Algoritmo Genético aplicado al problema de programación en procesos tecnológicos de maquinado con ambiente Flow Shop

Debido a las limitaciones de las técnicas de optimización convencionales, en el siguiente trabajo se presenta una metaheurística basada en un algoritmo genético (AG), para resolver problemas de programación de tipo flow shop, con el objetivo de minimizar el tiempo de finalización de todos los trabajos, más conocido como makespan. Este problema, considerado de difícil solución, es típico de la optimización combinatoria y se presenta en talleres con tecnología de maquinado, donde existen máquinas-herramientas convencionales y se fabrican diferentes tipos de piezas que tienen en común una misma ruta tecnológica (orden del proceso). La solución propuesta se probó con problemas clásicos publicados por otros autores, obteniéndose resultados satisfactorios en cuanto a la calidad de las soluciones encontradas y el tiempo de cómputo empleado.

Algoritmo genético aplicado a la programación en talleres de maquinado

En este trabajo se utiliza la metaheurística nombrada algoritmo genético, para dos variantes típicas de problemas de planificación presentes en un taller de maquinado de piezas: las variantes flujo general y flujo regular, y se ha seleccionado la minimización del tiempo de finalización de todos los trabajos o camino máximo, como objetivo a optimizar en un plan de trabajo. Este problema es considerado de difícil solución y es típico de la optimización combinatoria. Los resultados demuestran la calidad de las soluciones encontradas en correspondencia con el tiempo de cómputo empleado, al ser comparados con problemas clásicos reportados por otros autores. La representación propuesta de cada cromosoma genera el universo completo de soluciones factibles, donde es posible encontrar valores óptimos globales de solución y cumple con las restricciones del problema.

Reflexiones sobre la huerta y propuestas para su conservación. VII Jornadas en Defensa de la Huerta (La huerta, código genético del territorio y la sociedad)

Cátedra Arzobispo Loazes, Universidad de Alicante.

ACONSELHAMENTO PASTORAL E A LEITURA POPULAR DA BÍBLIA: UM DIÁLOGO COM O PENSAMENTO DE CARLOS MESTERS

O presente trabalho aborda as contribuições da Leitura Popular da Bíblia (LPB), na perspectiva de Carlos Mesters, para os processos de cuidado no Aconselhamento Pastoral (AP). Ao repensar criticamente os modelos de Aconselhamento Pastoral (AP), a partir dos principais autores publicados no Brasil sobre o tema, verifica-se que o como fazer do aconselhamento pastoral é fundamental. Da mesma forma que refletir o como usar a Bíblia nos processos de cuidado e auxílio no aconselhamento deveria estar diretamente relacionado ao saber escutar e discernir a necessidade do outro. Sendo assim, é proveitoso integrar à reflexão e prática do cuidado pastoral, enquanto aconselhamento, as perspectivas da espiritualidade e das ciências do comportamento humano com a metodologia da LPB. A LPB empresta seu modo hermenêutico de ver, julgar e agir e aproveita a pedagogia de Paulo Freire nos processos relacionais entre aconselhador/a e aconselhando/a. Este trabalho pretende assim propor uma leitura de mundo que parta da vida vivida levando em consideração a idade, etnia, situação socioeconômica, estado civil, gênero, etc., no sentido de proporcionar saúde integral ao ser humano. Este tipo de leitura articulada com as contribuições da LPB pode promover melhor as habilidades para a escuta que reconheça as relações no Aconselhamento Pastoral como um processo pedagógico e libertador entre aconselhador/a e aconselhando/a. Processo em que a leitura contextualizada, integral e libertadora da Bíblia e ciências humanas iluminam o caminho para uma vida mais humanizadora.

Conservação de material genético de espécies silvestres do bioma caatinga utilizando a manipulação oócitos inclusos em folículos ovarianos pré antrais (MOIFOPA)

The objective of the present thesis was to use the manipulation of oocytes enclosed in preantral follicles (MOEPF) as a tool for the female gametes rescue and optimization, from wild species of Caatinga biome. The thesis was divided into 4 experiments. At first experiment, it was performed the estimative and description of the agouti (Dasyprocta leporina) preantral follicles (PF) histologic and ultrastructural features, in which it was estimated 4419.8 ± 532.26 and 5397.52 ± 574.91 follicles for the right and left ovary, respectively, and the majority (86,63%) belonged to the primordial follicles category (P<0.05). Most of the population consists of morphologically normal follicles (70.78%), presenting a large and central nuclei and uniform cytoplasm. At ultrastructural evaluation it was verified the presence of a great number of round mitochondrias associated to lipid droplets. In the second experiment, it was performed the estimative and description of yellow-toothed cavies (Galea spixii) PF characteristics, also, the evaluation of the effect of solid surface vitrification (SSV) on the in situ PF morphology. The total of 416.0 ± 342.8 PF was estimated for the ovary pair and the presence of a large quantity of primary follicles (P<0.05) was evidenced. Most of the PF was morphologically normal (94.6%), in which the oocyte nuclei presented condensed granules of heterochromatin. Round or elongated shaped mitochondria constituted the most abundant organelles. In regard of the SSV, the protocol using the dimethylsulfoxide (DMSO) 3M possibility the preservation of 69.5% of morphologically normal PF, which was evidenced by the light and transmission electronic microscopy. At third experiment, the evaluation of the SSV procedure on the morphology and viability in situ PF form collared peccaries (Pecari tajacu) was performed. No differences were observed among treatments, in which the use of DMSO, ethylene glycol (EG) and dimethylformamide (DMF) as cryoprotectants, regardless its concentration, promoted the morphology preservation of much than 70% of PF. Concerning the PF viability, the DMSO and EG promoted the best preservation. The fourth experiment aimed to evaluate the effect of α MEM+ or TCM199 associated or not to 50 ng of FSHr on the morphology, activation and growth of collared peccaries PF, in vitro cultured (IVC) during 1 or 7 days and the effect on the extracellular matrix (ECM). After 7 days of IVC only the use of TCM199/FSH maintained the proportion of intact PF, similar to day 1(63.2%), however, no differences were observed among treatments (P>0.05). Also, an improvement of the proportion of intact growing PF was verified (P>0.05). By the Ag-NOR analysis it was observed that only the treatment using TCM199/FSH promoted the maintenance of cell proliferation similar to day 1 (P>0.05). The picrosirius red stain revealed that ECM remained intact in all treatments (P>0.05). Thus, as the general conclusion, the use of MOEPF in the refereed species allowed the knowledge of aspects related to its reproductive morphology and physiology, enabling the germplasm conservation, with the possibility of germplasm bank formation, as the elucidation of mechanisms related to the PF survive and in vitro development.

Estratégia de navegação com planejamento dinâmico e algoritmo genético aplicada a robôs móveis terrestres

This work proposes a new autonomous navigation strategy assisted by genetic algorithm with dynamic planning for terrestrial mobile robots, called DPNA-GA (Dynamic Planning Navigation Algorithm optimized with Genetic Algorithm). The strategy was applied in environments - both static and dynamic - in which the location and shape of the obstacles is not known in advance. In each shift event, a control algorithm minimizes the distance between the robot and the object and maximizes the distance from the obstacles, rescheduling the route. Using a spatial location sensor and a set of distance sensors, the proposed navigation strategy is able to dynamically plan optimal collision-free paths. Simulations performed in different environments demonstrated that the technique provides a high degree of flexibility and robustness. For this, there were applied several variations of genetic parameters such as: crossing rate, population size, among others. Finally, the simulation results successfully demonstrate the effectiveness and robustness of DPNA-GA technique, validating it for real applications in terrestrial mobile robots.

Estratégia de navegação com planejamento dinâmico e algoritmo genético aplicada a robôs móveis terrestres

This work proposes a new autonomous navigation strategy assisted by genetic algorithm with dynamic planning for terrestrial mobile robots, called DPNA-GA (Dynamic Planning Navigation Algorithm optimized with Genetic Algorithm). The strategy was applied in environments - both static and dynamic - in which the location and shape of the obstacles is not known in advance. In each shift event, a control algorithm minimizes the distance between the robot and the object and maximizes the distance from the obstacles, rescheduling the route. Using a spatial location sensor and a set of distance sensors, the proposed navigation strategy is able to dynamically plan optimal collision-free paths. Simulations performed in different environments demonstrated that the technique provides a high degree of flexibility and robustness. For this, there were applied several variations of genetic parameters such as: crossing rate, population size, among others. Finally, the simulation results successfully demonstrate the effectiveness and robustness of DPNA-GA technique, validating it for real applications in terrestrial mobile robots.

Estudio genético HLA en poblaciones iraníes: epidemiología, antropología y farmacogenética

The HLA system is the most polymorphic genetic system described in humans. It consists of several closely linked loci encoding cell surface glycoproteins whose best known function is activating immune system response through antigenic presentation. New loci and new alleles have been described since the discovery of this genetic system and the presently available DNA typing and sequencing of these new alleles have increased the variety of HLA allelism. Due to the fact that HLA gene frequencies have a large degree of variability and a remarkable geographical correlation, HLA genes are an important and useful tool to infer genetic background and ethnical composition of modern human populations and also for tracing migration of ancient ones. In addition, certain combinations of contiguous alleles due to the strong linkage disequilibrium between HLA neighbouring loci show a characteristic frequency or are distinctive in many present day populations. Thus, HLA genetic system is a unique tool for studying the origin of relatively isolated groups, like Turkmen, Azeri and Kurd people, the populations under study, living in North Iran, in the surrounding area of Caspian Sea. Finally, HLA polymorphism is crucial for the compatibility between donor and receptor in organ transplantation and several HLA alleles have been linked to diseases and to response to drug treatments, which accomplishes relationships of certain variants with different pathologies treatment including AIDS. This is important in personalized treatments design. Turkmen could be descendants of Oghuz tribes from Seljuq branch coming from Transoxiana region (Central Asia) contemporarily to the foundation of the Seljuk Empire in 10th century AD. Conversely, this people could belong to another group within the Oghuz, arriving to Iran five centuries later. Migrations of this people were initially developed peacefully, being vassals of the Safavid Empire, and later by violent raids. They speak a language belonging to the Turkish-Oghuz group. In Iran, Turkmen live in Golestan province, mainly in Türkmensähra (“Turkmen plain”) area and amount 1.5 million people (2% of Iranian population). Most of this people are Sunni Muslims...

Revisión sistemática y metanálisis del rendimiento diagnóstico de los hallazgos ecográficos componentes del sonograma genético realizado en el segundo trimestre de gestación para la detección de Síndrome de Down

El impacto que tienen los defectos congénitos sobre la salud de las personas afectadas, sus familias y sobre la sociedad en su conjunto es muy considerable. En España se estima que existe una prevalencia de anomalías cromosómicas hasta 2010 de 1,49% de los recién nacidos vivos. El Síndrome de Down (SD) es la tercera causa de defecto congénito y la primera de cromosomopatía, con una prevalencia de 23 por cada 10000 nacidos vivos. La importante morbilidad asociada en los individuos con síndrome de Down se acompaña de un alto coste económico, estimándose en 329750,63 euros por cada nuevo caso, constituyendo un cargo a lo largo de la vida de 1316 millones de euros. Por todo ello, la detección de esta alteración es la indicación más frecuente de diagnóstico prenatal invasivo. Las pruebas invasivas, como amniocentesis, biopsia de vellosidades coriales y cordocentesis, se asocian con un aumento del 1% del riesgo de aborto y, por tanto, sólo se realizan cuando se considera que hay una probabilidad elevada de que el feto tenga un defecto cromosómico, siendo por tanto fundamental una buena selección del grupo de gestantes de alto riesgo...