Investigação da participação de adrenoceptores α1 no efeito antinociceptivo da amitriptilina em um modelo de dor neuropática

Tricyclic antidepressants, such as amitriptyline, are inhibitors of serotonin and norepinephrine neuronal reuptake and this action has been implied in changes in pain threshold supporting its use to alleviate neuropathic pain. Although is known that 1 adrenoceptors participate in the antinociceptive effect of amitriptyline it is unclear which receptor subtype is the target for the increased synaptic levels of norepinephrine resultant from the inhibition of neuronal uptake. Paradoxically, several tricyclic antidepressants including amitriptyline also behave as antagonists of 1 adrenoceptors with different affinities for its subtypes: these drugs have 10 to 100-fold higher affinities for 1A than for 1B and 1D adrenoceptors. This work investigated the involvement of 1 adrenoceptors subtypes in the antinociceptive effect of the amitriptyline in a constriction of the sciatic nerve in rats by determining the effects of subtype selective 1 adrenoceptors antagonists. Fifteen days later, mechanical hyperalgesia was analyzed in a Randall-Selitto test. The 1A-selective antagonist RS100329 was the most potent antagonist of the contractions of the rat prostate, whereas the 1D-selective antagonist BMY 7378 (up to 100g/Kg) was unable to affect these contractions. The antagonist prazosin, BMY 7378 and 5-methyl urapidil inhibited the antinociceptive effect of the amitriptyline. However, the highly selective 1A adrenoceptor antagonist RS100329 was unable to affect the antinociception induced by amitriptyline. These results point out that 1B and/or 1D adrenoceptors, but not 1A, are involved in the antinociceptive effects of amitriptyline

O ensino de oncologia em enfermagem: um panorama do Brasil, Estados Unidos e outros países

The incidence of neoplasias has increased worldwide every year, and the training of qualified nurses for quality care provision to oncologic patients is necessary. This study aimed at identifying, in the literature, how oncology has been taught in the curricula of several undergraduate nursing programs in Brazil, the United States and other countries. The articles were located on Internet-based databases, namwly Lilacs and Scopus, from which 35 publications were found, and 18 articles were included. In Brazil, oncology is taught in undergraduate nursing programs in an isolated and punctual fashion, and it is not included in curricula. Parallelly, in the other countries included in the study, similarity was found as to this aspect; however, there is evidence of the implantation of elective and extracurricular courses. It is noteworthy that, in Brazil, there is evidence of government policies for oncology teaching and cancer control; nevertheless, such guidelines have not been concretized in curricula. The study showed a scenario in which oncology teaching in undergraduate nursing programs is insufficient or inexistent both in Brazil and in other countries, which compromises the training of future qualified professionals that will be attentive to that theme, since cancer is a frequent pathology, and the presence of nurses is fundamental for the care of such patients from diagnosis to cure, or even during occasional death

Sobre a questão da autonomia na prática docente com professores e professoras: leitura e diálogo

O estudo busca, num ato comprometido, aproximar-se das questões da autonomia na prática docente a partir do diálogo com autores(as) e com professoras(es) da rede pública de Ensino Básico com vistas no repensar da noção de autonomia na prática docente. Na primeira parte, familiarizo-me com o cenário no qual estamos inseridos: influências da globalização e da política neoliberal sobre as políticas educacionais brasileiras, como nos discursos dos PCNs e os currículos oficiais. Em seguida, dialogo com alguns autores sobre o que se compreende por autonomia e as questões da autonomia na prática docente. Com eles, vou descobrindo afinidades. Na segunda parte, em busca do diálogo com e entre professoras(es), organizei um grupo de discussão por meio de um curso. O Curso de Difusão Cultural - Leituras de Paulo Freire: autonomia e subjetividade - foi um espaço criado no intuito de fomentar o diálogo, a reflexão e a troca de saberes entre professoras(es) e alunas(os) de licenciatura a partir de escritos de Paulo Freire. A escolha dos textos pautou-se no entendimento destes como disparadores de reflexões que pudessem acercar-se do tema em estudo. Cada encontro apresentava uma leitura antecipada na qual sugeri que destacassem trechos a serem compartilhados e discutidos com os demais colegas no encontro seguinte. Durante as leituras, para cada texto, propus que escrevessem algo relacionando os trechos destacados com suas práticas docentes; nomeei esta atividade de produção escrita. Após o término dos encontros, os materiais de registros – gravações em audiovisual, produções escritas e anotações em caderno de registros – foram analisados. Nota-se que, mesmo diante de tantas incoerências de uma política educacional que pouco promove a legitimação de seu discurso, a autonomia na prática docente, como a compreendo neste estudo, não pode ser exclusivamente dada nem... (Resumo completo, clicar acesso eletrônico abaixo)

Investigação do envolvimento de subtipos de adrenoceptores α1 no efeito anti-imobilidade da imipramina no teste de suspensão pela cauda

Pós-graduação em Ciências Biológicas (Farmacologia) - IBB

Avaliação de danos oxidativos no DNA de linfócitos e estresse oxidativo no plasma de pacientes a cirurgia sob anestesia balanceada com sevoflurano

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Identidade e estudos organizacionais: em direção a um novo paradigma?

This paper aimes to contribute to the analyzes of Caldas and Wood Jr (1997) concerning to the concept of identity. That concept has been developed in Organization Studies under the propositions of Albert and Whetten (1985). In that way, identity concept has been defined by the following characteristics: centrality, distinctiveness and continuity. Nevertheless, a new paradigm has been emerging within social science. In this paper, we present a synthesis on how the concept of identity has been discussed in Social Psychology and Cultural Studies. For both theoretical perspectives, the ideas of centrality and durability are put into doubt, as identity is seen as dynamic and fragmentary. Besides that, we intend to show how the new paradigm is getting formed within Organizational Studies, especially considering international context. Considering that the emerging organizational ideas concerning identity show proximity with those proposed by Social Psychology and Cultural Studies, we raise possible questions that the new paradigm will have to face.

Economia da educação, inovação tecnológica e o conceito de capital humano

The paper shows the basic economic theories that support the rationality behind the financial and technological dominance in present social relations, and try to demonstrate the paradoxes and contradictions of the theoretical system, having as background elements from the Frankfurt School. From the field of theoretical economics of education, authors discuss the concept of human capital with its economical dimensions, presenting their affinities and disparities with Keynesians, neoclassical economics and the evolutionary economics of Schumpeter.

Os projetos políticos de Brasil e Venezuela para a América do Sul do século XXI: a UNASUL e a ALBA em uma perspectiva comparada

Coordenação de Aperfeiçoamento de Pessoal de Ensino Superior (CAPES)

Chega de Fiu Fiu: o papel do ciberfeminismo na construção do feminismo na era da Web 2.0

Esta monografia tem como objetivo abordar o ciberfeminismo, um fenômeno social e político recente, na construção do feminismo na era da Web 2.0 a partir de conteúdos produzidos por mulheres, para mulheres e sobre mulheres e veiculados na internet por meio de blogs e redes sociais. Para isso, será feito um estudo de caso do think tank Olga e seus desdobramentos em blog, redes sociais e campanhas contra o assédio sexual batizadas de Chega de Fiu Fiu. Para analisar esse material, o pensamento pós-estruturalista foi o escolhido, junto ao saber situado, por suas afinidades com a perspectiva feminista

Dois mineiros no meio de campo carioca: reflexões acerca da dialogia entre crônicas de drummond e campos

This text aims to analyze two chronicles: Drummond’s “Pelé, the Wizard”, and Campos’s “Mané Garrincha”. These texts, although they have been taken from various works, respectively, When the day is football (2006); and The Goal is needed: chronic sports (2008), both dealing with the same theme: Soccer. Therefore, we seek to raise reciprocal relationships between these two works, always in search of possible thematic-stylistic affinities present in the fiction of both authors. More specifically, we intend to present the two books, then analyze the two chronicles, considering that approach, too, by dazzle that manifest in relation to football and metalinguistic approach by giving the theme.

Da teoria crítica ao pós-estruturalismo: breves apontamentos para uma possível confrontação entre Adorno e Deleuze

The Frankfurt critical theory and the French post-structuralism are important lines of thought in the philosophy of education, which inspired several academic productions in recent decades. In the 1950s and 1960s, both opposed philosophical resistance against many types of totalitarianism. One big difference between the two lines of thought has been the critical of the dialectic considered an insufficient method to think about the difference (Deleuze) and the reaffirmation of a negative dialectic (Adorno). This article intends to analyze the thematic affinities and the differences of method between the thought of these two authors.

Estratégias de enfrentamento em crianças em situação pré-cirúrgica: relação com idade, sexo, experiência com cirurgia e estresse

This study's aim was to verify coping strategies among children aged between 7 and 12 years old who will be experiencing surgery and the potential relationship of coping strategies with sociodemographic variables, stress in children and in companions, and the child's prior experience with surgery. A total of 58 children hospitalized and waiting for elective surgeries responded to the Assessment Instrument of Coping to Hospitalization and an instrument to assess stress. The companion received a sociodemographic questionnaire and the Lipp Stress Symptom Inventory. Problem-solving strategies and distraction were the most frequent strategies used, while social withdrawal and opposition were the least frequent. Girls and children of stressful parents used emotion regulation strategies with significantly more frequency. Likewise, greater cognitive restructuring was observed in older children and those with prior experience with surgeries. The results show the need to consider the studied variables when developing pre-operative preparation programs.

Religiosidade e mito na obra de José Carlos Mariátegui e a teologia da libertação

Pós-graduação em Ciências Sociais - FCLAR

A afinidade com a Física: uma análise feita com estudantes da Universidade Federal de Mato Grosso do Sul (UFMS)

The aim of this study is to investigate aspects that influenced students of Physics at the Federal University of Mato Grosso do Sul (UFMS) to choose that course and the influence that their own teachers had on their decision. In order to do that, a questionnaire was prepared and answered by forty-five students of Physics (bachelor's course or teacher's course). In the results we highlighted that those students developed affinities with physics knowledge before choosing the course. The analysis suggests that the teacher, although not predominant in these choices, is an important catalyst, thus influencing students to choose a career in science co-operating.

Dos readymade ao design contemporâneo

From Marcel Duchamp’s readymade, tried to establish a historical overview with emphasis on the possible affinities between art and design from modernity, seeking to end weave such a reflection on the contemporary condition.