Pièces relatives à l'histoire de la ville de TULLE. III

Contient : Pièces diverses ; originaux et copies, parmi lesquels on remarque les suivants : ; Notice généalogique sur la maison d'Aubusson ; Généalogie de la famille de Varie ; Extrait des titres de la maison de Sainte-Aulaire ; Mandement d'André-Daniel de Sainte-Aulaire, évêque de Tulle, touchant l'usage des oeufs durant le carême (25 février 1710) ; Billet d'invitation au sacre dudit évêque (29 octobre 1702) ; imprimé ; Extrait des archives de Pompadour ; Extrait de registres d'hommages de l'évêché de Limoges ; Extrait des archives de Pompadour ; Billet d'invitation aux obsèques d'Antoine de Baluze, résident à la cour de Pologne (13 septembre 1681) ; imprimé ; Deux lettres d'A[ndré]-D[aniel de Sainte-Aulaire], évêque de Tulle, à Baluze (7 novembre 1715 et 4 juillet 1710) ; originaux ; Lettre du maréchal-duc de la Feuillade à Baluze (Versailles, 22 d��cembre 1688) ; original ; Lettre de Teyssier de Regis à Baluze (Uzerche, 21 janvier 1689) ; original ; Billet du maréchal-duc de La Feuillade à Baluze (24 février 1687) ; Extrait d'un registre du Trésor des chartes, certifié par G.-J.-B. de Goth, duc d'Epernon (20 février 1687), envoyé par lui au maréchal de La Feuillade ; Lettre de Duverdier à Baluze (Tulle, 14 février 1686) ; Deux lettres de l'abbé de Fouilhac à Baluze (s. d.) ; « Harangue prononcée dans l'officialité de Tulle par Me Jean-Baptiste Brossard, » copie de la main de Baluze ; « Carmen in laudem J.-B. Brossard, » en vers latins ; page d��tachée d'un imprimé ; Recueil de copies de la main de Baluze : ; Lettre de M. Lejeune, sans adresse (Paris, 7 avril 1674) ; Harangue prononcée par devant messieurs du chapitre de Tulle par Me Etienne Courrèze ; Harangue adressée à Mascaron, lors de son avènement au siège de Tulle, par le doyen de cette ville, Pierre de La Rue (1672) ; Harangue prononcée par M. le conseiller Lagarde au jour de son installation (4 septembre 1674) ; Requête burlesque de Me Jean-Baptiste Brossard à messieurs du sénéchal et du présidial de Tulle ; Mandement du roi au trésorier de l'Épargne de payer au sieur Baluze la somme de mille livres (26 octobre 1663) ; Deux quittances d��livrées par Guillaume, évêque de Tarse, au nom d'Etienne Baluze (1540) ; originaux, parchemin ; Quittance donnée par les syndics de l'église de Tulle à M. Baluze, commissaire enquêteur au sénéchal de ladite ville (21 novembre 1625) ; Généalogie de la famille Baluze ; Lettre de M. de Fenis à M. Baluze, avocat à Tulle (Bordeaux, 7 mars 1596) ; original ; Pièces concernant Antoine de Baluze : ; Deux lettres écrites [à Et. Baluze ?] de Varsovie par J.-C. de Baluze (s. d. et 12 juin 1716) ; Mémoire envoyé par le même original ; Lettre de [Marie-Louise], reine de Pologne à Louis XIV (28 janvier 1662) ; Lettre de J.-C. Baluze (19 d��cembre 1683) ; Lettre de recommandation [du roi de Pologne] pour Baluze ; Lettre de Jean-Casimir, roi de Pologne, à [Henri de la Motte-Houdancourt], archevêque d'Auch (18 mai 1663) ; Lettres du même à Louis XIV (20 janvier 1662 et 11 janvier 1664) ; Lettre du même au cardinal Mazarin (12 juillet 1660) ; original ; Lettre sans adresse de François Le Hérisson (Léopol en Russie, 30 novembre 1662) ; Note sur la carrière d'Antoine de Baluze en Pologne ; Deux lettres écrites de Varsovie par J.-C. Baluze (16 novembre et 31 août 1714) ; Notice, de la main de Baluze, sur son cousin Antoine Baluze ; Notice du même sur Jean-Casimir Baluze, fils d'Antoine ; Dissertatio de sanctis Claro, Laudo, Vlfardo, Baumado, par Et. Baluze ; imprimé, Tulle, 1656, 40 pages in-8° ; « Noel paschal, ou hymne sacro-burlesque pour l'heureux avènement de Monseigneur de Tulle [Louis de Rechignevoisin de Guron] en son evesché, par le sieur de Chateaunières, » envoyé d'Uzerche le 29 juin 1654

La Declaració quebequesa sobre els arxius en català: unir-se per reaccionar i actuar

Entre 2003 i 2005, els 1.000 arxivers quebequesos que treballaven en els 300 serveis d'arxius i que estaven agrupats en 9 associacions, es van unir per reaccionar davant de certes situacions o per actuar sobre el seu entorn. Aquestes accions els fan prendre conciència de la seva força col·lectiva i els inciten a treballar en la redacció d'una Declaració quebequesa sobre els arxius per traduir la seva implicació professional i les seves ganes de treballar per a la constitució, la conservació i la valorització dels arxius de la seva societat.

El nom fa la cosa? Les biblioteques per a pacients: una aproximació terminològica

En el marc d'un projecte més ampli d'estudi sobre les biblioteques per a pacients a Catalunya i Espanya, s'han detectat importants vacil·lacions terminològiques en les fonts bibliogràfiques consultades a l'hora de designar les biblioteques per a pacients. L'objectiu és reflexionar sobre el que implica aquesta diversitat de designacions possibles i detectar si els termes emprats descriuen el servei que s'ofereix a partir de la consulta de les següents fonts: obres de consulta generals, obres de consulta especialitzades (terminologia, diccionaris i enciclopèdies, llistes d��encapçalaments de matèria i tesaurus) i obres teòriques especialitzades en serveis bibliotecaris a pacients hospitalizats (monografies, articles, comunicacions, memòries i textos legals i normatius). Com que el problema va més enllà del català i el castellà, també s¿ha revisat bibliografia en anglès, francès i italià.

Ética ecológica y bioética: algunos apuntes

Desde fines del siglo XX muchos autores se han dedicado a reflexionar los alcances de la técnica humana y la acción del hombre en el mundo, desde diferentes matices. En lí­neas gruesas, se aprecia la reflexión de la ética aplicada en dos ámbitos: la bioética y la ética ecológica. Ambas son complementarias entanto una ética relacionada a la vida humana y los diferentes retos a los que la enfrenta su manipulación técnica, se vincula estrechamente con las conceptualizaciones y alcances prácticos de la manipulación técnica del ecosistema y la Biósfera, así­ como de los destinos de los componentes de estosecosistemas, considerados tanto a nivel de comunidades como de seres o entidades individuales. No podemos hablar de una Bioética centrada en los problemas de la vida humana, ni de una Ética ambiental centrada en las dinámicas y procesos colectivos, sin interpelar a ambas dimensiones y definir espacios de reflexióncomunes. Es una tarea acuciante para la ética aplicada huir de lo uní­voco y pensar desde la complejidad de lo real. Para ello, es necesario generar unas reflexiones que relacionan la especie humana con otros individuos y con otras especies, re-pensar el lugar que el hombre tiene en el cosmos y las conductas que puede asumir en función de la libertad y la racionalidad que lo caracterizan.A efectos prácticos, en la primera parte del trabajo analizará conceptos relevantes de la ética ecológica, en una segunda parte sus principales corrientes, los desarrollos conceptuales de cada cual y las crí­ticas internas relacionadas a sus contenidos y alcances prácticos. En la tercera parte analizará la relación de la ética ecológica y sus conceptos con la bioética, para delinear algunos escenarios analí­ticos deseables y posibles para el desarrollo de una bioética a la altura de la complejidad de los tiempos que hoy vivimos.

Funil de haines modificado: curvas de retenção de solos próximos à saturação

O movimento da água através da matriz do solo é geralmente modelado pelas equações de Darcy, Darcy-Buckingam e Richards, cujo uso está baseado no conhecimento de algumas propriedades físicas do solo, como, por exemplo, a distribuição de poros e a retenção de água pelo solo. A retenção de água pelo solo é conhecida a partir da determinação de sua curva de retenção (CR) ou curva característica. O primeiro objetivo deste trabalho foi apresentar um aparato simples, desenvolvido pela modificação do funil de placa porosa (funil de Haines), para a investigação e o levantamento de CRs detalhadas, em amostras de solos em condições de umidade próximas à saturação e em amostras com potenciais mátricos (ψm) que vão desde 0 kPa a aproximadamente -12 kPa (120 cm de altura de coluna de água). Foram investigados agregados de um Latossolo Vermelho distrófico (LVd) de uma região do Estado do Paraná, cujos diâmetros médios e densidades variaram, respectivamente, entre 1,6 e 5,7 cm e 1,01 e 1,31 g cm-3, e amostras arenosas reconstituídas com areias de diâmetros médios entre 0,106 mm e 2,000 mm, com dimensões fractais de fracionamento (Df) entre 2,5 e 3,0. O segundo objetivo do trabalho foi inferir a distribuição de poros das amostras investigadas. Isso foi conseguido utilizando-se os parâmetros de ajuste da curva de van Genuchtenaos pontos das CRs obtidas para a determinação da Função Capacidade de Água (FCA). Pela análise dessas FCAs, observou-se que as amostras de agregados de solo apresentaram um sistema poroso de maior complexidade; e que a variação da granulometria do solo arenoso está diretamente relacionada às modificações de suas propriedades de retenção de água. Finalmente, a variação na densidade dos agregados investigados não alterou significativamente o comportamento das curvas de retenção na faixa de tensões estudadas.

Lentivector immunization induces tumor antigen-specific B and T cell responses in vivo.

Expression of the cancer/germ-line antigen NY-ESO-1 by tumors elicits spontaneous humoral and cellular immune responses in some cancer patients. Development of vaccines capable of stimulating such comprehensive immune responses is desirable. We have produced recombinant lentivectors directing the intracellular synthesis of NY-ESO-1 (rLV/ESO) and have analyzed the in vivo immune response elicited by this vector. Single injection of rLV/ESO into HLA-A2-transgenic mice elicited long-lasting B and T cell responses against NY-ESO-1. CD8+ T cells against the HLA-A2-restricted peptide NY-ESO-1(157-165) were readily detectable ex vivo and showed restricted TCR Vbeta usage. Moreover, rLV/ESO elicited a far greater anti-NY-ESO-1(157-165) CD8+ T cell response than peptide- or protein-based vaccines. Anti-NY-ESO-1 antibodies were rapidly induced after immunization and their detection preceded that of the antigen-specific CD8+ T cells. The rLV/ESO also induced CD4+ T cells. These cells played an essential role as their depletion completely abrogated B cell and CD8+ T cell responses against NY-ESO-1. The induced CD4+ T cells were primarily directed against a single NY-ESO-1 epitope spanning amino acids 81-100. Altogether, our study shows that rLV/ESO induces potent and comprehensive immune responses in vivo.

Mapping the transcription start points of the Staphylococcus aureus eap, emp, and vwb promoters reveals a conserved octanucleotide sequence that is essential for expression of these genes.

Mapping the transcription start points of the eap, emp, and vwb promoters revealed a conserved octanucleotide sequence (COS). Deleting this sequence abolished the expression of eap, emp, and vwb. However, electrophoretic mobility shift assays gave no evidence that this sequence was a binding site for SarA or SaeR, known regulators of eap and emp.

Use of Incentive/Disincentive Contracting to Mitigate Work Zone Traffic Impacts, 2012

Incentive/disincentive clauses (I/D) are designed to award payments to contractors if they complete work ahead of schedule and to deduct payments if they exceed the completion time. A previously unanswered question is, “Did the costs of the actual work zone impacts that were avoided justify the incentives paid?” This report answers that question affirmatively based on an evaluation of 20 I/D projects in Missouri from 2008 to 2011. Road user costs (RUC) were used to quantify work zone impacts and included travel delays, vehicle operating costs, and crash costs. These were computed using work zone traffic conditions for partial-closure projects and detour volumes and routes for full-closure projects. Conditions during construction were compared to after construction. Crash costs were computed using Highway Safety Manual methodology. Safety Performance Functions produced annual crash frequencies that were translated into crash cost savings. In considering an average project, the percentage of RUC savings was around 13% of the total contract amount, or $444,389 of $3,464,620. The net RUC savings produced was around $7.2 million after subtracting the approximately $1.7 million paid in incentives. In other words, for every dollar paid in incentives, approximately 5.3 dollars of RUC savings resulted. I/D provisions were very successful in saving RUC for projects with full-closure, projects in urban areas, and emergency projects. Rural, non-emergency projects successfully saved RUC but not at the same level as other projects. The I/D contracts were also compared to all Missouri Department of Transportation contracts for the same time period. The results show that I/D projects had a higher on-time completion percentage and a higher number of bids per call than average projects. But I/D projects resulted in 4.52% higher deviation from programmed costs and possibly more changes made after the award. A survey of state transportation departments and contractors showed that both agreed to the same issues that affect the success of I/D contracts. Legal analysis suggests that liquidated damages is preferred to disincentives, since enforceability of disincentives may be an issue. Overall, in terms of work zone impact mitigation, I/D contracts are very effective at a relatively low cost.

Analysis of naturally acquired CD4+T-cell responses to MAGE-A3 and MAGE-A4 cancer/testis antigens in patients with resected head and neck squamous cell carcinoma

Despite advances in the medical and surgical treatment of Head and Neck (HN) squamous cell carcinoma (HNSCC), long term survival has remained unchanged in the last 20 years. The obvious limitations of traditional therapeutic options strongly urge the development of novel therapeutic approaches. The molecular cloning of tumor antigens recognized by T lymphocytes in recent years has provided targets for specific immunotherapy. In this regard, frequent expression of Cancer Testis Antigens (CTA) has been repeatedly observed among HN tumors. We analyzed CTA expression in 46 HNSCC patients and found that MAGE-A3 and/or -A4 CTA were positive in over 70% of samples, regardless of the anatomical site of primary tumors in the upper aerodigestive tract. Still, immune responses against these CTA in HNSCC patients have not yet been investigated in detail. In this study we assessed the responsiveness of HNSCC patient's lymphocytes against overlapping peptides spanning the entire MAGE-A3 and -A4 proteins. After depletion of CD4+CD25+ regulatory T cells, and following three rounds of in vitro stimulation with pools of overlapping peptides, peripheral blood mononuclear cells (PBMCs) of HNSCC patients were screened by IFN-g and TNF-a intracellular cytokine staining for reactivity against MAGE-A3 or -A4 derived peptides. Cytokine secreting CD4+ T cells, specific for several peptides, were detected in 7/7 patients. In contrast, only 2/5 PBMC from healthy donors showed weak T cell responses against 2 peptides. CD4+ T cells specific for one epitope MAGE-A3(281-295), previously described as an HLA-DR11 restricted epitope naturally processed and presented by dendritic cells and tumor cells, were detected in two patients. MAGE-A3(161-175) specific CD4+ T cells were found in one patient. Six MAGE-A3 and -A4 new epitopes are being characterized. Together, these data suggest that naturally acquired CD4+ T cell responses against CT antigens occur in vivo in HNSCC patients, providing a rational basis for the use of the identified peptides in vaccination protocols.

Parents living with HIV in a high-income country: do patients need specific support?

The number of HIV-infected persons with children and caregiving duties is likely to increase. From this statement, the present study was designed to establish how HIV infected caregivers organise their parenting routines and to determine their support needs. A further aim was to ascertain caregivers' perception of conspicuous behaviours displayed by their children. Finally, it sought to determine the extent to which the caregivers' assessment of their parenting activity is influenced by the required support and their children's perceived conspicuous behaviours. The study design was observational and cross-sectional. Sampling was based on the 7 HIV Outpatient Clinics associated with the national population-based Swiss HIV Cohort Study. It focused on persons living with HIV who are responsible for raising children below the age of 18. A total of 520 caregivers were approached and 261 participated. An anonymous, standardised, self-administered questionnaire was used for data collection. The data were analysed using descriptive statistical procedures and backward elimination multiple regression analysis. The 261 respondents cared for 406 children and adolescents under 18 years of age; the median age was 10 years. The caregivers' material resources were low. 70% had a net family income in a range below the median of Swiss net family income and 30% were dependent on welfare assistance. 73% were undergoing treatment with 86% reporting no physical impairments. The proportion of single caregivers was 34%. 92% of the children were living with their HIV infected caregivers. 80% of the children attended an institution such as a school or kindergarten during the day. 89% of the caregivers had access to social networks providing support. Nevertheless, caregivers required additional support in performing their parenting duties and indicated a need for assistance on the material level, in connection with legal problems and with participation in the labour market. 46% of the caregivers had observed one or more conspicuous behaviours displayed by their children, which indicates a challenging situation. However, most of these caregivers assessed their parenting activity very favourably. Backward elimination multiple regression analysis indicated that a smaller number of support needs, younger age of the eldest child and fewer physical impairments on the part of the caregiver enhance the caregivers' assessment of their parenting activity. Physicians should speak to caregivers living with HIV about their parenting responsibilities and provide the necessary scope for this subject in their consultation sessions. Physicians are in a position to draw their patients' attention to the services available to them.