jacques LE CLERC ; Fragments imprimés d'hymnologie, avec annotations de D. Jacques Le Clerc, petit in-8°, 5 feuillets

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Contient : 1 « Histoire de l'origine de la Ligue. Adoraverunt draconem, qui dedit potestatem bestiae... J'ecri ce que j'ai veu et seu, et dont j'ai fait quelque part... » ; 2 « Apologie pour messieurs de la maizon de Guize. Livre premier, qui traite en general de la calomnie, comme naturelle aus heretiques. Le commencement ne se trouve point. Sont toutes bourdes et impostures... » ; 3 « Rana lemanica. Est ranarum quoddam genus, pusillum quidem, sed procax... ». En latin ; 4 « Disceptatio an sit honestum sorori, religionem catholicam profitenti, lugere fratrem haereticum et lugubria sumere. Certum est apud omnes fere gentes... ». En latin ; 5 « Ludovicus d'Orleans, de suo exilio. Monsieur d'Orleans, dans l'ennuieus sejour de son exil, a ramassé les passages suivans... ». En latin ; 6 « Lettres » : pages 183 à 185, « au roi Henry IV, roi de France et de Navarre, pour le sieur de Rosieux,... Sire, qui considere vos victoires, il voit tout ce que... » ; page 187, « lettre de consolation à une dame. Madame, je regrette que le temps me soit si court... » ; pages 189 et 190, « lettre à une dame, lui renvoiant son livre et des vers sur la pudicité. Mademoizelle, je vous rend votre livre et delivre ma foi et mon obligation... »; pages 193 à 195, « C. V. domino Lopez, regalium magistro et caet. Facio interdum, V. C. quod caupones solent... », en latin; pages 197 à 199, « illustrissimo cardinali Alexandrino L. D'Orleans S. P. D. Quid tibi debeam, cardinalis illustrissime, et quantum tibi debeant filii mei... », en latin ; 7 « Des titres de chrestien et de catolique. L'Eglise est une vierge, belle dessus toutes les belles, chaste sur toutes les chastes... » ; 8 « Sedition des heretiques contre le pere Esmond, jesuite. Le pere Esmond, jezuite, comme il préchoit à Vienne en Dauphiné... » ; 9 « Maximes de pais et de guerre. Tant les vaincus que les vainqueurs doivent recourir à la pais... » ; 10 « Diverses remarques belles et curieuzes. Reparation d'honeur faite à la cour de parlement. Arrest donné contre monseigneur d'Espernon, pour quelques paroles dites mal à propos contre aucuns de la cour de parlement. La cour, par l'expres comandement du roi... » ; 11 « La vie de Huniades, roi de Hongrie. En la divizion de cet admirable empire romain, souz les enfans du grand Theodoze,... » ; 12 « D. Maeiero jurisconsulto et poetae. Non ego te Aonias per Belgica rura sorores... ». En latin. 22 vers

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This paper addresses the question of whether p-hydroxybenzoic acid, the common metabolite of parabens, possesses oestrogenic activity in human breast cancer cell lines. The alkyl esters of p-hydroxybenzoic acid (parabens) are used widely as preservatives in consumer products to which the human population is exposed and have been shown previously to possess oestrogenic activity and to be present in human breast tumour tissue, which is an oestrogen-responsive tissue. Recent work has shown p-hydroxybenzoic acid to give an oestrogenic response in the rodent uterotrophic assay. We report here that p-hydroxybenzoic acid possesses oestrogenic activity in a panel of assays in human breast cancer cell lines. p-Hydroxybenzoic acid was able to displace [H-3]oestradiol from cytosolic oestrogen receptor of MCF7 human breast cancer cells by 54% at 5 x 10(6)-fold molar excess and by 99% at 10(7)-fold molar excess. It was able to increase the expression of a stably integrated oestrogen responsive reporter gene (ERE-CAT) at a concentration of 5 x 10(-4) M in MCF7 cells after 24 h and 7 days, which could be inhibited by the anti-oestrogen ICI 182 780 (Faslodex, fulvestrant). Proliferation of two human breast cancer cell lines (MCF7, ZR-75-1) could be increased by 10(-5) M p-hydroxybenzoic acid. Following on from previous studies showing a decrease in oestrogenic activity of parabens with shortening of the linear alkyl chain length, this study has compared the oestrogenic activity of p-hydroxybenzoic acid where the alkyl grouping is no longer present with methylparaben, which has the shortest alkyl group. Intrinsic oestrogenic activity of p-hydroxybenzoic acid was similar to that of methylparaben in terms of relative binding to the oestrogen receptor but its oestrogenic activity on gene expression and cell proliferation was lower than that of methylparaben. It can be concluded that removal of the ester group from parabens does not abrogate its oestrogenic activity and that p-hydroxybenzoic acid can give oestrogenic responses in human breast cancer cells. Copyright (C) 2005 John Wiley & Sons, Ltd.

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Human breast cancer cells (MCF-7, T-47-D and ZR-75-1) can adapt to circumvent any reduced growth rate during long-term oestrogen deprivation, and this provides three model systems to investigate mechanisms of endocrine resistance in breast cancer. In this paper we report consistent differences in the effects of three growth inhibitors following long-term oestrogen deprivation in all three cell models. Long-term oestrogen deprivation of MCF-7, T-47-D and ZR-75-1 cells resulted in reduced growth inhibition by PD98059 (2–10 µg/ml), implying a loss of dependence on mitogen-activated protein kinase pathways for growth. The growth inhibitor LY294002 (2–10 µM) inhibited growth of both oestrogen-maintained and oestrogen-deprived cells with similar dose–responses, implying continued similar dependence on phosphoinositide 3-kinase (PI3K) pathways with no alteration after adaptation to oestrogen independent growth. However, by contrast, long-term oestrogen deprivation resulted in an increased sensitivity to growth inhibition by rapamycin, which was not reduced by readdition of oestradiol. The enhanced inhibition of long-term oestrogen-deprived MCF-7-ED, T-47-D-ED and ZR-75-1-ED cell growth by combining rapamycin with LY294002 at concentrations where each alone had little effect, offers preclinical support to the development of therapeutic combinations of rapamycin analogues with other PI3K inhibitors in endocrine-resistant breast cancer.

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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We present measurements of the process p (P) over bar -> WZ + X -> l 'nu(l ')l (l) over bar at root s = 1:96 TeV,where l and l ' are electrons or muons. Using 1 fb(-1) of data from the D0 experiment, we observe 13 candidates with an expected background of 4.5 +/- 0.6 events and measure a cross section sigma(WZ) = 2.7(-1.3)(+1.7) pb. From the number of observed events and the Z boson transverse momentum distribution, we limit the trilinear WWZ gauge couplings to -0: 17 <= lambda(Z) <= 0.21 (Delta k(Z) <= 0.29(lambda(Z) = 0) at the 95% C.L. for a form factor scale Lambda = 2 TeV. Further, assuming that Delta g(1)(Z) = Delta k(Z), we find -0.12 <= Delta k(Z) <= 0.29(lambda(Z) = 0) at the 95% C. L. These are the most restrictive limits on the WWZ couplings available to date.