PM2.5, PM10, and PM10-associated elements in the air in Bamako, Mali (2012-2013)

Saharan dust incursions and particulates emitted from human activities degrade air quality throughout West Africa, especially in the rapidly expanding urban centers in the region. Particulate matter (PM) that can be inhaled is strongly associated with increased incidence of and mortality from cardiovascular and respiratory diseases and cancer. Air samples collected in the capital of a Saharan-Sahelian country (Bamako, Mali) between September 2012 - July 2013 were found to contain inhalable PM concentrations that exceeded World Health Organization (WHO) and US Environmental Protection Agency (USEPA) PM2.5 and PM10 24-h limits 58 - 98% of days and European Union (EU) PM10 24-h limit 98% of days. Mean concentrations were 1.2-to-4.5 fold greater than existing limits. Inhalable PM was enriched in transition metals, known to produce reactive oxygen species and initiate the inflammatory reaction, and other potentially bioactive and biotoxic metals/metalloids. Eroded mineral dust composed the bulk of inhalable PM, whereas most enriched metals/metalloids were likely emitted from oil combustion, biomass burning, refuse incineration, vehicle traffic, and mining activities. Human exposure to inhalable PM and associated metals/metalloids over 24-h was estimated. The findings indicate that inhalable PM in the Sahara-Sahel region may present a threat to human health, especially in urban areas with greater inhalable PM and transition metal exposure.

Inherited structural controls on fault geometry, architecture and hydrothermal activity: an example from Grimsel Pass, Switzerland

Exhumed faults hosting hydrothermal systems provide direct insight into relationships between faulting and fluid flow, which in turn are valuable for making hydrogeological predictions in blind settings. The Grimsel Breccia Fault (Aar massif, Central Swiss Alps) is a late Neogene, exhumed dextral strike-slip fault with a maximum displacement of 25–45 m, and is associated with both fossil and active hydrothermal circulation. We mapped the fault system and modelled it in three dimensions, using the distinctive hydrothermal mineralisation as well as active thermal fluid discharge (the highest elevation documented in the Alps) to reveal the structural controls on fluid pathway extent and morphology. With progressive uplift and cooling, brittle deformation inherited the mylonitic shear zone network at Grimsel Pass; preconditioning fault geometry into segmented brittle reactivations of ductile shear zones and brittle inter-shear zone linkages. We describe ‘pipe’-like, vertically oriented fluid pathways: (1) within brittle fault linkage zones and (2) through alongstrike- restricted segments of formerly ductile shear zones reactivated by brittle deformation. In both cases, low-permeability mylonitic shear zones that escaped brittle reactivation provide important hydraulic seals. These observations show that fluid flow along brittle fault planes is not planar, but rather highly channelised into sub-vertical flow domains, with important implications for the exploration and exploitation of geothermal energy.

Trade, Foreign Investment and Myanmar's Economic Development during the Transition to an Open Economy

Throughout the 1990s and up to 2005, the adoption of an open-door policy substantially increased the volume of Myanmar's external trade. Imports grew more rapidly than exports in the 1990s owing to the release of pent-up consumer demand during the transition to a market economy. Accordingly, trade deficits expanded. Confronted by a shortage of foreign currency, the government after the late 1990s resorted to rigid controls over the private sector's trade activities. Despite this tightening of policy, Myanmar's external sector has improved since 2000 largely because of the emergence of new export commodities, namely garments and natural gas. Foreign direct investments in Myanmar significantly contributed to the exploration and development of new gas fields. As trade volume grew, Myanmar strengthened its trade relations with neighboring countries such as China, Thailand and India. Although the development of external trade and foreign investment inflows exerted a considerable impact on the Myanmar economy, the external sector has not yet begun to function as a vigorous engine for broad-based and sustainable development.

La Planificación de Áreas Mineras en Declive : Una respuesta multidimensional = Planning Declining Mining Areas. A multidimensional response

La actividad minera tiene un gran impacto sobre el territorio, probablemente más que ninguna otra de las actividades humanas, ya que transforma el espacio en todas sus dimensiones: ecológica, ambiental, social y económica. Cuando la reducción de la rentabilidad de la explotación conduce al cierre de ésta, la repercusión sobre su entorno puede llegar a ser brutal. Pero las explotaciones mineras son muy distintas entre ellas y los efectos que su abandono producen sobre el espacio en la que se enclavan pueden ser diversos, por lo que la decisión sobre el futuro de estas áreas no es simple y evidente. Aquí se propone desarrollar una propuesta de clasificación tipológica de las minas y sus regiones con el objetivo de determinar las estrategias de intervención más adecuadas para el futuro de estos espacios y sus habitantes. En concreto se busca diferenciar los conceptos de Mina, Parque Minero, Espacio Minero y Región Minera, todos ellos fruto de la interacción de la huella de la actividad minera con el medio físico, los enclaves urbanizados, y la estructura socioeconómica de la región en la que se enclavan. Mining activity is having a great impact on the territory, probably more than any other human activity, which transforms the space in all of its dimensions, ecological, environmental, social and economic. When reducing the profitability of the operation leads to the conclusion thereof, the impact on the environment can be brutal. But mining are very different between them and the effects they produce on their abandonment in space that interlock can be diverse, so the decision on the future of these areas is not simple and obvious. This proposal aims to develop a typological classification of mines and their regions in order to determine the most appropriate intervention strategies for the future of these spaces and their inhabitants. Specifically, it seeks to differentiate the concepts of Mine, Mining Park, Space Miner and Mining Region, all the result of the interaction of the mining footprint with the physical environment, the urbanized enclaves, and the socio-economic structure of the region which interlock. El presente libro reúne las ponencias presentadas por los investigadores de la red REUSE dentro del 1er Simposio de Reutilización del Espacio Minero; evento organizado por la Universidad Federal de Minas Gerais (UFMG) en Belo Horizonte, entre el 1 y el 3 de octubre de 2012, en el marco del 1er Seminario Internacional de Reconversión de Territorios. La red REUSE es una red realizada gracias a la financiación del programa CYTED

Exploring the active site of chorismate mutase by combinatorial mutagenesis and selection: the importance of electrostatic catalysis.

Chorismate mutase (EC 5.4.99.5) catalyzes the intramolecular rearrangement of chorismate to prephenate. Arg-90 in the active site of the enzyme from Bacillus subtilis is in close proximity to the substrate's ether oxygen and may contribute to efficient catalysis by stabilizing the presumed dipolar transition state that would result upon scission of the C--O bond. To test this idea, we have developed a novel complementation system for chorismate mutase activity in Escherichia coli by reengineering parts of the aromatic amino acid biosynthetic pathway. The codon for Arg-90 was randomized, alone and in combination with that for Cys-88, and active clones were selected. The results show that a positively charged residue either at position 88 (Lys) or 90 (Arg or Lys) is essential. Our data provide strong support for the hypothesis that the positive charge is required for stabilization of the transition state of the enzymatic chorismate rearrangement. The new selection system, in conjunction with combinatorial mutagenesis, renders the mechanism of the natural enzyme(s) accessible to further exploration and opens avenues for the improvement of first generation catalytic antibodies with chorismate mutase activity.

Fail-Safe Testing of Web Applications

This dissertation introduces an approach to generate tests to test fail-safe behavior for web applications. We apply the approach to a commercial web application. We build models for both behavioral and mitigation requirements. We create mitigation tests from an existing functional black box test suite by determining failure type and points of failure in the test suite and weaving required mitigation based on weaving rules to generate a test suite that tests proper mitigation of failures. A genetic algorithm (GA) is used to determine points of failure and type of failure that needs to be tested. Mitigation test paths are woven into the behavioral test at the point of failure based on failure specific weaving rules. A simulator was developed to evaluate choice of parameters for the genetic algorithm. We showed how to tune the fitness function and performed tuning experiments for GA to determine what values to use for exploration weight and prospecting weight. We found that higher defect densities make prospecting and mining more successful, while lower mitigation defect densities need more exploration. We compare efficiency and effectiveness of the approach. First, the GA approach is compared to random selection. The results show that the GA performance was better than random selection and that the approach was robust when the search space increased. Second, we compare the GA against four coverage criteria. The results of comparison show that test requirements generated by a genetic algorithm (GA) are more efficient than three of the four coverage criteria for large search spaces. They are equally effective. For small search spaces, the genetic algorithm is less effective than three of the four coverage criteria. The fourth coverage criteria is too weak and unable to find all defects in almost all cases. We also present a large case study of a mortgage system at one of our industrial partners and show how we formalize the approach. We evaluate the use of a GA to create test requirements. The evaluation includes choice of initial population, multiplicity of runs and a discussion of the cost of evaluating fitness. Finally, we build a selective regression testing approach based on types of changes (add, delete, or modify) that could occur in the behavioral model, the fault model, the mitigation models, the weaving rules, and the state-event matrix. We provide a systematic method by showing the formalization steps for each type of change to the various models.

Geothermal Electricity Generation in Colorado: Actual and Perceived Obstacles to Greater Implementation

The objective of this paper is to provide an analysis of the potential and obstacles to the development of geothermal energy resources in Colorado. Geothermal energy is the only renewable resource that can provide base-load electricity. While Colorado has significant geothermal energy potential, there are no such power plants. Layers of federal and state laws and regulations represent one barrier to further geothermal development. Transmission constraints represent another major barrier. High exploration and construction costs along with high-risk profiles for geothermal projects form another major barrier. Perceived barriers such as misunderstanding the impacts, risks, and benefits of geothermal energy hinder further development. Recommendations are provided to help overcome these obstacles.

Advanced interpretation of subsidence in Murcia (SE Spain) using A-DInSAR data – modelling and validation

Subsidence is a natural hazard that affects wide areas in the world causing important economic costs annually. This phenomenon has occurred in the metropolitan area of Murcia City (SE Spain) as a result of groundwater overexploitation. In this work aquifer system subsidence is investigated using an advanced differential SAR interferometry remote sensing technique (A-DInSAR) called Stable Point Network (SPN). The SPN derived displacement results, mainly the velocity displacement maps and the time series of the displacement, reveal that in the period 2004–2008 the rate of subsidence in Murcia metropolitan area doubled with respect to the previous period from 1995 to 2005. The acceleration of the deformation phenomenon is explained by the drought period started in 2006. The comparison of the temporal evolution of the displacements measured with the extensometers and the SPN technique shows an average absolute error of 3.9±3.8 mm. Finally, results from a finite element model developed to simulate the recorded time history subsidence from known water table height changes compares well with the SPN displacement time series estimations. This result demonstrates the potential of A-DInSAR techniques to validate subsidence prediction models as an alternative to using instrumental ground based techniques for validation.

Forensic analysis of buildings affected by mining subsidence based on Differential Interferometry (Part III)

This work presents a forensic analysis of buildings affected by mining subsidence, which is based on deformation data obtained by Differential Interferometry (DInSAR). The proposed test site is La Union village (Murcia, SE Spain) where subsidence was triggered in an industrial area due to the collapse of abandoned underground mining labours occurred in 1998. In the first part of this work the study area was introduced, describing the spatial and temporal evolution of ground subsidence, through the elaboration of a cracks map on the buildings located within the affected area. In the second part, the evolution of the most significant cracks found in the most damaged buildings was monitored using biaxial extensometric units and inclinometers. This article describes the work performed in the third part, where DInSAR processing of satellite radar data, available between 1998 and 2008, has permitted to determine the spatial and temporal evolution of the deformation of all the buildings of the study area in a period when no continuous in situ instrumental data is available. Additionally, the comparison of these results with the forensic data gathered in the 2005–2008 period, reveal that there is a coincidence between damaged buildings, buildings where extensometers register significant movements of cracks, and buildings deformation estimated from radar data. As a result, it has been demonstrated that the integration of DInSAR data into forensic analysis methodologies contributes to improve significantly the assessment of the damages of buildings affected by mining subsidence.

Notebook on geography, navigation, mensuration, and other subjects, ca. 1723-1743

This heavily illustrated notebook contains entries on the following topics, among others: geography; mensuration; navigation and the history of navigation; "the use of Gunter's Scale in plain sailing;" compasses; quadrants and their use; "the refraction of the stars observed by the famous Tycho Brahe;" the latitude and longitude of coasts in America, Europe, and Africa; oceans and islands; mountains and "burning mountains" (volcanoes); rivers and lakes; forests and deserts; maps and sea charts; and the uses of geometry and other measurements by carpenters, joiners, painters, glaziers, masons, and bricklayers. Many pages contain navigational problems and their detailed solutions, as well as chronologies of global exploration and lists of all known rivers, mountains, and other geographic features across the world, many with vivid descriptions. The last pages of the notebook contain entries made in December of 1743 regarding celestial measurements Prince took in Stratford, Connecticut, where he was staying with his brother.

World Map Showing Geomagnetic Meridians and Parallels, 1849 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Wachsende Karte der Magnetischen Meridiane und Parallelen : Gegründet auf die Beobachtungen der Declination welche sämmtlich auf das Jahr 1825 reducirt worden sind, von dem Schiffs Kapitain L. I. Duperrey. It was published by Stablstich (diretion v. Kleinecht) aus der Schweinfurter Geographischen Graviranstalt de Bibliographischen Instituts in [1849]. Scale [ca. 1:190,000,000]. Map in German. The image inside the map neatline is georeferenced to the surface of the earth and fit to a non-standard 'Mercator' projection with the central meridian at 180 degrees west. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as geomagnetic meridians, parallels, and magnetic declination, selected cities and other human settlements, shoreline features, and more. This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection and the Harvard University Library as part of the Open Collections Program at Harvard University project: Organizing Our World: Sponsored Exploration and Scientific Discovery in the Modern Age. Maps selected for the project correspond to various expeditions and represent a range of regions, originators, ground condition dates, scales, and purposes.

Nares Strait region, Canada and Greenland, 1853 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Chart exhibiting the discoveries of the second American-Grinnell-Expedition in search of Sir John Franklin : unrevised from the original material and projected on the spot by E.K. Kane. It was published by Lith of J. Bien in [1855]. Scale [ca. 1:400,000]. Covers the Nares Strait region, Greenland and Canada. The image inside the map neatline is georeferenced to the surface of the earth and fit to the 'NAD 1983 CSRS UTM Zone 19 North' projection. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows coastal features such as drainage, islands, capes, bays, tides, lines of ice, camps, and more. Relief shown by hachures. This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection and the Harvard University Library as part of the Open Collections Program at Harvard University project: Organizing Our World: Sponsored Exploration and Scientific Discovery in the Modern Age. Maps selected for the project correspond to various expeditions and represent a range of regions, originators, ground condition dates, scales, and purposes.

Mexico, United States, and Surroundings, 1811 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Carte du Mexique : et des pays limitrophes situés au nord et à l'est, dressée d'après la grande cart de la Nouvelle Espagne de Mr. A. de Humbold et d'autres materiaux par J. B. Poirson ; gravé par Barriere et l'écriture par L Aubert. It was published by F. Schoell in 1811. Scale [ca. 1:8,000,000]. Map in French. Covers portion of North America, including the United States from the 42nd parallel south, Mexico, the Caribbean Islands east to Haiti, and portions of Guatamala, Belize, and Honduras. The image inside the map neatline is georeferenced to the surface of the earth and fit to the 'World Mercator' projection. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as drainage, cities, indian settlements and other human settlements, territorial boundaries, shoreline features, and more. Relief is shown by hachures. Includes historical notes. This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection and the Harvard University Library as part of the Open Collections Program at Harvard University project: Organizing Our World: Sponsored Exploration and Scientific Discovery in the Modern Age. Maps selected for the project correspond to various expeditions and represent a range of regions, originators, ground condition dates, scales, and purposes.

Pacific Coast of Mexico, Central America, and the Region Around the Galapagos Islands Showing Route of the Steamer Albatross, 1891 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Explorations of the U. S. Fish Commission steamer Albatross : Lieut. Comdr. Z. L. Tanner U.S.N. Comdg. : Februrary to April 1891. It was printed for the Museum of Comparative Zoology, Harvard University in 1892. Scale [ca. 1:7,500,000]. Covers the Pacific Coast of Mexico, Central America, and the region around the Galapagos Islands. The image inside the map neatline is georeferenced to the surface of the earth and fit to the 'Mercator' projection. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as drainage, human settlements, shoreline features, bays, harbors, islands, and more. Relief shown by soundings and bathymetric isolines and tints. Shows the route of the Agassiz-Albatross Cruise 1891. This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection and the Harvard University Library as part of the Open Collections Program at Harvard University project: Organizing Our World: Sponsored Exploration and Scientific Discovery in the Modern Age. Maps selected for the project correspond to various expeditions and represent a range of regions, originators, ground condition dates, scales, and purposes.

Peru and Bolivia, 1842 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Peru & Bolivia. It was published by J. Arrowsmith 15 Febr. 1842. Scale [ca. 1:5,000,000]. Covers also parts of surrounding countries.The image inside the map neatline is georeferenced to the surface of the earth and fit to a non-standard 'World Sinusoidal' projection with the central meridian at 70.000000 degrees west. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as drainage, cities and other human settlements, territorial boundaries, shoreline features, and more. Relief is shown by hachures. This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection and the Harvard University Library as part of the Open Collections Program at Harvard University project: Organizing Our World: Sponsored Exploration and Scientific Discovery in the Modern Age. Maps selected for the project correspond to various expeditions and represent a range of regions, originators, ground condition dates, scales, and purposes.