Magnetostratigraphic synthesis of ODP Leg 123 sites

During ODP Leg 123, Sites 765 and 766 were drilled to examine the tectonic evolution, sedimentary history, and paleoceanography of the Argo Abyssal Plain and lower Exmouth Plateau. At each site, the quality of magnetostratigraphic and biostratigraphic records varies because of complicating factors, such as the predominance of turbidites, the presence of condensed horizons, or deposition beneath the CCD. Based primarily on the presence of nannofossils, the base of the sedimentary section at Site 765 was dated as Tithonian. A complete Cretaceous sequence was recovered at this site, although the sedimentation rate varies markedly through the section. The Cretaceous/Tertiary boundary is represented by a condensed horizon. The condensed Cenozoic sequence at Site 765 extends from the upper Paleocene to the lower Miocene. A dramatic increase in sedimentation rate was observed in the lower Miocene, and a 480-m-thick Neogene section is present. The Neogene section is continuous, except for a minor hiatus in the lower Pliocene. The base of the sedimentary section at Site 766 is Valanginian, in agreement with the site's position on marine magnetic anomaly Mil. Valanginian to Barremian sediments are terrigenous, with variable preservation of microfossils, and younger sediments are pelagic, with abundant well-preserved microfossils. Sedimentation rate is highest in the Lower Cretaceous and decreases continually upsection. Upper Cenozoic sediments are condensed, with several hiatuses.

Polypharmacy and specific comorbidities in university primary care settings.

AIMS Polypharmacy is associated with adverse events and multimorbidity, but data are limited on its association with specific comorbidities in primary care settings. We measured the prevalence of polypharmacy and inappropriate prescribing, and assessed the association of polypharmacy with specific comorbidities. METHODS We did a cross-sectional analysis of 1002 patients aged 50-80years followed in Swiss university primary care settings. We defined polypharmacy as ≥5 long-term prescribed drugs and multimorbidity as ≥2 comorbidities. We used logistic mixed-effects regression to assess the association of polypharmacy with the number of comorbidities, multimorbidity, specific sets of comorbidities, potentially inappropriate prescribing (PIP) and potential prescribing omission (PPO). We used multilevel mixed-effects Poisson regression to assess the association of the number of drugs with the same parameters. RESULTS Patients (mean age 63.5years, 67.5% ≥2 comorbidities, 37.0% ≥5 drugs) had a mean of 3.9 (range 0-17) drugs. Age, BMI, multimorbidity, hypertension, diabetes mellitus, chronic kidney disease, and cardiovascular diseases were independently associated with polypharmacy. The association was particularly strong for hypertension (OR 8.49, 95%CI 5.25-13.73), multimorbidity (OR 6.14, 95%CI 4.16-9.08), and oldest age (75-80years: OR 4.73, 95%CI 2.46-9.10 vs.50-54years). The prevalence of PPO was 32.2% and PIP was more frequent among participants with polypharmacy (9.3% vs. 3.2%, p<0.006). CONCLUSIONS Polypharmacy is common in university primary care settings, is strongly associated with hypertension, diabetes mellitus, chronic kidney disease and cardiovascular diseases, and increases potentially inappropriate prescribing. Multimorbid patients should be included in further trials for developing adapted guidelines and avoiding inappropriate prescribing.

Thrombospondin-2: A potent endogenous inhibitor of tumor growth and angiogenesis

Recent evidence suggests a potential role for thrombospondin-2 (TSP-2), a matricellular glycoprotein, in the regulation of primary angiogenesis. To directly examine the biological effect of TSP-2 expression on tumor growth and angiogenesis, human A431 squamous cell carcinoma cells, which do not express TSP-2, were stably transfected with a murine TSP-2 expression vector or with vector alone. A431 cells expressing TSP-2 did not show an altered growth rate, colony-forming ability, or susceptibility to induction of apoptosis in vitro. However, injection of TSP-2-transfected clones into the dermis of nude mice resulted in pronounced inhibition of tumor growth that was significantly stronger than the inhibition observed in A431 clones stably transfected with a thrombospondin-1 (TSP-1) expression vector, and combined overexpression of TSP-1 and TSP-2 completely prevented tumor formation. Extensive areas of necrosis were observed in TSP-2-expressing tumors, and both the density and the size of tumor vessels were significantly reduced, although tumor cell expression of the major tumor angiogenesis factor, vascular endothelial growth factor, was maintained at high levels. These findings establish TSP-2 as a potent endogenous inhibitor of tumor growth and angiogenesis.

Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microglia

A recently identified chemokine, fractalkine, is a member of the chemokine gene family, which consists principally of secreted, proinflammatory molecules. Fractalkine is distinguished structurally by the presence of a CX3C motif as well as transmembrane spanning and mucin-like domains and shows atypical constitutive expression in a number of nonhematopoietic tissues, including brain. We undertook an extensive characterization of this chemokine and its receptor CX3CR1 in the brain to gain insights into use of chemokine-dependent systems in the central nervous system. Expression of fractalkine in rat brain was found to be widespread and localized principally to neurons. Recombinant rat CX3CR1, as expressed in Chinese hamster ovary cells, specifically bound fractalkine and signaled in the presence of either membrane-anchored or soluble forms of fractalkine protein. Fractalkine stimulated chemotaxis and elevated intracellular calcium levels of microglia; these responses were blocked by anti-CX3CR1 antibodies. After facial motor nerve axotomy, dramatic changes in the levels of CX3CR1 and fractalkine in the facial nucleus were evident. These included increases in the number and perineuronal location of CX3CR1-expressing microglia, decreased levels of motor neuron-expressed fractalkine mRNA, and an alteration in the forms of fractalkine protein expressed. These data describe mechanisms of cellular communication between neurons and microglia, involving fractalkine and CX3CR1, which occur in both normal and pathological states of the central nervous system.

Gestational drive and the green-bearded placenta.

A "green beard" refers to a gene, or group of genes, that is able to recognize itself in other individuals and direct benefits to these individuals. Green-beard effects have been dismissed as implausible by authors who have implicitly assumed sophisticated mechanisms of perception and complex behavioral responses. However, many simple mechanisms for genes to "recognize" themselves exist at the maternal-fetal interface of viviparous organisms. Homophilic cell adhesion molecules, for example, are able to interact with copies of themselves on other cells. Thus, the necessary components of a green-beard effect -- feature, recognition, and response -- can be different aspects of the phenotype of a single gene. Other green-beard effects could involve coalitions of genes at closely linked loci. In fact, any form of epistasis between a locus expressed in a mother and a closely linked locus expressed in the fetus has the property of "self-recognition." Green-beard effects have many formal similarities to systems of meiotic drive and, like them, can be a source of intragenomic conflict.

Revisão taxonômica e filogenia do gênero Megalobrachium Stimpson, 1858 (Crustacea: Decapoda: Anomura: Porcellanidae)

O presente trabalho trata do gênero de porcelanídeos Megalolobrachium Stimpson, 1858 e está organizado em três partes: (1) uma revisão taxonômica das espécies atualmente atribuídas a Megalobrachium Stimpson, 1858; (2) uma revisão da diversidade morfológica do gênero em um contexto maior dentro de Porcellanidae; e (3) uma análise cladística a partir de dados morfológicos com o intuito de testar o monofiletismo de Megalobrachium e propor a primeira hipótese filogenética para o gênero. A revisão taxonômica se baseou no estudo de material abundante de diferentes localidades do Pacífico oriental e Atlântico ocidental. Uma nova espécie de Megalobrachium é descrita com base no material das costas pacíficas do Panamá e Colômbia, totalizando 13 espécies em Megalobrachium. Para a análise filogenética, foram obtidos 151 caracteres; o grupo-externo foi composto por quatro espécies de três gêneros: Pachycheles Stimpson, 1858, Pisidia Leach, 1820, e Porcellana Lamarck, 1801. Uma única árvore (314 passos; IC: 64; IR: 80) foi obtida, com dois clados. O primeiro clado inclui espécies com lobos da fronte marcadamente flexionados, flagelo da antena curto, com artículos longos, patas ambulatórias curtas e robustas, abdome subtriangular em machos, pleópodo feminino iv com três segmentos, e urópodos curtos. O segundo clado contém espécies com lobos da fronte não flexionados, flagelo da antena longo, com artículos curtos, patas ambulatórias longas e delgadas, abdome sub-retangular, pleópodo feminino iv com dois segmentos, urópodos longos. O primeiro clado corresponde a Porcellanopsis Rathbun, 1910 (espécie-tipo P. festae (Nobili, 1901)), previamente tratado como sinônimo de Megalobrachium. Contudo, a combinação de diferenças morfológicas entre Megalobrachium e Porcellanopsis justifica a revalidação de Porcellanopsis. Três espécies foram erroneamente registradas no Pacífico oriental (M. mortenseni Haig, 1962, P. rosea (Rathbun, 1900) e P. soriata (Say, 1818)); essas espécies são exclusivamente distribuídas no Atlântico ocidental.

Foucault e a filosofia

Michel Foucault foi um leitor perseverante, embora sui generis, de Kant, e é essa apropriação que iremos analisar. Começaremos pela longa introdução que fez para a sua tradução de Anthropologie in pragmatischer Hinsicht, mostrando aí o insucesso da antropologia pragmática kantiana. Prosseguiremos com o estudo da Crítica kantiana em Les Mots et les Choses, condição que definiu a transição da episteme Clássica para a Moderna, autorizando no entanto, e simultaneamente, a constituição de uma nova metafísica fora das representações e constituindo uma filosofia obcecada pelo homem, ao reduzir o seu campo de saber às “empiricidades” da vida, da linguagem e do trabalho. Nietzsche virá em seu socorro oferecendo com o “desaparecimento do homem” a promessa do renascimento da filosofia. Finalmente, num terceiro ponto, pensaremos a maneira como Foucault se inscreve mais directamente na recepção kantiana, prolongando-a e renovando-a através do destaque que deu ao “diagnóstico da actualidade” e à “ontologia de nós mesmos”, em vez da “analítica da verdade”, bem como à axiologia da revolução; presentes nos textos que escreveu já na década de 80 sobre Was ist Aufklärung? e Der Streit der Facultäten, definindo aí muito da sua própria condição de pensador, público e privado.

Verkehr und Kommunikation

Die Vorlage zu Finanzierung und Ausbau der Bahninfrastruktur (FABI) wurde in der Volksabstimmung angenommen. - Die «Milchkuh-Initiative» kam zustande. - Beide Parlamentskammern sprachen sich für den Bau einer zweiten Gotthardröhre aus, das Referendum dagegen wurde ergriffen. - Das Parlament beschloss, den Zahlungsrahmen für die Förderung des alpenquerenden Schienengüterverkehrs um fünf Jahre zu verlängern. - Der Streit zwischen Frankreich und der Schweiz um die Besteuerung des Schweizer Sektors im Euroairport Basel-Mulhouse ging in eine neue Runde. - Die Swiss sah sich einer verschärften Konkurrenz ausgesetzt.

Three Armenian folk-tunes,

Mode of access: Internet.

Health through diet; a practical guide to the uric-acid-free diet, founded on eighteen years' personal experience

Mode of access: Internet.

Sporting sonnets and other verses /

Mode of access: Internet.

Aus dem Leben Theodor von Bernhardis.

Edition varies.