Tuning DNA “strings”: Modulating the rate of DNA replication with mechanical tension

Recent experiments have measured the rate of replication of DNA catalyzed by a single enzyme moving along a stretched template strand. The dependence on tension was interpreted as evidence that T7 and related DNA polymerases convert two (n = 2) or more single-stranded template bases to double helix geometry in the polymerization site during each catalytic cycle. However, we find structural data on the T7 enzyme–template complex indicate n = 1. We also present a model for the “tuning” of replication rate by mechanical tension. This model considers only local interactions in the neighborhood of the enzyme, unlike previous models that use stretching curves for the entire polymer chain. Our results, with n = 1, reconcile force-dependent replication rate studies with structural data on DNA polymerase complexes.

On the Complex Dimensions of Nonlattice Fractal Strings in Connection with Dirichlet Polynomials

In this paper we give a new characterization of the closure of the set of the real parts of the zeros of a particular class of Dirichlet polynomials that is associated with the set of dimensions of fractality of certain fractal strings. We show, for some representative cases of nonlattice Dirichlet polynomials, that the real parts of their zeros are dense in their associated critical intervals, confirming the conjecture and the numerical experiments made by M. Lapidus and M. van Frankenhuysen in several papers.

On a conjecture of Lapidus and van Frankenhuysen

In this paper it is shown that a conjecture of Lapidus and van Frankenhuysen of 2003 on the existence of a vertical line such that the density of the complex dimensions of nonlattice fractal strings with M scaling ratios off this line vanishes in the limit as M→∞, fails on the class of nonlattice self-similar fractal strings.

Pulling the Strings: Party Group Coordinators in the European Parliament

Since its post-Lisbon increase in (legislative and non-legislative) powers, the European Parliament (EP) is more relevant than ever in the geographically diversified multilevel system of the EU. Party group coordinators occupy a crucial position in collective decision-making within the EP. However, knowledge about these pivotal actors is absent. This raises the question as to who these party group coordinators are, what they do, and what indeed makes a good coordinator. A new data set shows that in 2012, more than one-fifth of coordinators of the three largest and most influential groups are German, with British and Spanish coordinators ranking a distant second before Romanians. Among coordinators from NMS, only one-eighth were newcomers.

Elegy for strings : op. 58 /

Mode of access: Internet.

Quartet [E minor] for strings, Op. 16 /

Mode of access: Internet.

Quartet for strings. Op. 22.

Mode of access: Internet.

Quartet for strings, op. 16 /

Mode of access: Internet.

Serenade in G major : quartet for strings /

Mode of access: Internet.

Quartet for strings : Serenade in G major /

Caption title: Serenade in G major, for two violins, viola and violoncello.

Quartet for strings, Op. 16 /

Mode of access: Internet.

Phantasy quartet for strings = Fantaisie pour quatuor à cordes : op. 12 /

Mode of access: Internet.

Data compression for character strings /

Mode of access: Internet.

Quartet for strings.

Mode of access: Internet.

The random vibration of elastic strings-- theoretical.

"Materials Laboratory, Contract no. AF 33(616)-5426, project no. 7360."