Limit cycles for singular perturbation problems via inverse integrating factor

In this paper singularly perturbed vector fields Xε defined in ℝ2 are discussed. The main results use the solutions of the linear partial differential equation XεV = div(Xε)V to give conditions for the existence of limit cycles converging to a singular orbit with respect to the Hausdorff distance. © SPM.

Geração de padrões de corte n-grupos para a indústria moveleira

Neste artigo são apresentadas propostas de soluções para o problema de geração de padrões de corte n-grupos para o corte da matéria-prima na indústria moveleira. Este problema NP-difícil aparece em diversos outros processos industriais que incluem o corte de painéis retangulares grandes de tamanho padrão em retângulos menores. O planejamento dos cortes é um aspecto importante do planejamento da produção nestas indústrias, pois efeitos negativos tais como o perda de matériaprima e tempo de preparo da máquina de corte podem ser minimizados, diminuindo assim os custos de produção. É estudada a eficiência de modelos lineares inteiros para resolver o problema do corte guilhotinado bidimensional propostos em [33,34], bem como o seu uso na geração de colunas para o problema de corte de estoque. São usados dados reais de uma fábrica de móveis de pequeno porte característica do pólo moveleiro de Votuporanga/SP. Os resultados obtidos indicam que as estratégias propostas geram perdas dentro dos requisitos exigidos pela fábrica. © SPM.

Finiteness of hermitian levels of some algebras

We characterize the hermitian levels of quaternion and octonion algebras and of an 8-dimensional algebra D over the ground field F, constructed using a weak version of the Cayley-Dickson double process. It is shown that all values of the hermitian levels of quaternion algebras with the hat-involution also occur as hermitian levels of D. We give some limits to the levels of the algebra D over some ground field. © Soc. Paran. de Mat.

Aspectos económicos de la equidad de género

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Estrategias de desarrollo sectorial para los años ochenta: industria y agricultura

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Homeobox gene expression profile indicates HOXA5 as a candidate prognostic marker in oral squamous cell carcinoma

The search for molecular markers to improve diagnosis, individualize treatment and predict behavior of tumors has been the focus of several studies. This study aimed to analyze homeobox gene expression profile in oral squamous cell carcinoma (OSCC) as well as to investigate whether some of these genes are relevant molecular markers of prognosis and/or tumor aggressiveness. Homeobox gene expression levels were assessed by microarrays and qRT-PCR in OSCC tissues and adjacent non-cancerous matched tissues (margin), as well as in OSCC cell lines. Analysis of microarray data revealed the expression of 147 homeobox genes, including one set of six at least 2-fold up-regulated, and another set of 34 at least 2-fold down-regulated homeobox genes in OSCC. After qRT-PCR assays, the three most up-regulated homeobox genes (HOXA5, HOXD10 and HOXD11) revealed higher and statistically significant expression levels in OSCC samples when compared to margins. Patients presenting lower expression of HOXA5 had poorer prognosis compared to those with higher expression (P=0.03). Additionally, the status of HOXA5, HOXD10 and HOXD11 expression levels in OSCC cell lines also showed a significant up-regulation when compared to normal oral keratinocytes. Results confirm the presence of three significantly upregulated (>4-fold) homeobox genes (HOXA5, HOXD10 and HOXD11) in OSCC that may play a significant role in the pathogenesis of these tumors. Moreover, since lower levels of HOXA5 predict poor prognosis, this gene may be a novel candidate for development of therapeutic strategies in OSCC.

América Latina: la política industrial en el marco de la nueva Estrategia Internacional para el Desarrollo

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Estrategia de desarrollo agrícola para los años ochenta

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IL-4 and IL-13 inhibit IL-1β and TNF-α induced kinin B 1 and B2 receptors through a STAT6-dependent mechanism

Background and Purpose Bone resorption induced by interleukin-1β (IL-1β) and tumour necrosis factor (TNF-α) is synergistically potentiated by kinins, partially due to enhanced kinin receptor expression. Inflammation-induced bone resorption can be impaired by IL-4 and IL-13. The aim was to investigate if expression of B1 and B2 kinin receptors can be affected by IL-4 and IL-13. Experimental Approach We examined effects in a human osteoblastic cell line (MG-63), primary human gingival fibroblasts and mouse bones by IL-4 and IL-13 on mRNA and protein expression of the B1 and B2 kinin receptors. We also examined the role of STAT6 by RNA interference and using Stat6-/- mice. Key Results IL-4 and IL-13 decreased the mRNA expression of B1 and B2 kinin receptors induced by either IL-1β or TNF-α in MG-63 cells, intact mouse calvarial bones or primary human gingival fibroblasts. The burst of intracellular calcium induced by either bradykinin (B2 agonist) or des-Arg10-Lys-bradykinin (B1 agonist) in gingival fibroblasts pretreated with IL-1β was impaired by IL-4. Similarly, the increased binding of B1 and B2 ligands induced by IL-1β was decreased by IL-4. In calvarial bones from Stat6-deficient mice, and in fibroblasts in which STAT6 was knocked down by siRNA, the effect of IL-4 was decreased. Conclusions and Implications These data show, for the first time, that IL-4 and IL-13 decrease kinin receptors in a STAT6-dependent mechanism, which can be one important mechanism by which these cytokines exert their anti-inflammatory effects and impair bone resorption. © 2013 The Authors. British Journal of Pharmacology © 2013 The British Pharmacological Society.

Informe de la reunión de directores de energía e hidrocarburos de los países del Sistema de la Integración Centroamericana sobre temas para la actualización de la estrategia energética (Ciudad de Guatemala, Guatemala, 21 y 22 de abril de 2015)

1. El programa de trabajo de la Sede Subregional de la Comisión Económica para América Latina y el Caribe (CEPAL) en México ha incluido la realización de reuniones de expertos, las cuales tienen el propósito de discutir temas relevantes para los países con los que trabaja esta oficina subregional. En el caso de la energía, esas reuniones generalmente se han coorganizado con la Secretaría General del Sistema de la Integración Centroamericana (SG-SICA) y los organismos regionales especializados del sector energía. También se han realizado reuniones de expertos para examinar problemas específicos del sector energía de interés para algunos países. En algunos casos, estos eventos se han llevado a cabo con el apoyo de instituciones regionales y organismos de cooperación. 2. La CEPAL es parte de las instituciones que conforman el grupo interinstitucional de apoyo al proceso de integración y desarrollo energético de Centroamérica. En marzo de 2015 la SG-SICA y su Unidad de Coordinación Energética (UCE-SICA) solicitaron a la CEPAL su apoyo para organizar una reunión de expertos con los directores de energía e hidrocarburos de los países de la subregión, con el propósito de revisar y discutir los siguientes temas: a) actualización de la Estrategia Energética Sustentable Centroamericana; b) convergencia de políticas energéticas en países del SICA; c) seguimiento a proyectos y actividades de la agenda energética regional de la UCE-SICA, y d) temas relacionados con el funcionamiento de la UCE-SICA, así como agenda para la próxima reunión del Consejo de Ministros de Energía.

Essential oil composition of Croton palanostigma Klotzsch from north Brazil

Os óleos essenciais das folhas, ramos finos, galhos, cascas do caule e frutos de Croton palanostigma foram analisados por CG e CG-EM. Os componentes principais determinados no óleo das folhas foram linalol (25,4%), (E)-cariofileno (21,0%), metileugenol (17,2%) e β-elemeno (6,0%); no óleo dos ramos finos foram α-pineno (41,4%), limoneno (29,0%), sabineno (11,5%) e β-pineno (5,7%); no óleo dos galhos foram metileugenol (24,1%), (E)-metilisoeugenol (15,3%), α-pineno (11,2%) e (E)-cariofileno (8,5%); no óleo das cascas do caule foram a-pineno (31,6%), metileugenol (25,6%) e (E)-metilisoeugenol (23,7%); e no óleo dos frutos foram linalol (42,7%), metileugenol (16,3%) e β-elemeno (6,4%). Análise estatística mostrou que as folhas e os frutos apresentam significante similaridade entre si, assim como os galhos e as cascas do caule. Adicionalmente, o óleo obtido das cascas do caule possui elevada atividade larvicida sobre Artemia salina (CL₅₀, 3,71 ± 0,01 mg mL^-1).

Substratos e estaquia na produção de mudas de cacaueiro

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