266 resultados para RIÑÓN - BIOPSIA
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"Fourth edition."
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The function of criticism at the present time.--The literary influence of academies.--Maurice de Guérin.-- Eugénie de Guérin.--Heinrich Heine.--Pagan and medieval religious sentiment.--Joubert.--Spinoza.--Marcus Aurelius.--On translating Homer: three lectures.--On translating Homer: last words.--A French Eton.
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Includes index.
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This thesis presents a numerical and experimental investigation on applications of ultralong Raman fibre lasers in optical communications, supercontinuum generation and soliton transmission. The research work is divided in four main sections. The first involves the numerical investigation of URFL intra-cavity power and the relative intensity noise transfer evolution along the transmission span. The performance of the URFL is compared with amplification systems of similar complexity. In the case of intracavity power evolution, URFL is compared with a first order Raman amplification system. For the RIN transfer investigation, URFL is compared with a bi-directional dual wavelength pumping system. The RIN transfer function is investigated for several cavity design parameters such as span length, pump distribution and FBG reflectivity. The following section deals with experimental results of URFL cavities. The enhancement of the available spectral bandwidth in the C-band and its spectral flatness are investigated for single and multi-FBGs cavity system. Further work regarding extended URFL cavity in combination with Rayleigh scattering as random distributed feedback produced a laser cavity with dual wavelength outputs independent to each other. The last two sections relate to URFL application in supercontinuum (SC) generation and soliton transmission. URFL becomes an enhancement structure for SC generation. This thesis shows successful experimental results of SC generation using conventional single mode optical fibre and pumped with a continuous wave source. The last section is dedicated to soliton transmission and the study of soliton propagation dynamics. The experimental results of exact soliton transmission over multiple soliton periods using conventional single mode fibre are shown in this thesis. The effect of the input signal, pump distribution, span length and FBGs reflectivity on the soliton propagation dynamics is investigated experimentally and numerically.
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We report on the generation of 42 fs pulses at 1 µm in a completely fiber-integrated format, which are, to the best of our knowledge, the shortest from all-fiber-integrated Yb-doped fiber lasers to date. The ring fiber cavity incorporates anomalous-dispersion, solid-core photonic crystal fiber with low birefringence, which acts as a broadband, in-fiber Lyot filter to facilitate mode locking. The oscillator operates in the stretched-pulse regime under slight normal net cavity dispersion. The cavity generates 4.7 ps long pulses with a spectral bandwidth of 58.2 nm, which are dechirped to 42 fs via a grating pair compressor outside of the cavity. Relative intensity noise (RIN) of the laser is characterized, with the integrated RIN found to be 0.026% in the 3 Hz-250 kHz frequency range.
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A transmission performance investigation using ultra-long Raman fibre laser based amplification with different co-pump power is presented. We attribute Q2 factor degradation to RIN of co-pump and induced fibre laser as well as increased SBS.
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We present, for the first time, a detailed investigation of the impact of second order co-propagating Raman pumping on long-haul 100G WDM DP-QPSK coherent transmission of up to 7082 km using Raman fibre laser based configurations. Signal power and noise distributions along the fibre for each pumping scheme were characterised both numerically and experimentally. Based on these pumping schemes, the Q factor penalties versus co-pump power ratios were experimentally measured and quantified. A significant Q factor penalty of up to 4.15 dB was observed after 1666 km using symmetric bidirectional pumping, compared with counter-pumping only. Our results show that whilst using co-pumping minimises the intra-cavity signal power variation and amplification noise, the Q factor penalty with co-pumping was too great for any advantage to be seen. The relative intensity noise (RIN) characteristics of the induced fibre laser and the output signal, and the intra-cavity RF spectra of the fibre laser are also presented. We attribute the Q factor degradation to RIN induced penalty due to RIN being transferred from the first order fibre laser and second order co-pump to the signal. More importantly, there were two different fibre lasing regimes contributing to the amplification. It was random distributed feedback lasing when using counter-pumping only and conventional Fabry-Perot cavity lasing when using all bidirectional pumping schemes. This also results in significantly different performances due to different laser cavity lengths for these two classes of laser.
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A novel low-cost photonic PON-to-RoF bridge is presented, allowing simultaneous wireline and wireless multi-Gbps data transmission with minor impact on deployed PON networks. Simulation results show that the proposed scheme does not require narrow-linewidth lasers when envelope detector mobile terminals are used, since the transmission performance is not limited by the phase noise but by the RIN and the frequency difference between the two beating lasers. © 2013 IEEE.
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We demonstrate that a distributed Raman amplification scheme based on random distributed feedback (DFB) fiber laser enables bidirectional second-order Raman pumping without increasing relative intensity noise (RIN) of the signal. This extends the reach of 10 × 116 Gb/s DP-QPSK WDM transmission up to 7915 km, compared with conventional Raman amplification schemes. Moreover, this scheme gives the longest maximum transmission distance among all the Raman amplification schemes presented in this paper, whilst maintaining relatively uniform and symmetric signal power distribution, and is also adjustable in order to be highly compatible with different nonlinearity compensation techniques, including mid-link optical phase conjugation (OPC) and nonlinear Fourier transform (NFT).
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We propose and experimentally demonstrate a new method to extend the range of Brillouin optical time domain analysis (BOTDA) systems. It exploits the virtual transparency created by second-order Raman pumping in optical fibers. The idea is theoretically analyzed and experimentally demonstrated in a 50 km fiber. By working close to transparency, we also show that the measurement length of the BOTDA can be increased up to 100 km with 2 meter resolution. We envisage extensions of this technique to measurement lengths well beyond this value, as long as the issue of relative intensity noise (RIN) of the primary Raman pump can be avoided. © 2010 Optical Society of America.
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The thesis presents a detailed study of different Raman fibre laser (RFL) based amplification techniques and their applications in long-haul/unrepeatered coherent transmission systems. RFL based amplifications techniques were characterised from different aspects, including signal/noise power distributions, relative intensity noise (RIN), mode structures of induced Raman fibre lasers, and so on. It was found for the first time that RFL based amplification techniques could be divided into three categories in terms of the fibre laser regime, which were Fabry-Perot fibre laser with two FBGs, weak Fabry-Perot fibre laser with one FBG and very low reflection near the input, and random distributed feedback (DFB) fibre laser with one FBG. It was also found that lowering the reflection near the input could mitigate the RIN of the signal significantly, thanks to the reduced efficiency of the Stokes shift from the FW-propagated pump. In order to evaluate the transmission performance, different RFL based amplifiers were evaluated and optimised in long-haul coherent transmission systems. The results showed that Fabry-Perot fibre laser based amplifier with two FBGs gave >4.15 dB Q factor penalty using symmetrical bidirectional pumping, as the RIN of the signal was increased significantly. However, random distributed feedback fibre laser based amplifier with one FBG could mitigate the RIN of the signal, which enabled the use of bidirectional second order pumping and consequently give the best transmission performance up to 7915 km. Furthermore, using random DFB fibre laser based amplifier was proved to be effective to combat the nonlinear impairment, and the maximum reach was enhanced by >28% in mid-link single/dual band optical phase conjugator (OPC) transmission systems. In addition, unrepeatered transmission over >350 km fibre length using RFL based amplification technique were presented experimentally using DP-QPSK and DP-16QAM transmitter.
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A 2014–2020-as programozási időszak jogszabályi kialakításában az Európai Bizottság eredeti szándéka a minőségi és hatékony felhasználás volt, amelynek eszközrendszerét hosszú előkészítési folyamat során dolgozták ki a tagállamokkal. A tematikus forrásallokációban és abszorpciós ütemezésben is szigorodott felhasználás nem segítette elő a tagállami sajátosságokhoz illeszkedő, rugalmasabb programkialakítást, sem annak időbeni előrehaladását. A tartalmi megoldásokban is korlátozott tagállamok még bonyolultabb, és előzetesen átláthatatlanabb feltételek közé szorultak, ugyanakkor az intézményrendszeri kialakítások tekintetében ez a szigor kevésbé tapasztalható. Utóbbi jelenség azonban sok esetben nem javítja a felhasználást, ha szélsőséges változtatásokkal vagy bonyolult kialakítással terhelt. A hazai programozási tartalmakat, és intézményrendszert az uniós elvárások és lehetőségek tükrében bemutató tanulmány láttatja azokat a szűk keresztmetszeteket, amelyek között Magyarországnak (is) maradnia kell a fejlesztési források elnyerése, és a nettó pozíció érvényesítése érdekében.
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Receptor mediated endocytosis effectively removes the "ears" with which a cell would "hear" a signal conveyed by extracellular signaling molecules, but does not necessarily block the signaling pathway in which the endocytosed receptor participates. In the process of signal attenuation, this newly formed vesicle is fused with a phagosome and the receptor molecules are degraded. Receptor mediated endocytosis as a way to attenuate epidermal growth factor (EGF) and insulin signaling will be the focus here. Ras Interference 1 (Rin 1) is a multifunctional protein involved in intracellular membrane trafficking and receptor mediated endocytosis through its Rab5 Guanine Exchange Factor and SH2 domains. The goal of this investigation is to determine the role of key amino acids involved in the interaction of Rinl with Epidermal Growth Factor Receptor and Rab5. To elucidate this role, a number of point mutations have been created and the effects of each mutation on Rin 1 function will be investigated. Key amino acids in the SH2 and Vps9 Domain were identified and effects of mutations on rate of endocytosis were observed.
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El impacto que tienen los defectos congénitos sobre la salud de las personas afectadas, sus familias y sobre la sociedad en su conjunto es muy considerable. En España se estima que existe una prevalencia de anomalías cromosómicas hasta 2010 de 1,49% de los recién nacidos vivos. El Síndrome de Down (SD) es la tercera causa de defecto congénito y la primera de cromosomopatía, con una prevalencia de 23 por cada 10000 nacidos vivos. La importante morbilidad asociada en los individuos con síndrome de Down se acompaña de un alto coste económico, estimándose en 329750,63 euros por cada nuevo caso, constituyendo un cargo a lo largo de la vida de 1316 millones de euros. Por todo ello, la detección de esta alteración es la indicación más frecuente de diagnóstico prenatal invasivo. Las pruebas invasivas, como amniocentesis, biopsia de vellosidades coriales y cordocentesis, se asocian con un aumento del 1% del riesgo de aborto y, por tanto, sólo se realizan cuando se considera que hay una probabilidad elevada de que el feto tenga un defecto cromosómico, siendo por tanto fundamental una buena selección del grupo de gestantes de alto riesgo...
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Among the different possible amplification solutions offered by Raman scattering in optical fibers, ultra-long Raman lasers are particularly promising as they can provide quasi-losless second order amplification with reduced complexity, displaying excellent potential in the design of low-noise long-distance communication systems. Still, some of their advantages can be partially offset by the transfer of relative intensity noise from the pump sources and cavity-generated Stokes to the transmitted signal. In this paper we study the effect of ultra-long cavity design (length, pumping, grating reflectivity) on the transfer of RIN to the signal, demonstrating how the impact of noise can be greatly reduced by carefully choosing appropriate cavity parameters depending on the intended application of the system. © 2010 Copyright SPIE - The International Society for Optical Engineering.