Catalogue d'une collection de portraits et de quelques pièces historiques provenant du cabinet de M. A*** : seconde partie / [expert] Le Blanc

[Vente. Art. 1858-12-23 - 1858-12-24. Paris]

Notice d'une collection d'estampes, portraits et sujets sur l'histoire de France... dessins de madame Meyer... / [expert] Vignères

[Vente. Estampes. 1857-03-05. Paris]

Liver safety assessment: required data elements and best practices for data collection and standardization in clinical trials.

A workshop was convened to discuss best practices for the assessment of drug-induced liver injury (DILI) in clinical trials. In a breakout session, workshop attendees discussed necessary data elements and standards for the accurate measurement of DILI risk associated with new therapeutic agents in clinical trials. There was agreement that in order to achieve this goal the systematic acquisition of protocol-specified clinical measures and lab specimens from all study subjects is crucial. In addition, standard DILI terms that address the diverse clinical and pathologic signatures of DILI were considered essential. There was a strong consensus that clinical and lab analyses necessary for the evaluation of cases of acute liver injury should be consistent with the US Food and Drug Administration (FDA) guidance on pre-marketing risk assessment of DILI in clinical trials issued in 2009. A recommendation that liver injury case review and management be guided by clinicians with hepatologic expertise was made. Of note, there was agreement that emerging DILI signals should prompt the systematic collection of candidate pharmacogenomic, proteomic and/or metabonomic biomarkers from all study subjects. The use of emerging standardized clinical terminology, CRFs and graphic tools for data review to enable harmonization across clinical trials was strongly encouraged. Many of the recommendations made in the breakout session are in alignment with those made in the other parallel sessions on methodology to assess clinical liver safety data, causality assessment for suspected DILI, and liver safety assessment in special populations (hepatitis B, C, and oncology trials). Nonetheless, a few outstanding issues remain for future consideration.

Catalogue des tableaux modernes dont la vente aura lieu... le lundi 19 février 1872... : collection de feu le bon Michel de Trétaigne / [expert] Francis Petit

[Vente. Art. 1872-02-19. Paris]

Arqueología de la producción agrícola. Aplicación de técnicas de análisis estadístico y geocomputacional a un caso de estudio del IV-II milenio ANE en la Cuenca del Río Grande (Perú)

Muchas investigaciones arqueobotánicas, desde un enfoque cualitativo-descriptivo, limitan el propio campo de estudio a los análisis de presencia/ausencia y/o de frecuencia de taxones a partir de su recuento en los conjuntos vegetales. De esa manera, los datos proporcionados resultan ser inconcluyentes y no fiables para la reconstrucción del paleoambiente, la determinación de la dieta alimenticia y de la práctica económica realizada (recolección VS agricultura), y totalmente insuficientes para determinar los cambios históricos ocurridos en los procesos productivos. Por lo que concierne el Perú, desde los primeros estudios con referencia a restos vegetales recuperados en yacimientos arqueológicos, principalmente de la costa, se documenta el importante papel que han desarrollado las especies vegetales en la vida de las comunidades pre-hispánicas. No obstante la excepcional abundancia y óptima preservación de este tipo de material (botánico) en muchos de los yacimientos arqueológicos de esta región, gracias a las extremas condiciones climáticas y ambientales sobre todo de sus áridas zonas costeras, los estudios arqueobotánicos desarrollados hasta el momento son muy escasos y las limitaciones análiticas que presentan en su mayoría reflejan la poca importancia dada a las investigaciones arqueobotánicas. En el presente trabajo desarrollamos y aplicamos una metodología analítica de tipo cuantitativa para el estudio de los macrorestos vegetales procedentes de un yacimiento de la Costa sur del Perú. Con ello pretendemos obtener datos representativos y objetivos de los conjuntos analizados, cuyo procesado lleve a una exhaustiva y correcta interpretación de la información.

Catalogue of a remarkable collection of books in magnificent Modern bindings / formed by an amateur

[Vente (Livres). 1897-11-11. Londres]

Catalogue de la belle collection de tableaux anciens... appartenant à M. Barroilhet... / [expert] Ferdinand Laneuville

[Vente. Art. 1860-04-02 - 1860-04-03. Paris]

Catalogue de la riche collection de dessins anciens, composant le cabinet de M. A. Mouriau,... / [expert] Vignères

[Vente. Art. 1858-03-11 - 1858-03-12. Paris]

Comparisons of serum vitamin d levels, status, and determinants in populations with and without chronic kidney disease not requiring renal dialysis: a 24-hour urine collection population-based study.

OBJECTIVE: Vitamin D deficiency is frequent in the general population and might be even more prevalent among populations with kidney failure. We compared serum vitamin D levels, vitamin D insufficiency/deficiency status, and vitamin D level determinants in populations without chronic kidney disease (CKD) and with CKD not requiring renal dialysis. DESIGN AND METHODS: This was a cross-sectional, multicenter, population-based study conducted from 2010 to 2011. Participants were from 10 centers that represent the geographical and cultural diversity of the Swiss adult population (≥15 years old). INTERVENTION: CKD was defined using estimated glomerular filtration rate and 24-hour albuminuria. Serum vitamin D was measured by liquid chromatography-tandem mass spectrometry. Statistical procedures adapted for survey data were used. MAIN OUTCOME MEASURE: We compared 25-hydroxy-vitamin D (25(OH)D) levels and the prevalence of vitamin D insufficiency/deficiency (serum 25(OH)D < 30 ng/mL) in participants with and without CKD. We tested the interaction of CKD status with 6 a priori defined attributes (age, sex, body mass index, walking activity, serum albumin-corrected calcium, and altitude) on serum vitamin D level or insufficiency/deficiency status taking into account potential confounders. RESULTS: Overall, 11.8% (135 of 1,145) participants had CKD. The 25(OH)D adjusted means (95% confidence interval [CI]) were 23.1 (22.6-23.7) and 23.5 (21.7-25.3) ng/mL in participants without and with CKD, respectively (P = .70). Vitamin D insufficiency or deficiency was frequent among participants without and with CKD (75.3% [95% CI 69.3-81.5] and 69.1 [95% CI 53.9-86.1], P = .054). CKD status did not interact with major determinants of vitamin D, including age, sex, BMI, walking minutes, serum albumin-corrected calcium, or altitude for its effect on vitamin D status or levels. CONCLUSION: Vitamin D concentration and insufficiency/deficiency status are similar in people with or without CKD not requiring renal dialysis.

Identification and antifungal susceptibility of a large collection of yeast strains isolated in Tunisian hospitals.

Abstract In this study, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) was used as a rapid method to identify yeasts isolated from patients in Tunisian hospitals. When identification could not be exstablished with this procedure, sequencing of the internal transcribed spacer with 5.8S ribosomal DNA (rDNA) (ITS1-5.8S-ITS2) and D1/D2 domain of large-subunit (LSU rDNA) were employed as a molecular approach for species differentiation. Candida albicans was the dominant species (43.37% of all cases), followed by C. glabrata (16.55%), C. parapsilosis (13.23%), C. tropicalis (11.34%), C. dubliniensis (4.96%), and other species more rarely encountered in human diseases such as C. krusei, C. metapsilosis, C. lusitaniae, C. kefyr, C. palmioleophila, C. guilliermondii, C. intermedia, C. orthopsilosis, and C. utilis. In addition, other yeast species were obtained including Saccharomyces cerevisiae, Debaryomyces hansenii (anamorph known as C. famata), Hanseniaspora opuntiae, Kodamaea ohmeri, Pichia caribbica (anamorph known as C. fermentati), Trichosporon spp. and finally a novel yeast species, C. tunisiensis. The in vitro antifungal activities of fluconazole and voriconazole were determined by the agar disk diffusion test and Etest, while the susceptibility to additional antifungal agents was determined with the Sensititre YeastOne system. Our results showed low incidence of azole resistance in C. albicans (0.54%), C. tropicalis (2.08%) and C. glabrata (4.28%). In addition, caspofungin was active against most isolates of the collection with the exception of two K. ohmeri isolates. This is the first report to describe caspofungin resistant isolates of this yeast.