PIP-DB:the protein isoelectric point database

A protein's isoelectric point or pI corresponds to the solution pH at which its net surface charge is zero. Since the early days of solution biochemistry, the pI has been recorded and reported, and thus literature reports of pI abound. The Protein Isoelectric Point database (PIP-DB) has collected and collated these data to provide an increasingly comprehensive database for comparison and benchmarking purposes. A web application has been developed to warehouse this database and provide public access to this unique resource. PIP-DB is a web-enabled SQL database with an HTML GUI front-end. PIP-DB is fully searchable across a range of properties.

A New Charging and Billing Model and Architecture for the Ubiquitous Consumer Wireless World

In a Ubiquitous Consumer Wireless World (UCWW) environment the provision, administration and management of the authentication, authorization and accounting (AAA) policies and business services are provided by third-party AAA service providers (3P-AAA-SPs) who are independent of the wireless access network providers (ANPs). In this environment the consumer can freely choose any suitable ANP, based on his/her own preferences. This new AAA infrastructural arrangement necessitates assessing the impact and re-thinking the design, structure and location of ‘charging and billing’ (C&B) functions and services. This paper addresses C&B issues in UCWW, proposing potential architectural solutions for C&B realization. Implementation approaches of these novel solutions together with a software testbed for validation and performance evaluation are addressed.

Black churchgoers, environmental activism, and the preservation of nature in Miami, Florida

The goal of this project was to explore activism, attitudes, and imagery connecting Black churchgoers in Miami, Florida and the natural environment. The research approach was qualitative, began as exploratory research, and used the techniques of snowball sampling, participant observation, and semi-structured interviews. Three case studies representing various socio-economic levels, denominations, participant education levels, and environmental facets were chosen for in-depth ethnographic research. There are three major findings in the research. First, there is a link between the preservation of Black history and the preservation of the environment among Black churchgoers, who feel strong connections to a sense of place, rural life, and the past. However their work is strongly directed to bring about benefits for people and the environment in the present and the future. Second, public access to public lands is a basic and important right espoused by these Black churchgoing activists. Third, the vocabulary used by Black churchgoing activists regarding the natural environment differs from today's “mainstream” environmentalists. The concept of “beauty” is pivotal to Black appreciation of and activism toward the environment and is reminiscent of the early environmental protection movement in the United States and conservationists such as John Muir. These findings concerning how Black spirituality relates to the environment adds to the sparse literature on the subject, and provides for potential linkages between Blacks and “mainstream” environmental groups to benefit both parties. An understanding of the connections between Black spirituality and perceptions of the environment should facilitate the development of better programs to improve and protect the environment. Environmental projects may also address the social and economic needs of Black communities, churches, and congregations, as well as the ecosystem. ^

HomeBank: An Online Repository of Daylong Child-Centered Audio Recordings.

HomeBank is introduced here. It is a public, permanent, extensible, online database of daylong audio recorded in naturalistic environments. HomeBank serves two primary purposes. First, it is a repository for raw audio and associated files: one database requires special permissions, and another redacted database allows unrestricted public access. Associated files include metadata such as participant demographics and clinical diagnostics, automated annotations, and human-generated transcriptions and annotations. Many recordings use the child-perspective LENA recorders (LENA Research Foundation, Boulder, Colorado, United States), but various recordings and metadata can be accommodated. The HomeBank database can have both vetted and unvetted recordings, with different levels of accessibility. Additionally, HomeBank is an open repository for processing and analysis tools for HomeBank or similar data sets. HomeBank is flexible for users and contributors, making primary data available to researchers, especially those in child development, linguistics, and audio engineering. HomeBank facilitates researchers' access to large-scale data and tools, linking the acoustic, auditory, and linguistic characteristics of children's environments with a variety of variables including socioeconomic status, family characteristics, language trajectories, and disorders. Automated processing applied to daylong home audio recordings is now becoming widely used in early intervention initiatives, helping parents to provide richer speech input to at-risk children.

Narratives Around Iberian Culture at Valencia Museums and Archaeological Sites: From Official Discourses to Social Perceptions

Museums and archaeological sites are considered the most authoritative places for talking about the past and the heritage from a scientific perspective. In fact, visitors assume their discourses as reliable and indisputable. In spite of that, professionals of archaeology must critically analyse the production of narratives at heritage sites, since they often reflect social, political and identity issues related to the present-day realities. The aim of this paper is to study official and popular discourses about the Iberian culture (Iron Age) collected in museums and archaeological sites from Valencia region.

Photography, copyright, and the South Kensington experiment

Reviews the development of UK copyright law in the 19th century concerning photographs of works of art in public collections. Discusses the project at South Kensington Museum to sell photographs of works of art to the public at cost price, and the introduction of copyright protection for original photographs under the Fine Arts Copyright Act 1862. Considers the parliamentary debates on whether photography was worthy of copyright protection. Examines whether lessons should be learned now that digital technology offers the opportunity to improve public access to works of art.

Développement d’un indice du potentiel TOD pour l’agglomération de Montréal

Résumé : Les aménagements axés sur le transport en commun (transit-oriented development ou TOD) reposent sur la création de développements résidentiels à proximité d’un nœud de transport existant. Dans le cadre de cet essai, on cherche plutôt à identifier les quartiers existants de Montréal possédant déjà les caractéristiques propices à l’aménagement d’un TOD, mais mal desservis par les transports en commun. En s’inspirant d’une étude menée aux Pays-Bas, on a eu recours à une analyse spatiale multicritères afin de concevoir un «indice du potentiel TOD», comportant quatre critères jugés essentiels, soit : la densité d’habitants, la mixité des utilisations du sol, la mixité sociale, ainsi que la distance aux transports. Malgré la difficulté d’intégrer l’ensemble des critères identifiés dans la littérature, les résultats révèlent un fort potentiel TOD sur le Plateau Mont-Royal, dans le Sud-Ouest, Hochelaga-Maisonneuve et plus particulièrement dans Anjou et Saint-Michel. On recommande notamment un secteur situé dans Saint-Michel, dont le potentiel TOD pourrait être enrichi par la création de plus fortes connexions au réseau de transports en commun.

Implementação de programas de educação ambiental nas escolas municipais de Curitiba, Paraná, Brasil

O presente trabalho pretende analisar a implementação dos programas de Educação Ambiental nas escolas de ensino fundamental, da Rede Municipal de Ensino Público, do Município de Curitiba, no estado do Paraná, Brasil. Esta análise tem por objeto de estudo as ações desenvolvidas pelas escolas, no que se refere às condições de saúde e bem-estar, a partir do que estabelecem os Parâmetros Curriculares Nacionais. Buscou-se compreender como os conteúdos definidos por ‘temas transversais' propiciam a constituição de um espaço de transformação em nível municipal. Este trabalho se constrói com base em discussões sobre o conhecimento produzido na área de Educação Ambiental e pelo levantamento de informações por meio de entrevistas e questionários junto aos profissionais ligados aos órgãos municipais responsáveis e às escolas. A análise realizada demonstrou que os projetos implementados vêm surtindo efeito positivo sobre as transformações dos pensamentos relativos às questões ambientais, sofrendo descontinuidades devido às mudanças nas gestões políticas. ABSTRACT; This study aims to analyze the implementation of the Environment Education Programs in the schools of the Municipal Public Education Network, in the City of Curitiba, in the state of Paraná, Brazil. The object study on this analysis is the actions developed by the schools, referring the conditions of health and well-being, from what is established by the National Curricular Parameters. We try to understand how the contents defined for 'transversal subjects' can propitiate the constitution of a space of transformation in municipal level. This work is built on discussion about the knowledge produced in the area of Environment Education besides the survey of informations through interviews and questionnaires with professionals connected to the responsible offices and the schools. This analysis demonstrated that the implemented projects is causing positive effects on the transformations of the relative thoughts to the environment questions, come suffering discontinuities due to the changes in the managements politics. RESUMEN; Este proyecto tiene por objetivo examinar la implementación de los programas de educación ambiental en las escuelas de educación básica de la Red Municipal de Educación Pública, en la ciudad de Curitiba, Paraná, Brasil. El objeto de estudio de la análisis son las medidas adoptadas por las escuelas, con respecto a la salud y el bienestar, de acuerdo con lo establecido por los Parámetros Curriculares Nacionales. Tratamos de comprender como el contenido, tal como se define por "temas transversales" puede ofertar un espacio de transformación en el nivel municipal. Este trabajo se basa en los debates de los conocimientos producidos en el ámbito de la educación ambiental y por las informaciones planteadas a través de entrevistas y cuestionarios con los profesionales de los departamentos responsables y en las escuelas. El análisis mostró que los proyectos ejecutados han tenido efecto positiva en la transformación de ideas sobre cuestiones ambientales, sufriendo discontinuidades debidas a cambios en las gestiones políticas.

INTERNET EN LAS BIBLIOTECAS PÚBLICAS COSTARRICENSES: SU IMPORTANCIA PARA ACORTAR LA BRECHA DIGITAL

Al ser la biblioteca pública de acceso libre y gratuito, se constituye como uno de los medios de información y conocimiento que ofrece oportunidades a todos los miembros de la comunidad y desde donde se pueden hacer efectivos los derechos a la información, la educación, la cultura y la recreación.De acuerdo con la UNESCO, es responsabilidad de la bibliotecapública facilitar el acceso al conocimiento y a la información a través de Internet, y con ello lograr su desarrollo y evolución tecnológica.Actualmente, la biblioteca pública costarricense esta incursionando paulatinamente en el mundo de las TIC y está tratando de integrarse en la revolución digital para ofrecer servicios novedosos, de calidad y seguir siendo útiles para los ciudadanos (as), y a la vez, está procurando acortar la brecha digital de quienes tienen menos oportunidades.

O serviço de referência nas bibliotecas públicas em Portugal: modelo de desenvolvimento

O Serviço de Referência (SR), incorporando na sua organização, funcionamento e comunicação com o utilizador um conjunto de potencialidades proporcionadas pela tecnologia, assume um papel fundamental na luta contra a desigualdade e o analfabetismo digital, no fomento da literacia da informação e na criação de conhecimento. A percepção do valor e das fragilidades do SR nas bibliotecas públicas em Portugal levanta a questão sobre como contribuir para o seu desenvolvimento. A presente investigação, visando a construção de alicerces numa perspectiva de evolução, parte da análise de documentos orientadores internacionais da RUSA/ALA (Reference and User Services Association / American Library Association) e da IFLA (International Federation of Library Association) e da observação de características estruturais da Rede Nacional de Biblioteca Públicas (RNBP), para a concepção de soluções de desenvolvimento do SR a aplicar a esta realidade concreta. Seguindo um paradigma compreensivo indutivo, com uma orientação baseada na Grounded Theory, esta pesquisa privilegia o contexto da descoberta e a construção de uma teoria. No plano empírico cumpre uma complementaridade de técnicas qualitativas e quantitativas, com recurso a uma triangulação metodológica. O campo de análise abrange a totalidade das bibliotecas públicas portuguesas integradas na RNBP em Portugal. Visando aspectos funcionais e materiais, são analisados dados preexistentes e aplicadas técnicas de observação directa e inquérito por questionário. Visando aspectos sociais, são efectuadas seis entrevistas semi-estruturadas. Os resultados apontam para uma situação de estagnação das bibliotecas da RNBP e para um funcionamento não estruturado e informal do SR, na maioria dos casos em que se verifica a sua disponibilização. Fundamentada a necessidade de evolução, e do investimento que nele possa ser feito, é construído um modelo, seguindo uma estratégia por níveis, flexíveis e adaptáveis às necessidades e aos recursos de cada biblioteca, que visa o desenvolvimento incremental e congruente daquele serviço; Abstract: The Reference Service in public libraries in Portugal. Development model from international guidelines. Incorporating in its organization, procedures and communication with the users a set of tools brought by technology, Reference Service (RS) plays a key role in the struggle against inequality and digital illiteracy, promoting information literacy and creating knowledge. The perception of the value of RS and the weaknesses in public libraries in Portugal raise the question on how to contribute to its development. In order to build RS foundations on an evolutionary perspective, this research analyzes RUSA / ALA (Reference and User Services Association / American Library Association) and IFLA (International Federation of Library Association) international guidelines and the structural characteristics of the Portuguese National Public Library Network (RNBP), with the objective of creating a solution for the development of that service to be applied to this reality. Following an inductive comprehensive paradigm, with an orientation based on Grounded Theory, this research focuses on the context of discovery and the construction of a theory. Empirically it fulfils complementary qualitative and quantitative techniques, using a methodological triangulation. The field of analysis covers Portuguese public libraries integrating the RNBP. Aiming at functional and material aspects, direct observation techniques and a survey by questionnaire are applied. Targeting social aspects, six semistructured interviews are carried out. The results point to a situation of stagnation in the RNBP as well as the unstructured and informal performance of the SR, which justifies the need for evolution and investment. A model is constructed, following a strategy based on levels, flexible and adaptable to the needs and resources of each library, with the perspective of an incremental and consistent development of this service.

Gestão de listas de espera para cirurgia na rede hospitalar pública portuguesa : o sistema de informação dos programas de recuperação de listas de espera

Trabalho apresentado em CISTI 2016. 11.ª Conferência Ibérica de Sistemas e Tecnologias de Informação

The Case of the 35 Gigabyte Digital Record: OCR and Digital Workflows

This presentation was given at the Panhandle Library Access Network's (PLAN) Innovation Conference: Digitization- Preserving the Past for the Future Conference on August 14th, 2015. The presentation uses a specific collection of directories as a case study of the complications librarians and archivists face in digitizing older materials that may also be quite large, such as a directory. Prime OCR and Abbyy Fine Reader are discussed and their pros and cons covered. Troubleshooting and editing with Adobe Photoshop is also discussed.

Measuring Latency Variation in the Internet

We analyse two complementary datasets to quantify the latency variation experienced by internet end-users: (i) a large-scale active measurement dataset (from the Measurement Lab Network Diagnostic Tool) which shed light on long-term trends and regional differences; and (ii) passive measurement data from an access aggregation link which is used to analyse the edge links closest to the user. The analysis shows that variation in latency is both common and of significant magnitude, with two thirds of samples exceeding 100\,ms of variation. The variation is seen within single connections as well as between connections to the same client. The distribution of experienced latency variation is heavy-tailed, with the most affected clients seeing an order of magnitude larger variation than the least affected. In addition, there are large differences between regions, both within and between continents. Despite consistent improvements in throughput, most regions show no reduction in latency variation over time, and in one region it even increases. We examine load-induced queueing latency as a possible cause for the variation in latency and find that both datasets readily exhibit symptoms of queueing latency correlated with network load. Additionally, when this queueing latency does occur, it is of significant magnitude, more than 200\,ms in the median. This indicates that load-induced queueing contributes significantly to the overall latency variation.

Actividad física, imagen corporal y condiciones de vida. Un abordaje teórico desde los determinantes y la determinación social de la salud

El objetivo de este trabajo fue analizar la construcción social del conocimiento en Actividad física desde dos planteamientos teóricos de la salud centrando el análisis en la relación con la imagen corporal y las condiciones de vida. Se trata de un estudio teórico desde el análisis de contenido de corte narrativo de 98 artículos desarrollado en cinco etapas a través de: rastreo de documentos en bases de datos en el periodo 2000-2014, revisión de artículos, y análisis y hallazgos de significados, sentidos o contenidos. Como hallazgo importante se puede mencionar que en la literatura científica relacionada con la triada Actividad física-imagen corporal-condiciones de vida predomina la construcción del conocimiento a partir de modelos hegemónicos y dominantes que priorizan la intensidad, la frecuencia y el tiempo dedicado a la AF, la estandarización en la comparación de la apariencia física y la medición de elementos materiales en el modo de vivir de las personas, principalmente desde el abordaje de los determinantes sociales de la salud. Se concluye que es necesario revisar las poblaciones que incluyendo en los estudios al estar concentrados el conocimiento en solo unos grupos; así como se hace explícita la necesidad de revisar cuales son los aportes de la Educación Física y otras disciplinas (ciencias sociales) para una mayor comprensión teórica y práctica de la AF.

Análisis de los cambios epigenéticos en la metilación del DNA inducidos por la diabetes y sus posibles mecanismos

Los cambios epigenéticos son responsables de la aparición de muchas patologías humanas y sus causas son debido a factores ambientales como genéticos. Se ha descrito en enfermedades crónicas como la Diabetes Mellitus tipo 2 (T2DM) que se caracteriza por los estados de hiperglucemia y el incremento en el estrés oxidativo que conlleva a complicaciones micro y macro vasculares, asociado a una desmetilación global del genoma. Nuestra hipótesis corresponde a que los órganos diana son afectados por las alteraciones como la metilación e hidroximetilación como consecuencia del estrés oxidativo que luego repercuten en la persistencia de la enfermedad. Métodos: A partir de sangre periférica se analizaron los cambios globales en la metilación del DNA que son afectados por el estado metabólico de 60 individuos (40 pacientes, 20 controles sanos). Por técnicas de cuantificación se compararon los resultados obtenidos con los de la expresión de las enzimas involucradas. Por último, se realizó un estudio de microarreglos de metilación del DNA y de expresión obtenidos de la base de datos GEO para así comparar los resultados con nuestros datos experimentales. Resultados: Los pacientes diabéticos con pobre control metabólico presentaron mayores niveles de metilación que el grupo control y no se encontró alteración en las enzimas involucradas en este proceso. Los resultados fueron concordantes con el estudio de microarreglos. Conclusión: Los estudios experimentales y de microarreglos demostraron que la metilación es tejido específico y que existe una mayor oxidación en pacientes. Por ello proponemos una vía alterna de desmetilación no enzimática, basada en la oxidación directa de los grupos metilos generados por los estados oxidativos característicos de esta enfermedad.