An address on normal schools of agriculture for Farmers' institute workers : delivered by Prof. John Hamilton, before the meeting of the Pennsylvania farmers' normal institute held at Bellefonte, Pa., Oct. 11-14, 1904.

Mode of access: Internet.

Memoirs of John Frederic Oberlin, pastor of Waldbach, in the Ban de la Roche.

Narrative attributed to Sarah Atkins.

An address to the Phi Beta Kappa Society of Brown University. Delivered 5th September, 1832.

Mode of access: Internet.

Sermons and occasional services, selected from the papers of the late, Rev. John Hincks, with a memoir of the author,

"Memoir", pp. ix-xxvi.

Particulars of two concerts to be performed at the town hall, Beaumaris, August 28 and 30, 1832, under the auspices of the Cymmrodorion in Gwynedd. President, Sir R.B. Williams, Bulkeley; Conductor, John Parry.

Mode of access: Internet.

Voyage of the United States frigate Potomac : under the command of Commodore John Downes, during the circumnavigation of the globe, in the years 1831, 1832, 1833, and 1834; including a particular account of the engagement at Quallah-Battoo, on the coast of Sumatra; with all the official documents relating to the same /

Mode of access: Internet.

Voyage of the United States frigate Potomac, under the command of Commodore John Downes, during the circumnavigation of the globe, in the years 1831, 1832, 1833, and 1834.

Microfilm. Ann Arbor, Mich., University Microfilms [n.d.] (American culture series, Reel 352.6)

Proceedings of the general court martial convened for the trial of Commodore James Barron, Captain Charles Gordon, Mr. William Hook, and Captain John Hall, of the United States' ship Chesapeake, in the month of January, 1808 /

Mode of access: Internet.

John Osawatomie Brown der Negerheiland : Festschrift zur ersten Säkularfeier der Vereinigten Staaten von Nord-Amerika /

With: Schwarze Kabinette / Emil König -- Skizzen und Studien zur französischen Revolutions-Geschichte / von Karl Brunnemann.

Blockade of vascular smooth muscle cell proliferation and intimal thickening after balloon injury by the sulfated oligosaccharide PI-88: Phosphomannopentaose sulfate directly binds FGF-2, blocks cellular signaling, and inhibits proliferation

Percutaneous transluminal coronary angioplasty is a frequently used interventional technique to reopen arteries that have narrowed because of atherosclerosis. Restenosis, or renarrowing of the artery shortly after angioplasty, is a major limitation to the success of the procedure and is due mainly to smooth muscle cell accumulation in the artery wall at the site of balloon injury. In the present study, we demonstrate that the antiangiogenic sulfated oligosaccharide, PI-88, inhibits primary vascular smooth muscle cell proliferation and reduces intimal thickening 14 days after balloon angioplasty of rat and rabbit arteries. PI-88 reduced heparan sulfate content in the injured artery wall and prevented change in smooth muscle phenotype. However, the mechanism of PI-88 inhibition was not merely confined to the antiheparanase activity of this compound. PI-88 blocked extracellular signal-regulated kinase-1/2 (ERK1/2) activity within minutes of smooth muscle cell injury. It facilitated FGF-2 release from uninjured smooth muscle cells in vitro, and super-released FGF-2 after injury while inhibiting ERK1/2 activation. PI-88 inhibited the decrease in levels of FGF-2 protein in the rat artery wall within 8 minutes of injury. PI-88 also blocked injury-inducible ERK phosphorylation, without altering the clotting time in these animals. Optical biosensor studies revealed that PI-88 potently inhibited (K-i 10.3 nmol/L) the interaction of FGF-2 with heparan sulfate. These findings show for the first time the capacity of this sulfated oligosaccharide to directly bind FGF-2, block cellular signaling and proliferation in vitro, and inhibit injury-induced smooth muscle cell hyperplasia in two animal models. As such, this study demonstrates a new role for PI-88 as an inhibitor of intimal thickening after balloon angioplasty. The full text of this article is available online at http://www.circresaha.org.

O modelo gerencial da educa????o: contribui????es da experi??ncia da Inglaterra ao debate brasileiro

A gest??o do ensino b??sico na Inglaterra enfrentava fortes cr??ticas desde a d??cada de 1970. Havia uma s??rie de d??vidas sobre a capacidade de o modelo ingl??s proporcionar educa????o p??blica de qualidade, capaz de sustentar a competitividade econ??mica do pa??s. O modelo educacional neste per??odo era pouco suscet??vel ?? presta????o de contas no que se refere ?? qualidade, era majoritariamente analisado em termos dos montantes de recursos destinados ?? educa????o e excessivamente pautado pela autonomia pedag??gica dos professores. Desde 1988, com a publica????o do Education Reform Act (ERA), o sistema de educa????o b??sica na Inglaterra passou por uma reengenharia. O artigo tem por objetivo analisar as principais inova????es implementadas e seus desdobramentos ao longo dos governos conservadores de Margareth Thatcher (1979 ??? 1990) e John Major (1990 ??? 1997), e dos governos trabalhistas de Tony Blair (1997 ??? 2007) e Gordon Brown (2007 ??? 2010). A relev??ncia do tema est?? na discuss??o de uma das reformas educacionais mais influentes no mundo e na produ????o de insights sobre a tem??tica de administra????o da educa????o no Brasil.